Prss44 (serine protease 44) - Rat Genome Database

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Gene: Prss44 (serine protease 44) Rattus norvegicus
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Symbol: Prss44
Name: serine protease 44
RGD ID: 1560940
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in germ cell development; proteolysis; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human PRSS44P (serine protease 44, pseudogene); INTERACTS WITH bisphenol A; trichloroethene; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501060; protease, serine, 44; RGD1560940; similar to testis specific serine proteinase 3; Tessp4; testis serine protease 4
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,670,088 - 119,683,717 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,670,112 - 119,683,717 (+)EnsemblGRCr8
mRatBN7.28110,791,698 - 110,805,303 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,791,698 - 110,805,303 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,406,311 - 116,419,922 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,605,522 - 114,619,134 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,448,346 - 112,461,964 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8120,556,741 - 120,570,309 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive8122,661,679 - 122,675,251 (+)NCBILyon_Normotensive
Lyon_Hypertensive8121,151,391 - 121,164,955 (+)NCBILyon_Hypertensive
F344_StmMcwi8112,550,425 - 112,564,029 (+)NCBIF344_StmMcwi
Rnor_6.08119,083,900 - 119,097,707 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,083,900 - 119,097,707 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,423,162 - 118,436,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,196,265 - 115,209,775 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,074,270 - 110,087,887 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
extracellular space  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23536369  


Genomics

Comparative Map Data
Prss44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,670,088 - 119,683,717 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,670,112 - 119,683,717 (+)EnsemblGRCr8
mRatBN7.28110,791,698 - 110,805,303 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,791,698 - 110,805,303 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,406,311 - 116,419,922 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,605,522 - 114,619,134 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,448,346 - 112,461,964 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8120,556,741 - 120,570,309 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive8122,661,679 - 122,675,251 (+)NCBILyon_Normotensive
Lyon_Hypertensive8121,151,391 - 121,164,955 (+)NCBILyon_Hypertensive
F344_StmMcwi8112,550,425 - 112,564,029 (+)NCBIF344_StmMcwi
Rnor_6.08119,083,900 - 119,097,707 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,083,900 - 119,097,707 (+)Ensemblrn6Rnor6.0
Rnor_5.08118,423,162 - 118,436,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,196,265 - 115,209,775 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8110,074,270 - 110,087,887 (+)NCBICelera
Cytogenetic Map8q32NCBI
PRSS44P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,808,640 - 46,812,574 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,809,359 - 46,812,486 (-)Ensemblhg38GRCh38
GRCh37346,850,130 - 46,854,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,825,190 - 46,828,980 (-)NCBIBuild 36Build 36hg18NCBI36
Celera346,789,277 - 46,792,512 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,895,483 - 46,896,843 (-)NCBIHuRef
CHM1_1346,802,802 - 46,804,162 (-)NCBICHM1_1
T2T-CHM13v2.0346,824,738 - 46,828,672 (-)NCBIT2T-CHM13v2.0
Prss44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,642,987 - 110,647,067 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,643,062 - 110,653,591 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,813,919 - 110,817,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,813,994 - 110,824,523 (+)Ensemblmm10GRCm38
MGSCv379110,716,498 - 110,720,503 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,658,843 - 110,669,341 (+)NCBIMGSCv36mm8
Celera9110,544,865 - 110,548,871 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
LOC609278
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,000,525 - 42,005,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,916,711 - 41,921,662 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02042,483,116 - 42,488,067 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,452,205 - 42,488,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,724,543 - 41,729,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,125,420 - 42,130,363 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,406,478 - 42,411,428 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Prss44
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:77
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000048655, ENSRNOT00000051947
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 2 6 28 27 24 11 8 11 5 46 25 17 2 45 13 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000048655   ⟹   ENSRNOP00000047186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,670,112 - 119,674,419 (+)Ensembl
mRatBN7.2 Ensembl8110,791,719 - 110,796,003 (+)Ensembl
Rnor_6.0 Ensembl8119,083,921 - 119,088,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051947   ⟹   ENSRNOP00000044953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,670,112 - 119,683,717 (+)Ensembl
mRatBN7.2 Ensembl8110,791,698 - 110,805,303 (+)Ensembl
Rnor_6.0 Ensembl8119,083,900 - 119,097,707 (+)Ensembl
RefSeq Acc Id: NM_001109298   ⟹   NP_001102768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,670,112 - 119,683,717 (+)NCBI
mRatBN7.28110,791,698 - 110,805,303 (+)NCBI
Dahl_SR_JrHsd8120,556,741 - 120,570,309 (+)NCBI
Lyon_Normotensive8122,661,679 - 122,675,251 (+)NCBI
Lyon_Hypertensive8121,151,391 - 121,164,955 (+)NCBI
F344_StmMcwi8112,550,425 - 112,564,029 (+)NCBI
Rnor_6.08119,083,900 - 119,097,707 (+)NCBI
Rnor_5.08118,423,162 - 118,436,016 (+)NCBI
RGSC_v3.48115,196,265 - 115,209,775 (+)RGD
Celera8110,074,270 - 110,087,887 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401228   ⟹   NP_001388157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,670,112 - 119,674,419 (+)NCBI
mRatBN7.28110,791,698 - 110,796,005 (+)NCBI
Dahl_SR_JrHsd8120,556,741 - 120,561,038 (+)NCBI
Lyon_Normotensive8122,661,679 - 122,665,976 (+)NCBI
Lyon_Hypertensive8121,151,391 - 121,155,688 (+)NCBI
F344_StmMcwi8112,550,425 - 112,554,737 (+)NCBI
RefSeq Acc Id: XM_008766648   ⟹   XP_008764870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,670,088 - 119,674,419 (+)NCBI
mRatBN7.28110,791,890 - 110,796,005 (+)NCBI
Rnor_6.08119,084,154 - 119,088,207 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001102768   ⟸   NM_001109298
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PSW9 (UniProtKB/TrEMBL),   A6I3H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764870   ⟸   XM_008766648
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000047186   ⟸   ENSRNOT00000048655
Ensembl Acc Id: ENSRNOP00000044953   ⟸   ENSRNOT00000051947
RefSeq Acc Id: NP_001388157   ⟸   NM_001401228
- Peptide Label: isoform 1 precursor
- UniProtKB: D4A5V1 (UniProtKB/TrEMBL),   B5DF96 (UniProtKB/TrEMBL),   A6I3H1 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF96-F1-model_v2 AlphaFold B5DF96 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696341
Promoter ID:EPDNEW_R6861
Type:single initiation site
Name:Prss44_1
Description:protease, serine, 44
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,083,973 - 119,084,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560940 AgrOrtholog
BioCyc Gene G2FUF-29056 BioCyc
Ensembl Genes ENSRNOG00000030073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048655 ENTREZGENE
  ENSRNOT00000048655.7 UniProtKB/TrEMBL
  ENSRNOT00000051947 ENTREZGENE
  ENSRNOT00000051947.7 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:501060 UniProtKB/TrEMBL
NCBI Gene 501060 ENTREZGENE
PANTHER SERINE PROTEASE 42 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss44 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030073 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6I3H0 ENTREZGENE, UniProtKB/TrEMBL
  A6I3H1 ENTREZGENE, UniProtKB/TrEMBL
  B5DF96 ENTREZGENE, UniProtKB/TrEMBL
  D4A5V1 ENTREZGENE
  E9PSW9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A5V1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss44  serine protease 44  Prss44  protease, serine, 44  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560940  similar to testis specific serine proteinase 3   RGD1560940_predicted  similar to testis specific serine proteinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560940_predicted  similar to testis specific serine proteinase 3 (predicted)  LOC501060  similar to testis specific serine proteinase 3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501060  similar to testis specific serine proteinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL