MAPKAPK5 (MAPK activated protein kinase 5) - Rat Genome Database

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Gene: MAPKAPK5 (MAPK activated protein kinase 5) Homo sapiens
Analyze
Symbol: MAPKAPK5
Name: MAPK activated protein kinase 5
RGD ID: 1354160
HGNC Page HGNC:6889
Description: Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including Ras protein signal transduction; positive regulation of telomere maintenance; and stress-induced premature senescence. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; MK-5; MK5; NCFD; p38-regulated/activated protein kinase; PRAK
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MAPKAPK5P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,842,013 - 111,902,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,280,032 - 112,340,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBICelera
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IDA,TAS)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IEA)
protein-containing complex  (IEA)
septin cytoskeleton  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8636128   PMID:9468497   PMID:9480836   PMID:9628874   PMID:10708586   PMID:10978313   PMID:10978317   PMID:12117915   PMID:12130507   PMID:12171600   PMID:12477932   PMID:12808055  
PMID:14702039   PMID:15489334   PMID:17254968   PMID:18029348   PMID:18720373   PMID:19166925   PMID:19473979   PMID:19484198   PMID:19953087   PMID:20849292   PMID:20936779   PMID:21177870  
PMID:21329882   PMID:21336308   PMID:21531765   PMID:21575178   PMID:21675959   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22279049   PMID:23022185   PMID:23602568   PMID:23685072  
PMID:24309468   PMID:24651460   PMID:25241761   PMID:25383140   PMID:25416956   PMID:26080319   PMID:26758977   PMID:26972000   PMID:28089446   PMID:28514442   PMID:28941148   PMID:29987050  
PMID:30021884   PMID:31578200   PMID:31694235   PMID:32296183   PMID:32393512   PMID:32694731   PMID:32707033   PMID:33442026   PMID:33961781   PMID:34315543   PMID:35064619   PMID:35216969  
PMID:35256949   PMID:35439318   PMID:35468721   PMID:35575217   PMID:35748872   PMID:35844789   PMID:35944360   PMID:36581449   PMID:36736316   PMID:38113892  


Genomics

Comparative Map Data
MAPKAPK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,842,228 - 111,902,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,842,013 - 111,902,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,280,032 - 112,340,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,764,662 - 110,815,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,742,998 - 110,793,947NCBI
Celera12111,905,742 - 111,956,689 (+)NCBICelera
Cytogenetic Map12q24.12-q24.13NCBI
HuRef12109,293,372 - 109,344,645 (+)NCBIHuRef
CHM1_112112,247,967 - 112,299,159 (+)NCBICHM1_1
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBIT2T-CHM13v2.0
Mapkapk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,663,114 - 121,683,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,663,101 - 121,683,968 (-)EnsemblGRCm39 Ensembl
GRCm385121,525,051 - 121,545,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,525,038 - 121,545,905 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,975,060 - 121,995,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,785,668 - 121,806,509 (-)NCBIMGSCv36mm8
Celera5118,614,887 - 118,635,774 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.84NCBI
Mapkapk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,654,220 - 40,673,740 (+)NCBIGRCr8
mRatBN7.21234,993,520 - 35,013,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,994,092 - 35,013,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,166,747 - 36,185,867 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,777,956 - 36,797,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,830,405 - 35,849,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,510,378 - 40,529,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,510,378 - 40,529,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,377,614 - 42,396,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,128,538 - 36,147,493 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1236,658,764 - 36,677,720 (+)NCBICelera
Cytogenetic Map12q16NCBI
Mapkapk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554828,409,192 - 8,434,907 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,911,213 - 119,966,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,907,604 - 119,962,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,416,610 - 109,471,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,812,764 - 112,868,846 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,812,769 - 112,863,595 (+)Ensemblpanpan1.1panPan2
MAPKAPK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,380,551 - 9,420,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,319,180 - 9,419,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,542,771 - 9,581,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,640,243 - 9,679,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,640,197 - 9,679,147 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,595,507 - 9,634,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,658,467 - 9,697,479 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,611,599 - 9,650,628 (+)NCBIUU_Cfam_GSD_1.0
Mapkapk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,030,940 - 155,065,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,414,277 - 4,451,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,414,283 - 4,448,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,849,413 - 39,886,455 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,852,537 - 39,885,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,329,054 - 42,362,471 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,084,117 - 107,126,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,084,366 - 107,124,710 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,965,646 - 138,009,993 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,344,078 - 20,384,894 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,344,078 - 20,384,880 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPKAPK5
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13		 pathogenic
GRCh38/hg38 12q24.12(chr12:111724654-111867329)x3 copy number gain See cases [RCV000136802] Chr12:111724654..111867329 [GRCh38]
Chr12:112162458..112305133 [GRCh37]
Chr12:110646841..110789516 [NCBI36]
Chr12:12q24.12		 benign
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q24.12-24.13(chr12:112194796-112304163)x3 copy number gain See cases [RCV000447646] Chr12:112194796..112304163 [GRCh37]
Chr12:12q24.12-24.13		 benign|likely benign
GRCh37/hg19 12q24.12-24.13(chr12:112183921-112318246) copy number gain Abnormal esophagus morphology [RCV000416686] Chr12:112183921..112318246 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112183225-112327166) copy number gain Abnormal esophagus morphology [RCV000416877] Chr12:112183225..112327166 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q24.12-24.13(chr12:112195275-112304353)x3 copy number gain not provided [RCV000738050] Chr12:112195275..112304353 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112195275-112321569)x3 copy number gain not provided [RCV000738051] Chr12:112195275..112321569 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112199080-112304353)x3 copy number gain not provided [RCV000738052] Chr12:112199080..112304353 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12(chr12:112206895-112298257)x3 copy number gain not provided [RCV000738053] Chr12:112206895..112298257 [GRCh37]
Chr12:12q24.12		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112206895-112304353)x3 copy number gain not provided [RCV000738054] Chr12:112206895..112304353 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112206895-112336694)x3 copy number gain not provided [RCV000738055] Chr12:112206895..112336694 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112182465-112304353)x3 copy number gain not provided [RCV000750577] Chr12:112182465..112304353 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112182465-112308111)x3 copy number gain not provided [RCV000750578] Chr12:112182465..112308111 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12(chr12:112186274-112298257)x3 copy number gain not provided [RCV000750579] Chr12:112186274..112298257 [GRCh37]
Chr12:12q24.12		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112186274-112304353)x3 copy number gain not provided [RCV000750580] Chr12:112186274..112304353 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12-24.13(chr12:112186274-112321569)x3 copy number gain not provided [RCV000750581] Chr12:112186274..112321569 [GRCh37]
Chr12:12q24.12-24.13		 benign
GRCh37/hg19 12q24.12(chr12:111861041-112280895)x3 copy number gain not provided [RCV000762701] Chr12:111861041..112280895 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.501G>C (p.Leu167Phe) single nucleotide variant Inborn genetic diseases [RCV003251021] Chr12:111871102 [GRCh38]
Chr12:112308906 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.207_208dup (p.Ala70fs) microsatellite Neurocardiofaciodigital syndrome [RCV002248407] Chr12:111867587..111867588 [GRCh38]
Chr12:112305391..112305392 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.1077dup (p.Leu360fs) duplication Neurocardiofaciodigital syndrome [RCV002248408] Chr12:111888593..111888594 [GRCh38]
Chr12:112326397..112326398 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.1405G>A (p.Glu469Lys) single nucleotide variant not provided [RCV003129510] Chr12:111893050 [GRCh38]
Chr12:112330854 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.590C>T (p.Ala197Val) single nucleotide variant Syndromic disease [RCV002273239] Chr12:111880457 [GRCh38]
Chr12:112318261 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.1017C>G (p.Asn339Lys) single nucleotide variant not provided [RCV003129513] Chr12:111888535 [GRCh38]
Chr12:112326339 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.1324C>T (p.Arg442Cys) single nucleotide variant Inborn genetic diseases [RCV002905389] Chr12:111892969 [GRCh38]
Chr12:112330773 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.17A>G (p.Asp6Gly) single nucleotide variant Inborn genetic diseases [RCV002860000] Chr12:111842750 [GRCh38]
Chr12:112280554 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.445C>T (p.Leu149Phe) single nucleotide variant Inborn genetic diseases [RCV002798808] Chr12:111870322 [GRCh38]
Chr12:112308126 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.410G>A (p.Arg137Gln) single nucleotide variant Inborn genetic diseases [RCV002915190] Chr12:111870287 [GRCh38]
Chr12:112308091 [GRCh37]
Chr12:12q24.12		 likely benign
NM_003668.4(MAPKAPK5):c.1150G>A (p.Glu384Lys) single nucleotide variant Inborn genetic diseases [RCV003003975] Chr12:111888934 [GRCh38]
Chr12:112326738 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.638C>T (p.Pro213Leu) single nucleotide variant Inborn genetic diseases [RCV002789163] Chr12:111880505 [GRCh38]
Chr12:112318309 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.172A>C (p.Lys58Gln) single nucleotide variant Inborn genetic diseases [RCV002920890] Chr12:111866217 [GRCh38]
Chr12:112304021 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.139C>T (p.Arg47Trp) single nucleotide variant Inborn genetic diseases [RCV002965344] Chr12:111866184 [GRCh38]
Chr12:112303988 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.31A>G (p.Ile11Val) single nucleotide variant Inborn genetic diseases [RCV002959841] Chr12:111842764 [GRCh38]
Chr12:112280568 [GRCh37]
Chr12:12q24.12		 uncertain significance
NM_003668.4(MAPKAPK5):c.1180C>T (p.Arg394Ter) single nucleotide variant Neurocardiofaciodigital syndrome [RCV003228821] Chr12:111888964 [GRCh38]
Chr12:112326768 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.320G>T (p.Gly107Val) single nucleotide variant Neurocardiofaciodigital syndrome [RCV003228824] Chr12:111868788 [GRCh38]
Chr12:112306592 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.671del (p.Leu224fs) deletion Neurocardiofaciodigital syndrome [RCV003228822] Chr12:111883590 [GRCh38]
Chr12:112321394 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.1303C>T (p.Gln435Ter) single nucleotide variant Neurocardiofaciodigital syndrome [RCV003228823] Chr12:111890126 [GRCh38]
Chr12:112327930 [GRCh37]
Chr12:12q24.12		 pathogenic
NM_003668.4(MAPKAPK5):c.1005A>C (p.Glu335Asp) single nucleotide variant Inborn genetic diseases [RCV003343145] Chr12:111888523 [GRCh38]
Chr12:112326327 [GRCh37]
Chr12:12q24.12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1111
Count of miRNA genes:650
Interacting mature miRNAs:762
Transcripts:ENST00000546394, ENST00000547067, ENST00000547305, ENST00000547915, ENST00000549875, ENST00000550735, ENST00000551404, ENST00000552111, ENST00000553053, ENST00000602983
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D12S1333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712112,325,499 - 112,325,737UniSTSGRCh37
Build 3612110,809,882 - 110,810,120RGDNCBI36
Celera12111,950,962 - 111,951,198RGD
Cytogenetic Map12q24.13UniSTS
HuRef12109,338,962 - 109,339,196UniSTS
Marshfield Genetic Map12119.55UniSTS
Genethon Genetic Map12120.5UniSTS
deCODE Assembly Map12126.24UniSTS
Whitehead-YAC Contig Map12 UniSTS
RH17458  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712112,330,962 - 112,331,192UniSTSGRCh37
Build 3612110,815,345 - 110,815,575RGDNCBI36
Celera12111,956,423 - 111,956,653RGD
Cytogenetic Map12q24.13UniSTS
HuRef12109,344,379 - 109,344,609UniSTS
GeneMap99-GB4 RH Map12439.86UniSTS
NCBI RH Map12718.4UniSTS
MAPKAPK5_8828  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712112,330,775 - 112,331,301UniSTSGRCh37
Build 3612110,815,158 - 110,815,684RGDNCBI36
Celera12111,956,236 - 111,956,762RGD
HuRef12109,344,192 - 109,344,718UniSTS
A009W37  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712112,330,989 - 112,331,201UniSTSGRCh37
Build 3612110,815,372 - 110,815,584RGDNCBI36
Celera12111,956,450 - 111,956,662RGD
Cytogenetic Map12q24.13UniSTS
HuRef12109,344,406 - 109,344,618UniSTS
GeneMap99-GB4 RH Map12427.17UniSTS
NCBI RH Map12718.8UniSTS
G32924  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712112,330,989 - 112,331,201UniSTSGRCh37
Celera12111,956,450 - 111,956,662UniSTS
Cytogenetic Map12q24.13UniSTS
HuRef12109,344,406 - 109,344,618UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 624 417 670 95 640 79 2011 142 1169 213 884 1084 20 198 1277 3
Low 1815 2508 1056 529 1251 386 2345 2049 2565 206 576 529 155 1 1006 1511 2 2
Below cutoff 66 60 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001371479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC003029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF032437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW780199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG502445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000546394
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,488 - 111,870,307 (+)Ensembl
RefSeq Acc Id: ENST00000547067
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,887,578 - 111,893,157 (+)Ensembl
RefSeq Acc Id: ENST00000547305   ⟹   ENSP00000473541
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,475 - 111,843,396 (+)Ensembl
RefSeq Acc Id: ENST00000547915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,889,233 - 111,896,539 (+)Ensembl
RefSeq Acc Id: ENST00000549875   ⟹   ENSP00000473467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,734 - 111,893,060 (+)Ensembl
RefSeq Acc Id: ENST00000550735   ⟹   ENSP00000449667
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,228 - 111,902,222 (+)Ensembl
RefSeq Acc Id: ENST00000551404   ⟹   ENSP00000449381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,013 - 111,893,161 (+)Ensembl
RefSeq Acc Id: ENST00000552111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,885,438 - 111,890,141 (+)Ensembl
RefSeq Acc Id: ENST00000553053   ⟹   ENSP00000448408
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,842,483 - 111,888,525 (+)Ensembl
RefSeq Acc Id: ENST00000602983
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12111,843,032 - 111,843,423 (+)Ensembl
RefSeq Acc Id: NM_001371479   ⟹   NP_001358408
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371480   ⟹   NP_001358409
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371481   ⟹   NP_001358410
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371482   ⟹   NP_001358411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371483   ⟹   NP_001358412
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371484   ⟹   NP_001358413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371485   ⟹   NP_001358414
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371486   ⟹   NP_001358415
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371487   ⟹   NP_001358416
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003668   ⟹   NP_003659
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
GRCh3712112,280,032 - 112,331,228 (+)NCBI
Build 3612110,764,662 - 110,815,611 (+)NCBI Archive
HuRef12109,293,372 - 109,344,645 (+)NCBI
CHM1_112112,247,967 - 112,299,159 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
RefSeq Acc Id: NM_139078   ⟹   NP_620777
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,902,222 (+)NCBI
GRCh3712112,280,032 - 112,331,228 (+)NCBI
Build 3612110,764,662 - 110,815,611 (+)NCBI Archive
HuRef12109,293,372 - 109,344,645 (+)NCBI
CHM1_112112,247,967 - 112,299,159 (+)NCBI
T2T-CHM13v2.012111,819,139 - 111,879,131 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_620777   ⟸   NM_139078
- Peptide Label: isoform 2
- UniProtKB: Q9BVX9 (UniProtKB/Swiss-Prot),   Q86X46 (UniProtKB/Swiss-Prot),   O60491 (UniProtKB/Swiss-Prot),   B3KVA5 (UniProtKB/Swiss-Prot),   Q9UG86 (UniProtKB/Swiss-Prot),   Q8IW41 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003659   ⟸   NM_003668
- Peptide Label: isoform 1
- UniProtKB: Q8IW41 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001358408   ⟸   NM_001371479
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001358409   ⟸   NM_001371480
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001358410   ⟸   NM_001371481
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001358411   ⟸   NM_001371482
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001358412   ⟸   NM_001371483
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001358413   ⟸   NM_001371484
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001358414   ⟸   NM_001371485
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001358415   ⟸   NM_001371486
- Peptide Label: isoform 10
RefSeq Acc Id: NP_001358416   ⟸   NM_001371487
- Peptide Label: isoform 11
- UniProtKB: R4GN33 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000473541   ⟸   ENST00000547305
RefSeq Acc Id: ENSP00000473467   ⟸   ENST00000549875
RefSeq Acc Id: ENSP00000449667   ⟸   ENST00000550735
RefSeq Acc Id: ENSP00000449381   ⟸   ENST00000551404
RefSeq Acc Id: ENSP00000448408   ⟸   ENST00000553053
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8IW41-F1-model_v2 AlphaFold Q8IW41 1-473 view protein structure

Promoters
RGD ID:7225439
Promoter ID:EPDNEW_H18465
Type:initiation region
Name:MAPKAPK5_2
Description:mitogen-activated protein kinase-activated protein kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18466  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,020 - 111,842,080EPDNEW
RGD ID:7225441
Promoter ID:EPDNEW_H18466
Type:initiation region
Name:MAPKAPK5_1
Description:mitogen-activated protein kinase-activated protein kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18465  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812111,842,228 - 111,842,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6889 AgrOrtholog
COSMIC MAPKAPK5 COSMIC
Ensembl Genes ENSG00000089022 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000547305.1 UniProtKB/TrEMBL
  ENST00000549875 ENTREZGENE
  ENST00000549875.1 UniProtKB/TrEMBL
  ENST00000550735 ENTREZGENE
  ENST00000550735.7 UniProtKB/Swiss-Prot
  ENST00000551404 ENTREZGENE
  ENST00000551404.7 UniProtKB/Swiss-Prot
  ENST00000553053.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000089022 GTEx
HGNC ID HGNC:6889 ENTREZGENE
Human Proteome Map MAPKAPK5 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:8550 UniProtKB/Swiss-Prot
NCBI Gene 8550 ENTREZGENE
OMIM 606723 OMIM
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30633 PharmGKB
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KVA5 ENTREZGENE
  F8VRP2_HUMAN UniProtKB/TrEMBL
  MAPK5_HUMAN UniProtKB/Swiss-Prot
  O60491 ENTREZGENE
  Q86X46 ENTREZGENE
  Q8IW41 ENTREZGENE
  Q9BVX9 ENTREZGENE
  Q9UG86 ENTREZGENE
  R4GN33 ENTREZGENE, UniProtKB/TrEMBL
  R4GN93_HUMAN UniProtKB/TrEMBL
UniProt Secondary B3KVA5 UniProtKB/Swiss-Prot
  O60491 UniProtKB/Swiss-Prot
  Q86X46 UniProtKB/Swiss-Prot
  Q9BVX9 UniProtKB/Swiss-Prot
  Q9UG86 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 MAPKAPK5  MAPK activated protein kinase 5  MAPKAPK5  mitogen-activated protein kinase-activated protein kinase 5  Symbol and/or name change 5135510 APPROVED