Ercc4 (ERCC excision repair 4, endonuclease catalytic subunit) - Rat Genome Database

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Gene: Ercc4 (ERCC excision repair 4, endonuclease catalytic subunit) Rattus norvegicus
Analyze
Symbol: Ercc4
Name: ERCC excision repair 4, endonuclease catalytic subunit
RGD ID: 1560340
Description: Predicted to enable several functions, including DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Predicted to be involved in DNA metabolic process; cellular response to UV; and negative regulation of telomere maintenance. Predicted to act upstream of or within UV protection; nucleotide-excision repair; and regulation of autophagy. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH 3-aminobenzamide; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA repair endonuclease XPF; Ercc4 protein-like; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; LOC304719; RGD1560340; similar to ERCC4_MOUSE
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,926,085 - 2,958,176 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl102,920,455 - 2,955,539 (-)EnsemblGRCr8
mRatBN7.2102,416,259 - 2,448,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10954,977 - 983,174 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl102,419,038 - 2,448,369 (-)EnsemblmRatBN7.2
Rnor_6.0102,010,140 - 2,037,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl102,010,648 - 2,037,891 (-)Ensemblrn6Rnor6.0
Rnor_5.010897,883 - 925,957 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4102,144,262 - 2,177,554NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map10q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-aminobenzamide  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
GSK-J4  (ISO)
indometacin  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nimustine  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
veliparib  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inter-individual variation in nucleotide excision repair pathway is modulated by non-synonymous polymorphisms in ERCC4 and MBD4 genes. Allione A, etal., Mutat Res. 2013 Nov-Dec;751-752:49-54. doi: 10.1016/j.mrfmmm.2013.08.005. Epub 2013 Sep 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Nucleotide excision repair: new tricks with old bricks. Kamileri I, etal., Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22.
4. 1-Methyl-4-phenyl-pyridinium time-dependently alters expressions of oxoguanine glycosylase 1 and xeroderma pigmentosum group F protein in PC12 cells. Liu HM, etal., Neurosci Bull. 2010 Feb;26(1):1-7. doi: 10.1007/s12264-010-0922-3.
5. Prognostic Value of Excision Repair Cross-Complementing mRNA Expression in Gastric Cancer. Luo SS, etal., Biomed Res Int. 2018 Oct 17;2018:6204684. doi: 10.1155/2018/6204684. eCollection 2018.
6. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. McWilliams RR, etal., Cancer Res. 2008 Jun 15;68(12):4928-35. Epub 2008 Jun 10.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The multi-replication protein A (RPA) system--a new perspective. Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.
14. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Sijbers AM, etal., Cell. 1996 Sep 6;86(5):811-22.
15. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Wang C, etal., Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
16. Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy. West H, etal., JCO Precis Oncol. 2018 Nov;2:1-18. doi: 10.1200/PO.18.00090.
17. DNA repair pathway profiling and microsatellite instability in colorectal cancer. Yu J, etal., Clin Cancer Res. 2006 Sep 1;12(17):5104-11. doi: 10.1158/1078-0432.CCR-06-0547.
Additional References at PubMed
PMID:9722633   PMID:10413517   PMID:10644440   PMID:11790111   PMID:12571280   PMID:14690602   PMID:14728600   PMID:14729965   PMID:14734547   PMID:16678501   PMID:17055345   PMID:18443001  
PMID:18812185   PMID:19596235   PMID:22323595   PMID:22483113  


Genomics

Comparative Map Data
Ercc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,926,085 - 2,958,176 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl102,920,455 - 2,955,539 (-)EnsemblGRCr8
mRatBN7.2102,416,259 - 2,448,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10954,977 - 983,174 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl102,419,038 - 2,448,369 (-)EnsemblmRatBN7.2
Rnor_6.0102,010,140 - 2,037,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl102,010,648 - 2,037,891 (-)Ensemblrn6Rnor6.0
Rnor_5.010897,883 - 925,957 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4102,144,262 - 2,177,554NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map10q11NCBI
ERCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381613,920,154 - 13,952,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1613,920,138 - 13,952,348 (+)Ensemblhg38GRCh38
GRCh371614,014,011 - 14,046,205 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361613,921,524 - 13,949,705 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341613,921,523 - 13,949,705NCBI
Celera1614,189,206 - 14,221,394 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1613,931,501 - 13,963,699 (+)NCBIHuRef
CHM1_11614,013,994 - 14,046,211 (+)NCBICHM1_1
T2T-CHM13v2.01613,957,393 - 13,989,586 (+)NCBIT2T-CHM13v2.0
Ercc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391612,927,600 - 12,969,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1612,927,548 - 12,968,481 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381613,109,366 - 13,152,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,109,684 - 13,150,617 (+)Ensemblmm10GRCm38
MGSCv371613,109,829 - 13,152,102 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361613,023,314 - 13,062,312 (+)NCBIMGSCv36mm8
Celera1613,713,278 - 13,755,555 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map168.93NCBI
Ercc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,831,721 - 4,861,122 (-)Ensembl
ChiLan1.0NW_0049554424,833,453 - 4,861,201 (-)NCBIChiLan1.0ChiLan1.0
ERCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21814,450,518 - 14,488,695 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,233,313 - 18,271,502 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01612,848,334 - 12,880,480 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11614,272,417 - 14,304,496 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1614,272,417 - 14,304,496 (+)EnsemblpanPan2panpan1.1
ERCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1629,193,192 - 29,226,935 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl629,196,421 - 29,226,887 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha630,549,605 - 30,589,551 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0629,350,548 - 29,390,623 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl629,356,743 - 29,390,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1629,153,426 - 29,193,360 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0629,040,862 - 29,080,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0629,458,540 - 29,498,483 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ercc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,203,183 - 114,231,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,300,835 - 2,329,351 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,301,072 - 2,329,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl329,269,989 - 29,306,151 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1329,266,234 - 29,306,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2330,352,659 - 30,377,491 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1513,378,282 - 13,410,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl513,378,401 - 13,406,541 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606816,647,372 - 16,679,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247824,512,650 - 4,537,701 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247824,508,758 - 4,537,751 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ercc4
224 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:47
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000004563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1015893911Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004563   ⟹   ENSRNOP00000004563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl102,925,592 - 2,955,525 (-)Ensembl
mRatBN7.2 Ensembl102,419,038 - 2,448,369 (-)Ensembl
Rnor_6.0 Ensembl102,010,648 - 2,037,891 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089404   ⟹   ENSRNOP00000074477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl101,462,197 - 1,490,393 (+)Ensembl
mRatBN7.2 Ensembl10954,977 - 983,174 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103966   ⟹   ENSRNOP00000083739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl102,925,592 - 2,955,539 (-)Ensembl
mRatBN7.2 Ensembl102,419,038 - 2,448,369 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108933   ⟹   ENSRNOP00000087150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10955,010 - 969,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118820   ⟹   ENSRNOP00000083462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl102,920,455 - 2,955,539 (-)Ensembl
mRatBN7.2 Ensembl10954,977 - 970,153 (+)Ensembl
RefSeq Acc Id: XM_039087014   ⟹   XP_038942942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,926,085 - 2,958,176 (-)NCBI
mRatBN7.2102,416,259 - 2,448,364 (-)NCBI
RefSeq Acc Id: XM_039087015   ⟹   XP_038942943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,926,085 - 2,958,176 (-)NCBI
mRatBN7.2102,416,259 - 2,448,343 (-)NCBI
RefSeq Acc Id: XM_039087016   ⟹   XP_038942944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,926,085 - 2,955,386 (-)NCBI
mRatBN7.2102,416,259 - 2,448,343 (-)NCBI
RefSeq Acc Id: XM_039087017   ⟹   XP_038942945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,926,085 - 2,953,489 (-)NCBI
mRatBN7.2102,416,259 - 2,446,442 (-)NCBI
RefSeq Acc Id: XM_039087018   ⟹   XP_038942946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,926,085 - 2,942,991 (-)NCBI
mRatBN7.2102,416,259 - 2,435,939 (-)NCBI
RefSeq Acc Id: XR_005489982
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,929,830 - 2,958,176 (-)NCBI
mRatBN7.2102,422,774 - 2,448,343 (-)NCBI
RefSeq Acc Id: XR_005489983
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,933,166 - 2,958,176 (-)NCBI
mRatBN7.2102,426,101 - 2,448,343 (-)NCBI
Ensembl Acc Id: ENSRNOP00000004563   ⟸   ENSRNOT00000004563
RefSeq Acc Id: XP_038942942   ⟸   XM_039087014
- Peptide Label: isoform X1
- UniProtKB: D3ZT95 (UniProtKB/TrEMBL),   A0A0G2K855 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942944   ⟸   XM_039087016
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K855 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942943   ⟸   XM_039087015
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWK5 (UniProtKB/TrEMBL),   A0A0G2K855 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942945   ⟸   XM_039087017
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K855 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942946   ⟸   XM_039087018
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000083739   ⟸   ENSRNOT00000103966
Ensembl Acc Id: ENSRNOP00000083462   ⟸   ENSRNOT00000118820
Ensembl Acc Id: ENSRNOP00000074477   ⟸   ENSRNOT00000089404
Ensembl Acc Id: ENSRNOP00000087150   ⟸   ENSRNOT00000108933
Protein Domains
ERCC4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT95-F1-model_v2 AlphaFold D3ZT95 1-917 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560340 AgrOrtholog
BioCyc Gene G2FUF-26198 BioCyc
Ensembl Genes ENSRNOG00000048121 Ensembl
  ENSRNOG00000065745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000070542 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004563 ENTREZGENE
  ENSRNOT00000004563.8 UniProtKB/TrEMBL
  ENSRNOT00000089404.3 UniProtKB/TrEMBL
  ENSRNOT00000103966 ENTREZGENE
  ENSRNOT00000103966.2 UniProtKB/TrEMBL
  ENSRNOT00000118820.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10130 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro ERCC4_domain UniProtKB/TrEMBL
  Restrct_endonuc-II-like UniProtKB/TrEMBL
  RuvA_2-like UniProtKB/TrEMBL
  XPF UniProtKB/TrEMBL
  XPF_nuclease UniProtKB/TrEMBL
NCBI Gene 304719 ENTREZGENE
PANTHER DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
  DNA REPAIR ENDONUCLEASE XPF UniProtKB/TrEMBL
Pfam ERCC4 UniProtKB/TrEMBL
PharmGKB ERCC4 RGD
PhenoGen Ercc4 PhenoGen
RatGTEx ENSRNOG00000048121 RatGTEx
  ENSRNOG00000065745 RatGTEx
  ENSRNOG00000070542 RatGTEx
SMART ERCC4 UniProtKB/TrEMBL
Superfamily-SCOP SSF47781 UniProtKB/TrEMBL
  SSF52980 UniProtKB/TrEMBL
UniProt A0A0G2K855 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX01_RAT UniProtKB/TrEMBL
  D3ZT95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ercc4  ERCC excision repair 4, endonuclease catalytic subunit  Ercc4  ERCC excision repair 4, endonuclease catalytic subunit  Data merged from RGD:149736306 737654 PROVISIONAL
2021-08-09 Ercc4  ERCC excision repair 4, endonuclease catalytic subunit      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-06-01 Ercc4  ERCC excision repair 4, endonuclease catalytic subunit  Ercc4  excision repair cross-complementation group 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-12 Ercc4  excision repair cross-complementation group 4  Ercc4  excision repair cross-complementing rodent repair deficiency, complementation group 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Ercc4  excision repair cross-complementing rodent repair deficiency, complementation group 4  LOC100365348  Ercc4 protein-like  Data merged from RGD:2319230 1643240 APPROVED
2013-05-24 Ercc4  excision repair cross-complementing rodent repair deficiency, complementation group 4  LOC688631  similar to DNA repair endonuclease XPF (DNA excision repair protein ERCC-4)  Data merged from RGD:1586469 1643240 APPROVED
2010-05-05 LOC100365348  Ercc4 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-28 Ercc4  excision repair cross-complementing rodent repair deficiency, complementation group 4  RGD1560340_predicted  similar to ERCC4_MOUSE (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 RGD1560340_predicted  similar to ERCC4_MOUSE (predicted)  LOC683847  similar to DNA repair endonuclease XPF (DNA excision repair protein ERCC-4)  Data merged from RGD:1597832 1643240 APPROVED
2006-11-20 LOC683847  similar to DNA repair endonuclease XPF (DNA excision repair protein ERCC-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688631  similar to DNA repair endonuclease XPF (DNA excision repair protein ERCC-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1560340_predicted  similar to ERCC4_MOUSE (predicted)  LOC304719  similar to ERCC4_MOUSE  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304719  similar to ERCC4_MOUSE      Symbol and Name status set to provisional 70820 PROVISIONAL