Rgs13 (regulator of G-protein signaling 13) - Rat Genome Database

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Gene: Rgs13 (regulator of G-protein signaling 13) Rattus norvegicus
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Symbol: Rgs13
Name: regulator of G-protein signaling 13
RGD ID: 1562103
Description: Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and negative regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cytosol; nucleus; and plasma membrane. Orthologous to human RGS13 (regulator of G protein signaling 13); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498246; RGD1562103; similar to RGS13
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,472,604 - 58,505,922 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1358,472,604 - 58,505,922 (-)EnsemblGRCr8
mRatBN7.21355,922,290 - 55,955,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,922,395 - 55,955,648 (-)EnsemblmRatBN7.2
Rnor_6.01360,970,172 - 61,004,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,970,247 - 61,003,744 (-)Ensemblrn6Rnor6.0
Rnor_5.01365,957,018 - 65,989,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41358,016,245 - 58,042,762 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,997,004 - 56,031,895 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12193720  


Genomics

Comparative Map Data
Rgs13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,472,604 - 58,505,922 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1358,472,604 - 58,505,922 (-)EnsemblGRCr8
mRatBN7.21355,922,290 - 55,955,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,922,395 - 55,955,648 (-)EnsemblmRatBN7.2
Rnor_6.01360,970,172 - 61,004,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,970,247 - 61,003,744 (-)Ensemblrn6Rnor6.0
Rnor_5.01365,957,018 - 65,989,542 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41358,016,245 - 58,042,762 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,997,004 - 56,031,895 (-)NCBICelera
Cytogenetic Map13q21NCBI
RGS13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,636,147 - 192,660,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,636,061 - 192,660,311 (+)Ensemblhg38GRCh38
GRCh371192,605,277 - 192,629,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361190,871,905 - 190,896,013 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1165,715,071 - 165,739,113 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1163,841,268 - 163,865,380 (+)NCBIHuRef
CHM1_11194,027,097 - 194,051,266 (+)NCBICHM1_1
T2T-CHM13v2.01191,983,284 - 192,007,378 (+)NCBIT2T-CHM13v2.0
Rgs13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391144,013,083 - 144,053,240 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1144,014,392 - 144,053,110 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381144,137,386 - 144,177,372 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1144,138,654 - 144,177,372 (-)Ensemblmm10GRCm38
MGSCv371145,985,797 - 146,024,502 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361145,900,885 - 145,939,590 (-)NCBIMGSCv36mm8
Celera1146,698,430 - 146,735,959 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.56NCBI
Rgs13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,111,760 - 30,135,283 (+)Ensembl
ChiLan1.0NW_00495540630,111,770 - 30,134,605 (+)NCBIChiLan1.0ChiLan1.0
RGS13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2157,128,862 - 57,152,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,791,844 - 56,815,911 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,073,338 - 168,124,215 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,395,240 - 172,419,307 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,395,240 - 172,419,307 (+)EnsemblpanPan2panpan1.1
RGS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,291,146 - 6,316,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,291,182 - 6,315,198 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha386,385,503 - 6,413,908 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0386,305,783 - 6,334,197 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,308,730 - 6,334,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,304,512 - 6,332,968 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,670,204 - 6,698,602 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,905,903 - 6,934,312 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934481,181,016 - 81,210,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936638940,677 - 963,585 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936638940,691 - 963,585 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl101,057,622 - 1,082,222 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1101,056,920 - 1,082,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,695,589 - 2,702,748 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,775,602 - 36,802,311 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,776,345 - 36,791,180 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605537,725,660 - 37,749,745 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814916,732 - 931,380 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624814914,509 - 1,012,924 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs13
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11024,061,055 - 24,087,528 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs13
430 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000005163
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat

Markers in Region
RH130318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,949,084 - 55,949,278 (+)MAPPERmRatBN7.2
Rnor_6.01360,997,167 - 60,997,360NCBIRnor6.0
Rnor_5.01365,982,928 - 65,983,121UniSTSRnor5.0
RGSC_v3.41358,042,203 - 58,042,396UniSTSRGSC3.4
Celera1356,024,799 - 56,024,992UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 23 116 41 53 22 51 22 5 161 90 11 101 32 38 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000005163   ⟹   ENSRNOP00000005163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1358,472,604 - 58,505,922 (-)Ensembl
mRatBN7.2 Ensembl1355,922,395 - 55,955,648 (-)Ensembl
Rnor_6.0 Ensembl1360,970,247 - 61,003,744 (-)Ensembl
RefSeq Acc Id: NM_001427229   ⟹   NP_001414158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,472,604 - 58,505,922 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414158 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005163
  ENSRNOP00000005163.4
Ensembl Acc Id: ENSRNOP00000005163   ⟸   ENSRNOT00000005163
RefSeq Acc Id: NP_001414158   ⟸   NM_001427229
- UniProtKB: A6ICP8 (UniProtKB/TrEMBL),   D3ZCS1 (UniProtKB/TrEMBL)
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCS1-F1-model_v2 AlphaFold D3ZCS1 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562103 AgrOrtholog
BioCyc Gene G2FUF-18001 BioCyc
Ensembl Genes ENSRNOG00000003888 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005163 ENTREZGENE
  ENSRNOT00000005163.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/TrEMBL
InterPro Regulat_G_prot_signal_dom1 UniProtKB/TrEMBL
  Regulat_G_prot_signal_superfam UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
NCBI Gene 498246 ENTREZGENE
PANTHER PTHR10845:SF32 UniProtKB/TrEMBL
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/TrEMBL
Pfam RGS UniProtKB/TrEMBL
PhenoGen Rgs13 PhenoGen
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE RGS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003888 RatGTEx
SMART RGS UniProtKB/TrEMBL
Superfamily-SCOP Regulat_G_prot_signal_superfam UniProtKB/TrEMBL
UniProt A6ICP8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCS1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Rgs13  regulator of G-protein signaling 13  RGD1562103_predicted  similar to RGS13 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562103_predicted  similar to RGS13 (predicted)  LOC498246  similar to RGS13  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498246  similar to RGS13      Symbol and Name status set to provisional 70820 PROVISIONAL