Ptgdrl1 (prostaglandin D2 receptor-like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ptgdrl1 (prostaglandin D2 receptor-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ptgdrl1 (Ensembl: Ptgdr)
Name: prostaglandin D2 receptor-like 1 (Ensembl:prostaglandin D2 receptor)
RGD ID: 1565108
Description: Enables prostaglandin D receptor activity. Involved in negative regulation of cytosolic calcium ion concentration; positive regulation of penile erection; and vasodilation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor); INTERACTS WITH trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498475; PGD receptor; PGD2 receptor; prostaglandin D receptor; prostaglandin D2 receptor; prostaglandin D2 receptor-like; prostanoid DP receptor; Ptgdr; Ptgdrl; RGD1565108; similar to prostaglandin D2 receptor
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81520,552,125 - 20,561,220 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1520,552,125 - 20,561,220 (-)EnsemblGRCr8
mRatBN7.21518,072,357 - 18,081,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,072,361 - 18,081,437 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1520,868,960 - 20,876,140 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01521,832,240 - 21,833,082 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,082,450 - 20,089,630 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,089,077 - 18,095,979 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,088,897 - 18,096,039 (-)Ensemblrn6Rnor6.0
Rnor_5.01522,066,550 - 22,073,452 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41520,059,427 - 20,066,609 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1518,503,117 - 18,510,295 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9721719   PMID:10448933   PMID:17643322   PMID:18047485   PMID:18212515   PMID:19576888  


Genomics

Variants

.
Variants in Ptgdrl1
35 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat

Markers in Region
D15Mit3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,078,563 - 18,078,771 (+)MAPPERmRatBN7.2
mRatBN7.21517,362,897 - 17,363,086 (+)MAPPERmRatBN7.2
Rnor_6.01519,198,200 - 19,198,388NCBIRnor6.0
Rnor_6.01518,093,208 - 18,093,415NCBIRnor6.0
Rnor_5.01523,164,604 - 23,164,792UniSTSRnor5.0
Rnor_5.01522,070,681 - 22,070,888UniSTSRnor5.0
RGSC_v3.41519,348,148 - 19,348,337RGDRGSC3.4
RGSC_v3.41520,063,838 - 20,064,045UniSTSRGSC3.4
RGSC_v3.41519,348,149 - 19,348,337UniSTSRGSC3.4
RGSC_v3.41520,063,837 - 20,064,045RGDRGSC3.4
Celera1518,507,528 - 18,507,737UniSTS
Celera1517,318,461 - 17,318,649UniSTS
RGSC_v3.11519,348,149 - 19,348,337RGD
RH 3.4 Map15143.08RGD
RH 3.4 Map15143.08UniSTS
SHRSP x BN Map1515.3399RGD
SHRSP x BN Map1515.3399UniSTS
Cytogenetic Map15p14UniSTS
D15Got105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,078,701 - 18,078,780 (-)MAPPERmRatBN7.2
mRatBN7.21517,362,888 - 17,362,989 (+)MAPPERmRatBN7.2
Rnor_6.01519,198,191 - 19,198,291NCBIRnor6.0
Rnor_5.01523,164,595 - 23,164,695UniSTSRnor5.0
RGSC_v3.41519,348,139 - 19,348,240RGDRGSC3.4
RGSC_v3.41519,348,140 - 19,348,240UniSTSRGSC3.4
Celera1517,318,452 - 17,318,552UniSTS
RGSC_v3.11519,348,140 - 19,348,240RGD
RH 3.4 Map15144.42UniSTS
RH 3.4 Map15144.42RGD
Cytogenetic Map15p14UniSTS
BF391109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,072,372 - 18,072,479 (+)MAPPERmRatBN7.2
Rnor_6.01518,087,297 - 18,087,403NCBIRnor6.0
Rnor_5.01522,064,770 - 22,064,876UniSTSRnor5.0
RGSC_v3.41520,057,647 - 20,057,753UniSTSRGSC3.4
Celera1518,501,337 - 18,501,443UniSTS
RH 3.4 Map15156.3UniSTS
Cytogenetic Map15p14UniSTS
PMC58788P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,080,715 - 18,080,828 (+)MAPPERmRatBN7.2
mRatBN7.21517,360,870 - 17,360,983 (-)MAPPERmRatBN7.2
mRatBN7.21518,080,715 - 18,080,828 (-)MAPPERmRatBN7.2
mRatBN7.21517,360,870 - 17,360,983 (+)MAPPERmRatBN7.2
Rnor_6.01519,196,173 - 19,196,285NCBIRnor6.0
Rnor_6.01518,095,360 - 18,095,472NCBIRnor6.0
Rnor_5.01523,162,577 - 23,162,689UniSTSRnor5.0
Rnor_5.01522,072,833 - 22,072,945UniSTSRnor5.0
RGSC_v3.41519,346,122 - 19,346,234UniSTSRGSC3.4
RGSC_v3.41520,065,990 - 20,066,102UniSTSRGSC3.4
Celera1517,316,433 - 17,316,545UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 30 102 40 40 18 10 18 6 136 61 5 86 41 87 22 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000041790   ⟹   ENSRNOP00000042734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1520,552,125 - 20,561,220 (-)Ensembl
mRatBN7.2 Ensembl1518,072,361 - 18,081,437 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042545   ⟹   ENSRNOP00000048101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1519,790,499 - 19,797,873 (+)Ensembl
mRatBN7.2 Ensembl1517,360,304 - 17,367,679 (+)Ensembl
Rnor_6.0 Ensembl1518,088,897 - 18,096,039 (-)Ensembl
RefSeq Acc Id: NM_001135164   ⟹   NP_001128636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81520,552,125 - 20,561,220 (-)NCBI
mRatBN7.21518,072,357 - 18,081,452 (-)NCBI
Rnor_6.01518,089,077 - 18,095,979 (-)NCBI
Rnor_5.01522,066,550 - 22,073,452 (-)NCBI
RGSC_v3.41520,059,427 - 20,066,609 (-)RGD
Celera1518,503,117 - 18,510,295 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001128636 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD23564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042734
GenBank Protein Q9R261 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001128636   ⟸   NM_001135164
- UniProtKB: Q9R261 (UniProtKB/Swiss-Prot),   F1LS27 (UniProtKB/TrEMBL),   F1LLW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048101   ⟸   ENSRNOT00000042545
Ensembl Acc Id: ENSRNOP00000042734   ⟸   ENSRNOT00000041790

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LS27-F1-model_v2 AlphaFold F1LS27 1-310 view protein structure
AF-Q9R261-F1-model_v2 AlphaFold Q9R261 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565108 AgrOrtholog
BioCyc Gene G2FUF-14234 BioCyc
Ensembl Genes ENSRNOG00000031307 Ensembl, ENTREZGENE
  ENSRNOG00000031535 Ensembl
Ensembl Transcript ENSRNOT00000041790 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Pglndn_D_rcpt UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:498475 UniProtKB/Swiss-Prot
NCBI Gene 498475 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
  PTHR11866:SF14 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ptgdrl1 PhenoGen
PRINTS PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDDPR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031307 RatGTEx
  ENSRNOG00000031535 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt F1LLW6 ENTREZGENE
  F1LS27 ENTREZGENE
  PD2R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-02 Ptgdrl1  prostaglandin D2 receptor-like 1  Ptgdrl  prostaglandin D2 receptor-like  Name and Symbol changed 629549 APPROVED
2013-05-24 Ptgdrl  prostaglandin D2 receptor-like  LOC100365780  hypothetical LOC100365780  Data merged from RGD:2318405 1643240 APPROVED
2010-05-05 LOC100365780  hypothetical LOC100365780      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-25 Ptgdrl  prostaglandin D2 receptor-like  Ptgdr  prostaglandin D receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Ptgdr  prostaglandin D receptor  RGD1565108_predicted  similar to prostaglandin D2 receptor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565108_predicted  similar to prostaglandin D2 receptor (predicted)  LOC498475  similar to prostaglandin D2 receptor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498475  similar to prostaglandin D2 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL