Steap4 (STEAP4 metalloreductase) - Rat Genome Database

Name: Steap4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Steap4 (STEAP4 metalloreductase) Rattus norvegicus

Analyze

Symbol:

Steap4

Name:

STEAP4 metalloreductase

RGD ID:

1560331

Description:

Predicted to enable several functions, including FAD binding activity; heme binding activity; and oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor. Predicted to be involved in copper ion import; fat cell differentiation; and protein homotrimerization. Predicted to act upstream of or within iron import into cell. Predicted to be located in membrane and nucleoplasm. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP4 (STEAP4 metalloreductase); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ab1-219; LOC499991; metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4; STEAP family member 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STEAP4 (STEAP4 metalloreductase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Steap4 (STEAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Steap4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STEAP4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STEAP4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Steap4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STEAP4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STEAP4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Steap4 (STEAP4 metalloreductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	STEAP4 (STEAP4 metalloreductase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Steap4 (STEAP family member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	steap4 (STEAP family member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	steap4.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	steap4.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	27,032,096 - 27,054,769 (-)	NCBI		GRCr8
mRatBN7.2	4	26,077,182 - 26,099,859 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	26,054,671 - 26,099,859 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	31,062,973 - 31,085,424 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	26,989,171 - 27,011,628 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	25,366,207 - 25,388,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	23,112,682 - 23,135,354 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	23,090,029 - 23,135,354 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	23,040,108 - 23,062,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	22,688,597 - 22,711,432 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	21,558,227 - 21,580,908 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

andrographolide (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cocaine (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diallyl disulfide (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

diethyl maleate (ISO)

endosulfan (EXP)

flutamide (EXP)

fructose (EXP)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glycidyl methacrylate (ISO)

Heliotrine (EXP)

inulin (ISO)

iron atom (ISO)

iron(0) (ISO)

lead diacetate (EXP,ISO)

lead(0) (ISO)

Licochalcone B (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

methidathion (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Muraglitazar (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

Platyphylline (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

senecionine (EXP,ISO)

Senkirkine (EXP)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

Tesaglitazar (EXP)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tremolite asbestos (ISO)

tributylstannane (ISO)

triphenyl phosphate (EXP)

troglitazone (EXP,ISO)

vinclozolin (EXP)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

copper ion import (IBA,IEA,ISO)

fat cell differentiation (ISO,ISS)

iron import into cell (ISO)

iron ion transport (IEA)

protein homotrimerization (ISO)

Cellular Component

early endosome membrane (IEA)

endosome (IBA,ISO)

endosome membrane (IEA)

Golgi membrane (IEA)

membrane (ISO)

nucleoplasm (IEA,ISO)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

cupric reductase activity (IBA,IEA,ISO)

electron transfer activity (ISO)

FAD binding (ISO)

ferric-chelate reductase (NADPH) activity (IBA,IEA,ISO)

heme binding (ISO)

metal ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11443137	PMID:16609065	PMID:23533145	PMID:23733181	PMID:30337524	PMID:34583195

Genomics

Comparative Map Data

Steap4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	27,032,096 - 27,054,769 (-)	NCBI		GRCr8
mRatBN7.2	4	26,077,182 - 26,099,859 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	26,054,671 - 26,099,859 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	31,062,973 - 31,085,424 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	26,989,171 - 27,011,628 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	25,366,207 - 25,388,643 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	23,112,682 - 23,135,354 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	23,090,029 - 23,135,354 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	23,040,108 - 23,062,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	22,688,597 - 22,711,432 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	21,558,227 - 21,580,908 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI

STEAP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	88,270,892 - 88,306,894 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	88,270,892 - 88,306,894 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	87,900,207 - 87,936,209 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	87,743,680 - 87,774,145 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	87,552,405 - 87,580,857	NCBI
Celera	7	82,610,349 - 82,640,811 (-)	NCBI		Celera
Cytogenetic Map	7	q21.12	NCBI
HuRef	7	82,516,141 - 82,546,083 (-)	NCBI		HuRef
CHM1_1	7	87,836,261 - 87,866,753 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	89,521,348 - 89,557,349 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	87,237,102 - 87,267,587 (-)	NCBI

Steap4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	8,010,472 - 8,032,213 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	8,010,457 - 8,032,213 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	7,960,472 - 7,982,213 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	7,960,457 - 7,982,213 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	7,960,472 - 7,982,213 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	7,966,478 - 7,988,219 (+)	NCBI		MGSCv36	mm8
Celera	5	7,894,149 - 7,915,890 (+)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	3.37	NCBI

Steap4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	5,618,086 - 5,641,565 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	5,618,086 - 5,641,372 (-)	NCBI	ChiLan1.0	ChiLan1.0

