Cfap126 (cilia and flagella associated protein 126) - Rat Genome Database

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Gene: Cfap126 (cilia and flagella associated protein 126) Rattus norvegicus
Analyze
Symbol: Cfap126
Name: cilia and flagella associated protein 126
RGD ID: 1562658
Description: Predicted to be involved in cilium organization and flagellated sperm motility. Predicted to be located in apical plasma membrane and axonemal microtubule. Predicted to be active in axonemal B tubule inner sheath; ciliary basal body; and sperm flagellum. Orthologous to human CFAP126 (cilia and flagella associated protein 126); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498278; LOC498278; RGD1562658; similar to RIKEN cDNA 1700009P17; uncharacterized protein LOC498278; UPF0740 protein C1orf192 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,059,142 - 86,075,034 (+)NCBIGRCr8
mRatBN7.21383,526,657 - 83,542,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,526,657 - 83,542,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,032,342 - 86,048,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,430,580 - 87,446,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,662,280 - 84,678,253 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,480,058 - 89,495,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,480,058 - 89,495,949 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,107,559 - 94,123,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,995,646 - 87,012,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,158,501 - 83,174,105 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25296022  


Genomics

Comparative Map Data
Cfap126
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,059,142 - 86,075,034 (+)NCBIGRCr8
mRatBN7.21383,526,657 - 83,542,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,526,657 - 83,542,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,032,342 - 86,048,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,430,580 - 87,446,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,662,280 - 84,678,253 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,480,058 - 89,495,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,480,058 - 89,495,949 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,107,559 - 94,123,450 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,995,646 - 87,012,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,158,501 - 83,174,105 (+)NCBICelera
Cytogenetic Map13q24NCBI
CFAP126
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,364,733 - 161,367,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,364,733 - 161,367,876 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,334,523 - 161,337,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,601,145 - 159,604,288 (-)NCBINCBI36Build 36hg18NCBI36
Celera1134,401,651 - 134,404,794 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,691,299 - 132,694,451 (-)NCBIHuRef
CHM1_11162,730,776 - 162,733,928 (-)NCBICHM1_1
T2T-CHM13v2.01160,502,177 - 160,505,320 (-)NCBIT2T-CHM13v2.0
Cfap126
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,941,326 - 170,954,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,941,487 - 170,954,536 (+)EnsemblGRCm39 Ensembl
GRCm381171,113,912 - 171,126,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,113,918 - 171,126,967 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,051,792 - 173,057,098 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,958,336 - 172,963,642 (+)NCBIMGSCv36mm8
Celera1173,571,178 - 173,576,544 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.96NCBI
Cfap126
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546813,085,324 - 13,088,022 (-)NCBIChiLan1.0ChiLan1.0
CFAP126
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,486,728 - 88,489,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,176,991 - 88,180,459 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,774,574 - 136,777,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,684,924 - 140,686,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,685,157 - 140,688,063 (-)Ensemblpanpan1.1panPan2
CFAP126
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,158,212 - 21,176,889 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,158,108 - 21,161,261 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,232,675 - 21,251,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,275,553 - 21,294,210 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,275,466 - 21,278,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,172,675 - 21,191,256 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,578,927 - 21,581,942 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,986,919 - 22,005,579 (+)NCBIUU_Cfam_GSD_1.0
Cfap126
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,430,450 - 7,433,655 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936903638,391 - 642,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP126
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,120,477 - 89,133,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,108,048 - 89,133,525 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,964,842 - 96,990,454 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP126
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,608,511 - 2,612,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,608,942 - 2,611,852 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,665,794 - 1,670,890 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap126
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479421,878 - 53,363 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap126
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000050804
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
D13Got70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,530,449 - 83,530,566 (+)MAPPERmRatBN7.2
Rnor_6.01389,483,848 - 89,483,964NCBIRnor6.0
Rnor_5.01394,111,349 - 94,111,465UniSTSRnor5.0
RGSC_v3.41386,999,435 - 86,999,552RGDRGSC3.4
RGSC_v3.41386,999,436 - 86,999,552UniSTSRGSC3.4
RGSC_v3.11387,188,319 - 87,188,436RGD
Celera1383,162,004 - 83,162,120UniSTS
RH 2.0 Map13629.2RGD
Cytogenetic Map13q24UniSTS
RH129459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,542,182 - 83,542,373 (+)MAPPERmRatBN7.2
Rnor_6.01389,495,580 - 89,495,770NCBIRnor6.0
Rnor_5.01394,123,081 - 94,123,271UniSTSRnor5.0
RGSC_v3.41387,012,101 - 87,012,291UniSTSRGSC3.4
Celera1383,173,736 - 83,173,926UniSTS
RH 3.4 Map4219.03UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 108 91 90 59 25 59 6 218 97 88 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000050804   ⟹   ENSRNOP00000043416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,526,657 - 83,542,552 (+)Ensembl
Rnor_6.0 Ensembl1389,480,058 - 89,495,949 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113043   ⟹   ENSRNOP00000092503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,532,740 - 83,542,552 (+)Ensembl
RefSeq Acc Id: NM_001109075   ⟹   NP_001102545
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,059,142 - 86,075,034 (+)NCBI
mRatBN7.21383,526,657 - 83,542,552 (+)NCBI
Rnor_6.01389,480,058 - 89,495,949 (+)NCBI
Rnor_5.01394,107,559 - 94,123,450 (+)NCBI
RGSC_v3.41386,995,646 - 87,012,470 (+)RGD
Celera1383,158,501 - 83,174,105 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769752   ⟹   XP_008767974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,070,057 - 86,075,012 (+)NCBI
mRatBN7.21383,538,573 - 83,542,537 (+)NCBI
Rnor_6.01389,491,607 - 89,495,934 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090981   ⟹   XP_038946909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,070,057 - 86,075,012 (+)NCBI
mRatBN7.21383,538,530 - 83,542,537 (+)NCBI
RefSeq Acc Id: XM_063272544   ⟹   XP_063128614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,070,005 - 86,075,012 (+)NCBI
RefSeq Acc Id: NP_001102545   ⟸   NM_001109075
- UniProtKB: A6JFT6 (UniProtKB/TrEMBL),   D3ZCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767974   ⟸   XM_008769752
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000043416   ⟸   ENSRNOT00000050804
RefSeq Acc Id: XP_038946909   ⟸   XM_039090981
- Peptide Label: isoform X3
- UniProtKB: A6JFT7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092503   ⟸   ENSRNOT00000113043
RefSeq Acc Id: XP_063128614   ⟸   XM_063272544
- Peptide Label: isoform X1
- UniProtKB: A6JFT6 (UniProtKB/TrEMBL),   D3ZCQ6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCQ6-F1-model_v2 AlphaFold D3ZCQ6 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698993
Promoter ID:EPDNEW_R9517
Type:multiple initiation site
Name:Cfap126_1
Description:cilia and flagella associated protein 126
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,492,008 - 89,492,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562658 AgrOrtholog
BioCyc Gene G2FUF-17390 BioCyc
Ensembl Genes ENSRNOG00000034221 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050804.3 UniProtKB/TrEMBL
  ENSRNOT00000113043.1 UniProtKB/TrEMBL
InterPro Fltp UniProtKB/TrEMBL
KEGG Report rno:498278 UniProtKB/TrEMBL
NCBI Gene 498278 ENTREZGENE
PANTHER PROTEIN FLATTOP UniProtKB/TrEMBL
  PTHR34639 UniProtKB/TrEMBL
Pfam CFAP126 UniProtKB/TrEMBL
PhenoGen Cfap126 PhenoGen
RatGTEx ENSRNOG00000034221 RatGTEx
UniProt A0A8I6AGN8_RAT UniProtKB/TrEMBL
  A6JFT6 ENTREZGENE, UniProtKB/TrEMBL
  A6JFT7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCQ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-22 Cfap126  cilia and flagella associated protein 126  RGD1562658  similar to RIKEN cDNA 1700009P17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562658  similar to RIKEN cDNA 1700009P17   RGD1562658_predicted  similar to RIKEN cDNA 1700009P17 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562658_predicted  similar to RIKEN cDNA 1700009P17 (predicted)  LOC498278  similar to RIKEN cDNA 1700009P17  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498278  similar to RIKEN cDNA 1700009P17      Symbol and Name status set to provisional 70820 PROVISIONAL