Siva1 (SIVA1, apoptosis-inducing factor) - Rat Genome Database

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Gene: Siva1 (SIVA1, apoptosis-inducing factor) Rattus norvegicus
Analyze
Symbol: Siva1
Name: SIVA1, apoptosis-inducing factor
RGD ID: 1561872
Description: Predicted to enable tumor necrosis factor receptor superfamily binding activity; virus receptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; apoptotic signaling pathway; and negative regulation of NF-kappaB transcription factor activity. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis regulatory protein Siva; Cd27 binding protein (Hindu God of destruction); CD27-binding protein; CD27BP; Siva
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,526,416 - 137,530,790 (+)NCBIGRCr8
mRatBN7.26131,705,323 - 131,709,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,705,323 - 131,709,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,874,637 - 131,879,016 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,171,743 - 132,176,118 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,534,212 - 131,538,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,209,999 - 137,214,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,210,052 - 137,214,388 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,216,931 - 146,221,556 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,631,408 - 137,635,724 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,253,021 - 129,257,273 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1RatCharcot-Marie-Tooth disease axonal type 2O  ISOSIVA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease axonal type 2OClinVarPMID:28492532
Siva1Ratfocal segmental glomerulosclerosis 5  ISOSIVA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 5ClinVarPMID:28492532
Siva1Ratimmunodeficiency 132A  ISOSIVA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Herpes simplex encephalitis more ...ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1RatCoxsackievirus Infections  ISOSIVA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16683188

1 to 20 of 107 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1Rat(+)-catechin multiple interactionsISOSIVA1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SIVA1 mRNACTDPMID:24763279
Siva1Rat(1->4)-beta-D-glucan multiple interactionsISOSiva1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SIVA1 mRNACTDPMID:36331819
Siva1Rat(S)-nicotine decreases expressionISOSIVA1 (Homo sapiens)6480464Nicotine results in decreased expression of SIVA1 mRNACTDPMID:16949557
Siva1Rat1,2-dimethylhydrazine multiple interactionsISOSiva1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIVA1 mRNACTDPMID:22206623
Siva1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of SIVA1 mRNACTDPMID:17557909
Siva1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SIVA1 mRNA]CTDPMID:21215274
Siva1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SIVA1 mRNACTDPMID:33387578
Siva1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SIVA1 mRNACTDPMID:34747641
Siva1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SIVA1 mRNACTDPMID:21215274
Siva1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of SIVA1 mRNACTDPMID:21346803
Siva1Rat2-hydroxypropanoic acid decreases expressionISOSIVA1 (Homo sapiens)6480464Lactic Acid results in decreased expression of SIVA1 mRNACTDPMID:30851411
Siva1Rat3-methylcholanthrene increases expressionISOSiva1 (Mus musculus)6480464Methylcholanthrene results in increased expression of SIVA1 mRNACTDPMID:20713471
Siva1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of SIVA1 mRNACTDPMID:31881176
Siva1Ratacrolein multiple interactionsISOSIVA1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SIVA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SIVA1 mRNACTDPMID:32699268
Siva1Rataflatoxin B1 increases expressionISOSiva1 (Mus musculus)6480464Aflatoxin B1 results in increased expression of SIVA1 mRNACTDPMID:19770486
Siva1Ratalpha-pinene multiple interactionsISOSIVA1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SIVA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SIVA1 mRNACTDPMID:32699268
Siva1Ratamiodarone increases expressionISOSiva1 (Mus musculus)6480464Amiodarone results in increased expression of SIVA1 mRNACTDPMID:24535564
Siva1RatAroclor 1254 increases expressionISOSiva1 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in increased expression of SIVA1 mRNACTDPMID:23650126
Siva1Ratarsane increases methylationISOSIVA1 (Homo sapiens)6480464Arsenic results in increased methylation of SIVA1 promoterCTDPMID:21291286
Siva1Ratarsenic atom increases methylationISOSIVA1 (Homo sapiens)6480464Arsenic results in increased methylation of SIVA1 promoterCTDPMID:21291286

1 to 20 of 107 rows

Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1Ratactivation-induced cell death of T cells involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:16491128RGDPMID:16491128
Siva1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Siva1Ratextrinsic apoptotic signaling pathway involved_inISOSIVA1 (Homo sapiens)1624291 PMID:9177220RGDPMID:9177220
Siva1Ratextrinsic apoptotic signaling pathway involved_inIEAUniProtKB:O15304 and ensembl:ENSP000003292131600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1Ratextrinsic apoptotic signaling pathway involved_inIBAPANTHER:PTN001024117 and UniProtKB:O153041600115GO_REF:0000033GO_CentralGO_REF:0000033
Siva1Ratintrinsic apoptotic signaling pathway NOT|involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-21624291 PMID:12011449RGDPMID:12011449
Siva1Ratintrinsic apoptotic signaling pathway involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:12011449RGDPMID:12011449
Siva1Ratnegative regulation of canonical NF-kappaB signal transduction involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:16491128RGDPMID:16491128
Siva1Ratpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:15034012RGDPMID:15034012
Siva1Ratsymbiont entry into host cell involved_inIEAGO:00016181600115GO_REF:0000108GOCGO_REF:0000108
Siva1RatT cell apoptotic process involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:16491128RGDPMID:16491128
Siva1RatT cell receptor signaling pathway involved_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:16491128RGDPMID:16491128
1 to 12 of 12 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Siva1Ratcytoplasm located_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:12011449 and PMID:14739602RGDPMID:12011449 and PMID:14739602
Siva1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Siva1Ratmitochondrion located_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:12011449RGDPMID:12011449
Siva1Ratnucleoplasm located_inIEAUniProtKB:O15304 and ensembl:ENSP000003292131600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1Ratnucleoplasm located_inISOSIVA1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Siva1Ratnucleoplasm located_inISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291 PMID:15034012RGDPMID:15034012
Siva1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Siva1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Siva1RatCD27 receptor binding enablesISOSIVA1 (Homo sapiens)1624291UniProtKB:P26842 and PMID:9177220RGDPMID:9177220
Siva1RatCD27 receptor binding enablesIEAUniProtKB:O54926 and ensembl:ENSMUSP000000217281600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1RatCD27 receptor binding enablesISOSiva1 (Mus musculus)1624291UniProtKB:P41272 and PMID:12478477RGDPMID:12478477
Siva1RatCD27 receptor binding enablesIEAUniProtKB:O15304 and ensembl:ENSP000003292131600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1RatCD27 receptor binding enablesIBAMGI:1353606 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Siva1RatCD27 receptor binding enablesISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291UniProtKB:P26842 and PMID:16683188RGDPMID:16683188
Siva1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Siva1Ratprotein binding enablesISOSIVA1 (Homo sapiens) and UniProtKB:O15304-21624291UniProtKB:A0A0C4DG38 more ...RGDPMID:32296183
Siva1Ratprotein binding enablesISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291UniProtKB:Q07817 and PMID:12011449RGDPMID:12011449
Siva1Ratprotein binding enablesISOSIVA1 (Homo sapiens) and UniProtKB:O15304-11624291UniProtKB:P10415 more ...RGDPMID:12011449 more ...
Siva1Ratprotein binding enablesISOSIVA1 (Homo sapiens)1624291UniProtKB:P03129 more ...RGDPMID:16683188 more ...
Siva1Rattumor necrosis factor receptor binding enablesISOSiva1 (Mus musculus)1624291UniProtKB:O35714 more ...RGDPMID:12478477
Siva1Rattumor necrosis factor receptor binding enablesIEAUniProtKB:O54926 and ensembl:ENSMUSP000000217281600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1Ratvirus receptor activity enablesISOSiva1 (Mus musculus)1624291 PMID:11601913RGDPMID:11601913
Siva1Ratvirus receptor activity enablesIEAUniProtKB:O54926 and ensembl:ENSMUSP000000217281600115GO_REF:0000107EnsemblGO_REF:0000107
Siva1Ratzinc ion binding enablesISOSIVA1 (Homo sapiens) more ...1624291 PMID:16683188RGDPMID:16683188
1 to 16 of 16 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9177220   PMID:9853261   PMID:11601913   PMID:12011449   PMID:12477932   PMID:12478477   PMID:14739602   PMID:15034012   PMID:16491128   PMID:16683188   PMID:19251341  



Siva1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,526,416 - 137,530,790 (+)NCBIGRCr8
mRatBN7.26131,705,323 - 131,709,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,705,323 - 131,709,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,874,637 - 131,879,016 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,171,743 - 132,176,118 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,534,212 - 131,538,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,209,999 - 137,214,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,210,052 - 137,214,388 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,216,931 - 146,221,556 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,631,408 - 137,635,724 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,253,021 - 129,257,273 (+)NCBICelera
Cytogenetic Map6q32NCBI
SIVA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,753,147 - 104,759,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,753,147 - 104,768,494 (+)EnsemblGRCh38hg38GRCh38
GRCh3714105,219,484 - 105,225,991 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,290,515 - 104,297,041 (+)NCBINCBI36Build 36hg18NCBI36
Celera1485,274,542 - 85,281,070 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,416,458 - 85,422,986 (+)NCBIHuRef
CHM1_114105,157,086 - 105,163,614 (+)NCBICHM1_1
T2T-CHM13v2.01498,996,033 - 99,002,540 (+)NCBIT2T-CHM13v2.0
Siva1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,611,262 - 112,615,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,611,113 - 112,615,583 (+)EnsemblGRCm39 Ensembl
GRCm3812112,644,828 - 112,649,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,644,679 - 112,649,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712113,883,039 - 113,887,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,092,716 - 113,096,953 (+)NCBIMGSCv36mm8
Celera12113,858,455 - 113,862,779 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Siva1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,197,983 - 3,202,782 (+)NCBIChiLan1.0ChiLan1.0
SIVA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,935,284 - 105,941,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,151,787 - 105,158,327 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,404,148 - 85,408,254 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,196,118 - 105,202,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,196,118 - 105,202,678 (+)Ensemblpanpan1.1panPan2
SIVA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,309,400 - 72,313,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,309,447 - 72,313,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,815,163 - 71,819,494 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,584,386 - 72,588,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,583,252 - 72,588,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,267,010 - 72,271,332 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,310,264 - 72,314,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,709,843 - 72,714,165 (+)NCBIUU_Cfam_GSD_1.0
Siva1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,812,507 - 1,821,101 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621644,852 - 650,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621641,456 - 650,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIVA1
(Sus scrofa - pig)		 No map positions available.
SIVA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,689,233 - 82,695,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,689,254 - 82,695,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,110,198 - 70,116,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siva1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734530,711 - 535,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Siva1
16 total Variants

Predicted Target Of
Summary Value
Count of predictions:616
Count of miRNA genes:279
Interacting mature miRNAs:344
Transcripts:ENSRNOT00000031788, ENSRNOT00000065213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000031788   ⟹   ENSRNOP00000034257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,705,323 - 131,709,690 (+)Ensembl
Rnor_6.0 Ensembl6137,210,052 - 137,214,388 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065213   ⟹   ENSRNOP00000059044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,705,439 - 131,709,690 (+)Ensembl
Rnor_6.0 Ensembl6137,210,121 - 137,214,372 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118809   ⟹   ENSRNOP00000093784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,705,451 - 131,709,690 (+)Ensembl
RefSeq Acc Id: NM_001394537   ⟹   NP_001381466
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,526,416 - 137,530,790 (+)NCBI
mRatBN7.26131,705,323 - 131,709,697 (+)NCBI
Protein RefSeqs NP_001381466 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88866 (Get FASTA)   NCBI Sequence Viewer  
  EDL97423 (Get FASTA)   NCBI Sequence Viewer  
  EDL97424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034257
  ENSRNOP00000034257.4
GenBank Protein P59692 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000034257   ⟸   ENSRNOT00000031788
Ensembl Acc Id: ENSRNOP00000059044   ⟸   ENSRNOT00000065213
Ensembl Acc Id: ENSRNOP00000093784   ⟸   ENSRNOT00000118809
RefSeq Acc Id: NP_001381466   ⟸   NM_001394537
- UniProtKB: P59692 (UniProtKB/Swiss-Prot),   A6KBV7 (UniProtKB/TrEMBL),   A4FTX4 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P59692-F1-model_v2 AlphaFold P59692 1-177 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694850
Promoter ID:EPDNEW_R5375
Type:initiation region
Name:Siva1_1
Description:SIVA1, apoptosis-inducing factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06137,210,078 - 137,210,138EPDNEW


1 to 18 of 18 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35782 BioCyc
Ensembl Genes ENSRNOG00000028640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031788 ENTREZGENE
  ENSRNOT00000031788.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7318866 IMAGE-MGC_LOAD
InterPro Siva UniProtKB/Swiss-Prot
MGC_CLONE MGC:105767 IMAGE-MGC_LOAD
NCBI Gene 362791 ENTREZGENE
PANTHER APOPTOSIS REGULATORY PROTEIN SIVA UniProtKB/Swiss-Prot
  PTHR14365 UniProtKB/Swiss-Prot
Pfam Siva UniProtKB/Swiss-Prot
PhenoGen Siva1 PhenoGen
PIRSF Siva_cd27_bd UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028640 RatGTEx
UniProt A0A8I6GKF8_RAT UniProtKB/TrEMBL
  A4FTX4 ENTREZGENE, UniProtKB/TrEMBL
  A6KBV7 ENTREZGENE, UniProtKB/TrEMBL
  P59692 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Siva1  SIVA1, apoptosis-inducing factor  Siva_predicted  Cd27 binding protein (Hindu God of destruction) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 Siva_predicted  Cd27 binding protein (Hindu God of destruction) (predicted)  Siva  Cd27 binding protein (Hindu God of destruction)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Siva  Cd27 binding protein (Hindu God of destruction)      Symbol and Name status set to provisional 70820 PROVISIONAL