Tbc1d22b (TBC1 domain family, member 22B)

Gene: Tbc1d22b (TBC1 domain family, member 22B) Rattus norvegicus

Analyze

Symbol:

Tbc1d22b

Name:

TBC1 domain family, member 22B

RGD ID:

1564987

Description:

Predicted to enable 14-3-3 protein binding activity. Orthologous to human TBC1D22B (TBC1 domain family member 22B); INTERACTS WITH amphetamine; bisphenol A; fenvalerate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC502414; LOC502414; TBC1 domain family member 22B

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TBC1D22B (TBC1 domain family member 22B)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Tbc1d22b (TBC1 domain family, member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tbc1d22b (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TBC1D22B (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TBC1D22B (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tbc1d22b (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TBC1D22B (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TBC1D22B (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tbc1d22b (TBC1 domain family member 22B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TBC1D22A (TBC1 domain family member 22A)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	TBC1D22B (TBC1 domain family member 22B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tbc1d22b (TBC1 domain family, member 22B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tbc1d22b (TBC1 domain family, member 22B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GYP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5745	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tbc-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,620,716 - 7,676,809 (+)	NCBI		GRCr8
mRatBN7.2	20	7,619,096 - 7,675,232 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,619,240 - 7,675,231 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,322,218 - 8,378,138 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,683,370 - 7,739,294 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	8,156,586 - 8,212,516 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	8,216,097 - 8,278,344 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	8,235,607 - 8,276,394 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	10,434,810 - 10,477,829 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,880,190 - 7,921,453 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	9,157,057 - 9,212,231 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

dexamethasone (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

FR900359 (ISO)

genistein (EXP)

indometacin (ISO)

methimazole (EXP)

methoxychlor (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of cilium assembly (ISO)

Molecular Function

14-3-3 protein binding (ISO)

GTPase activator activity (IBA,IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17646400	PMID:23572552

Genomics

Comparative Map Data

Tbc1d22b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,620,716 - 7,676,809 (+)	NCBI		GRCr8
mRatBN7.2	20	7,619,096 - 7,675,232 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,619,240 - 7,675,231 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,322,218 - 8,378,138 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,683,370 - 7,739,294 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	8,156,586 - 8,212,516 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	8,216,097 - 8,278,344 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	8,235,607 - 8,276,394 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	10,434,810 - 10,477,829 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,880,190 - 7,921,453 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	9,157,057 - 9,212,231 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

TBC1D22B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	37,257,772 - 37,332,970 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	37,257,772 - 37,332,970 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	37,225,548 - 37,300,746 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	37,333,526 - 37,408,724 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	37,333,525 - 37,408,723	NCBI
Celera	6	38,780,572 - 38,855,711 (+)	NCBI		Celera
Cytogenetic Map	6	p21.2	NCBI
HuRef	6	36,944,503 - 37,019,647 (+)	NCBI		HuRef
CHM1_1	6	37,227,385 - 37,302,531 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	37,081,380 - 37,156,524 (+)	NCBI		T2T-CHM13v2.0

Tbc1d22b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	29,768,765 - 29,825,868 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	29,768,759 - 29,825,872 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	29,549,768 - 29,606,895 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	29,549,785 - 29,606,898 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	29,686,747 - 29,743,753 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	29,276,814 - 29,333,820 (+)	NCBI		MGSCv36	mm8
MGSCv36	17	28,763,075 - 28,819,028 (+)	NCBI		MGSCv36	mm8
Celera	17	30,089,887 - 30,147,409 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.43	NCBI

Tbc1d22b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	5,843,921 - 5,903,810 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	5,843,921 - 5,903,313 (-)	NCBI	ChiLan1.0	ChiLan1.0

TBC1D22B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	51,729,854 - 51,804,606 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	47,599,869 - 47,674,633 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	36,823,456 - 36,897,701 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	38,013,405 - 38,087,567 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	38,013,405 - 38,087,567 (+)	Ensembl	panpan1.1		panPan2

TBC1D22B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	6,289,704 - 6,367,643 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	6,292,459 - 6,415,382 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	6,309,345 - 6,392,716 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	6,755,782 - 6,839,180 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	6,755,545 - 6,832,855 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	6,292,260 - 6,375,621 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	6,374,672 - 6,458,047 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	6,473,618 - 6,557,026 (+)	NCBI		UU_Cfam_GSD_1.0

Tbc1d22b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	41,744,187 - 41,816,144 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	22,144,078 - 22,216,112 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	22,144,086 - 22,216,083 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TBC1D22B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	32,839,257 - 32,914,402 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	32,839,178 - 32,914,498 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	37,742,855 - 37,818,505 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TBC1D22B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	34,807,334 - 34,880,611 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	34,809,104 - 34,880,599 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	37,208,089 - 37,281,382 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tbc1d22b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	20,721,946 - 20,780,479 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	20,724,975 - 20,780,458 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tbc1d22b
429 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	523
Count of miRNA genes:	274
Interacting mature miRNAs:	350
Transcripts:	ENSRNOT00000000642
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat

Markers in Region

RH138173

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	7,657,572 - 7,657,731 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	8,261,973 - 8,262,131	NCBI	Rnor6.0
Rnor_5.0	20	10,461,388 - 10,461,546	UniSTS	Rnor5.0
RGSC_v3.4	20	7,904,010 - 7,904,168	UniSTS	RGSC3.4
Celera	20	9,195,268 - 9,195,426	UniSTS
RH 3.4 Map	20	94.9	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	24	11	4	13	4			66	27	34	4
Low		19	46	37	6	37	8	11	8	8	7	7	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY380821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000090298 ⟹ ENSRNOP00000069943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,636,821 - 7,675,231 (+)	Ensembl
Rnor_6.0 Ensembl	20	8,235,607 - 8,276,394 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093855 ⟹ ENSRNOP00000083239

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,619,240 - 7,675,231 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098523 ⟹ ENSRNOP00000081992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,632,303 - 7,675,231 (+)	Ensembl

RefSeq Acc Id:

NM_001025059 ⟹ NP_001020230

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,620,826 - 7,676,809 (+)	NCBI
mRatBN7.2	20	7,619,240 - 7,675,232 (+)	NCBI
Rnor_6.0	20	8,216,097 - 8,278,344 (+)	NCBI
Rnor_5.0	20	10,434,810 - 10,477,829 (+)	NCBI
RGSC_v3.4	20	7,880,190 - 7,921,453 (+)	RGD
Celera	20	9,157,057 - 9,212,231 (+)	RGD

Sequence:

