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Gene: Srsf4 (serine and arginine rich splicing factor 4) Rattus norvegicus

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Symbol:

Srsf4

Name:

serine and arginine rich splicing factor 4

RGD ID:

1561347

Description:

Enables sequence-specific mRNA binding activity. Involved in response to insulin. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human SRSF4 (serine and arginine rich splicing factor 4); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; bisphenol A; buspirone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC362612; RGD1561347; serine/arginine-rich splicing factor 4; Sfrs4; similar to Sfrs4 protein; splicing factor, arginine/serine-rich 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SRSF4 (serine and arginine rich splicing factor 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Srsf4 (serine and arginine-rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Srsf4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SRSF4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SRSF4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srsf4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SRSF4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Srsf4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Srsf4 (serine and arginine rich splicing factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SRSF5 (serine and arginine rich splicing factor 5)	HGNC	OrthoDB
Homo sapiens (human):	SRSF6 (serine and arginine rich splicing factor 6)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SRSF4 (serine and arginine rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SRSF4 (serine and arginine rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srsf4 (serine and arginine-rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srsf4 (serine and arginine-rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srsf4 (serine and arginine rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	srsf4 (serine and arginine rich splicing factor 4)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	B52	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	B52	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NPL3	Alliance	DIOPT (Hieranoid\|OrthoFinder\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NPL3	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rsp-1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rsp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	srsf4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	srsf4	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	149,345,538 - 149,373,309 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	149,345,422 - 149,374,609 (+)	Ensembl				GRCr8
mRatBN7.2	5	144,060,981 - 144,090,798 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,061,463 - 144,089,229 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	146,766,904 - 146,794,813 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	148,536,752 - 148,564,663 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	148,525,380 - 148,553,198 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	142,505,197 - 142,532,845 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

clear cell renal cell carcinoma (ISO)

colon adenocarcinoma (ISO)

Down syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

7,12-dimethyltetraphene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

bisphenol AF (ISO)

bisphenol F (ISO)

buspirone (EXP)

butanal (ISO)

butyric acid (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dihydroartemisinin (ISO)

dorsomorphin (ISO)

flutamide (EXP)

FR900359 (ISO)

furan (EXP)

Garcinol (ISO)

gentamycin (EXP)

graphene oxide (ISO)

GSK690693 (ISO)

ivermectin (ISO)

leflunomide (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nefazodone (EXP)

nimesulide (EXP)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hematopoietic progenitor cell differentiation (ISO)

mRNA processing (IEA)

negative regulation of mRNA splicing, via spliceosome (IEA,ISO)

response to insulin (IEP)

RNA splicing (IEA)

Cellular Component

cytoplasm (IBA)

nuclear speck (IEA,ISO)

nucleus (IBA)

Molecular Function

mRNA binding (IBA)

nucleic acid binding (IEA)

protein binding (ISO)

RNA binding (IEA)

sequence-specific mRNA binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas.	Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
4.	Aberrant expression of splicing factors in newly diagnosed acute myeloid leukemia.	Liu J, etal., Onkologie. 2012;35(6):335-40. doi: 10.1159/000338941. Epub 2012 May 22.
5.	Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.	Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
6.	Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors.	Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Proteomic analysis of amniotic fluid in pregnancies with Down syndrome.	Tsangaris GT, etal., Proteomics. 2006 Aug;6(15):4410-9.
11.	The spliceosome: design principles of a dynamic RNP machine.	Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
12.	Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.	Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.

Additional References at PubMed

PMID:12477932	PMID:15009664	PMID:21073651	PMID:22658674	PMID:22681889	PMID:24029230	PMID:25002582	PMID:25931508

Genomics

Comparative Map Data

Srsf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	149,345,538 - 149,373,309 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	149,345,422 - 149,374,609 (+)	Ensembl				GRCr8
mRatBN7.2	5	144,060,981 - 144,090,798 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,061,463 - 144,089,229 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	146,766,904 - 146,794,813 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	148,536,752 - 148,564,663 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	148,525,380 - 148,553,198 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	142,505,197 - 142,532,845 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SRSF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	29,147,743 - 29,181,900 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	29,147,743 - 29,181,922 (-)	Ensembl			hg38	GRCh38
GRCh37	1	29,474,255 - 29,508,412 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	29,346,946 - 29,380,948 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	29,294,980 - 29,328,977	NCBI
Celera	1	27,870,392 - 27,904,789 (-)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	27,726,138 - 27,760,578 (-)	NCBI		HuRef
CHM1_1	1	29,589,632 - 29,624,036 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	28,990,399 - 29,024,556 (-)	NCBI		T2T-CHM13v2.0

Srsf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	131,600,841 - 131,629,036 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	131,600,928 - 131,629,017 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	131,873,530 - 131,901,725 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	131,873,617 - 131,901,706 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	131,429,554 - 131,457,640 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	131,169,807 - 131,173,781 (+)	NCBI		MGSCv36	mm8
Celera	4	130,034,138 - 130,062,224 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	64.53	NCBI

Srsf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	8,142,500 - 8,174,869 (-)	Ensembl
ChiLan1.0	NW_004955452	8,143,850 - 8,174,830 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRSF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	197,661,303 - 197,695,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	196,780,466 - 196,814,798 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	28,418,297 - 28,452,595 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	29,444,263 - 29,490,360 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	29,444,269 - 29,478,035 (-)	Ensembl			panPan2	panpan1.1

SRSF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	71,418,626 - 71,434,140 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	71,394,037 - 71,471,997 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	67,983,412 - 68,010,251 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	71,967,829 - 71,993,683 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	2	68,796,130 - 68,822,742 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	69,803,922 - 69,830,460 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	70,801,912 - 70,828,510 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Srsf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	47,288,456 - 47,315,957 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	13,113,867 - 13,140,599 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	13,113,191 - 13,140,956 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRSF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	103,641,650 - 103,674,066 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	103,642,150 - 103,673,391 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	12,855,849 - 12,888,333 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srsf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	12,916,858 - 12,946,238 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	12,916,857 - 12,945,861 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Srsf4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	26,351,813 - 26,379,643 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Srsf4
270 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	68
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000013301
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

AW550192

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	144,088,647 - 144,088,786 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	150,060,182 - 150,060,320	NCBI	Rnor6.0
Rnor_5.0	5	153,738,904 - 153,739,042	UniSTS	Rnor5.0
RGSC_v3.4	5	150,758,353 - 150,758,491	UniSTS	RGSC3.4
Celera	5	142,532,258 - 142,532,396	UniSTS
Cytogenetic Map	5	q36	UniSTS

BF394391

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	144,067,672 - 144,067,762 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	150,039,209 - 150,039,298	NCBI	Rnor6.0
Rnor_5.0	5	153,717,931 - 153,718,020	UniSTS	Rnor5.0
RGSC_v3.4	5	151,146,572 - 151,146,661	UniSTS	RGSC3.4
RGSC_v3.4	5	150,737,379 - 150,737,468	UniSTS	RGSC3.4
Celera	5	142,511,407 - 142,511,496	UniSTS
RH 3.4 Map	5	988.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC160850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013301 ⟹ ENSRNOP00000013301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	149,345,422 - 149,374,609 (+)	Ensembl
mRatBN7.2 Ensembl	5	144,061,463 - 144,089,229 (+)	Ensembl
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108926 ⟹ ENSRNOP00000079743

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,061,900 - 144,089,229 (+)	Ensembl

RefSeq Acc Id:

NM_001108685 ⟹ NP_001102155

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	149,345,538 - 149,373,309 (+)	NCBI
mRatBN7.2	5	144,061,463 - 144,089,235 (+)	NCBI
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	RGD
Celera	5	142,505,197 - 142,532,845 (+)	NCBI

Sequence:

show sequence

CGCCGGGCTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTACCGCCGCCGCCGCCGCGCTTTCC
CTTCGCCGGCCGCCGCCTGAGGGGGGCCGGGGCCAGCCGCCGCCGGAATGCCGCGCGTGTACAT
CGGCCGCCTGAGCTACCAGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAG
ATCCTGGAGGTGGATCTGAAGAACGGGTATGGTTTTGTGGAGTTTGATGATCTGCGTGATGCAG
ATGATGCTGTTTATGAACTGAATGGCAAAGACCTCTGTGGTGAACGAGTCATTGTTGAGCATGC
CCGAGGCCCACGTCGGGACGGCAGTTACGGTTCTGGACGCAGTGGATATGGTTATCGAAGAAGT
GGCCGAGATAAATATGGTCCTCCTACTCGCACAGAGTACAGACTTATTGTGGAGAATCTGTCAA
GTCGATGCAGCTGGCAAGATCTAAAGGATTATATGCGTCAGGCAGGAGAAGTGACGTATGCAGA
TGCTCACAAGGGACGCAAAAACGAAGGAGTGATTGAATTTGTGTCTTACTCTGATATGAAAAGA
GCTTTGGAAAAGTTGGATGGAACTGAAGTCAACGGCAGAAAAATCAGATTAGTTGAAGACAAGC
CAGGTTCTAGACGGCGCCGGTCTTACTCCAGAAGCCGGAGTCACTCAAGGTCTCGCTCTCGAAG
CAGACATTCTCGGAAGAGCAGAAGCCGAAGTGGTAGCAGTAAAAGCAGCCATTCAAAGAGCCGC
TCTCGATCCAGGTCGGGTTCCCACTCCCGCAGCAAGAGCCGCAGCCGCAGCCAGAGCCGCAGTC
GCAGTAAGAAGGAGAAAAGCCGGAGCCCCAGCAAAGACAACAAGAGCCGCAGTCGCAGCCGCAG
CCCCGACAAGAGCCGAAGCAAAAGTAAAGACCATGCAGAGGACAAGCTCCAGAACAACGACAGC
GCTGGCAAAGCCAAGAGCCACAGCCCCAGCCGCCATGACAGTAAAAGTCGGAGCAGGAGCCAGG
AGAGGAGAGCAGAGGAGGAGAGGAGAAGCAGCACGAGCAGGGGTCACAGCCAGGAGAAGAGCCT
GCTTAAGAGCCGCAGCCGCAGCCGCAGCAAAGTGGGCAGCCGCAGCCGCAGCCGCAGCAAAAGC
AAGGACAAGCGGAAGGGCCGGAAGAGAAGCAGGGAAGAAAGTCGAAGCCGGAGCCGCAGCAAGA
GCGAGCGCAGCCGGAAGCATAGCAGCAAGCGGGACAGCAAAGTCAGCAGCAGCAGCAGCAAGAA
GAAGAAGGGAGACACCGACCACTCCCGGTCACCGTCCCGCTCAGTGTCAAAGGAGCGGGAACAT
GCCACGGCAGAGCCTGGCCAGAGGGAAAGCCGGGCTGAGGGTGAGAGCGAGGGTCCCAATCCAG
AGCCCCGGGCCAGGTCAAGATCCACTTCCAAATCCAAACCTAGTCTCCCGGCAGAGTCCCGCTC
CAGGTCAAAGTCAGCTTCAAAAACGCGCTCTCGGTCCAAGTCTCCATCCAGGTCTGCTTCCAGG
TCGCCCTCCCGGTCTAGATCCAGGTCCCACTCAAGGTCCTAACTGGCCATGCTGCGCTGGAACT
GCCGAGAAGTTTTTGTACATTTGGTAGCCGTAGCACAGGAGTGAAGTAGAACACCCGTCACTGC
TGTACATTAACTCCCCAAAGGTGTGTCTCAGTTGTTCAATCTCAGTGCTTCCTCGGTACCGCCT
CCCGGCGCCAGGCCTTCCCGCTCCACTGAAAAGCAGCTCCTCAAACTCCCTGTACTCACAGTAG
GACACCCAACGCCTTGGCTTTCAGGCCTGGCCACGGCTACAGGGAGCTCGGCACCTGGACGGCT
TCTCAGGCTGGAGTGATGGCGTAGGTAGGTGTGGTGAGCTCAGCCGTTTGCCCTTGAATTGATG
CCCTTTGATGTGTGCCACGTAGTGAAAGTGCAAGTCTTCAGTCTCCCACCACTTCGGTTTCCTG
TTTCTGGACTTAACAACCTTGTGAATAGCACAGTCAAGAGAAATGGATACCTGCATAGCCCATA
GGAAGTAACACTGTAGAGCTCCATATTCTGGTATTGTGATTATATTGTTTTATATTAAAAAAGG
AAAGAATTTTTTTTAATTTTATTTTTCCCCGTCTTGCAAAGTATAGTGGCCCCTGTTTCCATTA
AATTTGAATAAAGACTATTTTTGCTTGACAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102155	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI60850	(Get FASTA)	NCBI Sequence Viewer
	EDL80612	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013301
	ENSRNOP00000013301.4

RefSeq Acc Id:

NP_001102155 ⟸ NM_001108685

- UniProtKB:

G3V798 (UniProtKB/TrEMBL), A6ISR1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGER
VIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAG
EVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHS
RSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSHSRSKSRSRSQSRSRSKKEKSRSPSKDNKS
RSRSRSPDKSRSKSKDHAEDKLQNNDSAGKAKSHSPSRHDSKSRSRSQERRAEEERRSSTSRGH
SQEKSLLKSRSRSRSKVGSRSRSRSKSKDKRKGRKRSREESRSRSRSKSERSRKHSSKRDSKVS
SSSSKKKKGDTDHSRSPSRSVSKEREHATAEPGQRESRAEGESEGPNPEPRARSRSTSKSKPSL
PAESRSRSKSASKTRSRSKSPSRSASRSPSRSRSRSHSRS

hide sequence

Ensembl Acc Id:

ENSRNOP00000013301 ⟸ ENSRNOT00000013301

Ensembl Acc Id:

ENSRNOP00000079743 ⟸ ENSRNOT00000108926

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V798-F1-model_v2	AlphaFold	G3V798	1-488	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694090

Promoter ID:

EPDNEW_R4614

Type:

initiation region

Name:

Srsf4_1

Description:

serine and arginine rich splicing factor 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	150,032,983 - 150,033,043	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561347	AgrOrtholog
BioCyc Gene	G2FUF-39719	BioCyc
Ensembl Genes	ENSRNOG00000010007	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013301	ENTREZGENE
	ENSRNOT00000013301.7	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8363821	IMAGE-MGC_LOAD
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM2_SRSF4-like	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
	RRT5_SRSF_SR	UniProtKB/TrEMBL
KEGG Report	rno:362612	UniProtKB/TrEMBL
MGC_CLONE	MGC:187592	IMAGE-MGC_LOAD
NCBI Gene	362612	ENTREZGENE
PANTHER	RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN	UniProtKB/TrEMBL
	SERINE/ARGININE-RICH SPLICING FACTOR 4	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
PhenoGen	Srsf4	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010007	RatGTEx
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A6ISR1	ENTREZGENE, UniProtKB/TrEMBL
	B1H240_RAT	UniProtKB/TrEMBL
	G3V798	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Srsf4	serine and arginine rich splicing factor 4	Srsf4	serine/arginine-rich splicing factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Srsf4	serine/arginine-rich splicing factor 4	Sfrs4	splicing factor, arginine/serine-rich 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-22	Sfrs4	splicing factor, arginine/serine-rich 4	Srsf4	serine/arginine-rich splicing factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-13	Srsf4	serine/arginine-rich splicing factor 4	Sfrs4	splicing factor, arginine/serine-rich 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Sfrs4	splicing factor, arginine/serine-rich 4	RGD1561347	similar to Sfrs4 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1561347	similar to Sfrs4 protein	RGD1561347_predicted	similar to Sfrs4 protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1561347_predicted	similar to Sfrs4 protein (predicted)	LOC362612	similar to Sfrs4 protein	Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations