Naglu (N-acetyl-alpha-glucosaminidase) - Rat Genome Database

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Gene: Naglu (N-acetyl-alpha-glucosaminidase) Rattus norvegicus
Analyze
Symbol: Naglu
Name: N-acetyl-alpha-glucosaminidase
RGD ID: 1564228
Description: Predicted to enable alpha-N-acetylglucosaminidase activity and iron ion sequestering activity. Predicted to be involved in heparan sulfate proteoglycan catabolic process. Predicted to act upstream of or within several processes, including circulatory system development; nervous system development; and proteoglycan metabolic process. Predicted to be located in extracellular exosome. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-N-acetylglucosaminidase; LOC360630; N-acetylglucosaminidase, alpha; RGD1564228; similar to Naglu
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,501,864 - 86,509,333 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,501,836 - 86,509,315 (+)EnsemblGRCr8
mRatBN7.21086,001,545 - 86,009,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,001,566 - 86,008,972 (+)EnsemblmRatBN7.2
Rnor_6.01088,979,363 - 88,986,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,979,383 - 88,986,867 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,777,870 - 88,785,375 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,085,836 - 90,093,926 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,719,246 - 84,726,764 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
mifepristone  (EXP)
myo-inositol hexakisphosphate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naled  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
pentachlorophenol  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium cholate  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
amyloid precursor protein metabolic process  (ISO)
aorta development  (ISO)
aorta morphogenesis  (ISO)
astrocyte activation  (ISO)
astrocyte differentiation  (ISO)
autophagy  (ISO)
carbohydrate derivative metabolic process  (IEA)
cardiac muscle cell development  (ISO)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to oxidative stress  (ISO)
cerebellar Purkinje cell layer development  (ISO)
collagen metabolic process  (ISO)
cone retinal bipolar cell differentiation  (ISO)
cytoplasm organization  (ISO)
determination of adult lifespan  (ISO)
endothelium development  (ISO)
energy homeostasis  (ISO)
exploration behavior  (ISO)
ganglioside metabolic process  (ISO)
gene expression  (ISO)
glycoprotein metabolic process  (ISO)
glycosaminoglycan metabolic process  (ISO)
Golgi organization  (ISO)
hair follicle morphogenesis  (ISO)
heart development  (ISO)
heart valve development  (ISO)
heparan sulfate proteoglycan catabolic process  (IEA,ISO)
heparan sulfate proteoglycan metabolic process  (ISO)
heparin proteoglycan metabolic process  (IBA,ISO)
hormone metabolic process  (ISO)
inflammatory response  (ISO)
inner ear receptor cell development  (ISO)
left ventricular cardiac muscle tissue morphogenesis  (ISO)
limb development  (ISO)
lipid catabolic process  (ISO)
liver development  (ISO)
locomotor rhythm  (ISO)
locomotory behavior  (ISO)
lysosome organization  (ISO)
maintenance of blood-brain barrier  (ISO)
microglia differentiation  (ISO)
microglial cell activation  (ISO)
middle ear morphogenesis  (ISO)
mitral valve morphogenesis  (ISO)
motor behavior  (ISO)
multicellular organismal-level iron ion homeostasis  (ISO)
nerve development  (ISO)
neurogenesis  (ISO)
neuroinflammatory response  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein oxidation  (ISO)
protein processing  (ISO)
proteoglycan metabolic process  (ISO)
response to disaccharide  (ISO)
response to lipopolysaccharide  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
retinal rod cell development  (ISO)
rod bipolar cell differentiation  (ISO)
superoxide metabolic process  (ISO)
system development  (IEA)
toll-like receptor 4 signaling pathway  (ISO)
vacuole organization  (ISO)
vasculature development  (ISO)
vesicle tethering  (ISO)

Cellular Component
extracellular exosome  (IEA,ISO)
lysosomal lumen  (IEA,ISO)
membrane  (IEA)
vacuole  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase. Li HH, etal., Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14505-10.
2. Sanfilippo syndrome: profound deficiency of alpha-acetylglucosaminidase activity in organs and skin fibroblasts from type-B patients. O'Brien JS Proc Natl Acad Sci U S A. 1972 Jul;69(7):1720-2.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Sanfilippo type B syndrome (mucopolysaccharidosis III B): allelic heterogeneity corresponds to the wide spectrum of clinical phenotypes. Weber B, etal., Eur J Hum Genet. 1999 Jan;7(1):34-44.
8. Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications. Yogalingam G and Hopwood JJ, Hum Mutat. 2001 Oct;18(4):264-81.
9. Short-term enzyme replacement in the murine model of Sanfilippo syndrome type B. Yu WH, etal., Mol Genet Metab. 2000 Dec;71(4):573-80.
Additional References at PubMed
PMID:11153910   PMID:17712420   PMID:19056867   PMID:21082674   PMID:23360846   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Naglu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,501,864 - 86,509,333 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,501,836 - 86,509,315 (+)EnsemblGRCr8
mRatBN7.21086,001,545 - 86,009,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,001,566 - 86,008,972 (+)EnsemblmRatBN7.2
Rnor_6.01088,979,363 - 88,986,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,979,383 - 88,986,867 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,777,870 - 88,785,375 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,085,836 - 90,093,926 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,719,246 - 84,726,764 (+)NCBICelera
Cytogenetic Map10q31NCBI
NAGLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,536,241 - 42,544,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,536,241 - 42,544,449 (+)Ensemblhg38GRCh38
GRCh371740,688,259 - 40,696,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,941,477 - 37,949,993 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341737,941,476 - 37,949,992NCBI
Celera1737,343,885 - 37,352,401 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,452,897 - 36,461,477 (+)NCBIHuRef
CHM1_11740,923,793 - 40,932,309 (+)NCBICHM1_1
T2T-CHM13v2.01743,393,428 - 43,401,636 (+)NCBIT2T-CHM13v2.0
Naglu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,960,918 - 100,968,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,960,838 - 100,968,498 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,070,090 - 101,077,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,070,012 - 101,077,672 (+)Ensemblmm10GRCm38
MGSCv3711100,931,408 - 100,938,986 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,886,215 - 100,893,742 (+)NCBIMGSCv36mm8
Celera11112,366,211 - 112,373,780 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.15NCBI
Naglu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,445,338 - 16,450,062 (+)Ensembl
ChiLan1.0NW_00495545116,445,338 - 16,449,243 (+)NCBIChiLan1.0ChiLan1.0
NAGLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,440,123 - 22,448,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,330,125 - 24,338,167 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,772,054 - 14,780,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,996,420 - 15,004,124 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,996,420 - 15,004,242 (-)EnsemblpanPan2panpan1.1
NAGLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,407,296 - 20,414,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,407,281 - 20,414,056 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha919,869,143 - 19,875,907 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,126,245 - 21,133,008 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,126,249 - 21,133,008 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,912,074 - 19,918,837 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,177,305 - 20,184,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,281,366 - 20,288,130 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Naglu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,762,972 - 19,769,861 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,304,586 - 17,314,521 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,305,033 - 17,312,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAGLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,735,411 - 63,744,365 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,531,080 - 34,540,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naglu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,553,037 - 1,558,197 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,553,582 - 1,558,110 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Naglu
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,364,343 - 60,371,880 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Naglu
63 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:35
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000052157
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH134495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,008,718 - 86,008,899 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,549 - 88,986,729NCBIRnor6.0
Rnor_5.01088,785,045 - 88,785,225UniSTSRnor5.0
RGSC_v3.41090,093,240 - 90,093,420UniSTSRGSC3.4
