Rmdn1 (regulator of microtubule dynamics 1) - Rat Genome Database

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Gene: Rmdn1 (regulator of microtubule dynamics 1) Rattus norvegicus
Analyze
Symbol: Rmdn1
Name: regulator of microtubule dynamics 1
RGD ID: 1563085
Description: Predicted to enable microtubule binding activity. Predicted to be located in microtubule and spindle pole. Predicted to be active in mitochondrion; mitotic spindle pole; and spindle microtubule. Orthologous to human RMDN1 (regulator of microtubule dynamics 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam82b; family with sequence similarity 82, member B; LOC500419; MGC112702; regulator of microtubule dynamics protein 1; RMD-1; similar to RIKEN cDNA 2410005O16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8537,867,172 - 37,890,826 (+)NCBIGRCr8
mRatBN7.2533,070,267 - 33,093,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,070,265 - 33,127,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx535,186,377 - 35,209,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0536,778,935 - 36,802,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0536,718,075 - 36,741,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0533,580,891 - 33,604,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,580,944 - 33,638,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,235,214 - 38,258,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,210,399 - 34,233,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera532,160,469 - 32,183,998 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
microtubule  (IEA)
mitochondrion  (IBA,ISO)
mitotic spindle pole  (IBA,IEA,ISO)
spindle microtubule  (IBA,IEA,ISO)
spindle pole  (IEA)

Molecular Function
microtubule binding  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:18614015   PMID:26316108   PMID:34800366  


Genomics

Comparative Map Data
Rmdn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8537,867,172 - 37,890,826 (+)NCBIGRCr8
mRatBN7.2533,070,267 - 33,093,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,070,265 - 33,127,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx535,186,377 - 35,209,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0536,778,935 - 36,802,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0536,718,075 - 36,741,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0533,580,891 - 33,604,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,580,944 - 33,638,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,235,214 - 38,258,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,210,399 - 34,233,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera532,160,469 - 32,183,998 (+)NCBICelera
Cytogenetic Map5q13NCBI
RMDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38886,468,266 - 86,514,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl886,468,257 - 86,514,357 (-)EnsemblGRCh38hg38GRCh38
GRCh37887,484,578 - 87,526,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36887,553,694 - 87,590,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera883,679,304 - 83,713,917 (-)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef882,693,976 - 82,730,379 (-)NCBIHuRef
CHM1_1887,526,075 - 87,562,504 (-)NCBICHM1_1
T2T-CHM13v2.0887,588,507 - 87,634,595 (-)NCBIT2T-CHM13v2.0
Rmdn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39419,575,036 - 19,606,932 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl419,575,162 - 19,606,932 (+)EnsemblGRCm39 Ensembl
GRCm38419,575,035 - 19,606,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl419,575,162 - 19,606,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv37419,502,214 - 19,534,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36419,502,354 - 19,534,079 (+)NCBIMGSCv36mm8
Celera419,337,058 - 19,368,918 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.56NCBI
Rmdn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554174,068,135 - 4,092,788 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554174,067,981 - 4,092,421 (-)NCBIChiLan1.0ChiLan1.0
RMDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27103,870,948 - 103,916,804 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1879,409,793 - 79,455,655 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0883,121,882 - 83,209,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1885,138,666 - 85,178,896 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl885,138,773 - 85,173,650 (-)Ensemblpanpan1.1panPan2
RMDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12932,624,008 - 32,685,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2932,525,554 - 32,674,930 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2932,844,120 - 32,877,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02932,779,075 - 32,840,467 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,680,619 - 32,829,964 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,822,907 - 32,884,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,847,477 - 32,908,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02933,267,771 - 33,329,421 (-)NCBIUU_Cfam_GSD_1.0
Rmdn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530346,704,357 - 46,744,642 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365441,052,568 - 1,088,213 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365441,052,416 - 1,088,355 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RMDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl450,344,909 - 50,389,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1450,344,886 - 50,386,187 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2455,260,705 - 55,301,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RMDN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1881,657,337 - 81,696,900 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl881,657,533 - 81,691,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603959,253,437 - 59,294,483 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rmdn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247445,300,003 - 5,325,081 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247445,300,190 - 5,325,170 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rmdn1
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:522
Count of miRNA genes:264
Interacting mature miRNAs:324
Transcripts:ENSRNOT00000036050
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
BE121263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,070,813 - 33,070,977 (+)MAPPERmRatBN7.2
Rnor_6.0533,581,455 - 33,581,618NCBIRnor6.0
Rnor_5.0538,235,859 - 38,236,022UniSTSRnor5.0
RGSC_v3.4534,210,826 - 34,210,989UniSTSRGSC3.4
Celera532,160,896 - 32,161,059UniSTS
RH 3.4 Map5166.0UniSTS
Cytogenetic Map5q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036050   ⟹   ENSRNOP00000030229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,070,355 - 33,093,920 (+)Ensembl
Rnor_6.0 Ensembl533,581,028 - 33,604,564 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092054   ⟹   ENSRNOP00000071718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,070,265 - 33,127,328 (+)Ensembl
Rnor_6.0 Ensembl533,580,944 - 33,638,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100436   ⟹   ENSRNOP00000082921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,070,355 - 33,093,920 (+)Ensembl
RefSeq Acc Id: NM_001031663   ⟹   NP_001026833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,867,291 - 37,890,826 (+)NCBI
mRatBN7.2533,070,387 - 33,093,922 (+)NCBI
Rnor_6.0533,581,028 - 33,604,564 (+)NCBI
Rnor_5.0538,235,214 - 38,258,968 (+)NCBI
RGSC_v3.4534,210,399 - 34,233,936 (+)RGD
Celera532,160,469 - 32,183,998 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237933   ⟹   XP_006237995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,867,173 - 37,890,826 (+)NCBI
mRatBN7.2533,070,268 - 33,093,922 (+)NCBI
Rnor_6.0533,580,891 - 33,604,564 (+)NCBI
Rnor_5.0538,235,214 - 38,258,968 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005504511
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,867,172 - 37,889,459 (+)NCBI
mRatBN7.2533,070,267 - 33,092,549 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001026833 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98713 (Get FASTA)   NCBI Sequence Viewer  
  EDL98497 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030229.3
  ENSRNOP00000071718.1
  ENSRNOP00000082921.1
GenBank Protein Q4G069 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026833   ⟸   NM_001031663
- UniProtKB: Q4G069 (UniProtKB/Swiss-Prot),   A6IIC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237995   ⟸   XM_006237933
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G831 (UniProtKB/TrEMBL),   A6IIC7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071718   ⟸   ENSRNOT00000092054
Ensembl Acc Id: ENSRNOP00000030229   ⟸   ENSRNOT00000036050
Ensembl Acc Id: ENSRNOP00000082921   ⟸   ENSRNOT00000100436

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G069-F1-model_v2 AlphaFold Q4G069 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693602
Promoter ID:EPDNEW_R4113
Type:initiation region
Name:Rmdn1_1
Description:regulator of microtubule dynamics 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0533,581,004 - 33,581,064EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563085 AgrOrtholog
BioCyc Gene G2FUF-41839 BioCyc
Ensembl Genes ENSRNOG00000025145 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036050.5 UniProtKB/Swiss-Prot
  ENSRNOT00000092054.2 UniProtKB/TrEMBL
  ENSRNOT00000100436.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122806 IMAGE-MGC_LOAD
  IMAGE:7322407 IMAGE-MGC_LOAD
InterPro RMD1-3_a_helical_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500419 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112702 IMAGE-MGC_LOAD
  MGC:95033 IMAGE-MGC_LOAD
NCBI Gene 500419 ENTREZGENE
PANTHER REGULATOR OF MICROTUBULE DYNAMICS PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RMD1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rmdn1 PhenoGen
RatGTEx ENSRNOG00000025145 RatGTEx
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K167_RAT UniProtKB/TrEMBL
  A0A8I6G831 ENTREZGENE, UniProtKB/TrEMBL
  A6IIC7 ENTREZGENE, UniProtKB/TrEMBL
  Q4G069 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-17 Rmdn1  regulator of microtubule dynamics 1  Fam82b  family with sequence similarity 82, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Fam82b  family with sequence similarity 82, member B  LOC500419  similar to RIKEN cDNA 2410005O16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500419  similar to RIKEN cDNA 2410005O16      Symbol and Name status set to provisional 70820 PROVISIONAL