Steap4 (STEAP4 metalloreductase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Steap4 (STEAP4 metalloreductase) Heterocephalus glaber
Analyze
Symbol: Steap4
Name: STEAP4 metalloreductase
RGD ID: 18913751
Description: ENCODES a protein that exhibits cupric reductase activity (inferred); electron transfer activity (inferred); FAD binding (inferred); INVOLVED IN copper ion import (ortholog); iron import into cell (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metalloreductase STEAP4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248095,084,814 - 5,103,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248095,084,992 - 5,103,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Steap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248095,084,814 - 5,103,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248095,084,992 - 5,103,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
STEAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38788,270,892 - 88,306,894 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl788,270,892 - 88,306,894 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,900,207 - 87,936,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36787,743,680 - 87,774,145 (-)NCBINCBI36Build 36hg18NCBI36
Build 34787,552,405 - 87,580,857NCBI
Celera782,610,349 - 82,640,811 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef782,516,141 - 82,546,083 (-)NCBIHuRef
CHM1_1787,836,261 - 87,866,753 (-)NCBICHM1_1
T2T-CHM13v2.0789,521,348 - 89,557,349 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2787,237,102 - 87,267,587 (-)NCBI
Steap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,010,472 - 8,032,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,010,457 - 8,032,213 (+)EnsemblGRCm39 Ensembl
GRCm3857,960,472 - 7,982,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl57,960,457 - 7,982,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv3757,960,472 - 7,982,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3657,966,478 - 7,988,219 (+)NCBIMGSCv36mm8
Celera57,894,149 - 7,915,890 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.37NCBI
Steap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8427,032,096 - 27,054,769 (-)NCBIGRCr8
mRatBN7.2426,077,182 - 26,099,859 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl426,054,671 - 26,099,859 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx431,062,973 - 31,085,424 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,989,171 - 27,011,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0425,366,207 - 25,388,643 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0423,112,682 - 23,135,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl423,090,029 - 23,135,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0423,040,108 - 23,062,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,688,597 - 22,711,432 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera421,558,227 - 21,580,908 (-)NCBICelera
Cytogenetic Map4q12NCBI
Steap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554325,618,086 - 5,641,565 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554325,618,086 - 5,641,372 (-)NCBIChiLan1.0ChiLan1.0
STEAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26106,147,728 - 106,186,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17154,412,366 - 154,451,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0780,263,528 - 80,299,470 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,918,320 - 93,948,754 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,918,327 - 93,948,754 (-)Ensemblpanpan1.1panPan2
STEAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11414,319,895 - 14,345,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1414,321,757 - 14,327,720 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,892,008 - 13,917,634 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01414,131,025 - 14,155,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1414,129,628 - 14,155,148 (-)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl1414,085,062 - 14,111,604 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11414,295,085 - 14,320,670 (-)NCBIUMICH_Zoey_3.1
Steap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511827,329,679 - 27,355,494 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936763645,858 - 670,863 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936763645,910 - 671,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STEAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl968,546,465 - 68,570,424 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1968,549,142 - 68,570,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,984,352 - 75,005,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STEAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12160,653,504 - 60,680,414 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2160,653,454 - 60,680,323 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604243,423,109 - 43,451,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000006094   ⟹   ENSHGLP00000006020
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248095,084,814 - 5,103,980 (+)Ensembl
RefSeq Acc Id: XM_004862403   ⟹   XP_004862460
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248095,084,992 - 5,103,765 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862460 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006020
  ENSHGLP00100003332
GenBank Protein JAN96730 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004862460   ⟸   XM_004862403
- UniProtKB: A0A0P6J0P2 (UniProtKB/TrEMBL),   G5C4X9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000006020   ⟸   ENSHGLT00000006094


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004401 Ensembl, ENTREZGENE
  ENSHGLG00100002540 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000006094 ENTREZGENE
  ENSHGLT00100003391 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P5C_Rdtase_cat_N UniProtKB/TrEMBL
KEGG Report hgl:101704516 UniProtKB/TrEMBL
NCBI Gene Steap4 ENTREZGENE
PANTHER DUDULIN-RELATED UniProtKB/TrEMBL
  METALLOREDUCTASE STEAP4 UniProtKB/TrEMBL
Pfam F420_oxidored UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A0P6J0P2 ENTREZGENE, UniProtKB/TrEMBL
  G5C4X9 ENTREZGENE, UniProtKB/TrEMBL