Fcrl6 (Fc receptor-like 6) - Rat Genome Database

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Pathways
Gene: Fcrl6 (Fc receptor-like 6) Rattus norvegicus
Analyze
Symbol: Fcrl6
Name: Fc receptor-like 6
RGD ID: 1563939
Description: Predicted to enable MHC class II protein binding activity; protein phosphatase binding activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human FCRL6 (Fc receptor like 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell surface glycoprotein gp42; Gp42; LOC305103
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,595,058 - 87,604,657 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,595,058 - 87,604,949 (-)EnsemblGRCr8
mRatBN7.21385,062,709 - 85,072,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,066,694 - 85,072,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,565,846 - 87,575,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,966,119 - 88,975,598 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,150,861 - 86,160,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,982,814 - 90,992,415 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,982,814 - 90,992,406 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,501,915 - 95,511,516 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,601,569 - 88,611,170 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,671,572 - 84,681,173 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1845873   PMID:17213291   PMID:18991291   PMID:20519654   PMID:20933011  


Genomics

Comparative Map Data
Fcrl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,595,058 - 87,604,657 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,595,058 - 87,604,949 (-)EnsemblGRCr8
mRatBN7.21385,062,709 - 85,072,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,066,694 - 85,072,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,565,846 - 87,575,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,966,119 - 88,975,598 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,150,861 - 86,160,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,982,814 - 90,992,415 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,982,814 - 90,992,406 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,501,915 - 95,511,516 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,601,569 - 88,611,170 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,671,572 - 84,681,173 (-)NCBICelera
Cytogenetic Map13q24NCBI
FCRL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,800,512 - 159,816,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,800,511 - 159,816,262 (+)Ensemblhg38GRCh38
GRCh371159,770,302 - 159,786,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,038,797 - 158,052,671 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1132,840,594 - 132,854,468 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,128,599 - 131,142,473 (+)NCBIHuRef
CHM1_11161,167,524 - 161,181,398 (+)NCBICHM1_1
T2T-CHM13v2.01158,937,524 - 158,953,270 (+)NCBIT2T-CHM13v2.0
Fcrl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,423,081 - 172,445,889 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,424,209 - 172,430,118 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,595,514 - 172,618,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,596,642 - 172,602,551 (-)Ensemblmm10GRCm38
MGSCv371174,526,771 - 174,532,682 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,528,329 - 174,532,591 (-)NCBIMGSCv36mm8
Celera1175,452,446 - 175,458,803 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.0NCBI
Fcrl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546811,581,225 - 11,617,268 (+)NCBIChiLan1.0ChiLan1.0
LOC100974844
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,038,329 - 90,047,229 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,778,352 - 89,792,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,153,911 - 135,167,699 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,072,824 - 139,088,538 (+)NCBIPanPan1.1PanPan1.1panPan2
FCRL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,311,454 - 22,320,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,387,536 - 22,396,868 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03822,433,000 - 22,442,314 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UNSW_CanFamBas_1.03822,732,350 - 22,741,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,143,360 - 23,152,706 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fcrl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,950,574 - 5,960,521 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936740794,680 - 809,560 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCRL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,681,364 - 90,700,792 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1490,681,084 - 90,698,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,655,695 - 98,680,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223750
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,134,780 - 4,170,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,135,153 - 4,148,730 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660383,239,258 - 3,256,054 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcrl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247941,436,143 - 1,446,215 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fcrl6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11051,713,489 - 51,722,472 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fcrl6
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000000059
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 20 37 47 50 30 68 30 6 150 102 11 18 9 39 20 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000000059   ⟹   ENSRNOP00000000059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,595,058 - 87,601,461 (-)Ensembl
mRatBN7.2 Ensembl1385,067,286 - 85,069,112 (-)Ensembl
Rnor_6.0 Ensembl1390,982,814 - 90,992,406 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103749   ⟹   ENSRNOP00000091307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,599,043 - 87,604,949 (-)Ensembl
mRatBN7.2 Ensembl1385,066,694 - 85,072,600 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135709   ⟹   ENSRNOP00000101561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,595,058 - 87,604,648 (-)Ensembl
RefSeq Acc Id: NM_001164726   ⟹   NP_001158198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,595,058 - 87,604,657 (-)NCBI
mRatBN7.21385,062,709 - 85,072,308 (-)NCBI
Rnor_6.01390,982,814 - 90,992,415 (-)NCBI
Rnor_5.01395,501,915 - 95,511,516 (-)NCBI
RGSC_v3.41388,601,569 - 88,611,170 (-)RGD
Celera1384,671,572 - 84,681,173 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001158198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000101561
GenBank Protein P23505 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001158198   ⟸   NM_001164726
- Peptide Label: precursor
- UniProtKB: P23505 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000059   ⟸   ENSRNOT00000000059
Ensembl Acc Id: ENSRNOP00000091307   ⟸   ENSRNOT00000103749
Ensembl Acc Id: ENSRNOP00000101561   ⟸   ENSRNOT00000135709
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23505-F1-model_v2 AlphaFold P23505 1-233 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563939 AgrOrtholog
BioCyc Gene G2FUF-17298 BioCyc
Ensembl Genes ENSRNOG00000000055 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000135709 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_Fc_receptor UniProtKB/Swiss-Prot
NCBI Gene 305103 ENTREZGENE
PANTHER FC RECEPTOR-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
  IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
PhenoGen Fcrl6 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000055 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8I6ABT7_RAT UniProtKB/TrEMBL
  A0ABK0LAT6_RAT UniProtKB/TrEMBL
  F1LME1_RAT UniProtKB/TrEMBL
  GP42_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-17 Fcrl6  Fc receptor-like 6  LOC305103  cell surface glycoprotein gp42  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC305103  cell surface glycoprotein gp42      Symbol and Name status set to provisional 70820 PROVISIONAL