Arhgap42 (Rho GTPase activating protein 42) - Rat Genome Database

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Pathways
Gene: Arhgap42 (Rho GTPase activating protein 42) Rattus norvegicus
Analyze
Symbol: Arhgap42
Name: Rho GTPase activating protein 42
RGD ID: 1564081
Description: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of Rho protein signal transduction; negative regulation of systemic arterial blood pressure; and negative regulation of vascular associated smooth muscle contraction. Predicted to be located in cytoplasm. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500943; RGD1564081; rho GTPase-activating protein 42; similar to novel protein similar to human oligophrenin 1 (OPHN1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8814,436,478 - 14,666,588 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl814,419,256 - 14,666,385 (-)EnsemblGRCr8
mRatBN7.286,154,759 - 6,384,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl86,156,865 - 6,384,870 (-)EnsemblmRatBN7.2
Rnor_6.087,210,999 - 7,446,215 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl87,213,822 - 7,426,611 (-)Ensemblrn6Rnor6.0
Rnor_5.087,195,968 - 7,426,711 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.485,871,794 - 6,101,228 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera87,691,250 - 7,919,838 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24335996  


Genomics

Comparative Map Data
Arhgap42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8814,436,478 - 14,666,588 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl814,419,256 - 14,666,385 (-)EnsemblGRCr8
mRatBN7.286,154,759 - 6,384,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl86,156,865 - 6,384,870 (-)EnsemblmRatBN7.2
Rnor_6.087,210,999 - 7,446,215 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl87,213,822 - 7,426,611 (-)Ensemblrn6Rnor6.0
Rnor_5.087,195,968 - 7,426,711 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.485,871,794 - 6,101,228 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera87,691,250 - 7,919,838 (-)NCBICelera
Cytogenetic Map8q11NCBI
ARHGAP42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811100,687,288 - 100,993,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11100,687,288 - 100,993,941 (+)Ensemblhg38GRCh38
GRCh3711100,558,019 - 100,864,672 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611100,063,620 - 100,354,994 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1197,727,721 - 98,030,995 (+)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1196,494,881 - 96,798,724 (+)NCBIHuRef
CHM1_111100,441,819 - 100,744,897 (+)NCBICHM1_1
T2T-CHM13v2.011100,696,486 - 101,003,484 (+)NCBIT2T-CHM13v2.0
Arhgap42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,992,508 - 9,239,032 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,994,330 - 9,239,106 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3898,992,507 - 9,239,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,994,329 - 9,239,101 (-)Ensemblmm10GRCm38
MGSCv3798,994,953 - 9,239,013 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3698,956,170 - 9,200,943 (-)NCBIMGSCv36mm8
Celera96,374,598 - 6,617,500 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Arhgap42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554124,367,369 - 4,594,888 (+)Ensembl
ChiLan1.0NW_0049554124,367,369 - 4,601,653 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29101,497,116 - 101,803,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111102,585,722 - 102,891,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01195,655,874 - 95,962,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11199,159,631 - 99,463,457 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1199,159,634 - 99,460,060 (+)EnsemblpanPan2panpan1.1
ARHGAP42
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121597,306 - 842,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl21602,378 - 884,768 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha21610,982 - 898,628 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.021758,866 - 1,046,665 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl21762,118 - 1,046,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.121542,722 - 830,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.021628,840 - 916,548 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.021682,442 - 970,297 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494784,673,988 - 84,928,802 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365516,613,145 - 6,862,024 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365516,609,645 - 6,862,514 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl931,720,849 - 31,994,581 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1931,720,586 - 31,999,730 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2935,866,775 - 36,008,783 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,064,404 - 92,384,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,065,132 - 92,382,915 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604333,479,457 - 33,793,884 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248781,811,013 - 2,095,733 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248781,803,353 - 2,095,767 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgap42
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v184,780,434 - 5,005,059 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgap42
1689 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:136
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000009167, ENSRNOT00000031492
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat

