Mapkapk5 (MAPK activated protein kinase 5) - Rat Genome Database

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Gene: Mapkapk5 (MAPK activated protein kinase 5) Rattus norvegicus
Analyze
Symbol: Mapkapk5
Name: MAPK activated protein kinase 5
RGD ID: 1564113
Description: Predicted to enable several functions, including calmodulin binding activity; p53 binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including Ras protein signal transduction; negative regulation of TOR signaling; and regulation of gene expression. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH copper atom; copper(0); cypermethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAP kinase-activated protein kinase 5; MGC116327; mitogen-activated protein kinase-activated protein kinase 5; similar to MK-5 type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,654,423 - 40,677,170 (+)EnsemblGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)Ensemblrn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (ISO)
septin cytoskeleton  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:15538386   PMID:15577943   PMID:16973613   PMID:17254968   PMID:19166925   PMID:20640477   PMID:21329882   PMID:21336308   PMID:21531765   PMID:22508986  


Genomics

Comparative Map Data
Mapkapk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,654,423 - 40,677,170 (+)EnsemblGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)Ensemblrn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
MAPKAPK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,842,013 - 111,902,222 (+)Ensemblhg38GRCh38
GRCh3712112,280,032 - 112,340,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBICelera
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBIT2T-CHM13v2.0
Mapkapk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,663,114 - 121,683,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,663,101 - 121,683,968 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385121,525,051 - 121,545,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,525,038 - 121,545,905 (-)Ensemblmm10GRCm38
MGSCv375121,975,060 - 121,995,901 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365121,785,668 - 121,806,509 (-)NCBIMGSCv36mm8
Celera5118,614,887 - 118,635,774 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.84NCBI
Mapkapk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,409,192 - 8,434,907 (+)Ensembl
ChiLan1.0NW_0049554828,409,192 - 8,434,907 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,911,213 - 119,966,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,907,604 - 119,962,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,416,610 - 109,471,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,812,764 - 112,868,846 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,812,769 - 112,863,595 (+)EnsemblpanPan2panpan1.1
MAPKAPK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,380,551 - 9,420,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,319,180 - 9,419,236 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,542,771 - 9,581,769 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0269,640,243 - 9,679,215 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,640,197 - 9,679,147 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,595,507 - 9,634,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,658,467 - 9,697,479 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,611,599 - 9,650,628 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapkapk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,849,413 - 39,886,455 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11439,852,537 - 39,885,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,329,054 - 42,362,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,084,117 - 107,126,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,084,366 - 107,124,710 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037137,965,646 - 138,009,993 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,344,078 - 20,384,894 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474720,344,078 - 20,384,880 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapkapk5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11632,262,656 - 32,282,228 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapkapk5
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:4
Count of miRNA genes:2
Interacting mature miRNAs:2
Transcripts:ENSRNOT00000001817, ENSRNOT00000065314
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH139329  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81240,673,152 - 40,673,618 (+)Marker Load Pipeline
mRatBN7.21235,012,464 - 35,012,930 (+)MAPPERmRatBN7.2
Rnor_6.01240,528,751 - 40,529,216NCBIRnor6.0
Rnor_5.01242,395,987 - 42,396,452UniSTSRnor5.0
RGSC_v3.41236,146,912 - 36,147,377UniSTSRGSC3.4
Celera1236,677,133 - 36,677,598UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001817   ⟹   ENSRNOP00000001817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,654,423 - 40,677,170 (+)Ensembl
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)Ensembl
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065314   ⟹   ENSRNOP00000061902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,654,748 - 40,673,749 (+)Ensembl
mRatBN7.2 Ensembl1234,994,259 - 35,013,052 (+)Ensembl
Rnor_6.0 Ensembl1240,517,657 - 40,529,338 (+)Ensembl
RefSeq Acc Id: NM_001025761   ⟹   NP_001020932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,662,059 - 40,673,740 (+)NCBI
mRatBN7.21235,001,371 - 35,013,052 (+)NCBI
Rnor_6.01240,517,657 - 40,529,332 (+)NCBI
Rnor_5.01242,377,614 - 42,396,568 (+)NCBI
RGSC_v3.41236,128,538 - 36,147,493 (+)RGD
Celera1236,666,043 - 36,677,720 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001164043   ⟹   NP_001157515
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,780 - 40,673,740 (+)NCBI
mRatBN7.21234,994,092 - 35,013,052 (+)NCBI
Rnor_6.01240,510,378 - 40,529,332 (+)NCBI
Rnor_5.01242,377,614 - 42,396,568 (+)NCBI
RGSC_v3.41236,128,538 - 36,147,493 (+)RGD
Celera1236,658,764 - 36,677,720 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089701   ⟹   XP_038945629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,220 - 40,673,740 (+)NCBI
mRatBN7.21234,993,523 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_039089703   ⟹   XP_038945631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,224 - 40,673,740 (+)NCBI
mRatBN7.21234,993,524 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_039089704   ⟹   XP_038945632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,661,254 - 40,673,740 (+)NCBI
mRatBN7.21235,000,492 - 35,013,055 (+)NCBI
RefSeq Acc Id: XM_063271585   ⟹   XP_063127655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,223 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271586   ⟹   XP_063127656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,663,934 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271587   ⟹   XP_063127657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,662,939 - 40,673,740 (+)NCBI
RefSeq Acc Id: XM_063271588   ⟹   XP_063127658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,654,220 - 40,673,740 (+)NCBI
RefSeq Acc Id: NP_001020932   ⟸   NM_001025761
- Peptide Label: isoform 2
- UniProtKB: Q4KLJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157515   ⟸   NM_001164043
- Peptide Label: isoform 1
- UniProtKB: F1LN87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061902   ⟸   ENSRNOT00000065314
Ensembl Acc Id: ENSRNOP00000001817   ⟸   ENSRNOT00000001817
RefSeq Acc Id: XP_038945629   ⟸   XM_039089701
- Peptide Label: isoform X5
- UniProtKB: F1LN87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945631   ⟸   XM_039089703
- Peptide Label: isoform X1
- UniProtKB: F7FFP2 (UniProtKB/TrEMBL),   Q4KLJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945632   ⟸   XM_039089704
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127658   ⟸   XM_063271588
- Peptide Label: isoform X6
- UniProtKB: F1LN87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127655   ⟸   XM_063271585
- Peptide Label: isoform X2
- UniProtKB: Q4KLJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127657   ⟸   XM_063271587
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127656   ⟸   XM_063271586
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LN87-F1-model_v2 AlphaFold F1LN87 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564113 AgrOrtholog
BioCyc Gene G2FUF-19215 BioCyc
Ensembl Genes ENSRNOG00000001345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001817 ENTREZGENE
  ENSRNOT00000001817.9 UniProtKB/TrEMBL
  ENSRNOT00000065314 ENTREZGENE
  ENSRNOT00000065314.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381631 IMAGE-MGC_LOAD
InterPro CDPK_Ser/Thr_kinases UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:498183 UniProtKB/TrEMBL
MGC_CLONE MGC:116327 IMAGE-MGC_LOAD
NCBI Gene 498183 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Mapkapk5 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001345 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt F1LN87 ENTREZGENE, UniProtKB/TrEMBL
  F7FFP2 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mapkapk5  MAPK activated protein kinase 5  Mapkapk5  mitogen-activated protein kinase-activated protein kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Mapkapk5  mitogen-activated protein kinase-activated protein kinase 5  Mapkapk5  MAP kinase-activated protein kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mapkapk5  MAP kinase-activated protein kinase 5  MGC116327  similar to MK-5 type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC116327  similar to MK-5 type 2      Symbol and Name status set to provisional 70820 PROVISIONAL