Celera1084,726,434 - 84,726,614UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH142272  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,509,029 - 86,509,221 (+)Marker Load Pipeline
mRatBN7.21086,008,746 - 86,008,938 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,577 - 88,986,768NCBIRnor6.0
Rnor_5.01088,785,073 - 88,785,264UniSTSRnor5.0
RGSC_v3.41090,093,268 - 90,093,459UniSTSRGSC3.4
Celera1084,726,462 - 84,726,653UniSTS
RH 3.4 Map10875.29UniSTS
Cytogenetic Map10q32.1UniSTS
RH143446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,001,612 - 86,001,745 (+)MAPPERmRatBN7.2
Rnor_6.01088,979,443 - 88,979,575NCBIRnor6.0
Rnor_5.01088,777,939 - 88,778,071UniSTSRnor5.0
RGSC_v3.41090,085,856 - 90,085,988UniSTSRGSC3.4
Celera1084,719,326 - 84,719,458UniSTS
RH 3.4 Map10835.5UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000052157   ⟹   ENSRNOP00000051302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,501,836 - 86,509,315 (+)Ensembl
mRatBN7.2 Ensembl1086,001,566 - 86,008,972 (+)Ensembl
Rnor_6.0 Ensembl1088,979,383 - 88,986,867 (+)Ensembl
RefSeq Acc Id: NM_001427043   ⟹   NP_001413972
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,501,864 - 86,509,333 (+)NCBI
RefSeq Acc Id: XM_039087742   ⟹   XP_038943670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,502,186 - 86,509,315 (+)NCBI
mRatBN7.21086,001,837 - 86,009,049 (+)NCBI
RefSeq Acc Id: XM_039087745   ⟹   XP_038943673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,503,867 - 86,509,315 (+)NCBI
mRatBN7.21086,003,583 - 86,009,049 (+)NCBI
RefSeq Acc Id: XM_063269435   ⟹   XP_063125505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,502,277 - 86,509,315 (+)NCBI
RefSeq Acc Id: XM_063269437   ⟹   XP_063125507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,503,862 - 86,509,315 (+)NCBI
RefSeq Acc Id: XM_063269438   ⟹   XP_063125508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,503,868 - 86,509,315 (+)NCBI
Ensembl Acc Id: ENSRNOP00000051302   ⟸   ENSRNOT00000052157
RefSeq Acc Id: XP_038943670   ⟸   XM_039087742
- Peptide Label: isoform X2
- UniProtKB: A6HJ76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943673   ⟸   XM_039087745
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001413972   ⟸   NM_001427043
- Peptide Label: precursor
- UniProtKB: A6HJ73 (UniProtKB/TrEMBL),   D3ZZL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125505   ⟸   XM_063269435
- Peptide Label: isoform X1
- UniProtKB: A6HJ76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125507   ⟸   XM_063269437
- Peptide Label: isoform X3
- UniProtKB: A6HJ76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125508   ⟸   XM_063269438
- Peptide Label: isoform X5
Protein Domains
Alpha-N-acetylglucosaminidase C-terminal   Alpha-N-acetylglucosaminidase N-terminal   Alpha-N-acetylglucosaminidase tim-barrel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZL3-F1-model_v2 AlphaFold D3ZZL3 1-739 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697743
Promoter ID:EPDNEW_R8263
Type:initiation region
Name:Naglu_1
Description:N-acetyl-alpha-glucosaminidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,979,411 - 88,979,471EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564228 AgrOrtholog
BioCyc Gene G2FUF-23204 BioCyc
Ensembl Genes ENSRNOG00000032381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052157 ENTREZGENE
  ENSRNOT00000052157.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.379.10 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
  N-acetyl-b-d-glucoasminidase UniProtKB/TrEMBL
InterPro Chitobiase/Hex_dom_2-like UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  NAGLU UniProtKB/TrEMBL
  NAGLU_C UniProtKB/TrEMBL
  NAGLU_N UniProtKB/TrEMBL
  NAGLU_tim-barrel UniProtKB/TrEMBL
NCBI Gene 360630 ENTREZGENE
PANTHER ALPHA-N-ACETYLGLUCOSAMINIDASE UniProtKB/TrEMBL
  PTHR12872 UniProtKB/TrEMBL
Pfam NAGLU UniProtKB/TrEMBL
  NAGLU_C UniProtKB/TrEMBL
  NAGLU_N UniProtKB/TrEMBL
PhenoGen Naglu PhenoGen
RatGTEx ENSRNOG00000032381 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A6HJ73 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ76 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZL3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Naglu  N-acetyl-alpha-glucosaminidase  Naglu  N-acetylglucosaminidase, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-08 Naglu  N-acetylglucosaminidase, alpha  RGD1564228  similar to Naglu  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564228  similar to Naglu   RGD1564228_predicted  similar to Naglu (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564228_predicted  similar to Naglu (predicted)  LOC360630  similar to Naglu  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360630  similar to Naglu      Symbol and Name status set to provisional 70820 PROVISIONAL