PRLHR (prolactin releasing hormone receptor) - Rat Genome Database

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Gene: PRLHR (prolactin releasing hormone receptor) Homo sapiens
Analyze
Symbol: PRLHR
Name: prolactin releasing hormone receptor
RGD ID: 732732
HGNC Page HGNC:4464
Description: Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within feeding behavior and hormone metabolic process. Located in cilium. Implicated in hypertension.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 10; G-protein coupled receptor 10; GPR10; GR3; hGR3; MGC126539; MGC126541; prolactin releasing peptide receptor; prolactin-releasing hormone receptor; prolactin-releasing peptide receptor; prRP receptor; PrRPR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810118,589,997 - 118,595,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10118,589,997 - 118,595,648 (-)EnsemblGRCh38hg38GRCh38
GRCh3710120,349,509 - 120,355,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,342,906 - 120,345,150 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410120,343,633 - 120,344,746NCBI
Celera10114,083,566 - 114,085,810 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10113,981,999 - 113,984,243 (-)NCBIHuRef
CHM1_110120,637,272 - 120,639,516 (-)NCBICHM1_1
T2T-CHM13v2.010119,485,136 - 119,490,787 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
genetic disease  (IAGP)
hypertension  (IAGP)
obesity  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IDA,ISO)
membrane  (IEA)
neuron projection  (IBA,IEA)
plasma membrane  (IBA,IEA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. Franks PW, etal., Hypertension. 2004 Feb;43(2):224-8. Epub 2003 Dec 22.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Marchese A, etal., Genomics 1995 Sep 20;29(2):335-44.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat. Watanabe TK, etal., Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):355-66.
Additional References at PubMed
PMID:9607765   PMID:10475064   PMID:10498338   PMID:11030716   PMID:11641419   PMID:11923475   PMID:12126742   PMID:12417311   PMID:12477932   PMID:12716769   PMID:15123239   PMID:15164054  
PMID:15489334   PMID:15752583   PMID:15885496   PMID:16344560   PMID:19913121   PMID:20628086   PMID:21873635   PMID:22158540   PMID:22778259   PMID:23284171   PMID:26211894   PMID:26302849  
PMID:28154160   PMID:36724073   PMID:36922513  


Genomics

Comparative Map Data
PRLHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810118,589,997 - 118,595,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10118,589,997 - 118,595,648 (-)EnsemblGRCh38hg38GRCh38
GRCh3710120,349,509 - 120,355,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,342,906 - 120,345,150 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410120,343,633 - 120,344,746NCBI
Celera10114,083,566 - 114,085,810 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10113,981,999 - 113,984,243 (-)NCBIHuRef
CHM1_110120,637,272 - 120,639,516 (-)NCBICHM1_1
T2T-CHM13v2.010119,485,136 - 119,490,787 (-)NCBIT2T-CHM13v2.0
Prlhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,454,079 - 60,457,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,455,170 - 60,456,742 (-)EnsemblGRCm39 Ensembl
GRCm381960,465,641 - 60,468,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,466,732 - 60,468,304 (-)EnsemblGRCm38mm10GRCm38
MGSCv371960,542,636 - 60,544,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,521,404 - 60,522,967 (-)NCBIMGSCv36mm8
Celera1962,669,595 - 62,671,166 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Prlhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,592,735 - 269,594,422 (-)NCBIGRCr8
mRatBN7.21259,606,704 - 259,608,391 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,606,704 - 259,608,391 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1267,812,258 - 267,813,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,518,288 - 274,519,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,171,127 - 267,172,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01281,754,472 - 281,756,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1281,754,724 - 281,756,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,097,316 - 289,099,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,068,380 - 267,070,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,279,424 - 267,281,112 (-)NCBI
Celera1255,251,200 - 255,252,887 (-)NCBICelera
Cytogenetic Map1q55NCBI
Prlhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,192,018 - 23,193,130 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,192,018 - 23,193,130 (-)NCBIChiLan1.0ChiLan1.0
PRLHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,445,186 - 130,456,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,450,787 - 130,461,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,922,829 - 115,168,506 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110118,589,819 - 118,592,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10118,590,543 - 118,591,655 (-)Ensemblpanpan1.1panPan2
PRLHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,950,300 - 28,956,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,954,469 - 28,955,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,097,625 - 29,099,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,484,495 - 29,486,071 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,484,543 - 29,485,655 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,042,666 - 29,044,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,056,498 - 29,061,577 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,255,022 - 29,256,598 (-)NCBIUU_Cfam_GSD_1.0
Prlhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721317,378,820 - 17,384,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,180,436 - 8,181,548 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,177,111 - 8,181,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRLHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14128,614,131 - 128,619,457 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114128,617,352 - 128,619,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,132,093 - 140,134,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRLHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,399,821 - 111,402,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604872,660,323 - 72,667,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473728,094,507 - 28,095,941 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473728,093,837 - 28,099,377 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRLHR
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.11(chr10:107191100-118761489)x1 copy number loss See cases [RCV000052570] Chr10:107191100..118761489 [GRCh38]
Chr10:108950858..120521001 [GRCh37]
Chr10:108940848..120510991 [NCBI36]
Chr10:10q25.1-26.11		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q26.11-26.3(chr10:117866565-133554210)x3 copy number gain See cases [RCV000053589] Chr10:117866565..133554210 [GRCh38]
Chr10:119626076..135367714 [GRCh37]
Chr10:119616066..135217704 [NCBI36]
Chr10:10q26.11-26.3		 pathogenic
NM_004248.2(PRLHR):c.1068G>A (p.Lys356=) single nucleotide variant Malignant melanoma [RCV000068827] Chr10:118594177 [GRCh38]
Chr10:120353689 [GRCh37]
Chr10:120343679 [NCBI36]
Chr10:10q26.11		 not provided
GRCh37/hg19 10q25.2-26.3(chr10:114544537-135427143)x3 copy number gain not provided [RCV000847820] Chr10:114544537..135427143 [GRCh37]
Chr10:10q25.2-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q26.11(chr10:118330136-118685873)x3 copy number gain See cases [RCV000136498] Chr10:118330136..118685873 [GRCh38]
Chr10:120089648..120445385 [GRCh37]
Chr10:120079638..120435375 [NCBI36]
Chr10:10q26.11		 pathogenic
GRCh38/hg38 10q25.2-26.12(chr10:112701186-120970617)x3 copy number gain See cases [RCV000137511] Chr10:112701186..120970617 [GRCh38]
Chr10:114460945..122730130 [GRCh37]
Chr10:114450935..122720120 [NCBI36]
Chr10:10q25.2-26.12		 likely pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q25.3-26.13(chr10:117024753-124942806) copy number loss Distal 10q deletion syndrome [RCV000767564] Chr10:117024753..124942806 [GRCh37]
Chr10:10q25.3-26.13		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
NM_004248.3(PRLHR):c.200A>G (p.Tyr67Cys) single nucleotide variant Inborn genetic diseases [RCV003285579] Chr10:118595045 [GRCh38]
Chr10:120354557 [GRCh37]
Chr10:10q26.11		 uncertain significance
GRCh37/hg19 10q26.11(chr10:120104841-120361074)x3 copy number gain not provided [RCV000683214] Chr10:120104841..120361074 [GRCh37]
Chr10:10q26.11		 likely benign|uncertain significance
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_004248.3(PRLHR):c.1036C>T (p.Leu346=) single nucleotide variant not provided [RCV000947292] Chr10:118594209 [GRCh38]
Chr10:120353721 [GRCh37]
Chr10:10q26.11		 benign
GRCh37/hg19 10q25.1-26.3(chr10:110022170-135439095) copy number gain not provided [RCV000767665] Chr10:110022170..135439095 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q26.11-26.3(chr10:119996339-135427143)x3 copy number gain not provided [RCV001006356] Chr10:119996339..135427143 [GRCh37]
Chr10:10q26.11-26.3		 pathogenic
GRCh37/hg19 10q25.3-26.3(chr10:118247181-135435319)x3 copy number gain not provided [RCV001537903] Chr10:118247181..135435319 [GRCh37]
Chr10:10q25.3-26.3		 pathogenic
Single allele deletion not provided [RCV001391678] Chr10:119302758..124813305 [GRCh37]
Chr10:10q26.11-26.13		 likely pathogenic
GRCh37/hg19 10q25.3-26.12(chr10:118891670-122349064)x1 copy number loss Astigmatism [RCV001801230] Chr10:118891670..122349064 [GRCh37]
Chr10:10q25.3-26.12		 uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:108455687-135427143) copy number gain not specified [RCV002052891] Chr10:108455687..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q25.3-26.13(chr10:117019650-125217066) copy number loss not specified [RCV002052892] Chr10:117019650..125217066 [GRCh37]
Chr10:10q25.3-26.13		 pathogenic
NM_004248.3(PRLHR):c.698C>T (p.Thr233Ile) single nucleotide variant Inborn genetic diseases [RCV003285909] Chr10:118594547 [GRCh38]
Chr10:120354059 [GRCh37]
Chr10:10q26.11		 uncertain significance
GRCh37/hg19 10q26.11(chr10:120267084-120401081)x1 copy number loss not provided [RCV002474780] Chr10:120267084..120401081 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.139G>C (p.Val47Leu) single nucleotide variant Inborn genetic diseases [RCV002839912] Chr10:118595106 [GRCh38]
Chr10:120354618 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.170A>G (p.His57Arg) single nucleotide variant Inborn genetic diseases [RCV002841762] Chr10:118595075 [GRCh38]
Chr10:120354587 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.130G>T (p.Ala44Ser) single nucleotide variant Inborn genetic diseases [RCV002902654] Chr10:118595115 [GRCh38]
Chr10:120354627 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.13A>T (p.Thr5Ser) single nucleotide variant Inborn genetic diseases [RCV002762773] Chr10:118595232 [GRCh38]
Chr10:120354744 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.733T>A (p.Tyr245Asn) single nucleotide variant Inborn genetic diseases [RCV002743256] Chr10:118594512 [GRCh38]
Chr10:120354024 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.736G>C (p.Val246Leu) single nucleotide variant Inborn genetic diseases [RCV002765188] Chr10:118594509 [GRCh38]
Chr10:120354021 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.706C>T (p.Leu236Phe) single nucleotide variant Inborn genetic diseases [RCV002788589] Chr10:118594539 [GRCh38]
Chr10:120354051 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.370C>T (p.Pro124Ser) single nucleotide variant Inborn genetic diseases [RCV002742873] Chr10:118594875 [GRCh38]
Chr10:120354387 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.1070T>G (p.Ile357Arg) single nucleotide variant Inborn genetic diseases [RCV002673708] Chr10:118594175 [GRCh38]
Chr10:120353687 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.586G>A (p.Val196Met) single nucleotide variant Inborn genetic diseases [RCV002672863] Chr10:118594659 [GRCh38]
Chr10:120354171 [GRCh37]
Chr10:10q26.11		 likely benign
NM_004248.3(PRLHR):c.40T>A (p.Leu14Ile) single nucleotide variant Inborn genetic diseases [RCV002748152] Chr10:118595205 [GRCh38]
Chr10:120354717 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.484G>T (p.Val162Leu) single nucleotide variant Inborn genetic diseases [RCV002959782] Chr10:118594761 [GRCh38]
Chr10:120354273 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.629T>C (p.Leu210Pro) single nucleotide variant Inborn genetic diseases [RCV002677832] Chr10:118594616 [GRCh38]
Chr10:120354128 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.664C>A (p.Arg222Ser) single nucleotide variant Inborn genetic diseases [RCV003260133] Chr10:118594581 [GRCh38]
Chr10:120354093 [GRCh37]
Chr10:10q26.11		 uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
NM_004248.3(PRLHR):c.1075C>T (p.Pro359Ser) single nucleotide variant Inborn genetic diseases [RCV003354383] Chr10:118594170 [GRCh38]
Chr10:120353682 [GRCh37]
Chr10:10q26.11		 uncertain significance
NM_004248.3(PRLHR):c.740G>T (p.Arg247Leu) single nucleotide variant Inborn genetic diseases [RCV003376797] Chr10:118594505 [GRCh38]
Chr10:120354017 [GRCh37]
Chr10:10q26.11		 uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:111447991-133435388)x3 copy number gain not provided [RCV003484817] Chr10:111447991..133435388 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q25.1-26.3(chr10:111378692-135427143)x3 copy number gain Distal trisomy 10q [RCV003458955] Chr10:111378692..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q25.1-26.13(chr10:107129993-123817654)x3 copy number gain not specified [RCV003986891] Chr10:107129993..123817654 [GRCh37]
Chr10:10q25.1-26.13		 likely pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:881
Count of miRNA genes:298
Interacting mature miRNAs:315
Transcripts:ENST00000239032, ENST00000369169
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH71223  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710120,353,645 - 120,353,765UniSTSGRCh37
Build 3610120,343,635 - 120,343,755RGDNCBI36
Celera10114,084,295 - 114,084,415RGD
Cytogenetic Map10q26.13UniSTS
HuRef10113,982,728 - 113,982,848UniSTS
GeneMap99-GB4 RH Map429.92UniSTS
NCBI RH Map455.5UniSTS
GPR10_2105  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710120,353,459 - 120,354,323UniSTSGRCh37
Build 3610120,343,449 - 120,344,313RGDNCBI36
Celera10114,084,109 - 114,084,973RGD
HuRef10113,982,542 - 113,983,406UniSTS
PRLHR  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710120,353,858 - 120,354,574UniSTSGRCh37
Celera10114,084,508 - 114,085,224UniSTS
HuRef10113,982,941 - 113,983,657UniSTS
UniSTS:481643  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710120,353,644 - 120,354,756UniSTSGRCh37
Celera10114,084,294 - 114,085,406UniSTS
HuRef10113,982,727 - 113,983,839UniSTS
UniSTS:486969  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710120,353,580 - 120,354,830UniSTSGRCh37
Celera10114,084,230 - 114,085,480UniSTS
HuRef10113,982,663 - 113,983,913UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 131 1 1 151 45 5
Low 281 2 220 1 3 1 5 260 1463 9 230 15 1 1 4
Below cutoff 1643 956 515 147 617 94 1652 952 1625 76 808 687 58 1 483 1016 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000239032   ⟹   ENSP00000239032
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10118,589,997 - 118,595,648 (-)Ensembl
RefSeq Acc Id: ENST00000636925   ⟹   ENSP00000490073
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10118,594,095 - 118,595,369 (-)Ensembl
RefSeq Acc Id: NM_004248   ⟹   NP_004239
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810118,589,997 - 118,595,648 (-)NCBI
GRCh3710120,352,916 - 120,355,160 (-)ENTREZGENE
Build 3610120,342,906 - 120,345,150 (-)NCBI Archive
HuRef10113,981,999 - 113,984,243 (-)ENTREZGENE
CHM1_110120,637,272 - 120,639,516 (-)NCBI
T2T-CHM13v2.010119,485,136 - 119,490,787 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004239   ⟸   NM_004248
- UniProtKB: Q502U8 (UniProtKB/Swiss-Prot),   P49683 (UniProtKB/Swiss-Prot),   O75194 (UniProtKB/Swiss-Prot),   Q5VXR9 (UniProtKB/Swiss-Prot),   A5JUU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000490073   ⟸   ENST00000636925
RefSeq Acc Id: ENSP00000239032   ⟸   ENST00000239032
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49683-F1-model_v2 AlphaFold P49683 1-370 view protein structure

Promoters
RGD ID:7218787
Promoter ID:EPDNEW_H15140
Type:initiation region
Name:PRLHR_1
Description:prolactin releasing hormone receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810118,595,643 - 118,595,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4464 AgrOrtholog
COSMIC PRLHR COSMIC
Ensembl Genes ENSG00000119973 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239032 ENTREZGENE
  ENST00000239032.4 UniProtKB/Swiss-Prot
  ENST00000636925.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000119973 GTEx
HGNC ID HGNC:4464 ENTREZGENE
Human Proteome Map PRLHR Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prolrel_pep_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2834 ENTREZGENE
OMIM 600895 OMIM
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24235:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28847 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRPRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A5JUU5 ENTREZGENE, UniProtKB/TrEMBL
  O75194 ENTREZGENE
  P49683 ENTREZGENE, UniProtKB/Swiss-Prot
  Q502U8 ENTREZGENE
  Q5VXR9 ENTREZGENE
UniProt Secondary O75194 UniProtKB/Swiss-Prot
  Q502U8 UniProtKB/Swiss-Prot
  Q5VXR9 UniProtKB/Swiss-Prot