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Gene: Edaradd (EDAR associated via death domain) Rattus norvegicus

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Symbol:

Edaradd

Name:

EDAR associated via death domain

RGD ID:

1564010

Description:

Involved in positive regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm. Used to study hypohidrotic ectodermal dysplasia and otitis media. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain); INTERACTS WITH 17beta-estradiol; bisphenol A; 1,2-dimethylhydrazine (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ectodysplasin-A receptor-associated adapter protein; EDAR (ectodysplasin-A receptor)-associated death domain; EDAR-associated death domain; LOC498769; RGD1564010; similar to crinkled

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EDARADD (EDAR associated via death domain)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Edaradd (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Edaradd (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EDARADD (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EDARADD (EDAR associated death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Edaradd (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EDARADD (EDAR associated death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EDARADD (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Edaradd (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Edaradd (EDAR associated via death domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EDARADD (EDAR associated via death domain)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Edaradd (EDAR associated via death domain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	edaradd (EDAR-associated death domain)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	edaradd	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	edaradd	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Edaradd^swhKyo

Genetic Models:

WTC-swh/Kyo

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	92,850,791 - 92,894,808 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	92,831,613 - 92,894,361 (-)	Ensembl				GRCr8
mRatBN7.2	17	85,866,629 - 85,910,612 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	85,656,905 - 85,910,447 (-)	Ensembl				mRatBN7.2
Rnor_6.0	17	90,802,280 - 90,843,476 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,802,393 - 90,843,485 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	92,462,305 - 92,503,399 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	67,056,373 - 67,143,933 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	85,700,726 - 85,744,668 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ectodermal dysplasia (ISO)

ectodermal dysplasia 10A (ISO)

ectodermal dysplasia 10B (ISO)

ectodermal dysplasia 11A (ISO)

ectodermal dysplasia 11B (ISO)

genetic disease (ISO)

hypohidrotic ectodermal dysplasia (IAGP,ISO)

otitis media (IAGP)

tooth agenesis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

aldehydo-D-glucose (ISO)

Azaspiracid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

buta-1,3-diene (ISO)

corosolic acid (ISO)

curcumin (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diiodine (ISO)

dioxygen (ISO)

folic acid (ISO)

fructose (ISO)

genistein (ISO)

glucose (ISO)

indometacin (ISO)

iron dichloride (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

nickel dichloride (ISO)

nickel sulfate (ISO)

o-anisidine (ISO)

ozone (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

streptozocin (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

hair follicle development (ISO)

odontogenesis of dentin-containing tooth (ISO)

positive regulation of non-canonical NF-kappaB signal transduction (IMP)

signal transduction (IEA)

trachea gland development (ISO)

Cellular Component

cytoplasm (IEA)

Molecular Function

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal awl hair morphology (IAGP)

abnormal hair texture (IAGP)

abnormal mammary gland alveolus morphology (IAGP)

abnormal molar cusp morphology (IAGP)

abnormal submucosal gland morphology (IAGP)

abnormal tongue morphology (IAGP)

absent Meibomian glands (IAGP)

absent sweat gland (IAGP)

decreased body weight (IAGP)

decreased hair follicle number (IAGP)

mammary gland hypoplasia (IAGP)

small hair follicles (IAGP)

small male preputial gland (IAGP)

sparse hair (IAGP)

waved hair (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia.	Del-Pozo J, etal., Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037804. doi: 10.1242/dmm.037804.
2.	A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.	Kuramoto T, etal., BMC Genet. 2011 Oct 21;12:91. doi: 10.1186/1471-2156-12-91.
3.	Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17.	Kuramoto T, etal., J Hered. 2005 Jul-Aug;96(4):339-45. Epub 2005 Apr 13.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:544312	PMID:5893447	PMID:14699584	PMID:15973734	PMID:21873635

Genomics

Comparative Map Data

Edaradd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	92,850,791 - 92,894,808 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	92,831,613 - 92,894,361 (-)	Ensembl				GRCr8
mRatBN7.2	17	85,866,629 - 85,910,612 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	85,656,905 - 85,910,447 (-)	Ensembl				mRatBN7.2
Rnor_6.0	17	90,802,280 - 90,843,476 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,802,393 - 90,843,485 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	92,462,305 - 92,503,399 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	67,056,373 - 67,143,933 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	85,700,726 - 85,744,668 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

