Cnst (consortin, connexin sorting protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cnst (consortin, connexin sorting protein) Rattus norvegicus
Analyze
Symbol: Cnst
Name: consortin, connexin sorting protein
RGD ID: 1564833
Description: Predicted to enable connexin binding activity and phosphatase binding activity. Predicted to be involved in positive regulation of Golgi to plasma membrane protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane; trans-Golgi network; and transport vesicle. Orthologous to human CNST (consortin, connexin sorting protein); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: consortin; consortin-like; LOC100912475; LOC498297; RGD1564833; similar to 9630058J23Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81393,828,694 - 93,905,497 (+)NCBIGRCr8
mRatBN7.21391,296,740 - 91,373,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1391,296,142 - 91,373,531 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01397,838,325 - 97,915,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1397,838,361 - 97,913,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013102,848,124 - 102,925,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41395,246,290 - 95,323,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1390,847,901 - 90,924,738 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19389623   PMID:19864490   PMID:19946888  


Genomics

Comparative Map Data
Cnst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81393,828,694 - 93,905,497 (+)NCBIGRCr8
mRatBN7.21391,296,740 - 91,373,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1391,296,142 - 91,373,531 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01397,838,325 - 97,915,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1397,838,361 - 97,913,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013102,848,124 - 102,925,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41395,246,290 - 95,323,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1390,847,901 - 90,924,738 (+)NCBICelera
Cytogenetic Map13q26NCBI
CNST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,566,456 - 246,668,595 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1246,566,444 - 246,668,595 (+)EnsemblGRCh38hg38GRCh38
GRCh371246,729,758 - 246,831,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361244,796,429 - 244,897,049 (+)NCBINCBI36Build 36hg18NCBI36
Celera1220,016,987 - 220,121,650 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1217,197,253 - 217,218,839 (+)NCBIHuRef
HuRef1217,115,430 - 217,192,622 (+)NCBIHuRef
CHM1_11248,001,936 - 248,104,308 (+)NCBICHM1_1
T2T-CHM13v2.01245,987,346 - 246,091,605 (+)NCBIT2T-CHM13v2.0
Cnst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,374,009 - 179,455,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,373,935 - 179,455,043 (+)EnsemblGRCm39 Ensembl
GRCm381179,546,444 - 179,627,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,546,370 - 179,627,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,476,660 - 181,557,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,383,204 - 181,464,148 (+)NCBIMGSCv36mm8
Celera1186,617,507 - 186,698,192 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map183.57NCBI
Cnst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554069,473,398 - 9,529,996 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554069,441,441 - 9,531,792 (+)NCBIChiLan1.0ChiLan1.0
CNST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212,457,842 - 2,565,803 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112,675,362 - 2,782,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,184,419 - 222,291,611 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11227,538,079 - 227,761,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1227,563,246 - 227,759,310 (+)Ensemblpanpan1.1panPan2
CNST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1737,278,479 - 37,400,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl737,328,609 - 37,399,390 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha736,760,942 - 36,883,324 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0737,110,754 - 37,233,436 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl737,110,562 - 37,233,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1736,950,992 - 37,073,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0736,958,988 - 37,081,302 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0737,227,926 - 37,350,341 (+)NCBIUU_Cfam_GSD_1.0
Cnst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934450,250,159 - 50,347,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365264,397,357 - 4,497,850 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365264,399,886 - 4,497,185 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,046,429 - 19,139,655 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,046,384 - 19,139,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,753,164 - 21,762,574 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12583,592,133 - 83,706,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2583,595,348 - 83,706,697 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605585,869,816 - 85,986,093 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477113,021,322 - 13,082,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477113,012,415 - 13,115,092 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnst
613 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000003641
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH144271  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21391,372,484 - 91,372,663 (+)MAPPERmRatBN7.2
Rnor_6.01397,914,085 - 97,914,263NCBIRnor6.0
Rnor_5.013102,924,099 - 102,924,277UniSTSRnor5.0
RGSC_v3.41395,322,126 - 95,322,304UniSTSRGSC3.4
Celera1390,923,692 - 90,923,870UniSTS
RH 3.4 Map13607.2UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 14 6 19 6 8 11 74 31 35 11 8
Low 6 43 35 35 4 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003641   ⟹   ENSRNOP00000003641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1391,297,417 - 91,373,531 (+)Ensembl
Rnor_6.0 Ensembl1397,838,361 - 97,913,082 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119104   ⟹   ENSRNOP00000078188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1391,296,142 - 91,373,531 (+)Ensembl
RefSeq Acc Id: XM_006250411   ⟹   XP_006250473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81393,829,105 - 93,905,497 (+)NCBI
mRatBN7.21391,297,130 - 91,373,531 (+)NCBI
Rnor_6.01397,838,651 - 97,915,131 (+)NCBI
Rnor_5.013102,848,124 - 102,925,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091465   ⟹   XP_038947393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81393,828,855 - 93,905,497 (+)NCBI
mRatBN7.21391,296,889 - 91,373,531 (+)NCBI
RefSeq Acc Id: XM_573525   ⟹   XP_573525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81393,828,694 - 93,905,497 (+)NCBI
mRatBN7.21391,296,740 - 91,373,531 (+)NCBI
Rnor_6.01397,838,325 - 97,915,131 (+)NCBI
Rnor_5.013102,848,124 - 102,925,145 (+)NCBI
RGSC_v3.41395,246,290 - 95,323,173 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_006250473 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947393 (Get FASTA)   NCBI Sequence Viewer  
  XP_573525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003641
  ENSRNOP00000003641.8
  ENSRNOP00000078188
  ENSRNOP00000078188.1
Reference Protein Sequences
RefSeq Acc Id: XP_573525   ⟸   XM_573525
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250473   ⟸   XM_006250411
- Peptide Label: isoform X2
- UniProtKB: D3ZKK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003641   ⟸   ENSRNOT00000003641
RefSeq Acc Id: XP_038947393   ⟸   XM_039091465
- Peptide Label: isoform X3
- UniProtKB: A6JGF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078188   ⟸   ENSRNOT00000119104
Protein Domains
Consortin C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKK3-F1-model_v2 AlphaFold D3ZKK3 1-786 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564833 AgrOrtholog
BioCyc Gene G2FUF-17145 BioCyc
Ensembl Genes ENSRNOG00000002710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003641.8 UniProtKB/TrEMBL
  ENSRNOT00000119104.1 UniProtKB/TrEMBL
InterPro Consortin UniProtKB/TrEMBL
  Consortin_C UniProtKB/TrEMBL
KEGG Report rno:498297 UniProtKB/TrEMBL
NCBI Gene 498297 ENTREZGENE
PANTHER CONSORTIN UniProtKB/TrEMBL
  PTHR28581 UniProtKB/TrEMBL
Pfam Consortin_C UniProtKB/TrEMBL
PhenoGen Cnst PhenoGen
RatGTEx ENSRNOG00000002710 RatGTEx
UniProt A0A8I5ZKG8 ENTREZGENE, UniProtKB/TrEMBL
  A6JGF5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cnst  consortin, connexin sorting protein  LOC100912475  consortin-like  Data merged from RGD:6486562 737654 PROVISIONAL
2012-07-05 LOC100912475  consortin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Cnst  consortin, connexin sorting protein  RGD1564833  similar to 9630058J23Rik protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564833  similar to 9630058J23Rik protein   RGD1564833_predicted  similar to 9630058J23Rik protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564833_predicted  similar to 9630058J23Rik protein (predicted)  LOC498297  similar to 9630058J23Rik protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498297  similar to 9630058J23Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL