Slitrk2 (SLIT and NTRK-like family, member 2) - Rat Genome Database

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Gene: Slitrk2 (SLIT and NTRK-like family, member 2) Rattus norvegicus
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Symbol: Slitrk2
Name: SLIT and NTRK-like family, member 2
RGD ID: 1561361
Description: Predicted to be involved in axonogenesis; regulation of synapse assembly; and synaptic membrane adhesion. Is active in postsynaptic membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual developmental disorder 111. Orthologous to human SLITRK2 (SLIT and NTRK like family member 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309349; RGD1561361; similar to neuronal transmembrane protein Slitrk2; SLIT and NTRK-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X150,287,418 - 150,299,832 (+)NCBIGRCr8
mRatBN7.2X145,246,448 - 145,259,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX145,246,460 - 145,271,220 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX147,450,931 - 147,454,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X150,975,813 - 150,979,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X148,525,830 - 148,529,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X151,099,388 - 151,111,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX151,103,576 - 151,107,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X151,095,085 - 151,108,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X152,668,556 - 152,671,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX141,105,289 - 141,108,729 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Yim YS, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62. doi: 10.1073/pnas.1209881110. Epub 2013 Jan 23.
Additional References at PubMed
PMID:14550773   PMID:24613359   PMID:25989451   PMID:27273464   PMID:31745231  


Genomics

Comparative Map Data
Slitrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X150,287,418 - 150,299,832 (+)NCBIGRCr8
mRatBN7.2X145,246,448 - 145,259,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX145,246,460 - 145,271,220 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX147,450,931 - 147,454,371 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X150,975,813 - 150,979,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X148,525,830 - 148,529,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X151,099,388 - 151,111,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX151,103,576 - 151,107,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X151,095,085 - 151,108,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X152,668,556 - 152,671,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX141,105,289 - 141,108,729 (+)NCBICelera
Cytogenetic MapXq37NCBI
SLITRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X145,817,829 - 145,829,856 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX145,817,829 - 145,829,856 (+)EnsemblGRCh38hg38GRCh38
GRCh37X144,899,347 - 144,911,374 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X144,707,042 - 144,715,052 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X144,604,895 - 144,612,904NCBI
CeleraX145,211,704 - 145,219,715 (+)NCBICelera
Cytogenetic MapXq27.3NCBI
HuRefX133,868,009 - 133,873,011 (+)NCBIHuRef
CHM1_1X144,810,593 - 144,818,604 (+)NCBICHM1_1
T2T-CHM13v2.0X144,074,860 - 144,086,894 (+)NCBIT2T-CHM13v2.0
Slitrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X65,692,535 - 65,705,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX65,692,924 - 65,704,999 (+)EnsemblGRCm39 Ensembl
GRCm38X66,648,951 - 66,661,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX66,649,318 - 66,661,393 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X63,902,493 - 63,914,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X62,913,672 - 62,917,110 (+)NCBIMGSCv36mm8
CeleraX55,108,474 - 55,120,526 (-)NCBICelera
Cytogenetic MapXA7.1NCBI
cM MapX34.81NCBI
Slitrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955585479,798 - 486,363 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955585479,798 - 488,046 (-)NCBIChiLan1.0ChiLan1.0
SLITRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X145,142,571 - 145,154,591 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X145,146,178 - 145,158,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X134,853,269 - 134,865,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X145,230,940 - 145,238,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX145,235,542 - 145,238,079 (+)Ensemblpanpan1.1panPan2
SLITRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X114,576,526 - 114,584,471 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX114,581,070 - 114,583,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX100,438,007 - 100,445,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X116,597,295 - 116,605,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX116,597,210 - 116,609,305 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X113,722,487 - 113,730,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X115,929,087 - 115,937,038 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X115,659,264 - 115,667,220 (+)NCBIUU_Cfam_GSD_1.0
Slitrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X112,644,721 - 112,656,767 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365132,961,983 - 2,966,439 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365132,961,842 - 2,969,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLITRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX118,830,086 - 118,834,307 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X118,826,531 - 118,837,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X136,058,440 - 136,066,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLITRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X120,640,216 - 120,649,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX120,646,022 - 120,648,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606558,182,578 - 58,192,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slitrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248081,311,247 - 1,319,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248081,307,229 - 1,319,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slitrk2
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000015401
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 46 113 59 56 28 21 28 6 168 88 93 35 53 28