STEAP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	106,147,728 - 106,186,805 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	154,412,366 - 154,451,373 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	80,263,528 - 80,299,470 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	93,918,320 - 93,948,754 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	93,918,327 - 93,948,754 (-)	Ensembl	panpan1.1		panPan2

STEAP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	14,319,895 - 14,345,719 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	14,321,757 - 14,327,720 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	13,892,008 - 13,917,634 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	14,131,025 - 14,155,283 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	14,129,628 - 14,155,148 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	14	14,085,062 - 14,111,604 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	14,295,085 - 14,320,670 (-)	NCBI		UMICH_Zoey_3.1

Steap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	27,329,679 - 27,355,494 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936763	645,858 - 670,863 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936763	645,910 - 671,674 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STEAP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	68,546,465 - 68,570,424 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	68,549,142 - 68,570,350 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	74,984,352 - 75,005,812 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STEAP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	60,653,504 - 60,680,414 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	60,653,454 - 60,680,323 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	43,423,109 - 43,451,475 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Steap4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	5,084,814 - 5,103,980 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624809	5,084,992 - 5,103,765 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Steap4
144 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	667
Count of miRNA genes:	296
Interacting mature miRNAs:	378
Transcripts:	ENSRNOT00000011432, ENSRNOT00000048061
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	21333343	39505420	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21333343	44463908	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	22710685	34430484	Rat

Markers in Region

D4Got252

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	26,080,896 - 26,081,067 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	23,116,396 - 23,116,566	NCBI	Rnor6.0
Rnor_5.0	4	23,043,822 - 23,043,992	UniSTS	Rnor5.0
RGSC_v3.4	4	22,692,474 - 22,692,644	UniSTS	RGSC3.4
Celera	4	21,561,941 - 21,562,111	UniSTS
Cytogenetic Map	4	q12	UniSTS

RH127944

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	26,077,308 - 26,077,518 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	23,112,809 - 23,113,018	NCBI	Rnor6.0
Rnor_5.0	4	23,040,235 - 23,040,444	UniSTS	Rnor5.0
RGSC_v3.4	4	22,688,724 - 22,688,933	UniSTS	RGSC3.4
Celera	4	21,558,354 - 21,558,563	UniSTS
RH 3.4 Map	4	167.0	UniSTS
Cytogenetic Map	4	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		14	33	23	7	23	8	11		13	9	9	8
Low	3	19	20	14	12	14			28	18	22	2
Below cutoff		10	4	4		4			36	4	9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY325154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000011432 ⟹ ENSRNOP00000011432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	26,077,186 - 26,099,859 (-)	Ensembl
Rnor_6.0 Ensembl	4	23,112,686 - 23,135,354 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000048061 ⟹ ENSRNOP00000040139

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	26,054,671 - 26,099,859 (-)	Ensembl
Rnor_6.0 Ensembl	4	23,090,029 - 23,119,005 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089086 ⟹ ENSRNOP00000073833

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	26,079,566 - 26,099,859 (-)	Ensembl
Rnor_6.0 Ensembl	4	23,115,749 - 23,122,725 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117302 ⟹ ENSRNOP00000077113

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	26,077,264 - 26,099,859 (-)	Ensembl

RefSeq Acc Id:

NM_001044265 ⟹ NP_001037730

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	27,032,096 - 27,054,769 (-)	NCBI
mRatBN7.2	4	26,077,182 - 26,099,859 (-)	NCBI
Rnor_6.0	4	23,112,682 - 23,135,354 (-)	NCBI
Rnor_5.0	4	23,040,108 - 23,062,780 (-)	NCBI
RGSC_v3.4	4	22,688,597 - 22,711,432 (-)	RGD
Celera	4	21,558,227 - 21,580,908 (-)	RGD

Sequence:

show sequence

CTTAAAGGCGAGAGCCTGGAGCCGTCGCAGAGCACAGGCTGCCTACCTCACTCTACAAAGCTAA
AGGGCAGAGCCCACCAGCAGCTGCGTGCGCCAGACCAACGGCCCTCCGGGGACCTCCCGCAGTA
ATGGAGAAGACGTGTGCAGATGAGTTTCCTCTGACTGTGGATTCCTCAGAAAAGCAAGGCGTTG
TCTGCATTTTCGGAACAGGGGATTTCGGGAAATCATTGGGGTTGAAAATGCTTCAGTGTGGCTA
TTCTGTTGTTTTCGGGAGTCGAAACCCCCAGGTATCCAGCCTTCTGCCCAGGGGAGCAGAGGTC
CTGTGCTACTCAGAAGCAGCATCGAGGTCTGACGTCATAGTCCTGGCCGTGCACAGAGAGCATT
ATGATTTCCTCGCAGAATTAGCTGATTCTCTCAAAGGAAGAGTATTGATAGATGTCAGTAACAA
CCAAAAAATGAATCAGTATCCAGAATCAAACGCCGAGTACCTTGCTCAGCTGGTACCAGGAGCC
CACGTGGTCAAGGCATTTAACACCATCTCAGCCTGGGCTCTCCAGTCAGGAACACTAGATGCAA
GTCGGCAGGTGTTTGTCTGTGGAAATGACAGCAAAGCCAAGGACAGAGTGATGGACATTGCTCG
CACTCTTGGGCTCACTCCACTGGATCAAGGATCTCTCGTGGCAGCCAAGGAAATTGAAAACTAC
CCTCTGCAACTATTTCCCATGTGGAGGTTCCCTTTCTACTTGTCCTCTGGGCTGTGCGTCTTCT
TCTTTGTGTACTGCGCTATACGGGAAGTGATATACCCCTACGTGACTGGGAAGACAGATAGTAC
GTACCGCCTGGTTGTTTCCATCCCGAATCGTGTCTTTCCTATAACAGCACTTACCCTGCTGGCG
TTGGTGTACCTCCCTGGTATTCTCGCCGCCATTTTGCAGCTCTACCGAGGCACAAAGTACCGCC
GATTCCCAAACTGGCTTGACCATTGGATGCTTTGCAGAAAGCAACTGGGCTTGGTAGCTCTGGG
ATTTGCCTTCCTTCACGCCATCTACACCCTTGTGATTCCTATTCGTTACTACGTACGATGGAGG
CTGAGAAACGCGACCATTACTCAGGCCCTAACTAATAAAGACAGCCCATTCAGTTCCTCTACTG
CCTGGCTCAGTGATTCCTATCTGGCCCTGGGAATTCTGGGATTTTTTCTGTTTCTTCTCTTGGG
AATCACTTCCTTGCCATCAGTAAGCAACATGGTCAACTGGAGAGAGTTCCGGTTTGTCCAGTCC
AAACTGGGTTATCTGACCCTGGTCTTGTGCACAGCCCACACTTTGGTGTATGGTGGAAAGAGAT
TCCTCAGCCCTTCAATTCTAATATGGAGCCTTCCTTCAGCCTATATTCTGGCGCTCATCATCCC
CTGCACAGTGTTGGTGATGAAGTTTATCCTCATCATGCCGTGCATAGACAAGACCCTCACGCGC
ATCCGCCAGGGCTGGGAAAGGAAGTCAAAATATGCACAATCAACACTGAACGGAAAATCGGATA
TTTAAAATACGGTTGAATTTGCTGGGATTTCTGTACTACCTGTAGTGAGCGTTTAGAGCATAAC
GTGTCCAGTTACAAAAAAGCAATTTCTTGCGTCGTGGTCCTAAGTTCATCATCACGGAAGGACA
TGTTGCCTGACTCTGAAAGACGACCAGAATAGCAAGGGAGCACTGGTTACCTGAGTCATGTGAT
GACTCACCTCAGGCCTCCCTCACTTCCTTTCCCAGAAACCCCAGAGATGCCACCATGATTAGAT
TTACAGTTTCGTACTGCGAAGCTTCTTGATTTGGGCAACGTGCCTGACTTTTGAAGAGCTCCGG
AAGAGTGTGTGCAACTTCCTTCTCTAATTCAAGGGCTGTTGTAAGTGAAAAAACAACACTGTGG
TCATGCTAAAGATTTTGCTTGGCTTGCCCATACTGATCTGGGGGTATTCAGGGTTTGGCTGTAG
TGCTGAGCTCAAACCTAGAGCCTTATACATGAGCTACATACACCCCAGTCCTGCCATAGTGAGT
ATGTAGTCATGTGTACCCCTTAATTTTGCTTTCTACCAATATGGATAGTATGGGGAAGTATTTT
ATACTGCAACAAAAATATAACAATTGGTTTGAAGTAACCGTTCTTTGGATATATGAAATGCTAT
GTAATTGTCACAAGATCCTTCCTCTATAAGGGACGGCTTGAGGGGAGGTGGGGTAAGAGTTGAG
CTATCCTAAGTCGAGGGAAGATGGGGAAAGAGTGGAAGATCCATTGGGGTTTTCAAGTGCCATA
AGCAGAGAAGGGTTGATAACGGCCTTGTACAGAAATGTCAAATAACCCAGAATTTTAGCTAGTA
AGTAAGCAGATACAATAGAGTTTCACTATGCCGTTTGGTATCATTTAGGGGTCGTGGTGTGTTT
CCTGCATTATACATTTCAGATACTGTCCAGTATTAAGCATCTGTGAAATTAACTTCTAGTATAA
ACATGTAGCTTCCATAATCTGTCTTTGTTATCATTGTAAATGGTGCAGTTAAAGGGAATCATCT
GAAATCGTCGGTGCGAGGAGAAGATAGCTCAGAGAATTGTGGGACGCTGGGAAGAGGCGAGCGG
CAGTGAATCGGAAGCAACCGGCTCTGGCTTCCGGTGTGGATAGTGTCTTTCCCAAGGTGACCTT
CAGCAGGCTGAACACCCCTAGCTCCAGCTTGGAGCTAAAAGGAGATTTTTTGCATAATCTTCCC
ACGTGTCACTGAAATAAGGAAAAGGCATCGGGTTTGATATTTTTCTGCCTAATCCACAAAGGCT
GTTTTATTTTTCATTTTGCTAACTTTTATATCACACATCGCGTACACGATATCATACATTACAC
ACAATACAGGGATTTTTATGCAAAGCTCTTATGTAACACAGACATTTATTTTTACTATTGCCCT
AATAGATCACGCAGACCATATTCAGTTTTCACTAAGAGGACAGTTGAGGTAATGTCTTTGTACT
AACAAAATATTTCTGTATTTTCAATTATTTCCTTGGAATATTTTCCAAGAGTTAATAAAATTAA
AGAGTATTTGATAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001037730	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97353	(Get FASTA)	NCBI Sequence Viewer
	AAP92555	(Get FASTA)	NCBI Sequence Viewer
	EDL84328	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011432
	ENSRNOP00000011432.4
	ENSRNOP00000040139.2
	ENSRNOP00000073833.2
	ENSRNOP00000077113.1
	ENSRNOP00065024041
GenBank Protein	Q4V8K1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001037730 ⟸ NM_001044265

