Foxr2 (forkhead box R2) - Rat Genome Database

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Gene: Foxr2 (forkhead box R2) Rattus norvegicus
Analyze
Symbol: Foxr2
Name: forkhead box R2
RGD ID: 1564437
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human FOXR2 (forkhead box R2); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); epoxiconazole (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: forkhead box protein R2; LOC302583; RGD1564437; similar to forkhead box R2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,618,111 - 21,651,791 (-)NCBIGRCr8
mRatBN7.2X18,242,420 - 18,276,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,244,255 - 18,245,163 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X19,142,671 - 19,243,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,144,501 - 19,145,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X19,904,191 - 19,918,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,395,980 - 38,396,888 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,516,067 - 18,622,663 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15202009  


Genomics

Comparative Map Data
Foxr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,618,111 - 21,651,791 (-)NCBIGRCr8
mRatBN7.2X18,242,420 - 18,276,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,244,255 - 18,245,163 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X19,142,671 - 19,243,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,144,501 - 19,145,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X19,904,191 - 19,918,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,395,980 - 38,396,888 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,516,067 - 18,622,663 (-)NCBICelera
Cytogenetic MapXq12NCBI
FOXR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,623,400 - 55,626,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX55,623,400 - 55,626,192 (+)EnsemblGRCh38hg38GRCh38
GRCh37X55,649,833 - 55,652,625 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,666,558 - 55,668,483 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X55,532,853 - 55,534,778NCBI
CeleraX59,489,526 - 59,492,314 (+)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,700,710 - 52,703,498 (+)NCBIHuRef
CHM1_1X55,639,876 - 55,642,664 (+)NCBICHM1_1
T2T-CHM13v2.0X54,916,575 - 54,919,367 (+)NCBIT2T-CHM13v2.0
Foxr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,897,577 - 151,915,857 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,901,782 - 151,915,857 (+)EnsemblGRCm39 Ensembl
GRCm38X153,114,581 - 153,132,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,118,786 - 153,132,861 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,553,331 - 149,567,404 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,459,504 - 148,473,577 (+)NCBIMGSCv36mm8
CeleraX136,121,698 - 136,135,767 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
FOXR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,943,508 - 57,078,529 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,947,115 - 57,082,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,906,094 - 47,908,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X56,058,295 - 56,061,076 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX56,058,601 - 56,059,536 (+)Ensemblpanpan1.1panPan2
FOXR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,068,833 - 47,071,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX47,070,381 - 47,071,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX38,419,584 - 38,436,632 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X47,480,852 - 47,497,897 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX47,495,402 - 47,496,349 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,718,577 - 46,735,626 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X47,457,601 - 47,474,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X47,379,258 - 47,396,305 (+)NCBIUU_Cfam_GSD_1.0
Foxr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,988,820 - 39,990,116 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368191,044,654 - 1,045,598 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368191,044,648 - 1,045,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,178,487 - 48,179,434 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X48,174,318 - 48,181,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X54,301,567 - 54,302,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,694,672 - 51,696,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,695,241 - 51,696,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660865,731,728 - 5,733,651 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Foxr2
173 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:98
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000043382
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 96 9 7 3 13 6 93 5 43 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001432912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001835009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043382   ⟹   ENSRNOP00000045495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX18,244,255 - 18,245,163 (-)Ensembl
Rnor_6.0 EnsemblX19,144,501 - 19,145,409 (-)Ensembl
RefSeq Acc Id: XM_039100345   ⟹   XP_038956273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X21,618,111 - 21,651,791 (-)NCBI
mRatBN7.2X18,242,420 - 18,276,095 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001419841 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419842 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956273 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045495.2
Ensembl Acc Id: ENSRNOP00000045495   ⟸   ENSRNOT00000043382
RefSeq Acc Id: XP_038956273   ⟸   XM_039100345
Protein Domains
Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADV2-F1-model_v2 AlphaFold D4ADV2 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564437 AgrOrtholog
BioCyc Gene G2FUF-2828 BioCyc
Ensembl Genes ENSRNOG00000030619 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043382.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro FOX_transcription_regulators UniProtKB/TrEMBL
  TF_fork_head UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 302583 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN R1 UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN R2 UniProtKB/TrEMBL
Pfam Fork_head UniProtKB/TrEMBL
PhenoGen Foxr2 PhenoGen
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030619 RatGTEx
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt D4ADV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-21 Foxr2  forkhead box R2  RGD1564437  similar to forkhead box R2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564437  similar to forkhead box R2   RGD1564437_predicted  similar to forkhead box R2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564437_predicted  similar to forkhead box R2 (predicted)  LOC302583  similar to forkhead box R2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302583  similar to forkhead box R2      Symbol and Name status set to provisional 70820 PROVISIONAL