EDARADD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	236,348,259 - 236,484,930 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	236,348,257 - 236,502,915 (+)	Ensembl			hg38	GRCh38
GRCh37	1	236,511,559 - 236,648,230 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	234,624,303 - 234,714,631 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	232,883,720 - 232,974,049	NCBI
Celera	1	209,804,771 - 209,895,082 (+)	NCBI		Celera
Cytogenetic Map	1	q42.3-q43	NCBI
HuRef	1	207,012,849 - 207,103,467 (+)	NCBI		HuRef
CHM1_1	1	237,829,988 - 237,920,874 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	235,750,587 - 235,884,698 (+)	NCBI		T2T-CHM13v2.0

Edaradd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	12,486,090 - 12,535,413 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	12,487,513 - 12,535,319 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	12,471,209 - 12,520,535 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	12,472,632 - 12,520,438 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	12,569,175 - 12,612,715 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	12,531,162 - 12,574,879 (-)	NCBI		MGSCv36	mm8
Celera	13	12,393,096 - 12,436,757 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	4.77	NCBI

Edaradd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	3,711,549 - 3,777,528 (-)	Ensembl
ChiLan1.0	NW_004955492	3,709,819 - 3,777,506 (-)	NCBI	ChiLan1.0	ChiLan1.0

EDARADD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	12,702,380 - 12,787,405 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	12,914,211 - 12,999,256 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	211,973,108 - 212,043,142 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	217,042,359 - 217,043,804 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	216,960,418 - 217,044,046 (+)	NCBI			panPan2	panpan1.1
PanPan1.1 Ensembl	1	216,960,418 - 217,044,046 (+)	Ensembl			panPan2	panpan1.1

EDARADD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	3,608,545 - 3,659,357 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	3,610,079 - 3,669,789 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	3,654,946 - 3,715,144 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	3,629,190 - 3,689,391 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	3,629,181 - 3,690,451 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	3,641,762 - 3,701,937 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	3,758,964 - 3,819,177 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	3,979,463 - 4,039,647 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Edaradd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	40,226,404 - 40,281,250 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	16,395,935 - 16,446,146 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	16,394,753 - 16,446,102 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EDARADD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	54,925,771 - 54,990,848 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	54,924,156 - 54,992,206 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	58,899,859 - 58,965,928 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EDARADD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	73,537,185 - 73,625,338 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	73,538,944 - 73,626,038 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	75,628,044 - 75,715,344 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Edaradd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	14,132,710 - 14,191,423 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624775	14,132,455 - 14,191,604 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Edaradd
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	40,817,269 - 40,846,966 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	79
Count of miRNA genes:	74
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000003535
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat

Markers in Region

D17Got212

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	85,953,147 - 85,953,291 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	90,760,248 - 90,760,391	NCBI	Rnor6.0
Rnor_5.0	17	92,420,273 - 92,420,416	UniSTS	Rnor5.0
RGSC_v3.4	17	67,060,452 - 67,060,595	UniSTS	RGSC3.4
Celera	17	85,656,431 - 85,656,574	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

RH143797

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	85,956,944 - 85,957,044 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	90,756,495 - 90,756,594	NCBI	Rnor6.0
Rnor_5.0	17	92,416,520 - 92,416,619	UniSTS	Rnor5.0
RGSC_v3.4	17	67,056,699 - 67,056,798	UniSTS	RGSC3.4
Celera	17	85,652,677 - 85,652,776	UniSTS
Cytogenetic Map	17	q12.1	UniSTS

Genetic Models

This gene Edaradd is modified in the following models/strains:

WTC-swh/Kyo

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	150	91	90	59	91	59	6	354	191	11	129	80	92	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_574055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003535 ⟹ ENSRNOP00000003535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	92,853,614 - 92,894,361 (-)	Ensembl
mRatBN7.2 Ensembl	17	85,656,905 - 85,910,447 (-)	Ensembl
Rnor_6.0 Ensembl	17	90,802,393 - 90,843,485 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146491 ⟹ ENSRNOP00000101253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	92,831,613 - 92,894,361 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167701 ⟹ ENSRNOP00000101146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	92,850,886 - 92,894,361 (-)	Ensembl

