Ptrhd1 (peptidyl-tRNA hydrolase domain containing 1) - Rat Genome Database

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Gene: Ptrhd1 (peptidyl-tRNA hydrolase domain containing 1) Rattus norvegicus
Analyze
Symbol: Ptrhd1
Name: peptidyl-tRNA hydrolase domain containing 1
RGD ID: 1561792
Description: Predicted to enable peptidyl-tRNA hydrolase activity. Orthologous to human PTRHD1 (peptidyl-tRNA hydrolase domain containing 1); INTERACTS WITH bisphenol A; endosulfan; fipronil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC298861; LOC298861; putative peptidyl-tRNA hydrolase PTRHD1; RGD1561792; similar to CG14903-PA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,937,904 - 32,941,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,937,715 - 32,941,287 (+)EnsemblGRCr8
mRatBN7.2627,218,417 - 27,221,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,218,417 - 27,221,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,510,679 - 27,514,066 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,826,568 - 27,829,953 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,304,125 - 27,307,513 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,663,602 - 28,666,987 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,663,602 - 28,666,987 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,469,515 - 38,472,900 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4627,210,615 - 27,214,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,691,003 - 26,694,388 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23376485   PMID:34800366  


Genomics

Comparative Map Data
Ptrhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,937,904 - 32,941,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,937,715 - 32,941,287 (+)EnsemblGRCr8
mRatBN7.2627,218,417 - 27,221,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,218,417 - 27,221,805 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,510,679 - 27,514,066 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,826,568 - 27,829,953 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,304,125 - 27,307,513 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,663,602 - 28,666,987 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,663,602 - 28,666,987 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,469,515 - 38,472,900 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4627,210,615 - 27,214,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,691,003 - 26,694,388 (+)NCBICelera
Cytogenetic Map6q14NCBI
PTRHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,789,728 - 24,793,391 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,789,728 - 24,793,391 (-)Ensemblhg38GRCh38
GRCh37225,012,597 - 25,016,260 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,866,640 - 24,869,755 (-)NCBIBuild 36Build 36hg18NCBI36
Celera224,853,469 - 24,856,584 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,751,007 - 24,754,122 (-)NCBIHuRef
CHM1_1224,942,715 - 24,945,830 (-)NCBICHM1_1
T2T-CHM13v2.0224,824,528 - 24,828,191 (-)NCBIT2T-CHM13v2.0
Ptrhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,284,013 - 4,290,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,284,027 - 4,289,950 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38124,234,013 - 4,240,123 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,234,027 - 4,239,950 (+)Ensemblmm10GRCm38
MGSCv37124,234,027 - 4,237,560 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36124,241,695 - 4,247,980 (+)NCBIMGSCv36mm8
Celera124,166,527 - 4,170,060 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map122.04NCBI
Ptrhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,907,283 - 6,913,411 (-)Ensembl
ChiLan1.0NW_0049554696,909,627 - 6,913,411 (-)NCBIChiLan1.0ChiLan1.0
PTRHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,732,212 - 101,735,344 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,736,078 - 101,739,830 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,783,531 - 24,786,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,878,810 - 24,882,325 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,878,810 - 24,882,328 (-)EnsemblpanPan2panpan1.1
PTRHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,137,719 - 19,141,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,137,723 - 19,141,944 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1719,034,638 - 19,038,218 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,411,073 - 19,414,655 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,411,077 - 19,415,093 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,147,593 - 19,151,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,157,039 - 19,160,620 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,197,101 - 19,200,683 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptrhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,483,509 - 63,488,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,351,271 - 7,356,868 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,351,453 - 7,355,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTRHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13113,979,174 - 113,982,943 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,210,031 - 121,213,797 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTRHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,875,943 - 82,879,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,875,749 - 82,879,600 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604529,288,955 - 29,292,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptrhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,140,799 - 7,148,979 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,144,475 - 7,148,287 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptrhd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1724,894,873 - 24,897,955 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptrhd1
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:106
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000005402
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH128676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,221,270 - 27,221,451 (+)MAPPERmRatBN7.2
Rnor_6.0628,666,455 - 28,666,635NCBIRnor6.0
Rnor_5.0638,472,368 - 38,472,548UniSTSRnor5.0
RGSC_v3.4627,213,468 - 27,213,648UniSTSRGSC3.4
Celera626,693,856 - 26,694,036UniSTS
RH 3.4 Map6116.99UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 165 91 90 59 92 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005402   ⟹   ENSRNOP00000005402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,937,904 - 32,941,287 (+)Ensembl
mRatBN7.2 Ensembl627,218,417 - 27,221,805 (+)Ensembl
Rnor_6.0 Ensembl628,663,602 - 28,666,987 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149722   ⟹   ENSRNOP00000103240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,937,715 - 32,941,187 (+)Ensembl
RefSeq Acc Id: NM_001134524   ⟹   NP_001127996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,937,904 - 32,941,287 (+)NCBI
mRatBN7.2627,218,417 - 27,221,805 (+)NCBI
Rnor_6.0628,663,602 - 28,666,987 (+)NCBI
Rnor_5.0638,469,515 - 38,472,900 (+)NCBI
RGSC_v3.4627,210,615 - 27,214,000 (+)RGD
Celera626,691,003 - 26,694,388 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001127996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03030 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005402
  ENSRNOP00000005402.3
  ENSRNOP00000103240.1
RefSeq Acc Id: NP_001127996   ⟸   NM_001134524
- UniProtKB: D3ZBG6 (UniProtKB/TrEMBL),   A6HAH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005402   ⟸   ENSRNOT00000005402
Ensembl Acc Id: ENSRNOP00000103240   ⟸   ENSRNOT00000149722

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBG6-F1-model_v2 AlphaFold D3ZBG6 1-140 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694473
Promoter ID:EPDNEW_R4997
Type:multiple initiation site
Name:Ptrhd1_1
Description:peptidyl-tRNA hydrolase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0628,663,636 - 28,663,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561792 AgrOrtholog
BioCyc Gene G2FUF-38276 BioCyc
Ensembl Genes ENSRNOG00000004059 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005402 ENTREZGENE
  ENSRNOT00000005402.6 UniProtKB/TrEMBL
  ENSRNOT00000149722.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1490.10 UniProtKB/TrEMBL
InterPro Pep_tRNA_hydro_II_dom UniProtKB/TrEMBL
  Pep_tRNA_hydro_PTH2 UniProtKB/TrEMBL
  PTRHD1 UniProtKB/TrEMBL
KEGG Report rno:298861 UniProtKB/TrEMBL
NCBI Gene 298861 ENTREZGENE
PANTHER PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED UniProtKB/TrEMBL
  PTHR46194 UniProtKB/TrEMBL
Pfam PTH2 UniProtKB/TrEMBL
PhenoGen Ptrhd1 PhenoGen
RatGTEx ENSRNOG00000004059 RatGTEx
Superfamily-SCOP SSF102462 UniProtKB/TrEMBL
UniProt A0ABK0LCK3_RAT UniProtKB/TrEMBL
  A6HAH5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBG6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-25 Ptrhd1  peptidyl-tRNA hydrolase domain containing 1  RGD1561792  similar to CG14903-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561792  similar to CG14903-PA   RGD1561792_predicted  similar to CG14903-PA (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561792_predicted  similar to CG14903-PA (predicted)  LOC298861  similar to CG14903-PA  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC298861  similar to CG14903-PA      Symbol and Name status set to provisional 70820 PROVISIONAL