Med22 (mediator complex subunit 22) - Rat Genome Database

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Gene: Med22 (mediator complex subunit 22) Rattus norvegicus
Analyze
Symbol: Med22
Name: mediator complex subunit 22
RGD ID: 1564893
Description: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED22 (mediator complex subunit 22); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911917; LOC499762; mediator of RNA polymerase II transcription subunit 22; mediator of RNA polymerase II transcription subunit 22-like; RGD1564893; similar to surfeit 5 isoform b; Surf5; surfeit 5; surfeit locus protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,631,829 - 30,636,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,631,829 - 30,636,911 (-)EnsemblGRCr8
mRatBN7.2310,233,754 - 10,238,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,233,754 - 10,238,836 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,293,774 - 13,298,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,879,175 - 21,884,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,134,476 - 20,139,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,453,678 - 5,458,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,453,614 - 5,458,782 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl34,861,753 - 4,866,833 (-)Ensemblrn6Rnor6.0
Rnor_5.0310,815,588 - 10,820,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,802,594 - 5,807,676 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,031,784 - 5,036,866 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
core mediator complex  (IEA,ISO)
mediator complex  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14638676   PMID:15489334  


Genomics

Comparative Map Data
Med22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,631,829 - 30,636,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,631,829 - 30,636,911 (-)EnsemblGRCr8
mRatBN7.2310,233,754 - 10,238,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,233,754 - 10,238,836 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,293,774 - 13,298,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,879,175 - 21,884,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,134,476 - 20,139,539 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,453,678 - 5,458,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,453,614 - 5,458,782 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl34,861,753 - 4,866,833 (-)Ensemblrn6Rnor6.0
Rnor_5.0310,815,588 - 10,820,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,802,594 - 5,807,676 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,031,784 - 5,036,866 (-)NCBICelera
Cytogenetic Map3p13NCBI
MED22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,338,312 - 133,348,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,338,312 - 133,348,134 (-)Ensemblhg38GRCh38
GRCh379136,205,149 - 136,214,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,197,565 - 135,204,793 (-)NCBIBuild 36Build 36hg18NCBI36
Celera9106,758,235 - 106,765,458 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,707,690 - 105,714,932 (-)NCBIHuRef
CHM1_19136,357,935 - 136,365,175 (-)NCBICHM1_1
T2T-CHM13v2.09145,552,239 - 145,562,071 (-)NCBIT2T-CHM13v2.0
Med22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,795,279 - 26,800,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,795,274 - 26,800,689 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38226,905,267 - 26,910,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,905,262 - 26,910,677 (-)Ensemblmm10GRCm38
MGSCv37226,760,787 - 26,766,162 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36226,727,276 - 26,732,651 (-)NCBIMGSCv36mm8
Celera226,615,012 - 26,620,387 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.09NCBI
Med22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,697,585 - 2,704,748 (-)Ensembl
ChiLan1.0NW_0049555132,697,812 - 2,704,748 (-)NCBIChiLan1.0ChiLan1.0
MED22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,005,303 - 6,012,470 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,007,636 - 6,014,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,464,103 - 104,471,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,074,826 - 133,082,071 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,074,826 - 133,082,071 (-)EnsemblpanPan2panpan1.1
MED22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,777,374 - 49,783,501 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,058,862 - 49,065,030 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0950,651,412 - 50,657,573 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,651,433 - 50,657,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,413,881 - 49,420,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,755,313 - 49,761,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,833,322 - 49,839,492 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Med22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,833,410 - 199,839,412 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,535,640 - 3,542,338 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,535,646 - 3,541,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,955,473 - 272,961,596 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11272,956,119 - 272,961,618 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MED22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,787,771 - 4,794,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,789,061 - 4,795,011 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666058192,001 - 199,225 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,805,806 - 1,811,532 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247601,805,806 - 1,811,514 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Med22
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v159,743,891 - 9,749,264 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Med22
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:93
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000006720, ENSRNOT00000066193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
AW212655  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,234,035 - 10,234,169 (+)MAPPERmRatBN7.2
Rnor_6.034,862,035 - 4,862,168NCBIRnor6.0
Rnor_6.035,453,960 - 5,454,093NCBIRnor6.0
Rnor_5.0310,217,232 - 10,217,365UniSTSRnor5.0
Rnor_5.0310,815,870 - 10,816,003UniSTSRnor5.0
RGSC_v3.435,802,876 - 5,803,009UniSTSRGSC3.4
Celera35,032,066 - 5,032,199UniSTS
Cytogenetic Map3p12UniSTS
RH130861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,235,070 - 10,235,269 (+)MAPPERmRatBN7.2
Rnor_6.034,863,070 - 4,863,268NCBIRnor6.0
Rnor_6.035,454,995 - 5,455,193NCBIRnor6.0
Rnor_5.0310,218,267 - 10,218,465UniSTSRnor5.0
Rnor_5.0310,816,905 - 10,817,103UniSTSRnor5.0
RGSC_v3.435,803,911 - 5,804,109UniSTSRGSC3.4
Celera35,033,101 - 5,033,299UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 50 67 138 95 11 49 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006720   ⟹   ENSRNOP00000006720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,631,829 - 30,636,911 (-)Ensembl
mRatBN7.2 Ensembl310,233,754 - 10,238,836 (-)Ensembl
Rnor_6.0 Ensembl34,861,753 - 4,866,833 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066193   ⟹   ENSRNOP00000062301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl35,453,614 - 5,458,782 (-)Ensembl
RefSeq Acc Id: NM_001077679   ⟹   NP_001071147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,631,829 - 30,636,911 (-)NCBI
mRatBN7.2310,233,754 - 10,238,836 (-)NCBI
Rnor_6.035,453,678 - 5,458,760 (-)NCBI
Rnor_5.0310,815,588 - 10,820,670 (-)NCBI
RGSC_v3.435,802,594 - 5,807,676 (-)RGD
Celera35,031,784 - 5,036,866 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001071147 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0JPN6 (Get FASTA)   NCBI Sequence Viewer  
  AAI27520 (Get FASTA)   NCBI Sequence Viewer  
  EDL93463 (Get FASTA)   NCBI Sequence Viewer  
  EDL93464 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006720
  ENSRNOP00000006720.3
RefSeq Acc Id: NP_001071147   ⟸   NM_001077679
- UniProtKB: A0JPN6 (UniProtKB/Swiss-Prot),   A6JTI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062301   ⟸   ENSRNOT00000066193
Ensembl Acc Id: ENSRNOP00000006720   ⟸   ENSRNOT00000006720

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPN6-F1-model_v2 AlphaFold A0JPN6 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691916
Promoter ID:EPDNEW_R2441
Type:multiple initiation site
Name:Med22_1
Description:mediator complex subunit 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,458,763 - 5,458,823EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564893 AgrOrtholog
BioCyc Gene G2FUF-50330 BioCyc
Ensembl Genes ENSRNOG00000005059 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000049749 Ensembl
Ensembl Transcript ENSRNOT00000006720 ENTREZGENE
  ENSRNOT00000006720.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104131 IMAGE-MGC_LOAD
InterPro Med22 UniProtKB/Swiss-Prot
KEGG Report rno:499762 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156735 IMAGE-MGC_LOAD
NCBI Gene 499762 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 UniProtKB/Swiss-Prot
  PTHR12434 UniProtKB/Swiss-Prot
Pfam Med22 UniProtKB/Swiss-Prot
PhenoGen Med22 PhenoGen
RatGTEx ENSRNOG00000005059 RatGTEx
  ENSRNOG00000049749 RatGTEx
UniProt A0JPN6 ENTREZGENE
  A6JTI3 ENTREZGENE, UniProtKB/TrEMBL
  MED22_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Med22  mediator complex subunit 22  LOC100911917  mediator of RNA polymerase II transcription subunit 22-like  Data merged from RGD:6489628 737654 PROVISIONAL
2012-07-05 LOC100911917  mediator of RNA polymerase II transcription subunit 22-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Med22  mediator complex subunit 22  RGD1564893_predicted  similar to surfeit 5 isoform b (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564893_predicted  similar to surfeit 5 isoform b (predicted)  LOC499762  similar to surfeit 5 isoform b  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499762  similar to surfeit 5 isoform b      Symbol and Name status set to provisional 70820 PROVISIONAL