Markers in Region
D8Got343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,334,483 - 6,334,638 (+)MAPPERmRatBN7.2
Rnor_6.087,391,839 - 7,391,993NCBIRnor6.0
Rnor_5.087,376,732 - 7,376,886UniSTSRnor5.0
RGSC_v3.486,050,490 - 6,050,644UniSTSRGSC3.4
Celera87,870,222 - 7,870,376UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 34 59 6 298 134 11 141 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000031492   ⟹   ENSRNOP00000037659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,659,491 (-)Ensembl
mRatBN7.2 Ensembl86,156,865 - 6,368,306 (-)Ensembl
Rnor_6.0 Ensembl87,213,822 - 7,426,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102910   ⟹   ENSRNOP00000095180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,666,385 (-)Ensembl
mRatBN7.2 Ensembl86,156,865 - 6,384,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111399   ⟹   ENSRNOP00000083840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,666,385 (-)Ensembl
mRatBN7.2 Ensembl86,156,865 - 6,384,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113947   ⟹   ENSRNOP00000089518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,666,385 (-)Ensembl
mRatBN7.2 Ensembl86,156,865 - 6,384,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114748   ⟹   ENSRNOP00000078771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,495 - 14,592,717 (-)Ensembl
mRatBN7.2 Ensembl86,156,865 - 6,311,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128008   ⟹   ENSRNOP00000103601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,511,205 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140315   ⟹   ENSRNOP00000099973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,419,256 - 14,666,385 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149409   ⟹   ENSRNOP00000101347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl814,438,494 - 14,649,768 (-)Ensembl
RefSeq Acc Id: XM_006242515   ⟹   XP_006242577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8814,436,478 - 14,657,816 (-)NCBI
mRatBN7.286,154,759 - 6,369,154 (-)NCBI
Rnor_6.087,210,999 - 7,426,563 (-)NCBI
Rnor_5.087,195,968 - 7,426,711 (-)NCBI
Sequence:
RefSeq Acc Id: XM_576354   ⟹   XP_576354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8814,436,478 - 14,666,588 (-)NCBI
mRatBN7.286,154,759 - 6,384,497 (-)NCBI
Rnor_6.087,210,999 - 7,446,215 (-)NCBI
Rnor_5.087,195,968 - 7,426,711 (-)NCBI
RGSC_v3.485,871,794 - 6,101,228 (-)RGD
Sequence:
RefSeq Acc Id: XP_576354   ⟸   XM_576354
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242577   ⟸   XM_006242515
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000037659   ⟸   ENSRNOT00000031492
Ensembl Acc Id: ENSRNOP00000089518   ⟸   ENSRNOT00000113947
Ensembl Acc Id: ENSRNOP00000083840   ⟸   ENSRNOT00000111399
Ensembl Acc Id: ENSRNOP00000078771   ⟸   ENSRNOT00000114748
Ensembl Acc Id: ENSRNOP00000095180   ⟸   ENSRNOT00000102910
Ensembl Acc Id: ENSRNOP00000099973   ⟸   ENSRNOT00000140315
Ensembl Acc Id: ENSRNOP00000101347   ⟸   ENSRNOT00000149409
Ensembl Acc Id: ENSRNOP00000103601   ⟸   ENSRNOT00000128008
Protein Domains
PH   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M2Q1-F1-model_v2 AlphaFold F1M2Q1 1-826 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564081 AgrOrtholog
BioCyc Gene G2FUF-31748 BioCyc
Ensembl Genes ENSRNOG00000026821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031492.9 UniProtKB/TrEMBL
  ENSRNOT00000102910 ENTREZGENE
  ENSRNOT00000102910.2 UniProtKB/TrEMBL
  ENSRNOT00000111399.2 UniProtKB/TrEMBL
  ENSRNOT00000113947.2 UniProtKB/TrEMBL
  ENSRNOT00000114748.2 UniProtKB/TrEMBL
  ENSRNOT00000128008.1 UniProtKB/TrEMBL
  ENSRNOT00000140315.1 UniProtKB/TrEMBL
  ENSRNOT00000149409 ENTREZGENE
  ENSRNOT00000149409.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  GRAF_fam UniProtKB/TrEMBL
  PH_GRAF UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:500943 UniProtKB/TrEMBL
NCBI Gene 500943 ENTREZGENE
PANTHER OLIGOPHRENIN 1 UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 42 UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Arhgap42 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026821 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A8I5ZLH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACT5_RAT UniProtKB/TrEMBL
  A0A8I6APV4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L649_RAT UniProtKB/TrEMBL
  A0ABK0L8M9_RAT UniProtKB/TrEMBL
  A0ABK0LPX4_RAT UniProtKB/TrEMBL
  F1M2Q1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-09-15 Arhgap42  Rho GTPase activating protein 42  RGD1564081  similar to novel protein similar to human oligophrenin 1 (OPHN1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564081  similar to novel protein similar to human oligophrenin 1 (OPHN1)   RGD1564081_predicted  similar to novel protein similar to human oligophrenin 1 (OPHN1) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564081_predicted  similar to novel protein similar to human oligophrenin 1 (OPHN1) (predicted)  LOC500943  similar to novel protein similar to human oligophrenin 1 (OPHN1)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500943  similar to novel protein similar to human oligophrenin 1 (OPHN1)      Symbol and Name status set to provisional 70820 PROVISIONAL