Atp11b (ATPase phospholipid transporting 11B (putative))

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Gene: Atp11b (ATPase phospholipid transporting 11B (putative)) Rattus norvegicus

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Symbol:

Atp11b

Name:

ATPase phospholipid transporting 11B (putative)

RGD ID:

1561719

Description:

Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be located in early endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATPase, class VI, type 11B; LOC361929; phospholipid-transporting ATPase IF; probable phospholipid-transporting ATPase IF; similar to Potential phospholipid-transporting ATPase IF (ATPase class I type 11B) (ATPase IR)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATP11B (ATPase phospholipid transporting 11B (putative))	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Atp11b (ATPase, class VI, type 11B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Atp11b (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATP11B (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATP11B (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atp11b (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATP11B (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ATP11B (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atp11b (ATPase phospholipid transporting 11B (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ATP11B (ATPase phospholipid transporting 11B (putative))	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Atp11b (ATPase, class VI, type 11B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-211e20.10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-211e20.10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4301	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9981	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DNF3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	atp11b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	120,513,535 - 120,619,249 (+)	NCBI		GRCr8
mRatBN7.2	2	118,585,348 - 118,691,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	118,585,342 - 118,690,232 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	122,337,757 - 122,445,090 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	122,368,265 - 122,444,878 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	141,975,343 - 142,081,548 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	122,139,635 - 122,306,306 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	113,557,016 - 113,660,657 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Currarino syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-bromohexadecanoic acid (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

beta-hexachlorocyclohexane (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dextran sulfate (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

folpet (ISO)

geldanamycin (ISO)

hexadecanoic acid (ISO)

L-methionine (ISO)

MeIQx (ISO)

mercury dichloride (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium dichromate (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phospholipid translocation (IBA)

Cellular Component

early endosome membrane (ISO)

endoplasmic reticulum (IBA,ISO)

membrane (ISO)

phospholipid-translocating ATPase complex (ISO)

plasma membrane (IBA)

recycling endosome (IBA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATPase-coupled intramembrane lipid transporter activity (IBA)

magnesium ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19946888	PMID:21914794	PMID:35635573

Genomics

Comparative Map Data

Atp11b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	120,513,535 - 120,619,249 (+)	NCBI		GRCr8
mRatBN7.2	2	118,585,348 - 118,691,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	118,585,342 - 118,690,232 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	122,337,757 - 122,445,090 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	122,368,265 - 122,444,878 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	141,975,343 - 142,081,548 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	122,139,635 - 122,306,306 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	113,557,016 - 113,660,657 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

ATP11B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	182,793,504 - 182,921,629 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	182,793,503 - 182,923,011 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	182,511,292 - 182,639,417 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	183,993,985 - 184,122,117 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	180,945,823 - 181,073,871 (+)	NCBI		Celera
Cytogenetic Map	3	q26.33	NCBI
HuRef	3	179,916,059 - 180,044,192 (+)	NCBI		HuRef
CHM1_1	3	182,474,199 - 182,602,334 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	185,598,610 - 185,726,735 (+)	NCBI		T2T-CHM13v2.0

Atp11b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	35,808,104 - 35,910,425 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	35,808,255 - 35,910,425 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	35,754,044 - 35,856,276 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	35,754,106 - 35,856,276 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	35,653,060 - 35,755,198 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	35,945,687 - 36,047,825 (+)	NCBI		MGSCv36	mm8
Celera	3	35,644,402 - 35,742,612 (+)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	17.36	NCBI

Atp11b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	11,588,738 - 11,681,636 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	11,588,739 - 11,681,636 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP11B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	180,659,733 - 180,788,922 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	180,664,448 - 180,793,637 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	179,824,180 - 179,953,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	188,022,550 - 188,117,011 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	188,022,545 - 188,123,414 (+)	Ensembl	panpan1.1		panPan2

ATP11B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	15,802,376 - 15,916,896 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	15,829,063 - 15,914,842 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	19,892,109 - 20,007,628 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	15,710,979 - 15,826,496 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	15,710,934 - 15,825,156 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	15,751,710 - 15,867,212 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	15,732,931 - 15,847,688 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	15,975,821 - 16,090,792 (+)	NCBI		UU_Cfam_GSD_1.0

