C17h6orf52 (similar to human chromosome 6 open reading frame 52) - Rat Genome Database

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Pathways
Gene: C17h6orf52 (similar to human chromosome 6 open reading frame 52) Rattus norvegicus
Analyze
Symbol: C17h6orf52
Name: similar to human chromosome 6 open reading frame 52
RGD ID: 1562963
Description: Orthologous to human C6orf52 (chromosome 6 open reading frame 52); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498729; LOC498729; putative uncharacterized protein C6orf52 homolog; RGD1562963; similar to chromosome 6 open reading frame 52; uncharacterized protein LOC498729
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: C17h6orf52em2Mcwi
Genetic Models: LH-Chr 17LN-C17h6orf52em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,959,124 - 23,981,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1723,968,478 - 23,981,976 (+)EnsemblGRCr8
mRatBN7.21723,753,359 - 23,776,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,762,746 - 23,776,245 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1723,632,792 - 23,646,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,236,261 - 25,249,755 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,573,761 - 23,587,254 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,600,326 - 21,615,888 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,600,432 - 21,613,930 (+)Ensemblrn6Rnor6.0
Rnor_5.01723,581,681 - 23,595,498 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41729,733,271 - 29,746,771 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1723,432,376 - 23,445,886 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
C17h6orf52
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81723,959,124 - 23,981,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1723,968,478 - 23,981,976 (+)EnsemblGRCr8
mRatBN7.21723,753,359 - 23,776,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1723,762,746 - 23,776,245 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1723,632,792 - 23,646,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,236,261 - 25,249,755 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,573,761 - 23,587,254 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01721,600,326 - 21,615,888 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1721,600,432 - 21,613,930 (+)Ensemblrn6Rnor6.0
Rnor_5.01723,581,681 - 23,595,498 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41729,733,271 - 29,746,771 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1723,432,376 - 23,445,886 (+)NCBICelera
Cytogenetic Map17p12NCBI
C6orf52
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,671,422 - 10,694,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,671,418 - 10,694,797 (-)Ensemblhg38GRCh38
GRCh37610,671,655 - 10,695,030 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,779,637 - 10,795,769 (-)NCBIBuild 36Build 36hg18NCBI36
Celera611,900,143 - 11,923,522 (-)NCBICelera
Cytogenetic Map6p24.2NCBI
HuRef610,547,315 - 10,570,646 (-)NCBIHuRef
CHM1_1610,673,764 - 10,697,143 (-)NCBICHM1_1
T2T-CHM13v2.0610,539,141 - 10,562,610 (-)NCBIT2T-CHM13v2.0
C5H6orf52
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,321,055 - 25,337,142 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,310,715 - 21,326,808 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,512,465 - 10,535,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,792,736 - 10,815,260 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl610,792,736 - 10,815,257 (-)EnsemblpanPan2panpan1.1
C35H6orf52
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,422,161 - 10,436,031 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3510,422,255 - 10,432,336 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3510,370,981 - 10,385,023 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03510,526,377 - 10,540,527 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3510,526,554 - 10,540,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13510,355,805 - 10,369,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,402,708 - 10,416,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,723,241 - 11,737,288 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH6orf52
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494613,996,386 - 14,011,314 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365342,269,270 - 2,280,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C7H6orf52
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl77,430,542 - 7,437,789 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.177,430,420 - 7,438,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,742,836 - 7,750,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C17H6orf52
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,455,582 - 61,520,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1761,456,515 - 61,472,516 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604410,703,155 - 10,726,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH6orf52
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,212,087 - 15,223,534 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475615,212,870 - 15,229,681 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C14H6orf52
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11459,981,676 - 59,990,753 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C17h6orf52
340 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:146
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000060340
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat


Genetic Models
This gene C17h6orf52 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 81 59 6 344 181 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060340   ⟹   ENSRNOP00000057088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1723,968,478 - 23,981,976 (+)Ensembl
mRatBN7.2 Ensembl1723,762,746 - 23,776,245 (+)Ensembl
Rnor_6.0 Ensembl1721,600,432 - 21,613,930 (+)Ensembl
RefSeq Acc Id: NM_001145021   ⟹   NP_001138493
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,968,478 - 23,981,978 (+)NCBI
mRatBN7.21723,762,746 - 23,776,247 (+)NCBI
Rnor_6.01721,600,432 - 21,613,932 (+)NCBI
Rnor_5.01723,581,681 - 23,595,498 (+)NCBI
RGSC_v3.41729,733,271 - 29,746,771 (+)RGD
Celera1723,432,376 - 23,445,886 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253780   ⟹   XP_006253842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,966,635 - 23,981,978 (+)NCBI
mRatBN7.21723,762,094 - 23,776,251 (+)NCBI
Rnor_6.01721,600,326 - 21,615,888 (+)NCBI
Rnor_5.01723,581,681 - 23,595,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096007   ⟹   XP_038951935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,959,124 - 23,981,978 (+)NCBI
mRatBN7.21723,753,359 - 23,776,251 (+)NCBI
RefSeq Acc Id: XM_039096008   ⟹   XP_038951936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,959,134 - 23,981,978 (+)NCBI
mRatBN7.21723,753,400 - 23,776,251 (+)NCBI
RefSeq Acc Id: XM_063276689   ⟹   XP_063132759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81723,959,124 - 23,981,978 (+)NCBI
RefSeq Acc Id: NP_001138493   ⟸   NM_001145021
- UniProtKB: D4AAN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253842   ⟸   XM_006253780
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000057088   ⟸   ENSRNOT00000060340
RefSeq Acc Id: XP_038951935   ⟸   XM_039096007
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951936   ⟸   XM_039096008
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132759   ⟸   XM_063276689
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAN9-F1-model_v2 AlphaFold D4AAN9 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562963 AgrOrtholog
BioCyc Gene G2FUF-9727 BioCyc
Ensembl Genes ENSRNOG00000039379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060340 ENTREZGENE
  ENSRNOT00000060340.4 UniProtKB/TrEMBL
InterPro C6orf52-like UniProtKB/TrEMBL
  TSAP1_C UniProtKB/TrEMBL
KEGG Report rno:498729 UniProtKB/TrEMBL
NCBI Gene 498729 ENTREZGENE
PANTHER PTHR37457 UniProtKB/TrEMBL
  SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52 UniProtKB/TrEMBL
Pfam Trnau1ap UniProtKB/TrEMBL
PhenoGen C17h6orf52 PhenoGen
RatGTEx ENSRNOG00000039379 RatGTEx
UniProt D4AAN9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-03 C17h6orf52  similar to human chromosome 6 open reading frame 52  RGD1562963  similar to chromosome 6 open reading frame 52  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1562963  similar to chromosome 6 open reading frame 52   RGD1562963_predicted  similar to chromosome 6 open reading frame 52 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562963_predicted  similar to chromosome 6 open reading frame 52 (predicted)  LOC498729  similar to chromosome 6 open reading frame 52  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498729  similar to chromosome 6 open reading frame 52      Symbol and Name status set to provisional 70820 PROVISIONAL