- UniProtKB:

Q4V8K1 (UniProtKB/Swiss-Prot), A6K246 (UniProtKB/TrEMBL), A0A8I5Y5X8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEKTCADEFPLTVDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSVVFGSRNPQVSSLLPRGAEV
LCYSEAASRSDVIVLAVHREHYDFLAELADSLKGRVLIDVSNNQKMNQYPESNAEYLAQLVPGA
HVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKDRVMDIARTLGLTPLDQGSLVAAKEIENY
PLQLFPMWRFPFYLSSGLCVFFFVYCAIREVIYPYVTGKTDSTYRLVVSIPNRVFPITALTLLA
LVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHAIYTLVIPIRYYVRWR
LRNATITQALTNKDSPFSSSTAWLSDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQS
KLGYLTLVLCTAHTLVYGGKRFLSPSILIWSLPSAYILALIIPCTVLVMKFILIMPCIDKTLTR
IRQGWERKSKYAQSTLNGKSDI

hide sequence

RefSeq Acc Id:

ENSRNOP00000073833 ⟸ ENSRNOT00000089086

RefSeq Acc Id:

ENSRNOP00000040139 ⟸ ENSRNOT00000048061

RefSeq Acc Id:

ENSRNOP00000011432 ⟸ ENSRNOT00000011432

RefSeq Acc Id:

ENSRNOP00000077113 ⟸ ENSRNOT00000117302

Protein Domains

Ferric oxidoreductase Pyrroline-5-carboxylate reductase catalytic N-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8K1-F1-model_v2	AlphaFold	Q4V8K1	1-470	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692834

Promoter ID:

EPDNEW_R3357

Type:

single initiation site

Name:

Steap4_1

Description:

STEAP4 metalloreductase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	23,135,325 - 23,135,385	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560331	AgrOrtholog
BioCyc Gene	G2FUF-45815	BioCyc
Ensembl Genes	ENSRNOG00000008602	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00065018061	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011432	ENTREZGENE
	ENSRNOT00000011432.7	UniProtKB/Swiss-Prot
	ENSRNOT00000048061.5	UniProtKB/TrEMBL
	ENSRNOT00000089086.2	UniProtKB/TrEMBL
	ENSRNOT00000117302.1	UniProtKB/TrEMBL
	ENSRNOT00065030258	UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7387686	IMAGE-MGC_LOAD
InterPro	Fe3_Rdtase_TM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:499991	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:114383	IMAGE-MGC_LOAD
NCBI Gene	499991	ENTREZGENE
PANTHER	DUDULIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	METALLOREDUCTASE STEAP4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ferric_reduct	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Steap4	PhenoGen
RatGTEx	ENSRNOG00000008602	RatGTEx
	ENSRNOG00065018061	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K6J0_RAT	UniProtKB/TrEMBL
	A0A8I5Y5X8	ENTREZGENE, UniProtKB/TrEMBL
	A6K246	ENTREZGENE, UniProtKB/TrEMBL
	Q4V8K1	ENTREZGENE
	Q7TP88_RAT	UniProtKB/TrEMBL
	STEA4_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Steap4	STEAP4 metalloreductase	Steap4	STEAP family member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Steap4	STEAP family member 4	LOC499991	Ab1-219	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC499991	Ab1-219			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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