show sequence

GACCCACTGACCAGGCCTTCCCCCGGGCCAGAGCGATGGCCGCCGAGAACAGCAAGCAGTTCTG
GAAGAGGAGCGCCAAGCTGCCGGGGAGCATTCAGCCCGTGTATGGAGCCCAGCACCCTCCTCTG
GACCCTCGGCTCACCAAAAACTTCATCAAAGAACGGTCGAAAGTCAACTCAGTTCCTCTGAAGA
ACAAGAAGGCCTCCAGTTTCCACGAGTTTGCCCGGAATACCAGTGACGCTTGGGACATTGGCGA
TGATGAGGAAGAGGACCTTTCCTCACCGTCTCTCCAAACCCTGAACTCGAAAGTGGCTTTGGCC
ACTGCAGCCCAAGTCCTGGAAAACCACAGCAAGCTGAGGGTGAAACCGGAACGGTCGCAGTCGA
CAACATCGGACGTCCCTGCCAACTACAAGGTCATAAAGTCCAGCAGTGACGCCCAGCTGTCCCG
AAATTCCAGTGACACGTGCCTGAGGAACACACTCCACAAACAACAGTCTCTCCCTCTCCGGCCC
ATCATCCCCCTCGTCGCCCGGATCTCAGACCAGAATGCTTCTGGGGCCCCTCCAATGACAGTCC
GGGAGAAAACCCGCCTCGAAAAGTTCCGCCAGCTGCTTTCAAGCCACAACACTGACTTAGATGA
ACTGAGGAAGTGGAGCTGGCCAGGCGTTCCCAGGGAAGTTCGACCAGTGACCTGGAGACTGCTG
TCGGGCTATCTCCCGGCAAACACCGAGCGGCGCAAGCTGACCCTGCAGCGGAAGCGGGAGGAGT
ACTTTGGCTTCATTGAGCAGTATTATGACTCTCGGAATGAAGAGCACCACCAGGACACCTACAG
ACAGATTCACATTGACATTCCAAGGACGAACCCTCTCATTCCCTTGTTCCAGCAGCCGCTCGTC
CAGGAGATCTTTGAACGAATTCTCTTTATTTGGGCCATCCGACACCCTGCCAGTGGGTATGTCC
AGGGAATTAATGACCTGGTCACTCCGTTCTTTGTCGTCTTCCTCTCGGAATACGTGGAAGAGGA
TGTGGAGAACTTCGACGTGACCAACCTGTCTCAGGACATGCTGCGGAGCATTGAGGCCGACAGC
TTCTGGTGCATGAGCAAGCTCCTGGATGGGATCCAGGATAATTACACGTTTGCACAACCAGGGA
TCCAGAAGAAGGTCAAAGCGCTGGAAGAGCTCGTCAGCCGGATCGATGAGCAGGTACACAGTCA
CTTCAGGAGGTATGAGGTGGAGTACCTGCAGTTTGCCTTCCGGTGGATGAACAACCTGCTGATG
CGGGAGCTTCCCCTGCGCTGCACCATCCGCCTGTGGGATACCTACCAGTCTGAGCCAGAAGGCT
TCTCGCACTTCCATCTCTACGTGTGCGCCGCCTTCTTGATCAAGTGGAGGAAGGAGATTTTGGA
TGAGGAAGACTTTCAGGGCCTCCTCATGCTGCTGCAGAACCTGCCTACGATCCACTGGGGCAAC
GAGGAGATCGGGCTGCTGCTGGCTGAGGCCTACAGACTCAAGTACATGTTTGCGGACGCCCCCA
ACCACTACCGCCGATAGGTGCTGTCTCTCCTGGGGACCCAGACTGCCCCCATCTCTGATGGCAA
TTTCATCACTGTGGCCACCGTGCAAGCCGTGGACCCCGGCCAGGAACCACTCCTGCTGTACAAA
GCTCGCCCCCCCACCGCAGCCACCACCACCACCACCACCCAGGTCTTAACTTCCCAGCATCCGT
CACTTTGTCTCGGGATGTCTATCTGGGACCACTGTCAGTATTCTGTGCCGTGTGGATGGGCCGG
GCTCTGGGAGAGGGCAGAGGGAAAGGGAGAGTTCTCTTTCCCTGGAAGACACTGGACAAAAGAA
GGGGAGGCCCTGGGTCTGCCCCCCATTGTCCATCCTCACCTGCCAGCTCTGCCCAGGAACCAGC
TGGTGATGTTTTCTTTTACTTTCTTTTTTTAAACAAGGAAAACACACATTTTCTAATATGCCCA
AGGCATAGGGTGTTAGGCTCTGTGCTGTTGCTTCTGTGACTCAGATTGATCTGGTCACTGGTCA
GAGACACTTCGTTTTCAGAACACTCCCTGCTCTGCCTTTTTCCCCTCACTTCTCCTCCTCCTCC
TGTCCCAGCTGAGCCAGTGACCCAGTGAGTGAGCCCTTCCTCCTCAGGCAGAGGAGAGCCGCGT
TCATCATCCTGAGGAGAGGCCTGCACTCAAGGGCTGGGAAGTACGTTTGTCCTTTCCTCATTGG
TTATCTGTTCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTGTTTGTGTATATGTGAGTGTGGGTATGTATATGTGTGCATGTGCGTGCGTGCACATGACT
GTTTGTGAGTGTGCTAGTGTGTGTGTACAAGCCCATCAGCATTTTGTCACATGTCTGAATTTGT
GTCCAGACTAACCCATCAGAACCGGTTGGGAAGGACCCCAAGGACCAAGCGTCTGATGGTCCCT
CTCAAGGGACCACAGCAGGGGAGGGAGAAAGGGGGTTGTTTTGTTCCGTTTTAACCACCTTTTT
GAACCATTTTTCCAGGGCGAAGCCCTCCAAGATATTATGTATAAATTGTGTCATTATGTATATG
GGTAAAGGTGTACAAATCTATGTCCTCTTTGCAGCAGATATGATTTTATATTTATAGCGTGCGT
TGACAAGTGAAAGCAAGCTAGGCCTTTAGCACAGGTGGCTTAAGGGAGGGGTGGGGCCAGGTAG
AGGTGGCTGGAGGGTGTGGCCAGCAGATGGTCATCAGTCAGTGTCTCCGCCTTCTTTCTCTTCC
CTTACTCCCCACCCCTCCGCTGGCCTCTGAGGAAGATCTGCTCTGTCATCCGTTGCAGAGCTCC
GCTTTCCTCACCCCTCTCCCCACCCCAGGAAGGACGAGTCAGAGGCCTCCCTCAGGTTTTGTGG
CCCCAGCCTTGATCTTCTCAATGTAAGTCAGCACTGTGACAGAGCTGGCTGACAAGTCGGTGCC
AAGAGAAGGGGTCCCTGTATGTCCCCAAGGCCGGGAGCTCTTCCTGGAAAGTGGCATTAAGTGT
CCCCTACTACCACCATCACACCCCGCAGCTCAGGAGATGGAGGCCCCGGGCCAGAGTTTCCATG
TTTGGTGGTGGAGGAGGGGGAGGATGGAAGCCAGGAGCCATCGTCCCCTGGGGTGCCAGGCAGT
GTTTCCAGGGTGACACCCCGAAGTTCACTTCCTGTGTCACTCCACCTCAGGCCACACCTCACCC
CTGTGAGTTAGCTCCCTCAGCCAGGCTGTTTCTCAGGCGTTCTTCCCATCCCCCACCTGCCCCC
TGTGCCTCAGTAGCCTCCTCTTTCACAGGCGAGGACTCGAGACCCCCCCTCCAGCAGACTGAGT
AAAGACAGACTTGTGTTCCCAAGTGGTGGTTTTATTTTTTTAGTTTTATGTTTGTATGGGAAAT
TGTGGATAAAGTGAATGGACTGTAAATAAATGGTGTTTCCTCCTCCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_005497331

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,620,716 - 7,665,141 (+)	NCBI
mRatBN7.2	20	7,619,096 - 7,663,563 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020230	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ88436	(Get FASTA)	NCBI Sequence Viewer
	EDL96969	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069943.2
	ENSRNOP00000081992.1
	ENSRNOP00000083239
	ENSRNOP00000083239.1

RefSeq Acc Id:

NP_001020230 ⟸ NM_001025059

- UniProtKB:

Q6U1J1 (UniProtKB/TrEMBL), A6JJV3 (UniProtKB/TrEMBL), A0A8I5ZW76 (UniProtKB/TrEMBL), A0A8I5ZVI8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNSVPLKNKKASSFHEFAR
NTSDAWDIGDDEEEDLSSPSLQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPANYKVI
KSSSDAQLSRNSSDTCLRNTLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEKFRQL
LSSHNTDLDELRKWSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSR
NEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFV
VFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELV
SRIDEQVHSHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAF
LIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR

hide sequence

RefSeq Acc Id:

ENSRNOP00000069943 ⟸ ENSRNOT00000090298

RefSeq Acc Id:

ENSRNOP00000083239 ⟸ ENSRNOT00000093855

RefSeq Acc Id:

ENSRNOP00000081992 ⟸ ENSRNOT00000098523

Protein Domains

Rab-GAP TBC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JWM9-F1-model_v2	AlphaFold	A0A0G2JWM9	1-483	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564987	AgrOrtholog
BioCyc Gene	G2FUF-4367	BioCyc
Ensembl Genes	ENSRNOG00000059458	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000090298.2	UniProtKB/TrEMBL
	ENSRNOT00000093855	ENTREZGENE
	ENSRNOT00000093855.1	UniProtKB/TrEMBL
	ENSRNOT00000098523.1	UniProtKB/TrEMBL
Gene3D-CATH	putative rabgap domain of human tbc1 domain family member 14 like domains	UniProtKB/TrEMBL
	Ypt/Rab-GAP domain of gyp1p, domain 3	UniProtKB/TrEMBL
InterPro	Rab-GTPase_TBC_sf	UniProtKB/TrEMBL
	RabGAP/TBC_dom	UniProtKB/TrEMBL
KEGG Report	rno:502414	UniProtKB/TrEMBL
NCBI Gene	502414	ENTREZGENE
PANTHER	TBC1 DOMAIN FAMILY MEMBER 22B	UniProtKB/TrEMBL
	TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN	UniProtKB/TrEMBL
Pfam	TBC	UniProtKB/TrEMBL
PhenoGen	Tbc1d22b	PhenoGen
PROSITE	TBC_RABGAP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000059458	RatGTEx
SMART	TBC	UniProtKB/TrEMBL
Superfamily-SCOP	RabGAP_TBC	UniProtKB/TrEMBL
UniProt	A0A0G2JWM9_RAT	UniProtKB/TrEMBL
	A0A8I5ZVI8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZW76	ENTREZGENE, UniProtKB/TrEMBL
	A6JJV3	ENTREZGENE, UniProtKB/TrEMBL
	Q6U1J1	ENTREZGENE
UniProt Secondary	Q6U1J1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Tbc1d22b	TBC1 domain family, member 22B	LOC502414	hypothetical protein LOC502414	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC502414	hypothetical protein LOC502414			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar