Tsr2 (TSR2, ribosome maturation factor)

Gene: Tsr2 (TSR2, ribosome maturation factor) Rattus norvegicus

Analyze

Symbol:

Tsr2

Name:

TSR2, ribosome maturation factor

RGD ID:

1562416

Description:

Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 14 with mandibulofacial dysostosis. Orthologous to human TSR2 (TSR2 ribosome maturation factor); INTERACTS WITH amphetamine; bisphenol A; cobalt dichloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC317418; NEWGENE_1562416; pre-rRNA-processing protein TSR2 homolog; RGD1562416; similar to RIKEN cDNA 2310007F12; TSR2 ribosome maturation factor; TSR2, 20S rRNA accumulation, homolog; TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TSR2 (TSR2 ribosome maturation factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tsr2 (TSR2 20S rRNA accumulation)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tsr2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TSR2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TSR2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tsr2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TSR2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TSR2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tsr2 (TSR2 ribosome maturation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TSR2 (TSR2 ribosome maturation factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tsr2 (TSR2 20S rRNA accumulation)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tsr2 (TSR2 ribosome maturation factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14543	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	TSR2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y51H4A.15	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	23,507,141 - 23,515,711 (-)	NCBI		GRCr8
mRatBN7.2	X	20,064,102 - 20,072,673 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	20,064,103 - 20,072,620 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	17,502,402 - 17,510,917 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	22,612,665 - 22,621,180 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	20,593,349 - 20,601,866 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	20,141,406 - 20,146,082 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	20,144,432 - 20,232,639 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	20,968,908 - 20,977,426 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	X	20,321,354 - 20,329,877 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aarskog syndrome (ISO)

autistic disorder (ISO)

Cornelia de Lange syndrome 2 (ISO)

Diamond-Blackfan anemia 14 with mandibulofacial dysostosis (ISO)

Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (ISO)

genetic disease (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked Aarskog syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cobalt dichloride (EXP)

diethylstilbestrol (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

fipronil (EXP)

gentamycin (EXP)

inulin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

ozone (ISO)

p-toluidine (EXP)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

senecionine (ISO)

silicon dioxide (ISO)

T-2 toxin (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

Triptolide (EXP)

tungsten (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Tsr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	23,507,141 - 23,515,711 (-)	NCBI		GRCr8
mRatBN7.2	X	20,064,102 - 20,072,673 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	20,064,103 - 20,072,620 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	17,502,402 - 17,510,917 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	22,612,665 - 22,621,180 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	20,593,349 - 20,601,866 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	20,141,406 - 20,146,082 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	20,144,432 - 20,232,639 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	20,968,908 - 20,977,426 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	X	20,321,354 - 20,329,877 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

TSR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	54,440,404 - 54,448,032 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	54,440,404 - 54,448,032 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	54,466,837 - 54,474,465 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	54,483,578 - 54,488,455 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	58,299,414 - 58,304,291 (+)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	51,518,075 - 51,522,307 (+)	NCBI		HuRef
CHM1_1	X	54,457,507 - 54,462,384 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	53,731,260 - 53,738,888 (+)	NCBI		T2T-CHM13v2.0

Tsr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	149,870,090 - 149,879,539 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	149,870,090 - 149,879,539 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	151,087,094 - 151,096,543 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	151,087,094 - 151,096,543 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	147,521,637 - 147,531,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	146,428,025 - 146,437,234 (-)	NCBI		MGSCv36	mm8
Celera	X	133,307,018 - 133,317,146 (+)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	68.46	NCBI

Tsr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	1,698,136 - 1,703,404 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	1,698,926 - 1,703,404 (+)	NCBI	ChiLan1.0	ChiLan1.0

TSR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	55,829,012 - 55,833,962 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	55,832,617 - 55,837,566 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	46,643,659 - 46,648,829 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	54,875,679 - 54,883,324 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	54,875,696 - 54,880,809 (+)	Ensembl	panpan1.1		panPan2

TSR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	46,189,810 - 46,194,949 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	46,189,870 - 46,296,966 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	37,578,758 - 37,583,898 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	46,511,181 - 46,516,318 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	46,511,246 - 46,516,313 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	46,008,993 - 46,014,130 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	46,459,373 - 46,464,505 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	46,526,670 - 46,531,808 (+)	NCBI		UU_Cfam_GSD_1.0

Tsr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	39,010,776 - 39,015,724 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936751	1,350,481 - 1,358,110 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936751	1,350,542 - 1,355,449 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	47,186,643 - 47,192,452 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	47,186,610 - 47,192,465 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	53,043,987 - 53,049,415 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TSR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	50,532,958 - 50,555,179 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666086	4,515,626 - 4,523,216 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tsr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624909	2,310,718 - 2,315,538 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624909	2,311,494 - 2,316,358 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tsr2
27 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	846
Count of miRNA genes:	336
Interacting mature miRNAs:	457
Transcripts:	ENSRNOT00000003540
Prediction methods:	Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Markers in Region

RH128051

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	20,066,600 - 20,066,789 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	20,143,904 - 20,144,092	NCBI	Rnor6.0
Rnor_6.0	X	20,226,617 - 20,226,805	NCBI	Rnor6.0
Rnor_5.0	X	20,971,407 - 20,971,595	UniSTS	Rnor5.0
Rnor_5.0	X	20,888,694 - 20,888,882	UniSTS	Rnor5.0
RGSC_v3.4	X	40,407,246 - 40,407,434	UniSTS	RGSC3.4
Celera	X	20,323,852 - 20,324,040	UniSTS
RH 3.4 Map	X	211.43	UniSTS
Cytogenetic Map	X	q21	UniSTS

RH136927

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	20,064,191 - 20,064,397 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	20,141,495 - 20,141,700	NCBI	Rnor6.0
Rnor_6.0	X	20,224,208 - 20,224,413	NCBI	Rnor6.0
Rnor_5.0	X	20,886,285 - 20,886,490	UniSTS	Rnor5.0
Rnor_5.0	X	20,968,998 - 20,969,203	UniSTS	Rnor5.0
RGSC_v3.4	X	40,404,837 - 40,405,042	UniSTS	RGSC3.4
Celera	X	20,321,443 - 20,321,648	UniSTS
Cytogenetic Map	X	q21	UniSTS

Fgd1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	20,065,744 - 20,065,911 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	20,225,761 - 20,225,927	NCBI	Rnor6.0
Rnor_6.0	X	20,143,048 - 20,143,214	NCBI	Rnor6.0
Rnor_5.0	X	20,887,838 - 20,888,004	UniSTS	Rnor5.0
Rnor_5.0	X	20,970,551 - 20,970,717	UniSTS	Rnor5.0
RGSC_v3.4	X	40,406,390 - 40,406,556	UniSTS	RGSC3.4
Celera	X	20,322,996 - 20,323,162	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	26	18	18	2	18			74	24	33	9
Low	2	17	39	23	17	23	8	11		11	8	2	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001115027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003540 ⟹ ENSRNOP00000003540

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	20,226,542 - 20,232,635 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000072753 ⟹ ENSRNOP00000065693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	20,144,432 - 20,232,639 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098819 ⟹ ENSRNOP00000085935

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,064,103 - 20,072,474 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118302 ⟹ ENSRNOP00000078813

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	20,064,103 - 20,072,620 (-)	Ensembl

RefSeq Acc Id:

NM_001115027 ⟹ NP_001108499

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	23,507,142 - 23,515,659 (-)	NCBI
mRatBN7.2	X	20,064,103 - 20,072,620 (-)	NCBI
Rnor_6.0	X	20,141,406 - 20,146,082 (-)	NCBI
Rnor_5.0	X	20,968,908 - 20,977,426 (-)	NCBI
Celera	X	20,321,354 - 20,329,877 (-)	NCBI

Sequence:

show sequence

CCACGTGACCTAAACGGATGATGGCGGGCGCCGCGGAAGACGTGCGATTGCTCTTCGGAGCTGG
CGTCCGCGCCGCGCTGGAGGCTTGGCCTGCTTTACAGATCGCTGTGGAGAATGGCTTCGGGGGC
GTGCACAGCCAGGAGAAGGCCGAGTGGCTGGGGGGTGCAGTGGAGGATTACTTCATCGCCAATG
CTGACTTGGAGCTGGAAGAGATAGAAGATTTTCTTGGGGAGCTGATGACCACTGAGTTTGATAC
CGTTGTGGAAGATGGGAGTCTGCCCCAGGTGAGCCAGCAACTACAGACCATGTTCCACCACTTC
CAGAAGGGTGATGGGGCTGCTCTTCAGGAGATGACCTCTCATATCAACCAAAAAAAGTGCAAAG
TCACAGCTACCCCACTTAAGACGGCCAAAGAAACTGATGTGGCAGAAGATGATGTGGACAGCGT
GGAAGAAATGGAGGTGACAGCTACTAATGATGGGGCCACAACGGATGGGGTCTGCCCCCAGTCT
CAACCTTCTGATCCAGACTCCCAGACTATTAAGGAAGAGGATATAGTTGAAGATGGCTGGACCA
TTGTCCGGAGAAAGAAATGAGCAGGGCAGTACATGTTTGGGGCCCTTGTTTGTTGGGTGTTATG
AGAGACTTATAGGAGCTGTTTTTGGGGGAACTATACACCTCTGTTCTGGAAACCGTATCCCTTC
TTTGTTCCCATCCTTCCCTTCAGGGGAAGAAAAGCCCTAAAGTCCTTGGTTGTGGGGTTGATGA
GACCTATTCCAGCCCCTTGAATCTTAAGGTACCATATGAGAGATGAGACCAGGTTTCCCAGCAT
AGTGCCTCCTAGGTGCAGTGAATTGGAAGATGGGTGATAGGTGTGGATGTGGTTATAGAAGCCA
GGCTTGTGGAAAGTAGGCAGGTACATTTATGGAAAGGACCGGAATTCCACAGTGGGAGGCTGGC
TGGCTTGGCAATTGTGAGAAAAGCATACAGCTGGAAGAGAGATGTAGAAGTCTACATTCCCCAA
TGTCCCCACCCTAGCCTCCCACAGAGCATTCCCCAACCGACCAGAATTTTCATCCTCCTGGGAA
TTCTCCCCCTTGAATACCCTTGAGAGTTTGAAGGACTTAACTAAAAGTGGTGAACTTGGGAAAG
TTGGGCTGTTTTAAGTCCAGGGATGAGGCTTAAGATCTTAATAACATAACACTTTCTTGTTTAA
TTCATGATTTAACCTTGGAATCAGCTTTCTGAGAGCTGAGCTTCAAAATTCATCAAGAGAGTAG
TTTCTGCACCCTCCCCTCTCCCTTAGTAGCCTGGGACTTCGGACAAACGGACGGACCATAGCAG
TGCTCTGAAAGTTACTGTACGCCTGAAATAAACTGTATTTTTCTTTAAAAAACAGTATCCATTG
TCCTCCCCTCCCGCCCCCCCATTCCCGTCCTGCCCAGTGGCCCTGCCATGGATCTGGACGATAA
AATACTGGATTGCTTTGGGGCTAGGTAGAAGCTATAAGCCATGGGAAAGGCAAGAAGGGTCTAG
TCACCACCCCATGTAAAGTCATACATGTGAAGACACTGGCTGAGGAGGAAAGGGTGGATTGGGG
TCCCAGGGTCAGTAGCAGAGCTGGCACTTGAATCCAGGTCTCCTGCCTCTGGTACTTTTGTGGG
GAACTAGATGAAAGTAGGATCTGTGGGGTACTGGGAGGAAACAGACTAATTCAAGTGAGTCTAG
CAATTAGCTCCTGCCCTCCCTGGGGACAGGGATTTAAAAAATTAACATCAATGTAGGAATAGTT
TGTCTTTCTTTTTTAAAAAGCCCACATTTTGTGAAAAGATGAATTAAAAAACCCAAGACCCAGC
ATTCGGGATTGAAAGTGCCCTTGATGGGAATTCAAGTATTGACTGCATTGGGAGTGGGCTAGAG
CCCCCAATTGAACATGGGCAGCTGGAGTGTGGGGCAGGAACTCCCAGTTCCCCCCCCAAACCCT
CTAGGTCTTGTCTCGGGTCTGGGAGGCTTCAGGAGGTTCAGCAGTGGCTCCTGAAGCTGCCACT
GTTGTCTCCTCCATCTCCTTGTCCTCAGACAGTGTGGGCCCTGGGCAGAATGTGTCCCCACGGC
CCGCCCTGCCAAGCACAGCCATCCAGCGCCGCTGGAGTTCTTCTGTCTCTGGGCTGAAGTACCA
GCTTAGGTGGCTCTGGGTGATCTTGAAGACATGCCTCCTGTCTGGCCGCTCCCCTGCCTCAGGA
GGCCCCACCTCAAAGCCAATGAGGGGCAGGCTGCGTTGGGCTTTCACATCCTGGAGAGGAAGGA
CAGAGAGCTAGTGTCACTTAGGGCCAGACAGTATCCTCTGCCCAGTGAAACAACTTTGCACTGT
TCTGCTGTTTCCCTCTGTGAAAAACACTGCCTTCACTGTAATGAACATAAAGATGTCTGAACTG
GGACTAGAAGGCAGGCTGGTTACATGTCTATCTCCTCCCATGCCCAAATCAACTGCTAATCTTT
ACTATTACAGATGCAGTTCTTTCGCTAGTTCCTCTATCTGCCTATTCTGTTTTAGTGTCACACC
TAGAGGCTCCTGTCTCTGCTCCTGTTTTCTCCAGAAAGCCAGACTTCCCACCTCACCCTCATTT
TCCCCGTATCTTGGCCTCCAAACACTTCTACCTACCTGCTCTGTCATGTAAGGATAGGGGTTTT
TATTTTTCCCTTTGCTAGGCTTACCCTGTCCCTGCAGGACAAGGCATACAGGAGAAGGGCAGCC
CAGCTTTGTCAGATAGCTGGAGAAACCTGAAGGAGTAGGATGCACACCTGAGGGGCTCCATAGA
TGTACAGCACCAAGGGTTCATTCTCGGGAACCACAAACCATGCCTTGTGCCATCCTTTCCCACC
CTTCTCCATGTAGTGCAGGAAGCTGCAGATGACGCTGTTCTCAGCAGCCACTGAGGCCTGTTTC
TGTGATCAGAGACACAGTACAGGGTACATCAATGTTGATGGAAAGCTTTGCTCTTGGCTTAAAC
AGCCCCATAGTGTATGGACTATGTCTCAGACAGAGGTAGCAAAACTGTGCAAGTCATAGCTAAA
ATGATTTGGCCTTTGTCACTGAAATAAGCAGAGTGAGGCTTGGCTGCTGACTCTAACAACAATA
AGGGGTGTGCAGATTTCAGTGGGGACAGTGAAATAAATGCTGGCCAGATACTCTTCAAGCTAAG
GGACATTCACAGCTAACTCTTTTCATCTTTCATTATATACTTACTGCCTGCTCTGAGAAAGTCC
TTCTAATGTGATTAATGGGATGAGTGGGTGCCTAACACCATCTGTCTTAGAGTCCTAACAATAG
ATGAAAATGCAGGACTTCTGAGAAGAGCACAGAGGGTGTTTATGGGATTGAAATTAGCATAAAC
AAGGCATTTAAAATAGTTATGGTACAGAGGAAGCTCCCTTACATTTGGGATACCTTGATTTTAC
TTTTAAAAAAAAAATCACCCCACATATGTGTATATTCATGGTCCTAAAAGATAGGATCAGTATT
AACAGTGGCAACTTCTGGGTAAAGCACTATGTCTTATTTTGTGTTCTTATCCTATTTCACAATT
TAAAAATGTACTTAGTTCATTTTTAAATAATCCTATAGGCTAGCCTAGGTTATGCAGTGAGACT
CTGTCTGAAATAAAACGATACCTAGAAGCATTTTTCTGGTTGTACAACTTAGCCAAATATACTC
TCTGTGTTTCAGTTTCCTCATATGTAAATGAAGGATACGGGTATAGGTTGTTCAGTTACTGTAA
GAGTTAAGTGTTTAACATTCTTTAATAAAAATCCTTTTAACCCTT

hide sequence

RefSeq Acc Id:

XM_039099803 ⟹ XP_038955731

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	23,507,141 - 23,515,711 (-)	NCBI
mRatBN7.2	X	20,064,102 - 20,072,673 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001108499	(Get FASTA)	NCBI Sequence Viewer
	XP_038955731	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58695	(Get FASTA)	NCBI Sequence Viewer
	EDL86320	(Get FASTA)	NCBI Sequence Viewer
	EDL86322	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078813
	ENSRNOP00000078813.1
	ENSRNOP00000085935
	ENSRNOP00000085935.1

RefSeq Acc Id:	NP_001108499 ⟸ NM_001115027
- UniProtKB:	A6KL99 (UniProtKB/TrEMBL), B0BN59 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMAGAAEDVRLLFGAGVRAALEAWPALQIAVENGFGGVHSQEKAEWLGGAVEDYFIANADLELE EIEDFLGELMTTEFDTVVEDGSLPQVSQQLQTMFHHFQKGDGAALQEMTSHINQKKCKVTATPL KTAKETDVAEDDVDSVEEMEVTATNDGATTDGVCPQSQPSDPDSQTIKEEDIVEDGWTIVRRKK hide sequence

RefSeq Acc Id:

ENSRNOP00000065693 ⟸ ENSRNOT00000072753

RefSeq Acc Id:

ENSRNOP00000003540 ⟸ ENSRNOT00000003540

RefSeq Acc Id:	XP_038955731 ⟸ XM_039099803
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZLR7 (UniProtKB/TrEMBL), B0BN59 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000085935 ⟸ ENSRNOT00000098819

RefSeq Acc Id:

ENSRNOP00000078813 ⟸ ENSRNOT00000118302

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6B8-F1-model_v2	AlphaFold	G3V6B8	1-192	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562416	AgrOrtholog
BioCyc Gene	G2FUF-2778	BioCyc
Ensembl Genes	ENSRNOG00000002556	Ensembl
	ENSRNOG00000064917	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000098819	ENTREZGENE
	ENSRNOT00000098819.1	UniProtKB/TrEMBL
	ENSRNOT00000118302.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9023223	IMAGE-MGC_LOAD
InterPro	Pre-rRNA_process_TSR2	UniProtKB/TrEMBL
KEGG Report	rno:317418	UniProtKB/TrEMBL
MGC_CLONE	MGC:187725	IMAGE-MGC_LOAD
NCBI Gene	317418	ENTREZGENE
PANTHER	PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG	UniProtKB/TrEMBL
	PTHR21250	UniProtKB/TrEMBL
Pfam	WGG	UniProtKB/TrEMBL
PhenoGen	Tsr2	PhenoGen
RatGTEx	ENSRNOG00000002556	RatGTEx
	ENSRNOG00000064917	RatGTEx
UniProt	A0A8I5ZLR7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4W3_RAT	UniProtKB/TrEMBL
	A6KL99	ENTREZGENE, UniProtKB/TrEMBL
	B0BN59	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tsr2	TSR2, ribosome maturation factor	NEWGENE_1562416	TSR2, ribosome maturation factor	Data merged from RGD:11417743	737654	PROVISIONAL
2016-08-02	NEWGENE_1562416	TSR2, ribosome maturation factor			Symbol and Name status set to provisional	70820	PROVISIONAL
2016-04-27	Tsr2	TSR2, ribosome maturation factor	Tsr2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-11	Tsr2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	RGD1562416	similar to RIKEN cDNA 2310007F12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	RGD1562416	similar to RIKEN cDNA 2310007F12	RGD1562416	similar to RIKEN cDNA 2310007F12	Gene reactivated at release of RGSC5.0 assembly	2298974	REACTIVATED
2008-04-30	RGD1562416	similar to RIKEN cDNA 2310007F12	RGD1562416_predicted	similar to RIKEN cDNA 2310007F12 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1562416_predicted	similar to RIKEN cDNA 2310007F12 (predicted)	LOC317418	similar to RIKEN cDNA 2310007F12	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC317418	similar to RIKEN cDNA 2310007F12			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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