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Gene: Ppp1r3a (protein phosphatase 1, regulatory subunit 3A) Rattus norvegicus
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Symbol:
Ppp1r3a
Name:
protein phosphatase 1, regulatory subunit 3A
RGD ID:
1561312
Description:
Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC500036; protein phosphatase 1 regulatory subunit 3A; protein phosphatase 1, regulatory (inhibitor) subunit 3A; RGD1561312; similar to type 1 protein phosphatase targeting subunit RGL/GM
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 4 43,905,648 - 43,946,236 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 4 43,905,648 - 43,946,236 (-) Ensembl GRCr8 mRatBN7.2 4 42,937,353 - 42,980,195 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 4 42,939,599 - 42,980,638 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 4 47,935,810 - 47,976,403 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 4 43,856,823 - 43,897,416 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 4 42,265,462 - 42,306,053 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 4 41,171,486 - 41,212,116 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 41,171,486 - 41,212,072 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 4 40,763,443 - 40,804,029 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 4 40,195,325 - 40,235,913 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 4 38,272,622 - 38,313,215 (-) NCBI Celera Cytogenetic Map 4 q22 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
Ppp1r3a Rat (2,4,5-trichlorophenoxy)acetic acid decreases expression ISO Ppp1r3a (Mus musculus) 6480464 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA CTD PMID:18579281 Ppp1r3a Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ppp1r3a Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ppp1r3a Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PPP1R3A mRNA CTD PMID:27291303 Ppp1r3a Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ppp1r3a Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PPP1R3A mRNA CTD PMID:32109520 Ppp1r3a Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ppp1r3a Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Ppp1r3a Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PPP1R3A mRNA CTD PMID:28959563 Ppp1r3a Rat aflatoxin B1 decreases methylation ISO PPP1R3A (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PPP1R3A gene CTD PMID:27153756 Ppp1r3a Rat all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of PPP1R3A mRNA CTD PMID:20488242 Ppp1r3a Rat alpha-Zearalanol decreases expression EXP 6480464 Zeranol results in decreased expression of PPP1R3A mRNA CTD PMID:35163327 Ppp1r3a Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PPP1R3A mRNA CTD PMID:35163327 Ppp1r3a Rat arsane multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 FTO protein inhibits the reaction [Arsenic results in decreased expression of PPP1R3A mRNA] CTD PMID:38723480 Ppp1r3a Rat arsane decreases expression ISO Ppp1r3a (Mus musculus) 6480464 Arsenic results in decreased expression of PPP1R3A mRNA CTD PMID:38723480 Ppp1r3a Rat arsenic atom multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 FTO protein inhibits the reaction [Arsenic results in decreased expression of PPP1R3A mRNA] CTD PMID:38723480 Ppp1r3a Rat arsenic atom decreases expression ISO Ppp1r3a (Mus musculus) 6480464 Arsenic results in decreased expression of PPP1R3A mRNA CTD PMID:38723480 Ppp1r3a Rat arsenite(3-) decreases expression ISO Ppp1r3a (Mus musculus) 6480464 arsenite results in decreased expression of PPP1R3A mRNA CTD PMID:33053406 Ppp1r3a Rat benzo[a]pyrene increases methylation ISO PPP1R3A (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PPP1R3A 3' UTR; Benzo(a)pyrene results in increased methylation of more ... CTD PMID:27901495 Ppp1r3a Rat bis(2-ethylhexyl) phthalate increases expression ISO Ppp1r3a (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of PPP1R3A mRNA CTD PMID:28085963|PMID:35716406 Ppp1r3a Rat bis(2-ethylhexyl) phthalate decreases expression ISO Ppp1r3a (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of PPP1R3A mRNA CTD PMID:34319233 Ppp1r3a Rat bisphenol A decreases expression ISO Ppp1r3a (Mus musculus) 6480464 bisphenol A results in decreased expression of PPP1R3A mRNA CTD PMID:17706920 Ppp1r3a Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Ppp1r3a Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PPP1R3A mRNA CTD PMID:34947998 Ppp1r3a Rat bisphenol A increases expression ISO Ppp1r3a (Mus musculus) 6480464 bisphenol A results in increased expression of PPP1R3A mRNA CTD PMID:25594700 Ppp1r3a Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PPP1R3A mRNA CTD PMID:25181051 Ppp1r3a Rat bisphenol A multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 LHB protein affects the reaction [bisphenol A results in decreased expression of PPP1R3A mRNA] CTD PMID:17706920 Ppp1r3a Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Ppp1r3a Rat chlordecone decreases expression ISO Ppp1r3a (Mus musculus) 6480464 Chlordecone results in decreased expression of PPP1R3A mRNA CTD PMID:29980752 Ppp1r3a Rat copper(II) sulfate decreases expression ISO Ppp1r3a (Mus musculus) 6480464 Copper Sulfate results in decreased expression of PPP1R3A mRNA CTD PMID:18579281 Ppp1r3a Rat daunorubicin decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Daunorubicin results in decreased expression of PPP1R3A mRNA CTD PMID:26537877|PMID:28940058 Ppp1r3a Rat dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression more ... CTD PMID:33729688 Ppp1r3a Rat doxorubicin decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Doxorubicin results in decreased expression of PPP1R3A mRNA CTD PMID:26537877|PMID:28940058|PMID:29803840 Ppp1r3a Rat epoxiconazole decreases expression ISO Ppp1r3a (Mus musculus) 6480464 epoxiconazole results in decreased expression of PPP1R3A mRNA CTD PMID:35436446 Ppp1r3a Rat lipopolysaccharide multiple interactions ISO PPP1R3A (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PPP1R3A mRNA CTD PMID:35811015 Ppp1r3a Rat mitoxantrone decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Mitoxantrone results in decreased expression of PPP1R3A mRNA CTD PMID:26537877|PMID:28940058 Ppp1r3a Rat paracetamol affects expression ISO Ppp1r3a (Mus musculus) 6480464 Acetaminophen affects the expression of PPP1R3A mRNA CTD PMID:17562736 Ppp1r3a Rat paracetamol decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Acetaminophen results in decreased expression of PPP1R3A mRNA CTD PMID:26690555 Ppp1r3a Rat PCB138 multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ppp1r3a Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PPP1R3A mRNA CTD PMID:35163327 Ppp1r3a Rat pioglitazone multiple interactions ISO Ppp1r3a (Mus musculus) 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PPP1R3A mRNA CTD PMID:27935865 Ppp1r3a Rat potassium dichromate increases expression ISO Ppp1r3a (Mus musculus) 6480464 Potassium Dichromate results in increased expression of PPP1R3A mRNA CTD PMID:23608068 Ppp1r3a Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO PPP1R3A (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PPP1R3A mRNA CTD PMID:35811015 Ppp1r3a Rat sodium arsenite increases expression ISO Ppp1r3a (Mus musculus) 6480464 sodium arsenite results in increased expression of PPP1R3A mRNA CTD PMID:37682722 Ppp1r3a Rat sodium arsenite decreases expression ISO Ppp1r3a (Mus musculus) 6480464 sodium arsenite results in decreased expression of PPP1R3A mRNA CTD PMID:36209798 Ppp1r3a Rat sunitinib decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Sunitinib results in decreased expression of PPP1R3A mRNA CTD PMID:31533062 Ppp1r3a Rat testosterone enanthate affects expression ISO PPP1R3A (Homo sapiens) 6480464 testosterone enanthate affects the expression of PPP1R3A mRNA CTD PMID:17440010 Ppp1r3a Rat trichloroethene increases expression ISO Ppp1r3a (Mus musculus) 6480464 Trichloroethylene results in increased expression of PPP1R3A mRNA CTD PMID:28973375 Ppp1r3a Rat triclosan decreases expression ISO PPP1R3A (Homo sapiens) 6480464 Triclosan results in decreased expression of PPP1R3A mRNA CTD PMID:30510588 Ppp1r3a Rat valproic acid decreases methylation ISO PPP1R3A (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of PPP1R3A gene CTD PMID:29154799 Ppp1r3a Rat venlafaxine hydrochloride increases expression EXP 6480464 Venlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA CTD PMID:25423262 Ppp1r3a Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PPP1R3A mRNA CTD PMID:23160963
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
QTLs in Region (GRCr8)
2302371 Stl22 Serum triglyceride level QTL 22 5.15 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 13080146 58080146 Rat 2303585 Bw86 Body weight QTL 86 4 body mass (VT:0001259) body weight (CMO:0000012) 4 15644309 60644309 Rat 5685012 Bmd87 Bone mineral density QTL 87 5.1 tibia mineral mass (VT:1000283) bone mineral content (CMO:0001554) 4 35113290 80113290 Rat 1358352 Srcrt3 Stress Responsive Cort QTL 3 2.29 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 4 39431983 123203361 Rat 61445 Strs3 Sensitivity to stroke QTL 3 3 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) 4 41400577 86400577 Rat 8552906 Pigfal3 Plasma insulin-like growth factor 1 level QTL 3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 4 11038706 56038706 Rat 10755501 Bp390 Blood pressure QTL 390 2.5 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 4 27730518 170099664 Rat 8655949 Rf62 Renal function QTL 62 22 blood urea nitrogen amount (VT:0005265) plasma urea nitrogen level (CMO:0000586) 4 35396600 45429897 Rat 1331807 Rf31 Renal function QTL 31 2.988 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) 4 40490442 75726188 Rat 6478766 Anxrr47 Anxiety related response QTL 47 0.09637 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 4 11038706 56038706 Rat 61330 Eau1 Experimental allergic uveoretinitis QTL 1 0.0003 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 4 26234499 134199155 Rat 631642 Stl2 Serum triglyceride level QTL 2 3.3 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 5894575 57613242 Rat 6478769 Anxrr48 Anxiety related response QTL 48 0.02514 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 4 11038706 56038706 Rat 631261 Tcas3 Tongue tumor susceptibility QTL 3 6.88 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 4 11706604 92690519 Rat 2313401 Anxrr27 Anxiety related response QTL 27 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 4 18900697 63900697 Rat 8655961 Kidm43 Kidney mass QTL 43 18 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 4 37269577 82269577 Rat 631209 Bw2 Body weight QTL2 4.2 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 4 1 45429897 Rat 6909128 Pancm4 Pancreatic morphology QTL 4 11.35 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) 4 27862204 126119996 Rat 8694374 Bw155 Body weight QTL 155 3.39 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 4 11038706 56038706 Rat 2303168 Bp330 Blood pressure QTL 330 4.25 0.017 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 4 5889999 148002343 Rat 61475 Aia2 Adjuvant induced arthritis QTL 2 5.8 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 4 40471453 75939996 Rat 8694439 Bw168 Body weight QTL 168 9.57 0.001 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 4 41400603 86400603 Rat 61412 Pia2 Pristane induced arthritis QTL 2 3.9 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) 4 22288453 63245191 Rat 2290374 Gluco32 Glucose level QTL 32 6.27 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 4 38144194 45429897 Rat 8552807 Vie4 Viral induced encephalitis QTL 4 7.3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 4 18900697 63900697 Rat 6478724 Anxrr35 Anxiety related response QTL 35 0.00449 defecation behavior trait (VT:0010462) defecation measurement (CMO:0000997) 4 11038706 56038706 Rat 8655906 Rf60 Renal function QTL 60 3.8 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) 4 30448961 82336920 Rat 619616 Bp79 Blood pressure QTL 79 0.0292 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 4 5889999 50889999 Rat 7387227 Uae40 Urinary albumin excretion QTL 40 2.9 0.0052 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 4 18913151 63913151 Rat 6909122 Insul22 Insulin level QTL 22 4.63 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 4 27862204 62997402 Rat 1558651 Swd3 Spike wave discharge measurement QTL 3 4.62 0.000024 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) 4 41400577 86400577 Rat 1358203 Stl19 Serum triglyceride level QTL 19 2.8 0.002 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 21925151 66925151 Rat 70192 BpQTLcluster5 Blood pressure QTL cluster 5 4.183 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 4 1 63900697 Rat 9590304 Scort17 Serum corticosterone level QTL 17 4.96 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 4 11038706 56038706 Rat 1300139 Hrtrt6 Heart rate QTL 6 2.85 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 4 40490442 117737312 Rat 12798520 Anxrr55 Anxiety related response QTL 55 4.45 0.01 locomotor behavior trait (VT:0001392) number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715) 4 33538597 116185060 Rat 11530004 Niddm71 Non-insulin dependent diabetes mellitus QTL 71 0.001 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 4 33538816 53719714 Rat 2316958 Gluco58 Glucose level QTL 58 10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 4 12212457 182430611 Rat 1354665 Stl10 Serum triglyceride level QTL 10 3.57 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 22288453 45429897 Rat
