Clec7a (C-type lectin domain containing 7A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Clec7a (C-type lectin domain containing 7A) Rattus norvegicus
Analyze
Symbol: Clec7a
Name: C-type lectin domain containing 7A
RGD ID: 1565140
Description: Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of intracellular signal transduction; and response to fungus. Predicted to act upstream of or within several processes, including positive regulation of tumor necrosis factor production; regulation of intracellular signal transduction; and response to fungus. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A); PARTICIPATES IN phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; Clec7b; dectin-1; LOC502902; RGD1565140; similar to Clecsf12 protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,588,737 - 164,599,953 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4164,588,754 - 164,599,919 (-)EnsemblGRCr8
mRatBN7.24162,902,731 - 162,913,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,902,732 - 162,913,897 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4169,137,545 - 169,148,615 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,920,504 - 164,931,574 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,554,549 - 163,565,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,216,152 - 163,227,367 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,216,163 - 163,227,334 (-)Ensemblrn6Rnor6.0
Rnor_5.04211,859,714 - 211,870,889 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44166,723,515 - 166,734,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4151,587,575 - 151,598,651 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chitosan  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
furan  (ISO)
gardiquimod  (ISO)
glucose  (ISO)
GW 4064  (ISO)
indometacin  (EXP)
L-methionine  (ISO)
leukotriene C4  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
metam  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phthalaldehyde  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
vinclozolin  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antifungal innate immune response  (ISO)
apoptotic signaling pathway  (IEA,ISO)
cell activation  (ISO)
cell recognition  (IEA,ISO)
cell surface pattern recognition receptor signaling pathway  (IEA,ISO)
cell-cell adhesion  (ISO)
cellular response to molecule of fungal origin  (IEA,ISO)
detection of fungus  (IEA)
detection of molecule of fungal origin  (IEA,ISO)
detection of yeast  (ISO)
innate immune response  (IBA,ISO)
leukocyte activation involved in immune response  (ISO)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (IBA,IEA,ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell maturation  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cytokine production involved in immune response  (IBA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of lymphocyte activation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of respiratory burst  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
positive regulation of T-helper 17 type immune response  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of wound healing  (IEA,ISO)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of canonical NF-kappaB signal transduction  (IBA,ISO)
response to molecule of fungal origin  (ISO)
response to yeast  (ISO)
stimulatory C-type lectin receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses. Zhong J, etal., PLoS One. 2016 Mar 10;11(3):e0150114. doi: 10.1371/journal.pone.0150114. eCollection 2016.
Additional References at PubMed
PMID:11567029   PMID:12477932   PMID:18667041   PMID:19358895   PMID:20544345   PMID:21691936   PMID:22267217   PMID:23285072   PMID:24721111   PMID:25246527   PMID:25251945   PMID:32790017  


Genomics

Comparative Map Data
Clec7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,588,737 - 164,599,953 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4164,588,754 - 164,599,919 (-)EnsemblGRCr8
mRatBN7.24162,902,731 - 162,913,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,902,732 - 162,913,897 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4169,137,545 - 169,148,615 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,920,504 - 164,931,574 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,554,549 - 163,565,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,216,152 - 163,227,367 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,216,163 - 163,227,334 (-)Ensemblrn6Rnor6.0
Rnor_5.04211,859,714 - 211,870,889 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44166,723,515 - 166,734,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4151,587,575 - 151,598,651 (-)NCBICelera
Cytogenetic Map4q42NCBI
CLEC7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,116,777 - 10,130,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,116,777 - 10,130,258 (-)Ensemblhg38GRCh38
GRCh371210,269,376 - 10,282,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,160,643 - 10,174,135 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341210,171,190 - 10,174,103NCBI
Celera1215,430,059 - 15,443,548 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,012,523 - 10,026,010 (-)NCBIHuRef
CHM1_11210,238,652 - 10,252,134 (-)NCBICHM1_1
T2T-CHM13v2.01210,003,452 - 10,016,972 (-)NCBIT2T-CHM13v2.0
Clec7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,438,554 - 129,449,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,438,554 - 129,449,742 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386129,461,591 - 129,472,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,461,591 - 129,472,779 (-)Ensemblmm10GRCm38
MGSCv376129,411,609 - 129,422,795 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366129,427,284 - 129,438,465 (-)NCBIMGSCv36mm8
Celera6131,183,577 - 131,194,776 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.34NCBI
CLEC7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,604,637 - 15,617,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,599,522 - 15,614,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,161,780 - 10,174,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,410,384 - 10,425,452 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,410,384 - 10,425,452 (-)EnsemblpanPan2panpan1.1
CLEC7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,852,685 - 35,885,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,853,099 - 36,007,157 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2710,738,120 - 10,766,549 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02736,203,142 - 36,231,601 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,209,883 - 36,264,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,091,248 - 36,119,494 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,120,431 - 36,141,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,260,084 - 10,288,263 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clec7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,304,630 - 97,315,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936902436,312 - 446,076 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936902436,224 - 446,435 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,832,954 - 61,846,434 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1561,832,910 - 61,846,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,542,875 - 64,556,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLEC7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,989,520 - 10,007,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,995,203 - 10,006,746 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660892,066,063 - 2,084,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clec7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475226,871,292 - 26,891,910 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Clec7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1618,131,910 - 18,143,037 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clec7a
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:533
Count of miRNA genes:249
Interacting mature miRNAs:295
Transcripts:ENSRNOT00000052373, ENSRNOT00000059885
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH130710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24162,902,903 - 162,903,084 (+)MAPPERmRatBN7.2
Rnor_6.04163,216,335 - 163,216,515NCBIRnor6.0
Rnor_5.04211,859,887 - 211,860,067UniSTSRnor5.0
RGSC_v3.44166,723,688 - 166,723,868UniSTSRGSC3.4
Celera4151,587,748 - 151,587,928UniSTS
RH 3.4 Map41013.4UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 57 124 91 90 59 92 59 6 342 182 11 102 77 86 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000077793   ⟹   ENSRNOP00000069723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4164,592,948 - 164,599,919 (-)Ensembl
mRatBN7.2 Ensembl4162,904,376 - 162,913,897 (-)Ensembl
Rnor_6.0 Ensembl4163,217,813 - 163,227,334 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091552   ⟹   ENSRNOP00000073639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4164,588,754 - 164,599,827 (-)Ensembl
mRatBN7.2 Ensembl4162,902,732 - 162,913,805 (-)Ensembl
Rnor_6.0 Ensembl4163,216,163 - 163,227,242 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108367   ⟹   ENSRNOP00000087024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4164,588,754 - 164,599,827 (-)Ensembl
mRatBN7.2 Ensembl4162,902,732 - 162,913,805 (-)Ensembl
RefSeq Acc Id: NM_001173386   ⟹   NP_001166857
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,588,753 - 164,599,827 (-)NCBI
mRatBN7.24162,902,731 - 162,913,805 (-)NCBI
Rnor_6.04163,216,162 - 163,227,242 (-)NCBI
Rnor_5.04211,859,714 - 211,870,889 (-)NCBI
Celera4151,587,575 - 151,598,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237100   ⟹   XP_006237162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,588,737 - 164,599,944 (-)NCBI
mRatBN7.24162,902,731 - 162,913,924 (-)NCBI
Rnor_6.04163,216,152 - 163,227,365 (-)NCBI
Rnor_5.04211,859,714 - 211,870,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108259   ⟹   XP_038964187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,591,038 - 164,599,951 (-)NCBI
mRatBN7.24162,905,942 - 162,913,930 (-)NCBI
RefSeq Acc Id: XM_039108260   ⟹   XP_038964188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,593,286 - 164,599,953 (-)NCBI
mRatBN7.24162,907,264 - 162,913,931 (-)NCBI
RefSeq Acc Id: XR_001837491
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,590,388 - 164,599,949 (-)NCBI
mRatBN7.24162,904,367 - 162,913,929 (-)NCBI
Rnor_6.04163,217,851 - 163,227,367 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010065696
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,590,388 - 164,599,951 (-)NCBI
RefSeq Acc Id: NP_001166857   ⟸   NM_001173386
- UniProtKB: B5BUZ1 (UniProtKB/TrEMBL),   E9PTB9 (UniProtKB/TrEMBL),   A0A0G2JW33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237162   ⟸   XM_006237100
- Peptide Label: isoform X2
- UniProtKB: B5BUZ2 (UniProtKB/TrEMBL),   E9PTT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069723   ⟸   ENSRNOT00000077793
Ensembl Acc Id: ENSRNOP00000073639   ⟸   ENSRNOT00000091552
RefSeq Acc Id: XP_038964187   ⟸   XM_039108259
- Peptide Label: isoform X1
- UniProtKB: A6IM50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964188   ⟸   XM_039108260
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000087024   ⟸   ENSRNOT00000108367
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5BUZ1-F1-model_v2 AlphaFold B5BUZ1 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693435
Promoter ID:EPDNEW_R3960
Type:single initiation site
Name:Clec7a_1
Description:C-type lectin domain containing 7A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04163,227,268 - 163,227,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565140 AgrOrtholog
BioCyc Gene G2FUF-42780 BioCyc
Ensembl Genes ENSRNOG00000054251 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077793 ENTREZGENE
  ENSRNOT00000077793.3 UniProtKB/TrEMBL
  ENSRNOT00000091552 ENTREZGENE
  ENSRNOT00000091552.3 UniProtKB/TrEMBL
  ENSRNOT00000108367 ENTREZGENE
  ENSRNOT00000108367.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934181 IMAGE-MGC_LOAD
InterPro C-type_lectin UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CLEC7A UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/TrEMBL
KEGG Report rno:502902 UniProtKB/TrEMBL
MGC_CLONE MGC:188550 IMAGE-MGC_LOAD
NCBI Gene 502902 ENTREZGENE
PANTHER C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A UniProtKB/TrEMBL
  PTHR47218 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
PhenoGen Clec7a PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054251 RatGTEx
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
UniProt A0A0G2JW33 ENTREZGENE, UniProtKB/TrEMBL
  A6IM50 ENTREZGENE, UniProtKB/TrEMBL
  B2RYG9_RAT UniProtKB/TrEMBL
  B5BUZ1 ENTREZGENE, UniProtKB/TrEMBL
  B5BUZ2 ENTREZGENE, UniProtKB/TrEMBL
  E9PTB9 ENTREZGENE
  E9PTT6 ENTREZGENE
UniProt Secondary E9PTB9 UniProtKB/TrEMBL
  E9PTT6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Clec7a  C-type lectin domain containing 7A  Clec7a  C-type lectin domain family 7, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-08 Clec7a  C-type lectin domain family 7, member A  Clec7a  C-type lectin domain family 7, member a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Clec7a  C-type lectin domain family 7, member a  RGD1565140_predicted  similar to Clecsf12 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565140_predicted  similar to Clecsf12 protein (predicted)  LOC502902  similar to Clecsf12 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502902  similar to Clecsf12 protein      Symbol and Name status set to provisional 70820 PROVISIONAL