RefSeq Acc Id:

XM_574055 ⟹ XP_574055

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	92,850,791 - 92,894,808 (-)	NCBI
mRatBN7.2	17	85,866,629 - 85,910,612 (-)	NCBI
Rnor_6.0	17	90,802,280 - 90,843,476 (+)	NCBI
Rnor_5.0	17	92,462,305 - 92,503,399 (+)	NCBI
RGSC_v3.4	17	67,056,373 - 67,143,933 (+)	RGD

Sequence:

show sequence

GCGTCTCAGCCCGGGCCTGTGCAAGGAGCACGCTGGGAGCGCTTTGGTGTCCCAGCTGAGGGTG
AGATTAGGAACCGGGAAAGCTACCCGCGCATGCAGCAACCAGTGGAAGGTCAGCTGAAAGGCCC
TCCCAGCTGGGATCGCGTGGGAACCCCGTGGTGGGACCAGCGTTCTACACCCTAGGTACTGTTC
CGGGGGCCTCGCGGGGTCCTCTCGTGTCCAACCGAAACCCACGGGATCCTCTCCAGAGTTCTGG
AGAGACGCTCGCGCCAGGAAGGGGCTTTGCTAATTGCAGGAAGTGAGCACGAGGAAGAAGTGGC
AGAGATCAAGAGGAGGAAGATAGGGAGGAGGAGGAGCAGCAGGGCAAAGCGCTGAGAGAGAGTC
GCGCATTGCCAGGAGGTTGGGTCCCAGCGATCCTGCTGTTCTCAGGGGTCCCAGAGACTGCCTA
CCCCTGCTCAGACACTCATCTGTCCTCTCCTGGTCTTCATGGCTTCTCCGGATGACCCTCTGCG
CTCAGATCACATGGCAAAGGAGCCAGTGGAGGACACAGACCCCAGCACTTTATCCTTTGCCATG
TCAGACAAGTATCCCATTCAAGACACTGGCCTCCCTAAAGCTAAGGAGTGTGATGCAGTCACTT
CCAACTGCCCACCAAATTCTGATGATCAGCACCAGGGAGAAGAAAATGACTTTCCAGACAGCAC
TGGGGATCCCCTTTCAGGTGTCAGCAGAAACCAGCCATGCAAGGAAGGCTGCCCTTGCTCTTCC
TGCTCTCCTCGGGCTCCCACCATTAGTGACTTGCTCAACGATCAAGACTTGCTAGATGTGATCA
GGATAAAGCTGGATCCATGTCACCCGACTGTGAAGAACTGGAGGAATTTTGCCAGCAAATGGGG
CATGCCCTATGATGAGCTCTGCTTCCTGGAACAGAGGCCCCAGAGCCCCACACTGGAGTTCTTA
TTCCGAAACAGCCAGAGGACTGTAGGCCAACTGATGGAGCTCTGCCGACTTTATCACAGGGCTG
ACGTGGAGAAGATCCTGCGCAGGTGGGTTGATGAGGAGTGGCCCCACAGGGGACCCTTGGACGG
TTCCATGCACTTTTAGAATCCCCTCCCCTGGCATTGGCCGTACTGCATGCTGGAACAGCATGGA
TCGCAGGGACCTATGTGTTCCTGCTGTTAAGGTCTTCGGATGAGAATATAACACAGGCAGTGGT
TATCCCTGAAGCTGGTGGCTTGGGGAAGGACGGGTTGTTTCAAAAGCAGGTGTTTGTTTCCTTT
TGCACATTTGTTTTAATTTAATATTTGAACCTGGAACTGGGGAAGAATATTTTATAGGTCACAT
AGGGCCACAGCCTATGGCTGGGACAGAGCCATGCCAACATGGAACGAAAACTCTTCTTAAAAAC
TGCCAAAGATTGCAGCTTTCCCAAACTGTCAGTGTCTCTGGACACGTGCACGTCATCCCATACA
GGACCTTTGCATTCCCTGCCTAGTGGAGGAAAGCATGTAGAAGTCACCCTGGCCTGTTCACTGT
TCACAACAGTGTATTTCTGTTGCAAAAGGCTTTGGAGATCAAGAAGATACTATGCAATGTGGCC
CAGATATATGGGCTCCTTTGTTTTATTATTATCAAATACTTTTGTAATCTATAGGCTATCAATA
CTGTCATTGAATTTAGCATTTTACAAAGGAATACAAAATGTATGGTTTATGGGAGAAGAGAGTG
GGTTAGTGTCTTAGGAATGGCATTGACAAAGAATAGTGCTCAATATGGCCTTTTGGGCCCTAGG
GAGCTATCTCAGTGGTTACAGTGCTCACCAAATAAAGCATGAGAACCAGAGTCCAGGTCCCTGG
AACCCATATAAGTGAGGGAGTGAATGATATGGCAGCTCACCTGTCATTCCGGAAGAGATACCAA
TCCCGAGAACAAGATGGATAGCTAGACTAGGCACATGGACCAACACTGGGTTCAACTGAGAGAC
TCTTTCTCAATGAACAATGTGCAGAGTTGTTGAGGAAAACTTTCAACATCAACTTTGGGAGTCT
ATATGCACACACATGTACATGTACATCTGTATACATGTGCAACAACAATGTGTGTGCACACTGC
TCATGCGAACACACAGACACAGACAGACAAACAGACAGAGACAGACAGACAGACAGACAGACAG
ACAGACACACACACACACACACACACACACACACACACAAACACAGAGTAAATCTCTAAGAGAT
AAGGTCAAGGTTGGTCTGGAATGTAGC