Atp11b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	112,528,880 - 112,645,276 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936566	578,258 - 678,949 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936566	577,975 - 691,849 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP11B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	120,727,608 - 120,873,930 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	120,727,633 - 120,873,907 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	130,080,764 - 130,147,223 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP11B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	6,494,309 - 6,624,385 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	6,510,578 - 6,624,315 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	15,296,974 - 15,430,864 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp11b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	60,555,819 - 60,660,717 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	60,555,834 - 60,666,912 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp11b
234 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	279
Count of miRNA genes:	198
Interacting mature miRNAs:	220
Transcripts:	ENSRNOT00000016961, ENSRNOT00000071658
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	102803808	147803808	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	38573329	122609194	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	118111229	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	143657569	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	104559726	149559726	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	118111229	149559726	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	112103657	148076632	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	114654253	159654253	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

Markers in Region

AI715296

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	118,689,951 - 118,690,150 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	122,444,825 - 122,445,023	NCBI	Rnor6.0
Rnor_5.0	2	142,080,449 - 142,080,647	UniSTS	Rnor5.0
RGSC_v3.4	2	122,305,182 - 122,305,380	UniSTS	RGSC3.4
Celera	2	113,659,533 - 113,659,731	UniSTS
RH 3.4 Map	2	681.5	UniSTS
Cytogenetic Map	2	q25	UniSTS

AA945716

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	118,690,858 - 118,691,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	122,445,707 - 122,445,872	NCBI	Rnor6.0
Rnor_5.0	2	142,081,331 - 142,081,496	UniSTS	Rnor5.0
RGSC_v3.4	2	122,306,089 - 122,306,254	UniSTS	RGSC3.4
Celera	2	113,660,440 - 113,660,605	UniSTS
RH 3.4 Map	2	681.5	UniSTS
Cytogenetic Map	2	q25	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078321 ⟹ ENSRNOP00000072724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	118,614,555 - 118,690,215 (+)	Ensembl
Rnor_6.0 Ensembl	2	122,368,265 - 122,444,878 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094103 ⟹ ENSRNOP00000095604

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	118,624,729 - 118,690,215 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108850 ⟹ ENSRNOP00000081047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	118,608,715 - 118,690,232 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116170 ⟹ ENSRNOP00000088435

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	118,607,579 - 118,690,215 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117945 ⟹ ENSRNOP00000093840

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	118,585,342 - 118,690,215 (+)	Ensembl

RefSeq Acc Id:

NM_001427027 ⟹ NP_001413956

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,513,575 - 120,619,249 (+)	NCBI

RefSeq Acc Id:

XM_039103613 ⟹ XP_038959541

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,513,535 - 120,612,498 (+)	NCBI
mRatBN7.2	2	118,585,348 - 118,684,324 (+)	NCBI

RefSeq Acc Id:

XM_039103614 ⟹ XP_038959542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,513,535 - 120,612,499 (+)	NCBI
mRatBN7.2	2	118,585,349 - 118,684,325 (+)	NCBI

RefSeq Acc Id:

XM_039103615 ⟹ XP_038959543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,513,535 - 120,619,249 (+)	NCBI
mRatBN7.2	2	118,585,349 - 118,691,076 (+)	NCBI

RefSeq Acc Id:

XM_039103616 ⟹ XP_038959544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,568,984 - 120,619,249 (+)	NCBI
mRatBN7.2	2	118,640,807 - 118,691,076 (+)	NCBI

RefSeq Acc Id:

XM_063282060 ⟹ XP_063138130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	120,556,738 - 120,619,249 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001413956	(Get FASTA)	NCBI Sequence Viewer
	XP_038959541	(Get FASTA)	NCBI Sequence Viewer
	XP_038959542	(Get FASTA)	NCBI Sequence Viewer
	XP_038959543	(Get FASTA)	NCBI Sequence Viewer
	XP_038959544	(Get FASTA)	NCBI Sequence Viewer
	XP_063138130	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86520	(Get FASTA)	NCBI Sequence Viewer
	EDM01254	(Get FASTA)	NCBI Sequence Viewer
	EDM01255	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072724.2
	ENSRNOP00000081047.1
	ENSRNOP00000088435.1
	ENSRNOP00000093840.1
	ENSRNOP00000095604.1

Ensembl Acc Id:

ENSRNOP00000072724 ⟸ ENSRNOT00000078321

RefSeq Acc Id:	XP_038959541 ⟸ XM_039103613
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZQT8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038959543 ⟸ XM_039103615
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A6I4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038959542 ⟸ XM_039103614
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A6I4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038959544 ⟸ XM_039103616
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000088435 ⟸ ENSRNOT00000116170

Ensembl Acc Id:

ENSRNOP00000093840 ⟸ ENSRNOT00000117945

Ensembl Acc Id:

ENSRNOP00000095604 ⟸ ENSRNOT00000094103

Ensembl Acc Id:

ENSRNOP00000081047 ⟸ ENSRNOT00000108850

RefSeq Acc Id:	NP_001413956 ⟸ NM_001427027
- UniProtKB:	A0A8I6AJL0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138130 ⟸ XM_063282060
- Peptide Label:	isoform X4

Protein Domains

P-type ATPase C-terminal P-type ATPase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K3P7-F1-model_v2	AlphaFold	A0A0G2K3P7	1-1126	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561719	AgrOrtholog
BioCyc Gene	G2FUF-53331	BioCyc
Ensembl Genes	ENSRNOG00000052116	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078321.2	UniProtKB/TrEMBL
	ENSRNOT00000094103.1	UniProtKB/TrEMBL
	ENSRNOT00000108850.1	UniProtKB/TrEMBL
	ENSRNOT00000116170.1	UniProtKB/TrEMBL
	ENSRNOT00000117945.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/TrEMBL
	Calcium-transporting ATPase, cytoplasmic transduction domain A	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7302748	IMAGE-MGC_LOAD
InterPro	ATPase_P-typ_cyto_domN	UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/TrEMBL
	ATPase_P-typ_Plipid-transp	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom	UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A	UniProtKB/TrEMBL
	Cation_transp_P_typ_ATPase	UniProtKB/TrEMBL
	HAD-like_dom	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	P-type_ATPase_N	UniProtKB/TrEMBL
	P_typ_ATPase_c	UniProtKB/TrEMBL
	P_typ_ATPase_HD_dom	UniProtKB/TrEMBL
MGC_CLONE	MGC:105658	IMAGE-MGC_LOAD
NCBI Gene	361929	ENTREZGENE
PANTHER	PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE	UniProtKB/TrEMBL
	PTHR24092:SF57	UniProtKB/TrEMBL
Pfam	Cation_ATPase	UniProtKB/TrEMBL
	E1-E2_ATPase	UniProtKB/TrEMBL
	Hydrolase	UniProtKB/TrEMBL
	PhoLip_ATPase_C	UniProtKB/TrEMBL
	PhoLip_ATPase_N	UniProtKB/TrEMBL
PhenoGen	Atp11b	PhenoGen
PRINTS	CATATPASE	UniProtKB/TrEMBL
PROSITE	ATPASE_E1_E2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000052116	RatGTEx
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81653	UniProtKB/TrEMBL
	SSF81660	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
UniProt	A0A0G2K3P7_RAT	UniProtKB/TrEMBL
	A0A8I5ZQT8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6I4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AJL0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ATU1_RAT	UniProtKB/TrEMBL
	Q5RJS7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Atp11b	ATPase phospholipid transporting 11B (putative)	Atp11b	ATPase, class VI, type 11B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Atp11b	ATPase, class VI, type 11B	LOC361929	similar to Potential phospholipid-transporting ATPase IF (ATPase class I type 11B) (ATPase IR)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC361929	similar to Potential phospholipid-transporting ATPase IF (ATPase class I type 11B) (ATPase IR)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar