Qpct (glutaminyl-peptide cyclotransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Qpct (glutaminyl-peptide cyclotransferase) Rattus norvegicus
Analyze
Symbol: Qpct
Name: glutaminyl-peptide cyclotransferase
RGD ID: 1562284
Description: Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be located in extracellular region. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutaminyl cyclase; glutaminyl-peptide cyclotransferase (glutaminyl cyclase); glutaminyl-peptide cyclotransferase-like 1; hypothetical protein LOC313837; LOC313837; Qpctl1; RGD1562284; similar to Glutaminyl-peptide cyclotransferase precursor (QC); similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase); uncharacterized protein LOC313837
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,716,824 - 21,748,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl621,716,824 - 21,748,895 (-)EnsemblGRCr8
mRatBN7.2615,964,656 - 15,996,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx616,280,262 - 16,313,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0616,602,485 - 16,635,791 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0616,083,483 - 16,116,422 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.061,657,110 - 1,689,575 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)Ensemblrn6Rnor6.0
Rnor_5.061,647,419 - 1,679,764 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.461,845,425 - 1,878,423 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera615,630,306 - 15,661,878 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
gemfibrozil  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
ritodrine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Glutaminyl cyclases as novel targets for the treatment of septic arthritis. Hellvard A, etal., J Infect Dis. 2013 Mar 1;207(5):768-77. doi: 10.1093/infdis/jis729. Epub 2012 Nov 29.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7999256   PMID:21288892   PMID:23376485   PMID:23533145   PMID:25002582  


Genomics

Comparative Map Data
Qpct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,716,824 - 21,748,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl621,716,824 - 21,748,895 (-)EnsemblGRCr8
mRatBN7.2615,964,656 - 15,996,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx616,280,262 - 16,313,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0616,602,485 - 16,635,791 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0616,083,483 - 16,116,422 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.061,657,110 - 1,689,575 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)Ensemblrn6Rnor6.0
Rnor_5.061,647,419 - 1,679,764 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.461,845,425 - 1,878,423 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera615,630,306 - 15,661,878 (-)NCBICelera
Cytogenetic Map6q12NCBI
QPCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38237,344,630 - 37,373,322 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl237,342,827 - 37,373,322 (+)Ensemblhg38GRCh38
GRCh37237,571,773 - 37,600,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,425,257 - 37,453,969 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34237,483,519 - 37,512,115NCBI
Celera237,412,695 - 37,441,406 (+)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef237,311,579 - 37,340,390 (+)NCBIHuRef
CHM1_1237,501,200 - 37,529,906 (+)NCBICHM1_1
T2T-CHM13v2.0237,351,621 - 37,380,410 (+)NCBIT2T-CHM13v2.0
Qpct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,359,335 - 79,397,807 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,359,335 - 79,397,807 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381779,051,906 - 79,090,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,051,906 - 79,090,378 (+)Ensemblmm10GRCm38
MGSCv371779,451,246 - 79,489,583 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361778,956,964 - 78,995,436 (+)NCBIMGSCv36mm8
MGSCv361778,307,076 - 78,344,882 (+)NCBIMGSCv36mm8
Celera1783,366,401 - 83,403,264 (+)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.83NCBI
Qpct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,138,477 - 5,168,455 (+)Ensembl
ChiLan1.0NW_0049554415,138,477 - 5,168,056 (+)NCBIChiLan1.0ChiLan1.0
QPCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21289,106,271 - 89,135,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A89,110,245 - 89,139,229 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A37,371,848 - 37,400,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,136,537 - 38,165,254 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,136,532 - 38,165,254 (+)EnsemblpanPan2panpan1.1
QPCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,700,422 - 29,741,652 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,716,378 - 29,741,221 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1729,531,103 - 29,555,598 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01730,366,927 - 30,391,480 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,366,993 - 30,392,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,593,903 - 29,618,395 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,660,151 - 29,684,689 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,875,410 - 29,899,919 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Qpct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629242,264,101 - 42,294,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663929,363 - 959,668 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936663929,737 - 959,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QPCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,792,720 - 102,823,026 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13102,795,199 - 102,823,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,332,654 - 109,360,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QPCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,015,260 - 70,044,033 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,015,261 - 70,043,941 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604541,903,220 - 41,931,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qpct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473818,945,969 - 18,984,016 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473818,945,954 - 18,984,016 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Qpct
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1714,141,662 - 14,173,835 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Qpct
211 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000049672
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
RH128088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,964,967 - 15,965,183 (-)MAPPERmRatBN7.2
Rnor_6.061,689,048 - 1,689,263NCBIRnor6.0
Rnor_5.061,679,237 - 1,679,452UniSTSRnor5.0
RGSC_v3.461,877,742 - 1,877,957UniSTSRGSC3.4
Celera615,630,166 - 15,630,381UniSTS
Cytogenetic Map6q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 353 190 10 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049672   ⟹   ENSRNOP00000045568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl621,716,824 - 21,748,895 (-)Ensembl
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)Ensembl
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079864   ⟹   ENSRNOP00000072958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl621,716,824 - 21,748,895 (-)Ensembl
mRatBN7.2 Ensembl615,964,657 - 15,996,699 (-)Ensembl
Rnor_6.0 Ensembl61,657,332 - 1,689,123 (+)Ensembl
RefSeq Acc Id: NM_001134557   ⟹   NP_001128029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,716,824 - 21,748,895 (-)NCBI
mRatBN7.2615,964,656 - 15,996,730 (-)NCBI
Rnor_6.061,657,332 - 1,689,123 (+)NCBI
Rnor_5.061,647,419 - 1,679,764 (+)NCBI
RGSC_v3.461,845,425 - 1,878,423 (+)RGD
Celera615,630,306 - 15,661,878 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001399516   ⟹   NP_001386445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,716,824 - 21,748,895 (-)NCBI
mRatBN7.2615,964,656 - 15,996,730 (-)NCBI
RefSeq Acc Id: NP_001128029   ⟸   NM_001134557
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K497 (UniProtKB/TrEMBL),   A6H9U1 (UniProtKB/TrEMBL),   A6H9U2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072958   ⟸   ENSRNOT00000079864
Ensembl Acc Id: ENSRNOP00000045568   ⟸   ENSRNOT00000049672
RefSeq Acc Id: NP_001386445   ⟸   NM_001399516
- Peptide Label: isoform 1
- UniProtKB: D4AC85 (UniProtKB/TrEMBL),   A6H9U2 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M28

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC85-F1-model_v2 AlphaFold D4AC85 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694362
Promoter ID:EPDNEW_R4884
Type:initiation region
Name:Qpct_1
Description:glutaminyl-peptide cyclotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.061,657,320 - 1,657,380EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562284 AgrOrtholog
BioCyc Gene G2FUF-38498 BioCyc
BioCyc Pathway PWY-7942 [5-oxo-L-proline metabolism] BioCyc
BioCyc Pathway Image PWY-7942 BioCyc
Ensembl Genes ENSRNOG00000005705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049672 ENTREZGENE
  ENSRNOT00000049672.6 UniProtKB/TrEMBL
  ENSRNOT00000079864 ENTREZGENE
  ENSRNOT00000079864.3 UniProtKB/TrEMBL
Gene3D-CATH Zn peptidases UniProtKB/TrEMBL
InterPro M28_QC_like UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/TrEMBL, UniProtKB/TrEMBL
  QC/QCL UniProtKB/TrEMBL
KEGG Report rno:313837 UniProtKB/TrEMBL
NCBI Gene 313837 ENTREZGENE
PANTHER GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE UniProtKB/TrEMBL
  PTHR12283 UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/TrEMBL
PhenoGen Qpct PhenoGen
RatGTEx ENSRNOG00000005705 RatGTEx
Superfamily-SCOP Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A0A0G2K497 ENTREZGENE, UniProtKB/TrEMBL
  A6H9U1 ENTREZGENE, UniProtKB/TrEMBL
  A6H9U2 ENTREZGENE, UniProtKB/TrEMBL
  D4AC85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Qpct  glutaminyl-peptide cyclotransferase  Qpctl1  glutaminyl-peptide cyclotransferase-like 1  Data merged from RGD:621086 737654 APPROVED
2013-11-25 Qpct  glutaminyl-peptide cyclotransferase  RGD1562284  similar to Glutaminyl-peptide cyclotransferase precursor (QC)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-25 Qpctl1  glutaminyl-peptide cyclotransferase-like 1  Qpct  glutaminyl-peptide cyclotransferase  Name and Symbol changed 629549 APPROVED
2008-11-20 Qpct  glutaminyl-peptide cyclotransferase  Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562284  similar to Glutaminyl-peptide cyclotransferase precursor (QC)   RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)  RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  Name updated 1299863 APPROVED
2006-03-10 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)    similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  LOC313837  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313837  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)  Qpct  glutaminyl cyclase  Name updated 1299863 APPROVED
2004-09-10 Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)    glutaminyl cyclase  Name updated 1299863 APPROVED
2002-08-07 Qpct  glutaminyl cyclase      Symbol and Name status set to provisional 70820 PROVISIONAL