Sergef (secretion regulating guanine nucleotide exchange factor) - Rat Genome Database

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Gene: Sergef (secretion regulating guanine nucleotide exchange factor) Rattus norvegicus
Analyze
Symbol: Sergef
Name: secretion regulating guanine nucleotide exchange factor
RGD ID: 1563497
Description: Predicted to be involved in negative regulation of protein secretion. Predicted to be active in cytoplasm and nucleus. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365243; RGD1563497; secretion-regulating guanine nucleotide exchange factor; similar to Gnefr protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,085,950 - 106,288,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,085,953 - 106,312,484 (-)EnsemblGRCr8
mRatBN7.2196,949,660 - 97,152,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,949,661 - 97,152,496 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,335,680 - 102,538,499 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,807,664 - 111,010,491 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,098,054 - 104,300,867 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,461,327 - 102,664,978 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,461,329 - 102,664,951 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,546,392 - 103,741,968 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,974,978 - 97,181,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,197,981 - 91,399,879 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, etal., Front Genet. 2020 Dec 14;11:569572. doi: 10.3389/fgene.2020.569572. eCollection 2020.
Additional References at PubMed
PMID:10571079   PMID:12459492  


Genomics

Comparative Map Data
Sergef
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,085,950 - 106,288,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,085,953 - 106,312,484 (-)EnsemblGRCr8
mRatBN7.2196,949,660 - 97,152,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,949,661 - 97,152,496 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,335,680 - 102,538,499 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,807,664 - 111,010,491 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,098,054 - 104,300,867 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,461,327 - 102,664,978 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,461,329 - 102,664,951 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,546,392 - 103,741,968 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,974,978 - 97,181,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,197,981 - 91,399,879 (-)NCBICelera
Cytogenetic Map1q22NCBI
SERGEF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,788,048 - 18,013,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,788,043 - 18,013,047 (-)Ensemblhg38GRCh38
GRCh371117,809,595 - 18,034,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,766,171 - 17,991,213 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1117,942,106 - 18,166,667 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,492,854 - 17,717,359 (-)NCBIHuRef
CHM1_11117,809,310 - 18,034,174 (-)NCBICHM1_1
T2T-CHM13v2.01117,885,746 - 18,110,678 (-)NCBIT2T-CHM13v2.0
Sergef
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,092,583 - 46,289,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,092,578 - 46,289,231 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,443,159 - 46,642,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,443,154 - 46,639,807 (-)Ensemblmm10GRCm38
MGSCv37753,698,529 - 53,895,177 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,311,215 - 46,507,832 (-)NCBIMGSCv36mm8
Celera741,916,678 - 42,113,981 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.2NCBI
Sergef
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,584,839 - 32,796,725 (-)Ensembl
ChiLan1.0NW_00495541432,579,419 - 32,796,714 (-)NCBIChiLan1.0ChiLan1.0
SERGEF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,120,130 - 20,345,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,080,591 - 20,305,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,841,133 - 18,066,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,524,117 - 17,748,898 (-)NCBIPanPan1.1PanPan1.1panPan2
SERGEF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,321,334 - 40,540,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,321,371 - 40,540,664 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,820,922 - 40,040,358 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,425,810 - 41,645,276 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,425,821 - 41,645,241 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,438,547 - 40,657,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,646,432 - 40,865,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,984,861 - 41,204,276 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sergef
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,088,583 - 45,318,665 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,122,570 - 1,347,150 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,122,460 - 1,351,621 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERGEF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,114,178 - 41,356,038 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,114,174 - 41,356,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,178,020 - 44,417,161 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERGEF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,956,423 - 47,185,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038144,345,088 - 144,577,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sergef
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,399,174 - 9,624,590 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,399,166 - 9,624,591 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sergef
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12152,732,496 - 152,929,609 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sergef
2173 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:59
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000015352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Rat101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,146,283 - 97,146,439 (+)MAPPERmRatBN7.2
Rnor_6.01102,658,741 - 102,658,898NCBIRnor6.0
Rnor_5.01103,735,751 - 103,735,908UniSTSRnor5.0
RGSC_v3.4197,174,943 - 97,175,101RGDRGSC3.4
RGSC_v3.4197,174,944 - 97,175,101UniSTSRGSC3.4
Celera191,393,642 - 91,393,799UniSTS
RGSC_v3.1197,253,055 - 97,253,212RGD
RH 3.4 Map1909.1RGD
RH 3.4 Map1909.1UniSTS
RH 2.0 Map1609.2RGD
FHH x ACI Map151.1299RGD
Cytogenetic Map1q22UniSTS
RH137339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,949,683 - 96,949,863 (+)MAPPERmRatBN7.2
Rnor_6.01102,461,351 - 102,461,530NCBIRnor6.0
Rnor_5.01103,546,416 - 103,546,595UniSTSRnor5.0
RGSC_v3.4196,975,002 - 96,975,181UniSTSRGSC3.4
Celera191,198,005 - 91,198,184UniSTS
RH 3.4 Map1909.1UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 68 192 91 90 59 97 59 6 378 198 11 173 97 97 31 25 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001400924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001080802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001834929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005499054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015352   ⟹   ENSRNOP00000015352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,949,661 - 97,152,487 (-)Ensembl
Rnor_6.0 Ensembl1102,461,329 - 102,664,951 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096517   ⟹   ENSRNOP00000096028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,949,662 - 97,152,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097997   ⟹   ENSRNOP00000093927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,949,668 - 97,152,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111093   ⟹   ENSRNOP00000086898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,949,661 - 97,148,289 (-)Ensembl
RefSeq Acc Id: NM_001400924   ⟹   NP_001387853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,955 - 106,288,789 (-)NCBI
mRatBN7.2196,949,665 - 97,152,503 (-)NCBI
RefSeq Acc Id: XM_006229227   ⟹   XP_006229289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
Rnor_6.01102,461,327 - 102,664,978 (-)NCBI
Rnor_5.01103,546,392 - 103,741,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229229   ⟹   XP_006229291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
Rnor_6.01102,461,327 - 102,664,977 (-)NCBI
Rnor_5.01103,546,392 - 103,741,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100957   ⟹   XP_038956885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
RefSeq Acc Id: XM_039100958   ⟹   XP_038956886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
RefSeq Acc Id: XM_039100959   ⟹   XP_038956887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
RefSeq Acc Id: XM_039100961   ⟹   XP_038956889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
mRatBN7.2196,949,660 - 97,152,529 (-)NCBI
RefSeq Acc Id: XM_039100966   ⟹   XP_038956894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,260,668 - 106,288,815 (-)NCBI
mRatBN7.2197,124,362 - 97,152,529 (-)NCBI
RefSeq Acc Id: XM_063269165   ⟹   XP_063125235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,815 (-)NCBI
RefSeq Acc Id: XM_063269178   ⟹   XP_063125248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,617 (-)NCBI
RefSeq Acc Id: XM_063269181   ⟹   XP_063125251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,085,950 - 106,288,617 (-)NCBI
RefSeq Acc Id: XR_005499054
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,238,109 - 106,288,815 (-)NCBI
mRatBN7.2197,101,811 - 97,152,529 (-)NCBI
RefSeq Acc Id: XP_006229291   ⟸   XM_006229229
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AL11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229289   ⟸   XM_006229227
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AL11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015352   ⟸   ENSRNOT00000015352
RefSeq Acc Id: XP_038956886   ⟸   XM_039100958
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038956889   ⟸   XM_039100961
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038956887   ⟸   XM_039100959
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038956885   ⟸   XM_039100957
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038956894   ⟸   XM_039100966
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000086898   ⟸   ENSRNOT00000111093
Ensembl Acc Id: ENSRNOP00000093927   ⟸   ENSRNOT00000097997
Ensembl Acc Id: ENSRNOP00000096028   ⟸   ENSRNOT00000096517
RefSeq Acc Id: NP_001387853   ⟸   NM_001400924
- UniProtKB: D3ZN16 (UniProtKB/TrEMBL),   A6JBC2 (UniProtKB/TrEMBL),   A0A8I6AL11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125235   ⟸   XM_063269165
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AL11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125251   ⟸   XM_063269181
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063125248   ⟸   XM_063269178
- Peptide Label: isoform X8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN16-F1-model_v2 AlphaFold D3ZN16 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690071
Promoter ID:EPDNEW_R587
Type:multiple initiation site
Name:Sergef_1
Description:secretion regulating guanine nucleotide exchange factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,664,959 - 102,665,019EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563497 AgrOrtholog
BioCyc Gene G2FUF-59625 BioCyc
Ensembl Genes ENSRNOG00000011488 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015352 ENTREZGENE
  ENSRNOT00000015352.8 UniProtKB/TrEMBL
  ENSRNOT00000096517.2 UniProtKB/TrEMBL
  ENSRNOT00000097997 ENTREZGENE
  ENSRNOT00000097997.2 UniProtKB/TrEMBL
  ENSRNOT00000111093.2 UniProtKB/TrEMBL
  ENSRNOT00000140216.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
InterPro Reg_chr_condens UniProtKB/TrEMBL
  Reg_csome_cond/b-lactamase_inh UniProtKB/TrEMBL
  Ub_ligase/GEF_domain UniProtKB/TrEMBL
NCBI Gene 365243 ENTREZGENE
PANTHER ANKYRIN REPEAT-CONTAINING PROTEIN UniProtKB/TrEMBL
  REGULATOR OF CHROMOSOME CONDENSATION UniProtKB/TrEMBL
Pfam RCC1 UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  WD40_RLD UniProtKB/TrEMBL
PhenoGen Sergef PhenoGen
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011488 RatGTEx
Superfamily-SCOP RCC1/BLIP-II UniProtKB/TrEMBL
UniProt A0A8I6A4R2_RAT UniProtKB/TrEMBL
  A0A8I6AL11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQB4_RAT UniProtKB/TrEMBL
  A0ABK0L2Q4_RAT UniProtKB/TrEMBL
  A6JBC2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Sergef  secretion regulating guanine nucleotide exchange factor  RGD1563497_predicted  similar to Gnefr protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563497_predicted  similar to Gnefr protein (predicted)  LOC365243  similar to Gnefr protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365243  similar to Gnefr protein      Symbol and Name status set to provisional 70820 PROVISIONAL