Tlcd4 (TLC domain containing 4) - Rat Genome Database

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Gene: Tlcd4 (TLC domain containing 4) Rattus norvegicus
Analyze
Symbol: Tlcd4
Name: TLC domain containing 4
RGD ID: 1563041
Description: Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TLCD4 (TLC domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC365924; RGD1563041; similar to RIKEN cDNA 4930577M16; TLC domain-containing protein 4; Tmem56; transmembrane protein 56
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82211,969,612 - 212,044,883 (-)NCBIGRCr8
mRatBN7.22209,284,873 - 209,360,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,289,732 - 209,341,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2216,931,149 - 216,960,747 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02214,856,943 - 214,886,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02209,698,030 - 209,727,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02224,768,034 - 224,843,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2224,772,893 - 224,802,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02242,810,863 - 242,886,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42217,795,619 - 217,825,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2201,725,067 - 201,755,365 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
L-methionine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Tlcd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82211,969,612 - 212,044,883 (-)NCBIGRCr8
mRatBN7.22209,284,873 - 209,360,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,289,732 - 209,341,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2216,931,149 - 216,960,747 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02214,856,943 - 214,886,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02209,698,030 - 209,727,798 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02224,768,034 - 224,843,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2224,772,893 - 224,802,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02242,810,863 - 242,886,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42217,795,619 - 217,825,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2201,725,067 - 201,755,365 (-)NCBICelera
Cytogenetic Map2q42NCBI
TLCD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,092,517 - 95,197,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,117,355 - 95,197,607 (+)EnsemblGRCh38hg38GRCh38
GRCh37195,558,073 - 95,663,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,355,572 - 95,431,462 (+)NCBINCBI36Build 36hg18NCBI36
Celera193,837,320 - 93,917,579 (+)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,704,498 - 93,785,093 (+)NCBIHuRef
CHM1_1195,697,752 - 95,777,954 (+)NCBICHM1_1
T2T-CHM13v2.0194,940,904 - 95,045,995 (+)NCBIT2T-CHM13v2.0
Tlcd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393120,995,657 - 121,076,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3120,995,410 - 121,076,747 (-)EnsemblGRCm39 Ensembl
GRCm383121,202,008 - 121,283,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,201,761 - 121,283,098 (-)EnsemblGRCm38mm10GRCm38
MGSCv373120,904,926 - 120,966,234 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363121,194,031 - 121,255,339 (-)NCBIMGSCv36mm8
Celera3127,550,521 - 127,611,522 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Tlcd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955435278,510 - 346,391 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955435278,795 - 351,707 (+)NCBIChiLan1.0ChiLan1.0
TLCD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21131,826,076 - 131,906,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11130,980,759 - 131,061,450 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,754,839 - 97,859,777 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,505,151 - 96,585,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,506,056 - 96,580,115 (+)Ensemblpanpan1.1panPan2
LOC490151
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,131,376 - 54,234,519 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,136,690 - 54,234,683 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha656,830,091 - 56,936,347 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0654,503,453 - 54,608,225 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl654,508,103 - 54,601,304 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,177,753 - 54,284,024 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,164,650 - 54,268,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0654,617,534 - 54,721,134 (-)NCBIUU_Cfam_GSD_1.0
TLCD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,232,593 - 122,365,705 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,232,587 - 122,341,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,013,185 - 134,015,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLCD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,056,339 - 38,136,862 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,062,061 - 38,136,791 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603379,929,625 - 80,011,691 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tlcd4
708 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:657
Count of miRNA genes:282
Interacting mature miRNAs:352
Transcripts:ENSRNOT00000032324
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat

Markers in Region
RH142020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,288,652 - 209,288,838 (+)MAPPERmRatBN7.2
Rnor_6.02224,771,814 - 224,771,999NCBIRnor6.0
Rnor_5.02242,814,643 - 242,814,828UniSTSRnor5.0
RGSC_v3.42217,794,540 - 217,794,725UniSTSRGSC3.4
Celera2201,723,988 - 201,724,173UniSTS
RH 3.4 Map21501.0UniSTS
Cytogenetic Map2q41UniSTS
BF409351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,314,980 - 209,315,106 (+)MAPPERmRatBN7.2
Rnor_6.02224,798,224 - 224,798,349NCBIRnor6.0
Rnor_5.02242,841,053 - 242,841,178UniSTSRnor5.0
RGSC_v3.42217,820,863 - 217,820,988UniSTSRGSC3.4
Celera2201,750,777 - 201,750,902UniSTS
RH 3.4 Map21521.9UniSTS
Cytogenetic Map2q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 35 9 35 7 8 35 4 19 11 7
Low 3 43 22 6 10 6 1 3 39 31 22 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032324   ⟹   ENSRNOP00000033667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2209,289,732 - 209,341,353 (-)Ensembl
Rnor_6.0 Ensembl2224,772,893 - 224,802,997 (-)Ensembl
RefSeq Acc Id: NM_001135879   ⟹   NP_001129351
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,974,471 - 212,004,303 (-)NCBI
mRatBN7.22209,289,732 - 209,319,573 (-)NCBI
Rnor_6.02224,772,893 - 224,802,997 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
RGSC_v3.42217,795,619 - 217,825,516 (-)RGD
Celera2201,725,067 - 201,755,365 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233244   ⟹   XP_006233306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,028,785 (-)NCBI
mRatBN7.22209,284,873 - 209,340,898 (-)NCBI
Rnor_6.02224,768,034 - 224,824,172 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233246   ⟹   XP_006233308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,028,785 (-)NCBI
mRatBN7.22209,284,873 - 209,341,360 (-)NCBI
Rnor_6.02224,768,034 - 224,824,511 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233251   ⟹   XP_006233313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,044,883 (-)NCBI
mRatBN7.22209,284,873 - 209,360,156 (-)NCBI
Rnor_6.02224,768,034 - 224,843,198 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233252   ⟹   XP_006233314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,044,883 (-)NCBI
mRatBN7.22209,284,873 - 209,360,156 (-)NCBI
Rnor_6.02224,768,034 - 224,843,198 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233253   ⟹   XP_006233315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,025,931 (-)NCBI
mRatBN7.22209,284,873 - 209,340,897 (-)NCBI
Rnor_6.02224,768,034 - 224,824,172 (-)NCBI
Rnor_5.02242,810,863 - 242,886,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102801   ⟹   XP_038958729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,044,883 (-)NCBI
mRatBN7.22209,284,873 - 209,360,155 (-)NCBI
RefSeq Acc Id: XM_039102803   ⟹   XP_038958731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,044,883 (-)NCBI
mRatBN7.22209,284,873 - 209,360,155 (-)NCBI
RefSeq Acc Id: XM_063282294   ⟹   XP_063138364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,025,452 (-)NCBI
RefSeq Acc Id: XM_063282295   ⟹   XP_063138365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,025,452 (-)NCBI
RefSeq Acc Id: XM_063282296   ⟹   XP_063138366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82211,969,612 - 212,028,785 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001129351   ⟸   NM_001135879
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233314   ⟸   XM_006233252
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233313   ⟸   XM_006233251
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233308   ⟸   XM_006233246
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233315   ⟸   XM_006233253
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233306   ⟸   XM_006233244
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033667   ⟸   ENSRNOT00000032324
RefSeq Acc Id: XP_038958731   ⟸   XM_039102803
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958729   ⟸   XM_039102801
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138366   ⟸   XM_063282296
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138364   ⟸   XM_063282294
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138365   ⟸   XM_063282295
- Peptide Label: isoform X1
- UniProtKB: D4AAE5 (UniProtKB/TrEMBL)
Protein Domains
TLC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAE5-F1-model_v2 AlphaFold D4AAE5 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563041 AgrOrtholog
BioCyc Gene G2FUF-51420 BioCyc
Ensembl Genes ENSRNOG00000025160 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032324.5 UniProtKB/TrEMBL
InterPro TLC-dom UniProtKB/TrEMBL
KEGG Report rno:365924 UniProtKB/TrEMBL
NCBI Gene 365924 ENTREZGENE
PANTHER CT120 PROTEIN UniProtKB/TrEMBL
  TLC DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PhenoGen Tlcd4 PhenoGen
PROSITE TLC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025160 RatGTEx
SMART TLC UniProtKB/TrEMBL
UniProt D4AAE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tlcd4  TLC domain containing 4  Tmem56  transmembrane protein 56  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tmem56  transmembrane protein 56   Tmem56_predicted  transmembrane protein 56 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tmem56_predicted  transmembrane protein 56 (predicted)  RGD1563041_predicted  similar to RIKEN cDNA 4930577M16 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563041_predicted  similar to RIKEN cDNA 4930577M16 (predicted)  LOC365924  similar to RIKEN cDNA 4930577M16  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365924  similar to RIKEN cDNA 4930577M16      Symbol and Name status set to provisional 70820 PROVISIONAL