Sequence


Ensembl Acc Id: ENSRNOT00000015401   ⟹   ENSRNOP00000015401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX145,250,189 - 145,253,629 (+)Ensembl
Rnor_6.0 EnsemblX151,103,576 - 151,107,016 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094061   ⟹   ENSRNOP00000077976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX145,246,460 - 145,271,220 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108501   ⟹   ENSRNOP00000088481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX145,246,460 - 145,259,029 (+)Ensembl
RefSeq Acc Id: NM_001107587   ⟹   NP_001101057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X150,291,591 - 150,295,031 (+)NCBI
mRatBN7.2X145,250,189 - 145,253,629 (+)NCBI
Rnor_6.0X151,103,576 - 151,107,016 (+)NCBI
Rnor_5.0X151,095,085 - 151,108,778 (+)NCBI
RGSC_v3.4X152,668,556 - 152,671,996 (+)RGD
CeleraX141,105,289 - 141,108,729 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257626   ⟹   XP_006257688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X150,287,418 - 150,299,832 (+)NCBI
mRatBN7.2X145,246,448 - 145,259,983 (+)NCBI
Rnor_6.0X151,099,388 - 151,111,816 (+)NCBI
Rnor_5.0X151,095,085 - 151,108,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602027   ⟹   XP_017457516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X150,287,427 - 150,299,832 (+)NCBI
mRatBN7.2X145,246,448 - 145,259,983 (+)NCBI
Rnor_6.0X151,099,388 - 151,111,816 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279973   ⟹   XP_063136043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X150,291,387 - 150,299,832 (+)NCBI
RefSeq Acc Id: NP_001101057   ⟸   NM_001107587
- Peptide Label: precursor
- UniProtKB: D3ZK41 (UniProtKB/TrEMBL),   A6K520 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257688   ⟸   XM_006257626
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457516   ⟸   XM_017602027
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000015401   ⟸   ENSRNOT00000015401
Ensembl Acc Id: ENSRNOP00000088481   ⟸   ENSRNOT00000108501
Ensembl Acc Id: ENSRNOP00000077976   ⟸   ENSRNOT00000094061
RefSeq Acc Id: XP_063136043   ⟸   XM_063279973
- Peptide Label: isoform X1
- UniProtKB: A6K520 (UniProtKB/TrEMBL),   D3ZK41 (UniProtKB/TrEMBL)
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZK41-F1-model_v2 AlphaFold D3ZK41 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561361 AgrOrtholog
BioCyc Gene G2FUF-827 BioCyc
Ensembl Genes ENSRNOG00000011562 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015401.7 UniProtKB/TrEMBL
  ENSRNOT00000094061.1 UniProtKB/TrEMBL
  ENSRNOT00000108501.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR-contain_N UniProtKB/TrEMBL
KEGG Report rno:309349 UniProtKB/TrEMBL
NCBI Gene 309349 ENTREZGENE
PANTHER PTHR45773 UniProtKB/TrEMBL
  SLIT AND NTRK-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
PhenoGen Slitrk2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011562 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A6K520 ENTREZGENE, UniProtKB/TrEMBL
  D3ZK41 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slitrk2  SLIT and NTRK-like family, member 2   Slitrk2_predicted  SLIT and NTRK-like family, member 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Slitrk2_predicted  SLIT and NTRK-like family, member 2 (predicted)  RGD1561361_predicted  similar to neuronal transmembrane protein Slitrk2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1561361_predicted  similar to neuronal transmembrane protein Slitrk2 (predicted)  LOC309349  similar to neuronal transmembrane protein Slitrk2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309349  similar to neuronal transmembrane protein Slitrk2      Symbol and Name status set to provisional 70820 PROVISIONAL