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Protein Sequences


Protein RefSeqs	NP_001419240	(Get FASTA)	NCBI Sequence Viewer
	XP_574055	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL83158	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003535
	ENSRNOP00000003535.5
	ENSRNOP00000101146.1
	ENSRNOP00000101253.1

RefSeq Acc Id:

XP_574055 ⟸ XM_574055

- Sequence:

show sequence

MASPDDPLRSDHMAKEPVEDTDPSTLSFAMSDKYPIQDTGLPKAKECDAVTSNCPPNSDDQHQG
EENDFPDSTGDPLSGVSRNQPCKEGCPCSSCSPRAPTISDLLNDQDLLDVIRIKLDPCHPTVKN
WRNFASKWGMPYDELCFLEQRPQSPTLEFLFRNSQRTVGQLMELCRLYHRADVEKILRRWVDEE
WPHRGPLDGSMHF

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Ensembl Acc Id:

ENSRNOP00000003535 ⟸ ENSRNOT00000003535

Ensembl Acc Id:

ENSRNOP00000101253 ⟸ ENSRNOT00000146491

Ensembl Acc Id:

ENSRNOP00000101146 ⟸ ENSRNOT00000167701

Protein Domains

Death

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LYE0-F1-model_v2	AlphaFold	F1LYE0	1-205	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564010	AgrOrtholog
BioCyc Gene	G2FUF-8454	BioCyc
Ensembl Genes	ENSRNOG00000002624	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003535	ENTREZGENE
	ENSRNOT00000003535.8	UniProtKB/TrEMBL
	ENSRNOT00000146491.1	UniProtKB/TrEMBL
	ENSRNOT00000167701.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
InterPro	Death	UniProtKB/TrEMBL
	DEATH-like	UniProtKB/TrEMBL
	EDARADD	UniProtKB/TrEMBL
KEGG Report	rno:498769	UniProtKB/TrEMBL
NCBI Gene	498769	ENTREZGENE
PANTHER	ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN	UniProtKB/TrEMBL
	PTHR28469	UniProtKB/TrEMBL
Pfam	Death	UniProtKB/TrEMBL
PhenoGen	Edaradd	PhenoGen
RatGTEx	ENSRNOG00000002624	RatGTEx
Superfamily-SCOP	DEATH_like	UniProtKB/TrEMBL
UniProt	A0ABK0LCU7_RAT	UniProtKB/TrEMBL
	A0ABK0LD68_RAT	UniProtKB/TrEMBL
	A6KTE4	ENTREZGENE, UniProtKB/TrEMBL
	F1LYE0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-17	Edaradd	EDAR-associated death domain	Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	RGD1564010_predicted	similar to crinkled (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564010_predicted	similar to crinkled (predicted)	LOC498769	similar to crinkled	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498769	similar to crinkled			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype