Tm4sf19 (transmembrane 4 L six family member 19) - Rat Genome Database

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Gene: Tm4sf19 (transmembrane 4 L six family member 19) Rattus norvegicus
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Symbol: Tm4sf19
Name: transmembrane 4 L six family member 19
RGD ID: 1560486
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in actin cytoskeleton and filopodium. Predicted to be active in membrane. Orthologous to human TM4SF19 (transmembrane 4 L six family member 19); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288044; RGD1560486; similar to hypothetical protein BC013113; transmembrane 4 L6 family member 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,876,714 - 81,899,603 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1181,877,435 - 81,888,484 (-)EnsemblGRCr8
mRatBN7.21168,372,945 - 68,386,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,210,434 - 77,221,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,875,160 - 69,886,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,899,548 - 68,910,766 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,607,735 - 71,619,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)Ensemblrn6Rnor6.0
Rnor_5.01174,692,458 - 74,703,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,189,725 - 70,201,499 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1167,805,997 - 67,817,558 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (ISO)
filopodium  (ISO)
membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tm4sf19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,876,714 - 81,899,603 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1181,877,435 - 81,888,484 (-)EnsemblGRCr8
mRatBN7.21168,372,945 - 68,386,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,210,434 - 77,221,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,875,160 - 69,886,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,899,548 - 68,910,766 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,607,735 - 71,619,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)Ensemblrn6Rnor6.0
Rnor_5.01174,692,458 - 74,703,220 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,189,725 - 70,201,499 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1167,805,997 - 67,817,558 (-)NCBICelera
Cytogenetic Map11q22NCBI
TM4SF19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,323,547 - 196,338,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,319,342 - 196,338,503 (-)Ensemblhg38GRCh38
GRCh373196,050,418 - 196,065,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,534,816 - 197,549,655 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3194,630,617 - 194,645,455 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,347,379 - 193,362,525 (-)NCBIHuRef
CHM1_13196,021,242 - 196,036,106 (-)NCBICHM1_1
T2T-CHM13v2.03199,043,086 - 199,057,713 (-)NCBIT2T-CHM13v2.0
Tm4sf19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,218,823 - 32,227,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,219,324 - 32,227,045 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381632,400,012 - 32,409,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,400,506 - 32,408,227 (+)Ensemblmm10GRCm38
MGSCv371632,400,592 - 32,408,313 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361632,189,634 - 32,197,108 (+)NCBIMGSCv36mm8
MGSCv361632,320,526 - 32,327,762 (+)NCBIMGSCv36mm8
Celera1632,884,981 - 32,892,660 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1622.66NCBI
Tm4sf19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,531,012 - 12,537,156 (-)Ensembl
ChiLan1.0NW_00495542012,532,435 - 12,558,861 (-)NCBIChiLan1.0ChiLan1.0
TM4SF19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,194,558 - 194,200,254 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,201,166 - 194,208,276 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,670,511 - 193,674,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,612,836 - 203,617,267 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,608,788 - 203,616,808 (-)EnsemblpanPan2panpan1.1
Tm4sf19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,921,081 - 124,929,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784959,921 - 964,175 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936784959,924 - 964,175 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TM4SF19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,759,539 - 133,767,956 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113133,759,122 - 133,770,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TM4SF19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,858,641 - 90,878,981 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,875,041 - 90,878,711 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604164,669,013 - 64,685,085 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tm4sf19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,484,712 - 61,487,335 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473061,484,511 - 61,487,458 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tm4sf19
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1417,214,733 - 17,226,958 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tm4sf19
653 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000002396
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 63 161 79 78 47 70 47 6 298 166 11 139 65 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002396   ⟹   ENSRNOP00000002396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1181,877,435 - 81,882,823 (-)Ensembl
mRatBN7.2 Ensembl1168,371,647 - 68,384,591 (-)Ensembl
Rnor_6.0 Ensembl1171,606,239 - 71,619,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127897   ⟹   ENSRNOP00000110069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1181,877,435 - 81,888,484 (-)Ensembl
RefSeq Acc Id: NM_001105873   ⟹   NP_001099343
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,878,436 - 81,889,646 (-)NCBI
mRatBN7.21168,373,380 - 68,384,591 (-)NCBI
Rnor_6.01171,607,735 - 71,619,108 (-)NCBI
Rnor_5.01174,692,458 - 74,703,220 (-)NCBI
RGSC_v3.41170,189,725 - 70,201,499 (-)RGD
Celera1167,805,997 - 67,817,558 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088111   ⟹   XP_038944039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,888,317 (-)NCBI
mRatBN7.21168,372,945 - 68,383,236 (-)NCBI
RefSeq Acc Id: XM_039088113   ⟹   XP_038944041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,899,603 (-)NCBI
mRatBN7.21168,372,945 - 68,386,192 (-)NCBI
RefSeq Acc Id: XM_039088115   ⟹   XP_038944043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,876,714 - 81,888,516 (-)NCBI
mRatBN7.21168,372,945 - 68,383,224 (-)NCBI
RefSeq Acc Id: NP_001099343   ⟸   NM_001105873
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002396   ⟸   ENSRNOT00000002396
RefSeq Acc Id: XP_038944041   ⟸   XM_039088113
- Peptide Label: isoform X1
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944039   ⟸   XM_039088111
- Peptide Label: isoform X1
- UniProtKB: D4ADI7 (UniProtKB/TrEMBL),   A6IRS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944043   ⟸   XM_039088115
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000110069   ⟸   ENSRNOT00000127897

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADI7-F1-model_v2 AlphaFold D4ADI7 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560486 AgrOrtholog
BioCyc Gene G2FUF-21092 BioCyc
Ensembl Genes ENSRNOG00000001757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002396 ENTREZGENE
  ENSRNOT00000002396.7 UniProtKB/TrEMBL
  ENSRNOT00000127897.1 UniProtKB/TrEMBL
InterPro L6_membrane UniProtKB/TrEMBL
KEGG Report rno:288044 UniProtKB/TrEMBL
NCBI Gene 288044 ENTREZGENE
PANTHER PTHR14198 UniProtKB/TrEMBL
  TRANSMEMBRANE 4 L6 FAMILY MEMBER 19 UniProtKB/TrEMBL
Pfam L6_membrane UniProtKB/TrEMBL
PhenoGen Tm4sf19 PhenoGen
RatGTEx ENSRNOG00000001757 RatGTEx
UniProt A0ABK0M1N8_RAT UniProtKB/TrEMBL
  A6IRS1 ENTREZGENE, UniProtKB/TrEMBL
  D4ADI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Tm4sf19  transmembrane 4 L six family member 19  RGD1560486_predicted  similar to hypothetical protein BC013113 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560486_predicted  similar to hypothetical protein BC013113 (predicted)  LOC288044  similar to hypothetical protein BC013113  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC288044  similar to hypothetical protein BC013113      Symbol and Name status set to provisional 70820 PROVISIONAL