Cers6 (ceramide synthase 6) - Rat Genome Database

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Gene: Cers6 (ceramide synthase 6) Rattus norvegicus
Analyze
Symbol: Cers6
Name: ceramide synthase 6
RGD ID: 1561599
Description: Predicted to enable sphingosine N-acyltransferase activity. Involved in oligodendrocyte development and positive regulation of oligodendrocyte apoptotic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CERS6 (ceramide synthase 6); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; Lass6; LOC366065; RGD1561599; similar to longevity assurance homolog 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,038,520 - 74,287,544 (+)NCBIGRCr8
mRatBN7.2353,630,637 - 53,879,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,630,959 - 53,876,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,031,533 - 57,280,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,615,110 - 65,863,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,377,005 - 63,625,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,094,240 - 55,338,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0361,707,597 - 61,950,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,979,559 - 51,252,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera353,194,291 - 53,442,587 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cers6RatCOVID-19  ISOCERS6 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cers6Ratsubstance-related disorder  ISOCERS6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20098672

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Object Symbol
Species
Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Cers6Rat(1->4)-beta-D-glucan multiple interactionsISOCers6 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CERS6 mRNACTDPMID:36331819
Cers6Rat(S)-nicotine multiple interactionsISOCERS6 (Homo sapiens)6480464[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNACTDPMID:28065790
Cers6Rat1,2-dimethylhydrazine decreases expressionISOCers6 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of LASS6 mRNACTDPMID:22206623
Cers6Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CERS6 mRNACTDPMID:29097150
Cers6Rat17beta-estradiol affects expressionISOCERS6 (Homo sapiens)6480464Estradiol affects the expression of CERS6 mRNACTDPMID:14699072
Cers6Rat17beta-estradiol increases expressionISOCERS6 (Homo sapiens)6480464Estradiol results in increased expression of CERS6 mRNACTDPMID:31614463
Cers6Rat17beta-estradiol decreases expressionISOCers6 (Mus musculus)6480464Estradiol results in decreased expression of CERS6 mRNACTDPMID:39298647
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCers6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CERS6 mRNACTDPMID:24058054
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CERS6 mRNACTDPMID:33387578
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCers6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CERS6 mRNACTDPMID:28238261
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCers6 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LASS6 mRNACTDPMID:25975270
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CERS6 mRNACTDPMID:22298810 and PMID:32109520
Cers6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCERS6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of CERS6 mRNACTDPMID:17101203
Cers6Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Cers6Rat2,3,7,8-Tetrachlorodibenzofuran multiple interactionsISOCers6 (Mus musculus)6480464AHR gene mutant form inhibits the reaction [2 more ...CTDPMID:34097992
Cers6Rat2,3,7,8-Tetrachlorodibenzofuran increases expressionISOCers6 (Mus musculus)64804642 more ...CTDPMID:34097992
Cers6Rat2-hydroxypropanoic acid increases expressionISOCERS6 (Homo sapiens)6480464Lactic Acid results in increased expression of CERS6 mRNACTDPMID:30851411
Cers6Rat4,4'-sulfonyldiphenol decreases expressionISOCers6 (Mus musculus)6480464bisphenol S results in decreased expression of CERS6 mRNACTDPMID:39298647
Cers6Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CERS6 mRNACTDPMID:30047161
Cers6Ratacrylamide increases expressionISOCERS6 (Homo sapiens)6480464Acrylamide results in increased expression of CERS6 mRNACTDPMID:32763439

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Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cers6Ratceramide biosynthetic process involved_inISOCers6 (Mus musculus)1624291 PMID:23760501 and PMID:26620563RGDPMID:23760501 and PMID:26620563
Cers6Ratceramide biosynthetic process acts_upstream_of_or_withinISOCers6 (Mus musculus)1624291 PMID:15823095RGDPMID:15823095
Cers6Ratceramide biosynthetic process involved_inIEAUniProtKB:Q6ZMG9 and ensembl:ENSP000003065791600115GO_REF:0000107EnsemblGO_REF:0000107
Cers6Ratceramide biosynthetic process involved_inIEAARBA:ARBA000274191600115GO_REF:0000117UniProtGO_REF:0000117
Cers6Ratceramide biosynthetic process involved_inIBACGD:CAL0000185837 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cers6Ratceramide biosynthetic process involved_inIEAInterPro:IPR0164391600115GO_REF:0000002InterProGO_REF:0000002
Cers6Ratceramide biosynthetic process involved_inISOCERS6 (Homo sapiens)1624291 PMID:17609214 and PMID:17977534RGDPMID:17609214 and PMID:17977534
Cers6Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Cers6Ratoligodendrocyte development  IEP 156431059 RGD 
Cers6Ratpositive regulation of oligodendrocyte apoptotic process  IMP 156431059 RGD 
Cers6Ratsphingolipid biosynthetic process acts_upstream_of_or_withinISOCers6 (Mus musculus)1624291 PMID:15823095RGDPMID:15823095
Cers6Ratsphingolipid metabolic process involved_inIEAUniPathway:UPA002221600115GO_REF:0000041UniProtGO_REF:0000041
1 to 12 of 12 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
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Original Reference(s)
Cers6Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cers6Ratendoplasmic reticulum located_inISOCers6 (Mus musculus)1624291 PMID:15823095RGDPMID:15823095
Cers6Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cers6Ratmembrane located_inIEAUniRule:UR0004009931600115GO_REF:0000104UniProtGO_REF:0000104
Cers6Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cers6Ratmembrane located_inIEAInterPro:IPR0066341600115GO_REF:0000002InterProGO_REF:0000002
Cers6Ratnucleus located_inIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Cers6Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Cers6Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
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Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Cers6RatDNA binding enablesIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Cers6RatDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-03711600115GO_REF:0000043UniProtGO_REF:0000043
Cers6RatDNA binding enablesIEAInterPro:IPR0013561600115GO_REF:0000002InterProGO_REF:0000002
Cers6Ratprotein binding enablesISOCERS6 (Homo sapiens)1624291UniProtKB:P30556 more ...RGDPMID:28298427 more ...
Cers6Ratprotein binding enablesISOCERS6 (Homo sapiens) and UniProtKB:Q6ZMG9-21624291UniProtKB:O75396 and PMID:32296183RGDPMID:32296183
Cers6Ratprotein binding enablesISOCers6 (Mus musculus)1624291UniProtKB:Q8R104 and PMID:26620563RGDPMID:26620563
Cers6Ratsphingosine N-acyltransferase activity enablesISOCERS6 (Homo sapiens)1624291 PMID:17609214 and PMID:17977534RGDPMID:17609214 and PMID:17977534
Cers6Ratsphingosine N-acyltransferase activity enablesIEAARBA:ARBA000264311600115GO_REF:0000117UniProtGO_REF:0000117
Cers6Ratsphingosine N-acyltransferase activity enablesIEAInterPro:IPR0164391600115GO_REF:0000002InterProGO_REF:0000002
Cers6Ratsphingosine N-acyltransferase activity enablesIBACGD:CAL0000185837 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cers6Ratsphingosine N-acyltransferase activity enablesISOCers6 (Mus musculus)1624291 PMID:15823095 and PMID:23760501RGDPMID:15823095 and PMID:23760501
Cers6Ratsphingosine N-acyltransferase activity enablesIEAUniProtKB:Q6ZMG9 and ensembl:ENSP000003065791600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 12 of 12 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. Novgorodov SA, etal., J Biol Chem. 2011 Feb 11;286(6):4644-58. doi: 10.1074/jbc.M110.164392. Epub 2010 Dec 10.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15823095   PMID:17609214   PMID:17977534   PMID:19946888   PMID:23760501   PMID:26620563  



Cers6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,038,520 - 74,287,544 (+)NCBIGRCr8
mRatBN7.2353,630,637 - 53,879,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,630,959 - 53,876,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,031,533 - 57,280,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,615,110 - 65,863,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,377,005 - 63,625,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,094,240 - 55,338,370 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0361,707,597 - 61,950,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,979,559 - 51,252,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera353,194,291 - 53,442,587 (+)NCBICelera
Cytogenetic Map3q21NCBI
CERS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,456,272 - 168,775,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,456,249 - 168,775,134 (+)EnsemblGRCh38hg38GRCh38
GRCh372169,312,782 - 169,631,644 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,021,081 - 169,339,398 (+)NCBINCBI36Build 36hg18NCBI36
Build 342169,138,341 - 169,456,659NCBI
Celera2162,921,561 - 163,239,455 (+)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2161,192,334 - 161,510,650 (+)NCBIHuRef
CHM1_12169,318,813 - 169,637,448 (+)NCBICHM1_1
T2T-CHM13v2.02168,914,043 - 169,232,607 (+)NCBIT2T-CHM13v2.0
Cers6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,691,489 - 68,944,628 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,691,785 - 68,944,626 (+)EnsemblGRCm39 Ensembl
GRCm38268,861,145 - 69,114,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,861,441 - 69,114,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37268,699,614 - 68,949,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,662,396 - 68,912,129 (+)NCBIMGSCv36mm8
Celera270,531,557 - 70,777,053 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.53NCBI
Cers6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,642,341 - 5,920,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,636,678 - 5,920,377 (-)NCBIChiLan1.0ChiLan1.0
CERS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,093,865 - 71,419,931 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,108,853 - 71,434,905 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,711,661 - 56,036,909 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,180,442 - 173,504,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,180,436 - 173,498,553 (+)Ensemblpanpan1.1panPan2
CERS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,307,461 - 13,608,123 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,308,110 - 13,602,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,317,100 - 13,619,138 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,421,960 - 13,724,119 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,421,381 - 13,724,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,508,151 - 13,809,389 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,494,552 - 13,796,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,607,070 - 13,909,590 (+)NCBIUU_Cfam_GSD_1.0
Cers6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,590,704 - 130,882,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,740,601 - 11,027,067 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,735,327 - 11,027,019 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,927,130 - 75,261,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,927,088 - 75,261,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,094,841 - 84,360,268 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CERS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,972,795 - 54,299,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,972,376 - 54,294,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,236,257 - 145,554,226 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cers6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,208,478 - 6,511,708 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,208,976 - 6,511,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cers6
1669 total Variants

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000058763
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 52 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

1 to 10 of 52 rows
D3Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8374,222,699 - 74,222,903 (+)Marker Load Pipeline
mRatBN7.2353,814,841 - 53,815,045 (+)MAPPERmRatBN7.2
Rnor_6.0355,278,824 - 55,279,027NCBIRnor6.0
Rnor_5.0361,890,756 - 61,890,959UniSTSRnor5.0
RGSC_v3.4351,195,217 - 51,195,421RGDRGSC3.4
RGSC_v3.4351,195,218 - 51,195,421UniSTSRGSC3.4
RGSC_v3.1351,091,590 - 51,091,793RGD
Celera353,377,734 - 53,377,917UniSTS
RH 3.4 Map4528.12UniSTS
RH 3.4 Map4528.12RGD
SHRSP x BN Map336.0899UniSTS
SHRSP x BN Map336.0899RGD
FHH x ACI Map339.47RGD
Cytogenetic Map3q21UniSTS
D3Chm63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,781,112 - 53,781,346 (+)MAPPERmRatBN7.2
Rnor_6.0355,245,276 - 55,245,509NCBIRnor6.0
Rnor_5.0361,857,234 - 61,857,467UniSTSRnor5.0
RGSC_v3.4351,161,661 - 51,161,895RGDRGSC3.4
RGSC_v3.4351,161,662 - 51,161,895UniSTSRGSC3.4
Celera353,344,358 - 53,344,591UniSTS
Cytogenetic Map3q21UniSTS
RH132016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,632,717 - 53,632,908 (+)MAPPERmRatBN7.2
Rnor_6.0355,096,345 - 55,096,535NCBIRnor6.0
Rnor_5.0361,710,185 - 61,710,375UniSTSRnor5.0
RGSC_v3.4350,981,133 - 50,981,323UniSTSRGSC3.4
Celera353,196,396 - 53,196,586UniSTS
Cytogenetic Map3q21UniSTS
BE106939  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,855,527 - 53,855,726 (+)MAPPERmRatBN7.2
Rnor_6.0355,318,627 - 55,318,825NCBIRnor6.0
Rnor_5.0361,930,559 - 61,930,757UniSTSRnor5.0
RGSC_v3.4351,237,259 - 51,237,457UniSTSRGSC3.4
Celera353,418,422 - 53,418,620UniSTS
RH 3.4 Map4402.04UniSTS
Cytogenetic Map3q21UniSTS
AU049900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,814,084 - 53,814,330 (+)MAPPERmRatBN7.2
Rnor_6.0355,278,067 - 55,278,312NCBIRnor6.0
Rnor_5.0361,889,999 - 61,890,244UniSTSRnor5.0
RGSC_v3.4351,194,461 - 51,194,706UniSTSRGSC3.4
Celera353,376,977 - 53,377,222UniSTS
Cytogenetic Map3q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000058763   ⟹   ENSRNOP00000055558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,630,959 - 53,874,822 (+)Ensembl
Rnor_6.0 Ensembl355,094,637 - 55,338,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105502   ⟹   ENSRNOP00000078641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,630,959 - 53,874,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111194   ⟹   ENSRNOP00000088922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl353,631,007 - 53,876,848 (+)Ensembl
RefSeq Acc Id: NM_001399362   ⟹   NP_001386291
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,861 - 74,287,544 (+)NCBI
mRatBN7.2353,630,977 - 53,879,692 (+)NCBI
RefSeq Acc Id: NM_001399363   ⟹   NP_001386292
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,861 - 74,287,544 (+)NCBI
mRatBN7.2353,630,977 - 53,879,692 (+)NCBI
RefSeq Acc Id: XM_039106361   ⟹   XP_038962289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,038,520 - 74,259,005 (+)NCBI
mRatBN7.2353,630,637 - 53,836,221 (+)NCBI
RefSeq Acc Id: XM_063284272   ⟹   XP_063140342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,212,154 - 74,287,542 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001386291 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386292 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962289 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79047 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055558
  ENSRNOP00000055558.4
  ENSRNOP00000078641.1
  ENSRNOP00000088922
  ENSRNOP00000088922.1
1 to 10 of 10 rows
Ensembl Acc Id: ENSRNOP00000055558   ⟸   ENSRNOT00000058763
RefSeq Acc Id: XP_038962289   ⟸   XM_039106361
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000088922   ⟸   ENSRNOT00000111194
Ensembl Acc Id: ENSRNOP00000078641   ⟸   ENSRNOT00000105502
RefSeq Acc Id: NP_001386291   ⟸   NM_001399362
- Peptide Label: isoform 1
- UniProtKB: F1LTP8 (UniProtKB/TrEMBL),   A0A8I5ZL71 (UniProtKB/TrEMBL)
Homeobox   TLC

Name Modeler Protein Id AA Range Protein Structure
AF-F1LTP8-F1-model_v2 AlphaFold F1LTP8 1-392 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692119
Promoter ID:EPDNEW_R2634
Type:initiation region
Name:Cers6_1
Description:ceramide synthase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,094,623 - 55,094,683EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49518 BioCyc
Ensembl Genes ENSRNOG00000024595 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058763 ENTREZGENE
  ENSRNOT00000058763.5 UniProtKB/TrEMBL
  ENSRNOT00000105502.1 UniProtKB/TrEMBL
  ENSRNOT00000111194 ENTREZGENE
  ENSRNOT00000111194.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeodomain UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Longevity_assurance_LAG1_LAC1 UniProtKB/TrEMBL
  TLC-dom UniProtKB/TrEMBL
NCBI Gene 366065 ENTREZGENE
PANTHER CERAMIDE SYNTHASE 6 UniProtKB/TrEMBL
  PTHR12560 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PhenoGen Cers6 PhenoGen
PIRSF LAG1_LAC1 UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024595 RatGTEx
SMART TLC UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I5ZL71 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A742 ENTREZGENE, UniProtKB/TrEMBL
  A6HLZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LTP8 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Cers6  ceramide synthase 6  Lass6  LAG1 homolog, ceramide synthase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Lass6  LAG1 homolog, ceramide synthase 6  RGD1561599_predicted  similar to longevity assurance homolog 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561599_predicted  similar to longevity assurance homolog 6 (predicted)  LOC366065  similar to longevity assurance homolog 6  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366065  similar to longevity assurance homolog 6      Symbol and Name status set to provisional 70820 PROVISIONAL