Patj (PATJ, crumbs cell polarity complex component) - Rat Genome Database

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Pathways
Gene: Patj (PATJ, crumbs cell polarity complex component) Rattus norvegicus
Analyze
Symbol: Patj
Name: PATJ, crumbs cell polarity complex component
RGD ID: 1565362
Description: Predicted to be involved in several processes, including establishment of apical/basal cell polarity; positive regulation of epithelial cell migration; and tight junction assembly. Part of protein-containing complex. Orthologous to human PATJ (PATJ crumbs cell polarity complex component); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitriptyline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: InaD-like (Drosophila); InaD-like 2; InaD-like 2 (Drosophila); inaD-like protein; Inadl; Inadl2; LOC313382; PDZ domain protein; PDZ domain protein (Drosophila inaD-like); RGD1565362; similar to channel-interacting pdz domain protein isoform 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: PatjTn(sb-T2/Bart3)2.343Mcwi
Genetic Models: F344-PatjTn(sb-T2/Bart3)2.343Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,177,557 - 118,480,301 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,177,565 - 118,480,301 (+)EnsemblGRCr8
mRatBN7.25113,061,985 - 113,364,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,062,118 - 113,364,807 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5115,640,473 - 115,944,504 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,365,825 - 117,669,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,428,349 - 117,732,383 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,038,548 - 117,340,308 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,052,260 - 117,340,336 (+)Ensemblrn6Rnor6.0
Rnor_5.05120,981,525 - 121,281,044 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45118,806,744 - 119,131,114 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5111,633,199 - 111,931,738 (+)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Bufotalin  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibenzo[a,l]pyrene  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ketamine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
morphine  (ISO)
Muraglitazar  (EXP)
N-methyl-N-nitrosourea  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
Tesaglitazar  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Wong EW, etal., Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62. Epub 2008 Jul 10.
Additional References at PubMed
PMID:11964389   PMID:14758363   PMID:15225788   PMID:18596123   PMID:19056867   PMID:20152177   PMID:22006950   PMID:22337881   PMID:23533145   PMID:25636444  


Genomics

Comparative Map Data
Patj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,177,557 - 118,480,301 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5118,177,565 - 118,480,301 (+)EnsemblGRCr8
mRatBN7.25113,061,985 - 113,364,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,062,118 - 113,364,807 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5115,640,473 - 115,944,504 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,365,825 - 117,669,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,428,349 - 117,732,383 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,038,548 - 117,340,308 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,052,260 - 117,340,336 (+)Ensemblrn6Rnor6.0
Rnor_5.05120,981,525 - 121,281,044 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45118,806,744 - 119,131,114 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5111,633,199 - 111,931,738 (+)NCBICelera
Cytogenetic Map5q33NCBI
PATJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,742,480 - 62,163,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,742,477 - 62,178,675 (+)Ensemblhg38GRCh38
GRCh37162,208,152 - 62,629,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,980,737 - 62,402,180 (+)NCBIBuild 36Build 36hg18NCBI36
Celera160,496,772 - 60,918,615 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef160,320,895 - 60,742,543 (+)NCBIHuRef
CHM1_1162,323,629 - 62,744,942 (+)NCBICHM1_1
T2T-CHM13v2.0161,621,342 - 62,042,561 (+)NCBIT2T-CHM13v2.0
Patj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39498,283,803 - 98,607,840 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl498,284,022 - 98,607,840 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38498,395,560 - 98,719,603 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl498,395,785 - 98,719,603 (+)Ensemblmm10GRCm38
MGSCv37498,062,517 - 98,386,294 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36497,887,844 - 98,211,621 (+)NCBIMGSCv36mm8
Celera496,759,588 - 97,075,177 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.6NCBI
Patj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,409,623 - 27,629,731 (-)Ensembl
ChiLan1.0NW_00495542327,408,334 - 27,637,065 (-)NCBIChiLan1.0ChiLan1.0
PATJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21164,694,360 - 165,117,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,844,049 - 164,266,301 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0160,993,316 - 61,416,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,832,424 - 63,233,073 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,832,424 - 63,247,074 (+)EnsemblpanPan2panpan1.1
PATJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1547,913,433 - 48,268,043 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl547,914,284 - 48,256,861 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha547,973,462 - 48,335,754 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0548,097,120 - 48,453,049 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl548,097,122 - 48,452,964 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1548,051,707 - 48,405,688 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0547,998,363 - 48,352,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0548,260,886 - 48,617,091 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Patj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505875,084,131 - 75,401,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652225,143 - 332,126 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493652215,136 - 233,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PATJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6150,245,497 - 150,605,544 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16150,248,714 - 150,605,565 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26138,472,898 - 138,557,009 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PATJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12070,910,594 - 71,300,877 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2070,910,447 - 71,301,424 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603346,104,468 - 46,515,476 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Patj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474231,550,498 - 31,719,424 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474231,510,784 - 31,725,256 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Patj
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1155,804,846 - 56,078,723 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Patj
2035 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:615
Count of miRNA genes:253
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000010112, ENSRNOT00000010211, ENSRNOT00000057943, ENSRNOT00000065197
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1298077Bp157Blood pressure QTL 157arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5114474223121056531Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Rat25  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85118,176,414 - 118,176,602 (+)Marker Load Pipeline
mRatBN7.25113,060,909 - 113,061,097 (+)MAPPERmRatBN7.2
Rnor_6.05117,037,089 - 117,037,276NCBIRnor6.0
Rnor_5.05120,979,996 - 120,980,183UniSTSRnor5.0
RGSC_v3.45118,805,536 - 118,805,723UniSTSRGSC3.4
RGSC_v3.45118,805,535 - 118,805,723RGDRGSC3.4
Celera5111,631,991 - 111,632,178UniSTS
RGSC_v3.15118,810,762 - 118,810,949RGD
RH 3.4 Map5789.6UniSTS
RH 3.4 Map5789.6RGD
SHRSP x BN Map561.5499RGD
SHRSP x BN Map561.5499UniSTS
Cytogenetic Map5q33UniSTS
RH143216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,364,282 - 113,364,390 (+)MAPPERmRatBN7.2
Rnor_6.05117,339,784 - 117,339,891NCBIRnor6.0
Rnor_5.05121,280,905 - 121,281,012UniSTSRnor5.0
RGSC_v3.45119,131,961 - 119,132,068UniSTSRGSC3.4
Celera5111,931,214 - 111,931,321UniSTS
RH 3.4 Map5794.9UniSTS
Cytogenetic Map5q33UniSTS
RH142079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,362,916 - 113,363,115 (+)MAPPERmRatBN7.2
Rnor_6.05117,338,418 - 117,338,616NCBIRnor6.0
Rnor_5.05121,279,539 - 121,279,737UniSTSRnor5.0
RGSC_v3.45119,130,595 - 119,130,793UniSTSRGSC3.4
Celera5111,929,848 - 111,930,046UniSTS
RH 3.4 Map958.2UniSTS
Cytogenetic Map5q33UniSTS
AU049786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,246,624 - 113,246,759 (+)MAPPERmRatBN7.2
Rnor_6.05117,222,689 - 117,222,823NCBIRnor6.0
Rnor_5.05121,165,800 - 121,165,934UniSTSRnor5.0
RGSC_v3.45119,007,905 - 119,008,039UniSTSRGSC3.4
Celera5111,814,675 - 111,814,791UniSTS
Cytogenetic Map5q33UniSTS
UniSTS:234969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,335,953 - 113,336,240 (+)MAPPERmRatBN7.2
Rnor_6.05117,311,488 - 117,311,774NCBIRnor6.0
Rnor_5.05121,252,809 - 121,253,095UniSTSRnor5.0
RGSC_v3.45119,103,292 - 119,103,578UniSTSRGSC3.4
Celera5111,903,153 - 111,903,439UniSTS
Cytogenetic Map5q33UniSTS


Genetic Models
This gene Patj is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF313483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010211   ⟹   ENSRNOP00000010211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,623 - 118,480,301 (+)Ensembl
mRatBN7.2 Ensembl5113,062,118 - 113,364,807 (+)Ensembl
Rnor_6.0 Ensembl5117,052,260 - 117,340,336 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094178   ⟹   ENSRNOP00000092161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,623 - 118,447,579 (+)Ensembl
mRatBN7.2 Ensembl5113,062,118 - 113,332,082 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095175   ⟹   ENSRNOP00000079221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,623 - 118,480,301 (+)Ensembl
mRatBN7.2 Ensembl5113,062,118 - 113,364,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101438   ⟹   ENSRNOP00000077045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,623 - 118,480,301 (+)Ensembl
mRatBN7.2 Ensembl5113,062,118 - 113,364,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103328   ⟹   ENSRNOP00000097148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,322,670 - 118,478,699 (+)Ensembl
mRatBN7.2 Ensembl5113,207,165 - 113,363,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132099   ⟹   ENSRNOP00000103339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,623 - 118,477,166 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165802   ⟹   ENSRNOP00000105981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5118,177,565 - 118,479,908 (+)Ensembl
RefSeq Acc Id: NM_080398   ⟹   NP_536323
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,623 - 118,480,301 (+)NCBI
mRatBN7.25113,062,118 - 113,364,807 (+)NCBI
Rnor_6.05117,038,630 - 117,340,308 (+)NCBI
Celera5111,633,199 - 111,931,738 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763915   ⟹   XP_008762137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,298,341 (+)NCBI
mRatBN7.25113,062,054 - 113,182,942 (+)NCBI
Rnor_6.05117,038,616 - 117,159,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763916   ⟹   XP_008762138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,323,416 - 118,479,916 (+)NCBI
mRatBN7.25113,207,170 - 113,364,422 (+)NCBI
Rnor_6.05117,181,442 - 117,339,923 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109186   ⟹   XP_038965114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,479,916 (+)NCBI
mRatBN7.25113,062,054 - 113,364,422 (+)NCBI
RefSeq Acc Id: XM_039109188   ⟹   XP_038965116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,479,916 (+)NCBI
mRatBN7.25113,062,054 - 113,364,422 (+)NCBI
RefSeq Acc Id: XM_063287100   ⟹   XP_063143170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,479,916 (+)NCBI
RefSeq Acc Id: XM_063287101   ⟹   XP_063143171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,479,916 (+)NCBI
RefSeq Acc Id: XM_063287102   ⟹   XP_063143172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,177,557 - 118,479,916 (+)NCBI
RefSeq Acc Id: XM_063287103   ⟹   XP_063143173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,326,581 - 118,479,916 (+)NCBI
RefSeq Acc Id: XP_008762137   ⟸   XM_008763915
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008762138   ⟸   XM_008763916
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GME4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_536323   ⟸   NM_080398
- UniProtKB: F1MAD2 (UniProtKB/Swiss-Prot),   A0A8I6AG04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010211   ⟸   ENSRNOT00000010211
RefSeq Acc Id: XP_038965114   ⟸   XM_039109186
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMD2 (UniProtKB/TrEMBL),   A0A8I6AG04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965116   ⟸   XM_039109188
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AG04 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077045   ⟸   ENSRNOT00000101438
Ensembl Acc Id: ENSRNOP00000092161   ⟸   ENSRNOT00000094178
Ensembl Acc Id: ENSRNOP00000079221   ⟸   ENSRNOT00000095175
Ensembl Acc Id: ENSRNOP00000097148   ⟸   ENSRNOT00000103328
RefSeq Acc Id: XP_063143171   ⟸   XM_063287101
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AG04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143172   ⟸   XM_063287102
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZJD2 (UniProtKB/TrEMBL),   A0A8I6AG04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143170   ⟸   XM_063287100
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AG04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143173   ⟸   XM_063287103
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000103339   ⟸   ENSRNOT00000132099
Ensembl Acc Id: ENSRNOP00000105981   ⟸   ENSRNOT00000165802
Protein Domains
L27   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAD2-F1-model_v2 AlphaFold F1MAD2 1-1836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565362 AgrOrtholog
BioCyc Gene G2FUF-40588 BioCyc
Ensembl Genes ENSRNOG00000007551 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010211 ENTREZGENE
  ENSRNOT00000010211.9 UniProtKB/Swiss-Prot
  ENSRNOT00000095175 ENTREZGENE
  ENSRNOT00000101438 ENTREZGENE
  ENSRNOT00000103328 ENTREZGENE
  ENSRNOT00000165802 ENTREZGENE
Gene3D-CATH 1.20.1440.360 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
InterPro L27_2 UniProtKB/Swiss-Prot
  L27_dom UniProtKB/Swiss-Prot
  L27_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_scaffold UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:140581 UniProtKB/Swiss-Prot
NCBI Gene Patj ENTREZGENE
PANTHER INAD-LIKE PROTEIN UniProtKB/Swiss-Prot
  MULTIPLE PDZ DOMAIN PROTEIN UniProtKB/Swiss-Prot
Pfam L27_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Patj PhenoGen
PROSITE L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007551 RatGTEx
SMART L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
UniProt A0A8I5ZJD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GME4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LS64_RAT UniProtKB/TrEMBL
  A0ABK0LUK2_RAT UniProtKB/TrEMBL
  F1MAD2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-18 Inadl  InaD-like (Drosophila)  Inadl2  InaD-like 2 (Drosophila)  Data merged from RGD:621378 737654 APPROVED
2008-03-20 Inadl2  InaD-like 2 (Drosophila)  Inadl  InaD-like (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Inadl  InaD-like (Drosophila)  RGD1565362_predicted  similar to channel-interacting PDZ domain protein isoform 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565362_predicted  similar to channel-interacting PDZ domain protein isoform 1 (predicted)  LOC313382  similar to channel-interacting PDZ domain protein isoform 1  Symbol and Name status set to approved 1299863 APPROVED
2005-01-20 Inadl  InaD-like (Drosophila)    PDZ domain protein (Drosophila inaD-like)  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may participate in TRPC3 protein mediated 1alpha,25(OH)(2)D(3) modulation of CCE in muscle and osteoblastic cells 1304343