Cibar2 (CBY1 interacting BAR domain containing 2) - Rat Genome Database

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Gene: Cibar2 (CBY1 interacting BAR domain containing 2) Rattus norvegicus
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Symbol: Cibar2
Name: CBY1 interacting BAR domain containing 2
RGD ID: 1560673
Description: Predicted to be involved in cilium assembly. Predicted to be located in centriole. Predicted to be active in ciliary basal body and ciliary transition zone. Orthologous to human CIBAR2 (CBY1 interacting BAR domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CBY1-interacting BAR domain-containing protein 2; Fam92b; family with sequence similarity 92, member B; LOC361423; RGD1560673; similar to FLJ44299 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,126,231 - 65,138,015 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,125,383 - 65,138,032 (-)EnsemblGRCr8
mRatBN7.21948,217,617 - 48,229,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,215,486 - 48,229,404 (-)EnsemblmRatBN7.2
Rnor_6.01953,740,763 - 53,754,738 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,743,383 - 53,754,602 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,469,023 - 64,483,509 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41950,484,967 - 50,515,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1947,471,228 - 47,484,566 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27528616  


Genomics

Comparative Map Data
Cibar2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,126,231 - 65,138,015 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,125,383 - 65,138,032 (-)EnsemblGRCr8
mRatBN7.21948,217,617 - 48,229,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,215,486 - 48,229,404 (-)EnsemblmRatBN7.2
Rnor_6.01953,740,763 - 53,754,738 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,743,383 - 53,754,602 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,469,023 - 64,483,509 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41950,484,967 - 50,515,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1947,471,228 - 47,484,566 (-)NCBICelera
Cytogenetic Map19q12NCBI
CIBAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,098,358 - 85,112,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1685,098,358 - 85,112,472 (-)Ensemblhg38GRCh38
GRCh371685,131,964 - 85,146,078 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361683,689,466 - 83,703,615 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1669,434,172 - 69,448,321 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,884,227 - 70,898,379 (-)NCBIHuRef
CHM1_11686,543,493 - 86,557,642 (-)NCBICHM1_1
T2T-CHM13v2.01691,164,997 - 91,179,113 (-)NCBIT2T-CHM13v2.0
Cibar2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,893,136 - 120,904,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,893,136 - 120,904,205 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388120,166,397 - 120,177,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8120,166,397 - 120,177,466 (-)Ensemblmm10GRCm38
MGSCv378122,690,297 - 122,701,369 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368123,052,375 - 123,063,446 (-)NCBIMGSCv36mm8
Celera8124,386,967 - 124,397,816 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map869.09NCBI
Cibar2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541478,603 - 486,046 (-)Ensembl
ChiLan1.0NW_004955541478,437 - 486,171 (-)NCBIChiLan1.0ChiLan1.0
CIBAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21894,850,546 - 94,864,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116100,767,715 - 100,781,936 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01665,768,014 - 65,782,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11685,106,709 - 85,120,815 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1685,106,709 - 85,120,815 (-)EnsemblpanPan2panpan1.1
CIBAR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1567,465,646 - 67,477,709 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl567,465,800 - 67,476,672 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha567,479,175 - 67,490,519 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0567,697,049 - 67,708,402 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl567,696,363 - 67,708,203 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1567,713,044 - 67,724,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0567,547,376 - 67,558,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0567,962,282 - 67,973,658 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cibar2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,344,243 - 27,355,629 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366413,099,616 - 3,109,969 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIBAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl63,710,213 - 3,720,198 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.163,709,429 - 3,720,199 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,283,063 - 4,293,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CIBAR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1570,511,431 - 70,525,861 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl570,511,534 - 70,525,197 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660475,217,230 - 5,233,725 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cibar2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247461,798,912 - 1,807,608 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247461,799,521 - 1,808,415 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cibar2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11739,807,580 - 39,819,149 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:90
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000035651
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 6 41 135 52 51 22 27 22 6 204 88 116 74 83 29 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000035651   ⟹   ENSRNOP00000036092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1965,125,383 - 65,138,032 (-)Ensembl
mRatBN7.2 Ensembl1948,215,486 - 48,229,404 (-)Ensembl
Rnor_6.0 Ensembl1953,743,383 - 53,754,602 (-)Ensembl
RefSeq Acc Id: XM_063278678   ⟹   XP_063134748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,126,231 - 65,138,015 (-)NCBI
RefSeq Acc Id: XR_010060265
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,128,417 - 65,132,355 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063134748 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92697 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036092
  ENSRNOP00000036092.6
Ensembl Acc Id: ENSRNOP00000036092   ⟸   ENSRNOT00000035651
RefSeq Acc Id: XP_063134748   ⟸   XM_063278678
- UniProtKB: A6IZL9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCB9-F1-model_v2 AlphaFold D3ZCB9 1-292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560673 AgrOrtholog
BioCyc Gene G2FUF-5493 BioCyc
Ensembl Genes ENSRNOG00000021714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035651 ENTREZGENE
  ENSRNOT00000035651.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  BAR_FAM92 UniProtKB/TrEMBL
  DUF1208 UniProtKB/TrEMBL
NCBI Gene 361423 ENTREZGENE
PANTHER CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  DUF1208 UniProtKB/TrEMBL
Pfam DUF1208 UniProtKB/TrEMBL
PhenoGen Cibar2 PhenoGen
RatGTEx ENSRNOG00000021714 RatGTEx
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
UniProt A6IZL9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCB9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-09 Cibar2  CBY1 interacting BAR domain containing 2  Fam92b  family with sequence similarity 92, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam92b  family with sequence similarity 92, member B  RGD1560673_predicted  similar to FLJ44299 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560673_predicted  similar to FLJ44299 protein (predicted)  LOC361423  similar to FLJ44299 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361423  similar to FLJ44299 protein      Symbol and Name status set to provisional 70820 PROVISIONAL