Wdr75 (WD repeat domain 75) - Rat Genome Database

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Gene: Wdr75 (WD repeat domain 75) Rattus norvegicus
Analyze
Symbol: Wdr75
Name: WD repeat domain 75
RGD ID: 1564869
Description: Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human WDR75 (WD repeat domain 75); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314545; LRRG00118; similar to CG12050-PA; WD repeat-containing protein 75
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,395,232 - 55,425,412 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,395,222 - 55,425,412 (+)EnsemblGRCr8
mRatBN7.2947,903,214 - 47,933,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl947,903,200 - 47,933,399 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,429,616 - 56,459,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,552,439 - 61,582,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,848,437 - 59,878,610 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,687,845 - 52,717,808 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,687,868 - 52,717,809 (+)Ensemblrn6Rnor6.0
Rnor_5.0952,353,665 - 52,383,624 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4944,849,323 - 44,873,180 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera945,578,427 - 45,602,289 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IBA,IEA,ISO)
small-subunit processome  (IEA,ISO)

Molecular Function
protein binding  (ISO)
RNA binding  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17699751   PMID:22658674   PMID:22681889   PMID:24912190  


Genomics

Comparative Map Data
Wdr75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,395,232 - 55,425,412 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl955,395,222 - 55,425,412 (+)EnsemblGRCr8
mRatBN7.2947,903,214 - 47,933,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl947,903,200 - 47,933,399 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx956,429,616 - 56,459,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,552,439 - 61,582,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,848,437 - 59,878,610 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,687,845 - 52,717,808 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,687,868 - 52,717,809 (+)Ensemblrn6Rnor6.0
Rnor_5.0952,353,665 - 52,383,624 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4944,849,323 - 44,873,180 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera945,578,427 - 45,602,289 (+)NCBICelera
Cytogenetic Map9q22NCBI
WDR75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382189,441,474 - 189,475,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2189,441,429 - 189,479,063 (+)Ensemblhg38GRCh38
GRCh372190,306,200 - 190,340,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,014,404 - 190,048,509 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2183,901,218 - 183,935,325 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,165,790 - 182,199,902 (+)NCBIHuRef
CHM1_12190,312,056 - 190,346,161 (+)NCBICHM1_1
T2T-CHM13v2.02189,930,767 - 189,964,846 (+)NCBIT2T-CHM13v2.0
Wdr75
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39145,834,313 - 45,862,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl145,834,326 - 45,862,779 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38145,795,153 - 45,823,638 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl145,795,166 - 45,823,619 (+)Ensemblmm10GRCm38
MGSCv37145,852,346 - 45,880,458 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36145,740,047 - 45,768,159 (+)NCBIMGSCv36mm8
Celera146,127,754 - 46,155,866 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.87NCBI
Wdr75
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554039,352,615 - 9,383,206 (-)Ensembl
ChiLan1.0NW_0049554039,352,615 - 9,383,206 (-)NCBIChiLan1.0ChiLan1.0
WDR75
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,133,976 - 92,168,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,148,959 - 92,183,200 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B76,748,487 - 76,782,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B194,668,211 - 194,702,343 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B194,668,211 - 194,702,343 (+)EnsemblpanPan2panpan1.1
WDR75
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137157,400 - 191,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37157,455 - 190,916 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha371,127,984 - 1,162,166 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03746,253 - 80,392 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3746,310 - 80,394 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13758,984 - 93,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03726,641 - 61,083 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03755,367 - 89,511 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wdr75
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,308,723 - 148,335,802 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365068,500,752 - 8,529,698 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365068,502,795 - 8,529,305 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR75
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1593,981,215 - 94,026,707 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11593,981,054 - 94,026,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215104,503,605 - 104,547,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR75
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11074,953,086 - 74,989,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1074,953,072 - 74,991,458 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040124,487,868 - 124,524,883 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr75
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899785,343 - 818,855 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624899786,447 - 818,310 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wdr75
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14121,653,785 - 121,682,831 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wdr75
135 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000050275
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH130012  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2947,933,085 - 47,933,276 (+)MAPPERmRatBN7.2
Rnor_6.0952,717,495 - 52,717,685NCBIRnor6.0
Rnor_5.0952,383,311 - 52,383,501UniSTSRnor5.0
RGSC_v3.4944,872,987 - 44,873,177UniSTSRGSC3.4
Celera945,602,096 - 45,602,286UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000050275   ⟹   ENSRNOP00000044241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl955,401,235 - 55,425,412 (+)Ensembl
mRatBN7.2 Ensembl947,909,212 - 47,933,399 (+)Ensembl
Rnor_6.0 Ensembl952,693,831 - 52,717,688 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083864   ⟹   ENSRNOP00000074925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl955,395,222 - 55,425,411 (+)Ensembl
mRatBN7.2 Ensembl947,903,200 - 47,933,399 (+)Ensembl
Rnor_6.0 Ensembl952,687,868 - 52,717,809 (+)Ensembl
RefSeq Acc Id: NM_001399180   ⟹   NP_001386109
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,395,232 - 55,425,412 (+)NCBI
mRatBN7.2947,903,214 - 47,933,399 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386109 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS66209 (Get FASTA)   NCBI Sequence Viewer  
  EDL99124 (Get FASTA)   NCBI Sequence Viewer  
  EDL99125 (Get FASTA)   NCBI Sequence Viewer  
  EDL99126 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044241.1
  ENSRNOP00000074925
  ENSRNOP00000074925.1
Ensembl Acc Id: ENSRNOP00000074925   ⟸   ENSRNOT00000083864
Ensembl Acc Id: ENSRNOP00000044241   ⟸   ENSRNOT00000050275
RefSeq Acc Id: NP_001386109   ⟸   NM_001399180
- UniProtKB: A0A0G2K9A7 (UniProtKB/TrEMBL),   A6INT4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9A7-F1-model_v2 AlphaFold A0A0G2K9A7 1-829 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696648
Promoter ID:EPDNEW_R7172
Type:multiple initiation site
Name:Wdr75_1
Description:WD repeat domain 75
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0952,687,867 - 52,687,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564869 AgrOrtholog
BioCyc Gene G2FUF-27636 BioCyc
Ensembl Genes ENSRNOG00000003825 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050275.3 UniProtKB/TrEMBL
  ENSRNOT00000083864 ENTREZGENE
  ENSRNOT00000083864.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Quinonprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDR75 UniProtKB/TrEMBL
NCBI Gene 314545 ENTREZGENE
PANTHER WD REPEAT-CONTAINING PROTEIN 75 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 75 UniProtKB/TrEMBL
Pfam Beta-prop_WDR75_1st UniProtKB/TrEMBL
  Beta-prop_WDR75_2nd UniProtKB/TrEMBL
PhenoGen Wdr75 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003825 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K9A7 ENTREZGENE, UniProtKB/TrEMBL
  A6INT4 ENTREZGENE, UniProtKB/TrEMBL
  A6INT5_RAT UniProtKB/TrEMBL
  A6INT6_RAT UniProtKB/TrEMBL
  Q6QI90_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Wdr75  WD repeat domain 75  LOC314545  similar to CG12050-PA  Symbol and Name updated 1299863 APPROVED
2006-02-09 LOC314545  similar to CG12050-PA      Symbol and Name status set to provisional 70820 PROVISIONAL