Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rerg | Rat | 17beta-estradiol | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA] | CTD | PMID:21185374 | Rerg | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of RERG mRNA | CTD | PMID:26496021 | Rerg | Rat | 17beta-estradiol | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Estradiol results in increased expression of RERG mRNA | CTD | PMID:19167446|PMID:21185374|PMID:31614463 | Rerg | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RERG mRNA | CTD | PMID:19574409 | Rerg | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RERG mRNA | CTD | PMID:34747641 | Rerg | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RERG gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 more ... | CTD | PMID:19574409 | Rerg | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RERG mRNA | CTD | PMID:20188158 | Rerg | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression more ... | CTD | PMID:28628672 | Rerg | Rat | 3-methylcholanthrene | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to RERG promoter] | CTD | PMID:20348232 | Rerg | Rat | 3-methylcholanthrene | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Methylcholanthrene results in decreased expression of RERG mRNA | CTD | PMID:20348232 | Rerg | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of RERG mRNA | CTD | PMID:18648102 | Rerg | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Rerg (Mus musculus) | 6480464 | bisphenol S results in increased expression of RERG mRNA | CTD | PMID:30951980 | Rerg | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of RERG gene | CTD | PMID:31601247 | Rerg | Rat | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Decitabine co-treated with TFAP2C protein] results in increased expression of RERG mRNA; TFAP2C protein promotes more ... | CTD | PMID:19458056 | Rerg | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of RERG mRNA | CTD | PMID:24780913 | Rerg | Rat | 7,12-dimethyltetraphene | decreases expression | EXP | | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RERG mRNA | CTD | PMID:19480007 | Rerg | Rat | actinomycin D | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of RERG mRNA | CTD | PMID:38460933 | Rerg | Rat | aflatoxin B1 | decreases methylation | ISO | RERG (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of RERG gene | CTD | PMID:27153756 | Rerg | Rat | all-trans-retinoic acid | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Tretinoin results in increased expression of RERG mRNA | CTD | PMID:21934132 | Rerg | Rat | all-trans-retinoic acid | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RERG mRNA | CTD | PMID:23724009 | Rerg | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of RERG mRNA | CTD | PMID:35163327 | Rerg | Rat | aristolochic acid A | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of RERG mRNA | CTD | PMID:33212167 | Rerg | Rat | arsenous acid | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of RERG mRNA | CTD | PMID:26705709 | Rerg | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of RERG gene | CTD | PMID:35440735 | Rerg | Rat | benzo[a]pyrene | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of RERG mRNA | CTD | PMID:22228805 | Rerg | Rat | benzo[a]pyrene | decreases methylation | ISO | RERG (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of RERG 5' UTR | CTD | PMID:27901495 | Rerg | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of RERG mRNA | CTD | PMID:26496021 | Rerg | Rat | bisphenol A | increases expression | ISO | Rerg (Mus musculus) | 6480464 | bisphenol A results in increased expression of RERG mRNA | CTD | PMID:30951980 | Rerg | Rat | bisphenol A | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RERG mRNA | CTD | PMID:25912373 | Rerg | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RERG mRNA | CTD | PMID:25181051|PMID:30816183 | Rerg | Rat | bisphenol F | increases expression | ISO | Rerg (Mus musculus) | 6480464 | bisphenol F results in increased expression of RERG mRNA | CTD | PMID:30951980 | Rerg | Rat | Butylbenzyl phthalate | increases methylation | ISO | Rerg (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of RERG intron | CTD | PMID:28392331 | Rerg | Rat | cadmium dichloride | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | CGP 52608 | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to RERG gene] | CTD | PMID:28238834 | Rerg | Rat | chlorpyrifos | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RERG mRNA | CTD | PMID:32715474 | Rerg | Rat | choline | multiple interactions | ISO | Rerg (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Rerg | Rat | cisplatin | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Cisplatin results in increased expression of RERG mRNA | CTD | PMID:27392435 | Rerg | Rat | cisplatin | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of RERG mRNA | CTD | PMID:27392435 | Rerg | Rat | copper(II) chloride | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | coumestrol | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RERG mRNA; [Coumestrol co-treated with ESR1 more ... | CTD | PMID:18310284|PMID:19167446 | Rerg | Rat | coumestrol | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Coumestrol results in increased expression of RERG mRNA | CTD | PMID:19167446 | Rerg | Rat | Cuprizon | affects expression | EXP | | 6480464 | Cuprizone affects the expression of RERG mRNA | CTD | PMID:26577399 | Rerg | Rat | cytarabine | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of RERG mRNA | CTD | PMID:21198554 | Rerg | Rat | DDE | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | dexamethasone | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of RERG mRNA | CTD | PMID:22733784 | Rerg | Rat | dexamethasone | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression more ... | CTD | PMID:28628672 | Rerg | Rat | diarsenic trioxide | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of RERG mRNA | CTD | PMID:26705709 | Rerg | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of RERG mRNA | CTD | PMID:21266533 | Rerg | Rat | dibutyl phthalate | increases expression | ISO | Rerg (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of RERG mRNA | CTD | PMID:17361019|PMID:21266533 | Rerg | Rat | dorsomorphin | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Rerg | Rat | Enterolactone | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RERG mRNA | CTD | PMID:19167446 | Rerg | Rat | ethanol | increases expression | ISO | Rerg (Mus musculus) | 6480464 | Ethanol results in increased expression of RERG mRNA | CTD | PMID:30319688 | Rerg | Rat | ethanol | affects splicing | ISO | Rerg (Mus musculus) | 6480464 | Ethanol affects the splicing of RERG mRNA | CTD | PMID:30319688 | Rerg | Rat | folic acid | multiple interactions | ISO | Rerg (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Rerg | Rat | fonofos | increases methylation | ISO | RERG (Homo sapiens) | 6480464 | Fonofos results in increased methylation of RERG promoter | CTD | PMID:22847954 | Rerg | Rat | fulvestrant | affects response to substance | ISO | RERG (Homo sapiens) | 6480464 | RERG affects the susceptibility to fulvestrant | CTD | PMID:24169358 | Rerg | Rat | fulvestrant | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of RERG gene | CTD | PMID:31601247 | Rerg | Rat | genistein | increases expression | ISO | Rerg (Mus musculus) | 6480464 | Genistein results in increased expression of RERG mRNA | CTD | PMID:32186404 | Rerg | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of RERG mRNA | CTD | PMID:33387578 | Rerg | Rat | indometacin | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression more ... | CTD | PMID:28628672 | Rerg | Rat | L-methionine | multiple interactions | ISO | Rerg (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Rerg | Rat | lead diacetate | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | lead acetate results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of RERG mRNA | CTD | PMID:30047161 | Rerg | Rat | methylmercury chloride | affects expression | EXP | | 6480464 | methylmercuric chloride affects the expression of RERG mRNA | CTD | PMID:20864626 | Rerg | Rat | methylmercury chloride | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of RERG mRNA | CTD | PMID:23179753 | Rerg | Rat | nickel atom | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Nickel results in decreased expression of RERG mRNA | CTD | PMID:24768652|PMID:25583101 | Rerg | Rat | Nutlin-3 | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of RERG mRNA | CTD | PMID:38460933 | Rerg | Rat | ozone | multiple interactions | ISO | Rerg (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Rerg | Rat | paracetamol | affects expression | ISO | Rerg (Mus musculus) | 6480464 | Acetaminophen affects the expression of RERG mRNA | CTD | PMID:17562736 | Rerg | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of RERG mRNA | CTD | PMID:33387578 | Rerg | Rat | parathion | increases methylation | ISO | RERG (Homo sapiens) | 6480464 | Parathion results in increased methylation of RERG promoter | CTD | PMID:22847954 | Rerg | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of RERG mRNA | CTD | PMID:35163327 | Rerg | Rat | phenobarbital | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of RERG mRNA | CTD | PMID:19482888 | Rerg | Rat | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of RERG mRNA | CTD | PMID:30047161 | Rerg | Rat | phenobarbital | multiple interactions | ISO | Rerg (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of RERG mRNA] | CTD | PMID:19482888 | Rerg | Rat | raloxifene | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA] | CTD | PMID:21185374 | Rerg | Rat | resveratrol | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of RERG mRNA | CTD | PMID:19167446 | Rerg | Rat | SB 431542 | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Rerg | Rat | silicon dioxide | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of RERG mRNA | CTD | PMID:25895662 | Rerg | Rat | sodium arsenate | increases expression | ISO | Rerg (Mus musculus) | 6480464 | sodium arsenate results in increased expression of RERG mRNA | CTD | PMID:21795629 | Rerg | Rat | sodium arsenite | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | sulforaphane | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of RERG mRNA | CTD | PMID:31838189 | Rerg | Rat | sunitinib | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of RERG mRNA | CTD | PMID:31533062 | Rerg | Rat | tamoxifen | increases expression | ISO | Rerg (Mus musculus) | 6480464 | Tamoxifen results in increased expression of RERG mRNA | CTD | PMID:25123088 | Rerg | Rat | terbufos | increases methylation | ISO | RERG (Homo sapiens) | 6480464 | terbufos results in increased methylation of RERG promoter | CTD | PMID:22847954 | Rerg | Rat | thiram | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | Thiram results in decreased expression of RERG mRNA | CTD | PMID:38568856 | Rerg | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of RERG mRNA | CTD | PMID:33387578 | Rerg | Rat | trichostatin A | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [trichostatin A co-treated with TFAP2C protein] results in increased expression of RERG mRNA; TFAP2C protein more ... | CTD | PMID:19458056 | Rerg | Rat | trichostatin A | increases expression | ISO | RERG (Homo sapiens) | 6480464 | trichostatin A results in increased expression of RERG mRNA | CTD | PMID:24935251 | Rerg | Rat | triclosan | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Triclosan results in increased expression of RERG mRNA | CTD | PMID:30510588 | Rerg | Rat | trimellitic anhydride | decreases expression | ISO | Rerg (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of RERG mRNA | CTD | PMID:19042947 | Rerg | Rat | valproic acid | affects expression | ISO | RERG (Homo sapiens) | 6480464 | Valproic Acid affects the expression of RERG mRNA | CTD | PMID:25979313 | Rerg | Rat | valproic acid | increases expression | ISO | RERG (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RERG mRNA | CTD | PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:28001369 | Rerg | Rat | valproic acid | multiple interactions | ISO | RERG (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Rerg | Rat | zoledronic acid | decreases expression | ISO | RERG (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of RERG mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||






















