Bex1 (brain expressed X-linked 1) - Rat Genome Database

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Gene: Bex1 (brain expressed X-linked 1) Rattus norvegicus
Analyze
Symbol: Bex1 (Ensembl: LOC100912195)
Name: brain expressed X-linked 1 (Ensembl:protein BEX1-like)
RGD ID: 1564643
Description: Predicted to enable molecular function inhibitor activity and signaling receptor binding activity. Acts upstream of or within negative regulation of neuron differentiation and positive regulation of neuroblast proliferation. Located in cytoplasm and nucleus. Orthologous to human BEX1 (brain expressed X-linked 1) and BEX2 (brain expressed X-linked 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bex; Bex1h; Bex2; brain expressed gene 1; brain expressed X-linked 2; brain expressed, X-linked 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2; brain-expressed X-linked protein 2 homolog; EG2RVC
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X104,010,639 - 104,012,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX104,010,371 - 104,011,236 (-)EnsemblGRCr8
mRatBN7.2X99,219,014 - 99,220,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,219,014 - 99,220,958 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,348,442 - 101,349,946 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,859,049 - 104,860,553 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,416,099 - 102,417,603 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,761,388 - 106,771,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X106,338,663 - 106,364,379 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,527,737 - 123,529,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,925,644 - 99,927,040 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
Ethylenethiourea  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
N-nitrosodiethylamine  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, etal., Gene. 2005 Aug 29;357(1):18-28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. Vilar M, etal., EMBO J. 2006 Mar 22;25(6):1219-30. Epub 2006 Feb 23.
Additional References at PubMed
PMID:15033532   PMID:19198660   PMID:25612294   PMID:29572119  


Genomics

Comparative Map Data
Bex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X104,010,639 - 104,012,143 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX104,010,371 - 104,011,236 (-)EnsemblGRCr8
mRatBN7.2X99,219,014 - 99,220,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,219,014 - 99,220,958 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,348,442 - 101,349,946 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,859,049 - 104,860,553 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,416,099 - 102,417,603 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,761,388 - 106,771,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X106,338,663 - 106,364,379 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,527,737 - 123,529,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,925,644 - 99,927,040 (+)NCBICelera
Cytogenetic MapXq32NCBI
BEX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X103,309,346 - 103,310,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX103,309,345 - 103,311,298 (-)Ensemblhg38GRCh38
GRCh37X102,564,274 - 102,565,918 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,450,930 - 102,452,601 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X102,370,419 - 102,372,090NCBI
CeleraX103,003,273 - 103,004,973 (-)NCBICelera
Cytogenetic MapXq22.2NCBI
HuRefX92,227,655 - 92,229,355 (-)NCBIHuRef
CHM1_1X102,457,260 - 102,458,960 (-)NCBICHM1_1
T2T-CHM13v2.0X101,756,321 - 101,757,965 (-)NCBIT2T-CHM13v2.0
Bex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,114,721 - 135,116,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX135,114,721 - 135,116,262 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X136,213,972 - 136,215,513 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,213,972 - 136,215,513 (-)Ensemblmm10GRCm38
MGSCv37X132,748,511 - 132,750,052 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X131,560,336 - 131,561,877 (-)NCBIMGSCv36mm8
CeleraX119,530,386 - 119,531,927 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.4NCBI

Variants

.
Variants in Bex1
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:92
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000048996
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH130926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,230,274 - 99,230,454 (+)MAPPERmRatBN7.2
Rnor_6.0X106,776,796 - 106,776,975NCBIRnor6.0
Rnor_5.0X106,353,357 - 106,353,536UniSTSRnor5.0
RGSC_v3.4X123,539,468 - 123,539,647UniSTSRGSC3.4
CeleraX99,915,607 - 99,915,786UniSTS
Cytogenetic MapXq35UniSTS
RH134506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,219,051 - 99,219,259 (+)MAPPERmRatBN7.2
Rnor_6.0X106,763,333 - 106,763,533NCBIRnor6.0
Rnor_6.01116,565,827 - 116,566,034NCBIRnor6.0
Rnor_5.01117,724,239 - 117,724,446UniSTSRnor5.0
RGSC_v3.4X123,527,774 - 123,527,981UniSTSRGSC3.4
CeleraX99,926,796 - 99,927,003UniSTS
Cytogenetic MapXq35UniSTS
RH126864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,219,015 - 99,219,251 (+)MAPPERmRatBN7.2
Rnor_6.01116,565,791 - 116,566,026NCBIRnor6.0
Rnor_5.01117,724,203 - 117,724,438UniSTSRnor5.0
Rnor_5.0X106,565,167 - 106,565,438UniSTSRnor5.0
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 50 54 125 82 11 48 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000048996   ⟹   ENSRNOP00000039471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX104,010,599 - 104,011,236 (-)Ensembl
mRatBN7.2 EnsemblX99,219,014 - 99,220,958 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172286   ⟹   ENSRNOP00000098885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX104,010,371 - 104,011,236 (-)Ensembl
RefSeq Acc Id: NM_001037365   ⟹   NP_001032442
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,010,639 - 104,012,143 (-)NCBI
mRatBN7.2X99,219,014 - 99,220,518 (-)NCBI
Rnor_6.0X106,761,388 - 106,771,656 (-)NCBI
Rnor_5.0X106,338,663 - 106,364,379 (+)NCBI
RGSC_v3.4X123,527,737 - 123,529,133 (-)RGD
CeleraX99,925,644 - 99,927,040 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032442 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX40672 (Get FASTA)   NCBI Sequence Viewer  
  EDL85807 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039471
GenBank Protein Q3MKQ2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032442   ⟸   NM_001037365
- UniProtKB: Q6XUZ8 (UniProtKB/Swiss-Prot),   Q3MKQ2 (UniProtKB/Swiss-Prot),   A0A096MIT8 (UniProtKB/TrEMBL),   A6KT21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039471   ⟸   ENSRNOT00000048996
Ensembl Acc Id: ENSRNOP00000098885   ⟸   ENSRNOT00000172286

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3MKQ2-F1-model_v2 AlphaFold Q3MKQ2 1-128 view protein structure
AF-Q3MKQ1-F1-model_v2 AlphaFold Q3MKQ1 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564643 AgrOrtholog
BioCyc Gene G2FUF-1633 BioCyc
Ensembl Genes ENSRNOG00000033844 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000048996 ENTREZGENE
InterPro BEX UniProtKB/Swiss-Prot
  TF_A-like/BEX UniProtKB/Swiss-Prot
KEGG Report rno:501625 UniProtKB/Swiss-Prot
NCBI Gene 501625 ENTREZGENE
PANTHER PROTEIN BEX1 UniProtKB/Swiss-Prot
  PTHR19430 UniProtKB/Swiss-Prot
Pfam BEX UniProtKB/Swiss-Prot
PhenoGen Bex1 PhenoGen
PIRSF BEX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033844 RatGTEx
UniProt A0A096MIT8 ENTREZGENE, UniProtKB/TrEMBL
  A6KT21 ENTREZGENE, UniProtKB/TrEMBL
  BEX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6XUZ8 ENTREZGENE
UniProt Secondary Q6XUZ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-07 Bex1  brain expressed X-linked 1  Bex1l  brain expressed X-linked 1 like  Name and Symbol changed 629549 APPROVED
2023-12-07 Bex1l  brain expressed X-linked 1 like  Bex2  brain expressed X-linked 2  Name and Symbol changed 629549 APPROVED
2022-03-31 Bex2  brain expressed X-linked 2  Bex2  brain-expressed X-linked protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-03-21 Bex2  brain-expressed X-linked protein 2  Bex1h  brain-expressed X-linked protein 1 homolog  Name and Symbol changed 629549 APPROVED
2022-03-21 Bex1h  brain-expressed X-linked protein 1 homolog  Bex1  brain expressed, X-linked 1  Name and Symbol changed 629549 APPROVED
2008-03-03 Bex1  brain expressed gene 1  Bex1  brain expressed X-linked 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Bex1  brain expressed X-linked 1      Symbol and Name status set to provisional 70820 PROVISIONAL