Rnf224 (ring finger protein 224) - Rat Genome Database

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Gene: Rnf224 (ring finger protein 224) Rattus norvegicus
Analyze
Symbol: Rnf224
Name: ring finger protein 224
RGD ID: 1564535
Description: Predicted to enable metal ion binding activity. Orthologous to human RNF224 (ring finger protein 224); INTERACTS WITH bisphenol A; Cuprizon; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC366004; RGD1564535; similar to RiNg Finger protein (rnf-1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,448,248 - 28,450,576 (-)NCBIGRCr8
mRatBN7.238,050,088 - 8,052,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,051,475 - 8,051,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,154,799 - 11,157,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,741,028 - 19,743,356 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,930,871 - 17,933,199 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,454,077 - 2,458,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,455,571 - 2,456,041 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,435,362 - 2,437,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,400,680 - 3,401,150 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,876,616 - 2,880,682 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rnf224
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,448,248 - 28,450,576 (-)NCBIGRCr8
mRatBN7.238,050,088 - 8,052,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,051,475 - 8,051,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,154,799 - 11,157,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,741,028 - 19,743,356 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,930,871 - 17,933,199 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,454,077 - 2,458,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,455,571 - 2,456,041 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,435,362 - 2,437,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,400,680 - 3,401,150 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera32,876,616 - 2,880,682 (-)NCBICelera
Cytogenetic Map3p13NCBI
RNF224
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,227,502 - 137,229,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,227,502 - 137,229,640 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,121,954 - 140,124,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,241,972 - 139,243,359 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map9q34.3NCBI
HuRef9109,581,280 - 109,583,416 (+)NCBIHuRef
CHM1_19140,270,752 - 140,272,824 (+)NCBICHM1_1
T2T-CHM13v2.09149,465,171 - 149,467,309 (+)NCBIT2T-CHM13v2.0
Rnf224
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,124,487 - 25,126,799 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,124,488 - 25,126,799 (-)EnsemblGRCm39 Ensembl
GRCm38225,234,476 - 25,236,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,234,476 - 25,236,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,089,996 - 25,092,307 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,056,485 - 25,058,796 (-)NCBIMGSCv36mm8
Celera224,962,266 - 24,964,577 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.09NCBI
Rnf224
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,224,740 - 5,227,395 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,224,740 - 5,227,395 (+)NCBIChiLan1.0ChiLan1.0
RNF224
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,170,605 - 2,173,091 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,172,912 - 2,175,424 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,287,236 - 108,289,186 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,255,866 - 137,257,947 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,255,866 - 137,257,947 (+)Ensemblpanpan1.1panPan2
RNF224
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,445,143 - 48,445,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,445,143 - 48,445,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,630,642 - 47,632,185 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,305,495 - 49,307,038 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,306,311 - 49,307,081 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,081,896 - 48,083,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,380,713 - 48,382,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,427,866 - 48,429,409 (-)NCBIUU_Cfam_GSD_1.0
Rnf224
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,611,509 - 202,612,542 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936669762,545 - 763,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF224
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,143,949 - 314,145,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNF224
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112959,725 - 962,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,344,606 - 4,346,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf224
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760726,458 - 728,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000062001
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 4 7 1 6
Below cutoff 1 10 4 3 7 8 31 7 12 5 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000062001   ⟹   ENSRNOP00000058710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,051,475 - 8,051,945 (-)Ensembl
Rnor_6.0 Ensembl32,455,571 - 2,456,041 (-)Ensembl
RefSeq Acc Id: NM_001399328   ⟹   NP_001386257
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,448,248 - 28,450,576 (-)NCBI
mRatBN7.238,050,088 - 8,052,416 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386257 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058710
  ENSRNOP00000058710.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000058710   ⟸   ENSRNOT00000062001
RefSeq Acc Id: NP_001386257   ⟸   NM_001399328
- UniProtKB: D3ZL60 (UniProtKB/TrEMBL)
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZL60-F1-model_v2 AlphaFold D3ZL60 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564535 AgrOrtholog
BioCyc Gene G2FUF-50472 BioCyc
Ensembl Genes ENSRNOG00000040284 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000062001 ENTREZGENE
  ENSRNOT00000062001.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf-RING_LisH UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:366004 UniProtKB/TrEMBL
NCBI Gene 366004 ENTREZGENE
PANTHER RING FINGER PROTEIN 224 UniProtKB/TrEMBL
  RING FINGER PROTEIN 224 UniProtKB/TrEMBL
Pfam zf-RING_UBOX UniProtKB/TrEMBL
PhenoGen Rnf224 PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000040284 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt D3ZL60 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-10 Rnf224  ring finger protein 224  RGD1564535  similar to RiNg Finger protein (rnf-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564535  similar to RiNg Finger protein (rnf-1)   RGD1564535_predicted  similar to RiNg Finger protein (rnf-1) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564535_predicted  similar to RiNg Finger protein (rnf-1) (predicted)  LOC366004  similar to RiNg Finger protein (rnf-1)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366004  similar to RiNg Finger protein (rnf-1)      Symbol and Name status set to provisional 70820 PROVISIONAL