Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) - Rat Genome Database

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Gene: Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Rattus norvegicus
Analyze
Symbol: Appl2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
RGD ID: 1563028
Description: Predicted to enable phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of metabolic process; and positive regulation of endocytosis. Predicted to be located in cytoplasmic vesicle; nucleus; and ruffle membrane. Predicted to be active in endosome membrane. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2); INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; LOC362860; RGD1563028; similar to DIP13 beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,019,480 - 22,072,386 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl722,022,963 - 22,072,385 (+)EnsemblGRCr8
mRatBN7.2720,135,248 - 20,184,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,135,375 - 20,184,754 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx722,105,205 - 22,156,954 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,267,960 - 24,319,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,044,969 - 24,096,718 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,256,179 - 26,306,128 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)Ensemblrn6Rnor6.0
Rnor_5.0726,387,115 - 26,436,564 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4722,279,273 - 22,328,427 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera717,339,053 - 17,386,872 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adiponectin-activated signaling pathway  (IEA,ISO)
cell surface receptor signaling pathway  (IEA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cold acclimation  (IEA,ISO)
diet induced thermogenesis  (IEA,ISO)
glucose homeostasis  (IEA,ISO,ISS)
homeostatic process  (IEA)
negative regulation of cellular response to insulin stimulus  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of D-glucose import across plasma membrane  (IEA,ISO,ISS)
negative regulation of fatty acid oxidation  (IEA,ISO)
negative regulation of neural precursor cell proliferation  (IEA,ISO)
negative regulation of neurogenesis  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISO)
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  (IEA,ISO)
positive regulation of macropinocytosis  (IEA,ISO)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
protein homotetramerization  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  (IEA)
regulation of fibroblast migration  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
regulation of innate immune response  (IEA,ISO)
regulation of phagocytosis  (IEA)
regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
signaling  (IBA)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15016378   PMID:18034774   PMID:19056867   PMID:19661063   PMID:21645192   PMID:22871113   PMID:23055524   PMID:24879834   PMID:25328665   PMID:25568335   PMID:26445298  
PMID:26583432   PMID:27219021   PMID:28965332   PMID:29467283   PMID:29675572  


Genomics

Comparative Map Data
Appl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,019,480 - 22,072,386 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl722,022,963 - 22,072,385 (+)EnsemblGRCr8
mRatBN7.2720,135,248 - 20,184,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,135,375 - 20,184,754 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx722,105,205 - 22,156,954 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,267,960 - 24,319,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,044,969 - 24,096,718 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,256,179 - 26,306,128 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)Ensemblrn6Rnor6.0
Rnor_5.0726,387,115 - 26,436,564 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4722,279,273 - 22,328,427 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera717,339,053 - 17,386,872 (+)NCBICelera
Cytogenetic Map7q13NCBI
APPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812105,173,300 - 105,236,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12105,172,485 - 105,236,221 (-)Ensemblhg38GRCh38
GRCh3712105,567,078 - 105,629,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBIBuild 36Build 36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
T2T-CHM13v2.012105,135,121 - 105,197,990 (-)NCBIT2T-CHM13v2.0
Appl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,435,897 - 83,484,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)Ensemblmm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBIMGSCv36mm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.29NCBI
Appl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,503,020 - 39,540,335 (-)Ensembl
ChiLan1.0NW_00495540539,503,020 - 39,540,069 (-)NCBIChiLan1.0ChiLan1.0
APPL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210113,243,186 - 113,306,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112113,239,582 - 113,302,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012102,755,388 - 102,818,686 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112106,150,955 - 106,214,038 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12106,151,969 - 106,206,879 (-)EnsemblpanPan2panpan1.1
APPL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,192,261 - 33,243,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1033,111,933 - 33,162,406 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01034,033,756 - 34,084,221 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1034,033,772 - 34,084,225 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,769,093 - 33,819,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,053,225 - 34,103,854 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,246,325 - 34,297,170 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Appl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494516,467,066 - 16,530,048 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364929,477,373 - 9,526,692 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364929,477,483 - 9,526,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,356,067 - 79,412,235 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,650,763 - 82,706,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
APPL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,400,093 - 100,469,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11100,400,084 - 100,462,507 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037144,551,093 - 144,614,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Appl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,789,022 - 3,827,079 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247503,789,015 - 3,827,079 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Appl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11164,855,509 - 164,907,613 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Appl2
626 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:164
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000010986
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat

Markers in Region
RH129999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,184,460 - 20,184,647 (+)MAPPERmRatBN7.2
Rnor_6.0726,305,833 - 26,306,019NCBIRnor6.0
Rnor_5.0726,436,269 - 26,436,455UniSTSRnor5.0
RGSC_v3.4722,328,134 - 22,328,320UniSTSRGSC3.4
Celera717,386,579 - 17,386,765UniSTS
RH 3.4 Map7115.45UniSTS
Cytogenetic Map7q13UniSTS
D19286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,184,319 - 20,184,521 (+)MAPPERmRatBN7.2
Rnor_6.0726,305,692 - 26,305,893NCBIRnor6.0
Rnor_5.0726,436,128 - 26,436,329UniSTSRnor5.0
RGSC_v3.4722,327,993 - 22,328,194UniSTSRGSC3.4
Celera717,386,438 - 17,386,639UniSTS
Cytogenetic Map7q13UniSTS
AA850515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,184,316 - 20,184,515 (+)MAPPERmRatBN7.2
Rnor_6.0726,305,689 - 26,305,887NCBIRnor6.0
Rnor_5.0726,436,125 - 26,436,323UniSTSRnor5.0
RGSC_v3.4722,327,990 - 22,328,188UniSTSRGSC3.4
Celera717,386,435 - 17,386,633UniSTS
RH 3.4 Map7115.2UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 87 59 6 351 187 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010986   ⟹   ENSRNOP00000010986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl722,022,963 - 22,072,385 (+)Ensembl
mRatBN7.2 Ensembl720,135,375 - 20,184,754 (+)Ensembl
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110485   ⟹   ENSRNOP00000087969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl722,030,274 - 22,071,495 (+)Ensembl
mRatBN7.2 Ensembl720,142,642 - 20,183,865 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132552   ⟹   ENSRNOP00000102264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl722,022,963 - 22,071,495 (+)Ensembl
RefSeq Acc Id: NM_001108741   ⟹   NP_001102211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,023,009 - 22,072,384 (+)NCBI
mRatBN7.2720,135,375 - 20,184,754 (+)NCBI
Rnor_6.0726,256,459 - 26,306,126 (+)NCBI
Rnor_5.0726,387,115 - 26,436,564 (+)NCBI
RGSC_v3.4722,279,273 - 22,328,427 (+)RGD
Celera717,339,053 - 17,386,872 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241201   ⟹   XP_006241263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,019,480 - 22,072,386 (+)NCBI
mRatBN7.2720,135,248 - 20,184,757 (+)NCBI
Rnor_6.0726,256,179 - 26,306,128 (+)NCBI
Rnor_5.0726,387,115 - 26,436,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079421   ⟹   XP_038935349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,048,631 - 22,072,386 (+)NCBI
mRatBN7.2720,161,000 - 20,184,757 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102211 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241263 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935349 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68167 (Get FASTA)   NCBI Sequence Viewer  
  B4F779 (Get FASTA)   NCBI Sequence Viewer  
  EDM17085 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010986
  ENSRNOP00000010986.4
RefSeq Acc Id: NP_001102211   ⟸   NM_001108741
- UniProtKB: B4F779 (UniProtKB/TrEMBL),   A0A8I6A8C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241263   ⟸   XM_006241201
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8C2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010986   ⟸   ENSRNOT00000010986
RefSeq Acc Id: XP_038935349   ⟸   XM_039079421
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000087969   ⟸   ENSRNOT00000110485
Ensembl Acc Id: ENSRNOP00000102264   ⟸   ENSRNOT00000132552
Protein Domains
BAR   PH   PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4F779-F1-model_v2 AlphaFold B4F779 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695105
Promoter ID:EPDNEW_R5630
Type:initiation region
Name:Appl2_1
Description:adaptor protein, phosphotyrosine interacting with PH domain andleucine zipper 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0726,256,462 - 26,256,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563028 AgrOrtholog
BioCyc Gene G2FUF-34590 BioCyc
Ensembl Genes ENSRNOG00000008174 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010986 ENTREZGENE
  ENSRNOT00000010986.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  BAR_APPL2 UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  DP13A/B UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_DP13A/B UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
  PTB_APPL UniProtKB/Swiss-Prot
KEGG Report rno:362860 UniProtKB/Swiss-Prot
NCBI Gene 362860 ENTREZGENE
PANTHER ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 UniProtKB/Swiss-Prot
  DCC-INTERACTING PROTEIN 13-BETA UniProtKB/Swiss-Prot
Pfam BAR_3 UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  PID UniProtKB/Swiss-Prot
PhenoGen Appl2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PID UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008174 RatGTEx
SMART PTB UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF103657 UniProtKB/Swiss-Prot
UniProt A0A8I6A8C2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAN1_RAT UniProtKB/TrEMBL
  B4F779 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Appl2  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2  Appl2  adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Appl2  adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2  RGD1563028_predicted  similar to DIP13 beta (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563028_predicted  similar to DIP13 beta (predicted)  LOC362860  similar to DIP13 beta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362860  similar to DIP13 beta      Symbol and Name status set to provisional 70820 PROVISIONAL