Tmtc4 (transmembrane O-mannosyltransferase targeting cadherins 4) - Rat Genome Database

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Gene: Tmtc4 (transmembrane O-mannosyltransferase targeting cadherins 4) Rattus norvegicus
Analyze
Symbol: Tmtc4
Name: transmembrane O-mannosyltransferase targeting cadherins 4
RGD ID: 1560183
Description: Predicted to enable ATPase binding activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein O-linked glycosylation via mannose. Predicted to act upstream of or within outer hair cell apoptotic process; positive regulation of endoplasmic reticulum calcium ion concentration; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human TMTC4 (transmembrane O-mannosyltransferase targeting cadherins 4); INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290501; RGD1560183; similar to hypothetical protein FLJ14624; transmembrane and tetratricopeptide repeat containing 4; transmembrane and TPR repeat-containing protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,406,795 - 106,463,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15106,407,597 - 106,463,210 (-)EnsemblGRCr8
mRatBN7.215100,000,157 - 100,056,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,000,152 - 100,056,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15103,934,395 - 103,989,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,033,002 - 105,088,315 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,960,254 - 102,015,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd15105,480,532 - 105,536,059 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive15104,565,581 - 104,621,098 (-)NCBILyon_Normotensive
Lyon_Hypertensive15105,357,049 - 105,412,566 (-)NCBILyon_Hypertensive
F344_StmMcwi15103,341,585 - 103,396,902 (-)NCBIF344_StmMcwi
Rnor_6.015109,338,762 - 109,394,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,339,564 - 109,394,927 (-)Ensemblrn6Rnor6.0
Rnor_5.015112,719,672 - 112,776,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415108,061,644 - 108,118,409 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1598,771,432 - 98,822,061 (-)NCBICelera
Cytogenetic Map15q25NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IBA,IEA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:28973932   PMID:30188326  


Genomics

Comparative Map Data
Tmtc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,406,795 - 106,463,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15106,407,597 - 106,463,210 (-)EnsemblGRCr8
mRatBN7.215100,000,157 - 100,056,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,000,152 - 100,056,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15103,934,395 - 103,989,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,033,002 - 105,088,315 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,960,254 - 102,015,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd15105,480,532 - 105,536,059 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive15104,565,581 - 104,621,098 (-)NCBILyon_Normotensive
Lyon_Hypertensive15105,357,049 - 105,412,566 (-)NCBILyon_Hypertensive
F344_StmMcwi15103,341,585 - 103,396,902 (-)NCBIF344_StmMcwi
Rnor_6.015109,338,762 - 109,394,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,339,564 - 109,394,927 (-)Ensemblrn6Rnor6.0
Rnor_5.015112,719,672 - 112,776,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415108,061,644 - 108,118,409 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1598,771,432 - 98,822,061 (-)NCBICelera
Cytogenetic Map15q25NCBI
TMTC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813100,603,625 - 100,675,075 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13100,603,625 - 100,675,633 (-)Ensemblhg38GRCh38
GRCh3713101,255,879 - 101,327,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,054,091 - 100,125,104 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1382,100,323 - 82,171,290 (-)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1381,852,124 - 81,922,919 (-)NCBIHuRef
CHM1_113101,226,332 - 101,297,360 (-)NCBICHM1_1
T2T-CHM13v2.01399,818,881 - 99,890,298 (-)NCBIT2T-CHM13v2.0
Tmtc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,156,383 - 123,220,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14123,156,383 - 123,221,447 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3814122,918,971 - 122,983,285 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,918,971 - 122,984,035 (-)Ensemblmm10GRCm38
MGSCv3714123,318,197 - 123,382,483 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614122,054,155 - 122,118,441 (-)NCBIMGSCv36mm8
Celera14121,477,235 - 121,541,523 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1466.04NCBI
Tmtc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,213,186 - 10,266,116 (+)Ensembl
ChiLan1.0NW_00495540410,213,186 - 10,266,581 (+)NCBIChiLan1.0ChiLan1.0
TMTC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,128,729 - 102,198,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113100,796,197 - 100,866,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01381,771,668 - 81,841,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113100,910,362 - 100,976,186 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13100,910,277 - 100,976,164 (-)EnsemblpanPan2panpan1.1
TMTC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,483,799 - 50,554,421 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,485,190 - 50,555,587 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2250,263,878 - 50,334,503 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02250,925,991 - 50,996,638 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2250,926,526 - 50,996,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,572,800 - 50,643,346 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,609,172 - 50,673,857 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,646,448 - 50,717,077 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmtc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945185,837,799 - 185,889,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647210,062,827 - 10,113,238 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647210,062,811 - 10,114,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMTC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,361,229 - 69,443,039 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11169,361,219 - 69,442,769 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,623,518 - 76,705,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMTC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,228,673 - 79,299,249 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl379,228,571 - 79,293,006 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604635,737,161 - 35,806,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmtc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479310,588,037 - 10,641,260 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479310,587,703 - 10,640,634 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmtc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1121,918,364 - 1,974,522 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:151
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000019602
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat

Markers in Region
C87317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,000,464 - 100,000,605 (+)MAPPERmRatBN7.2
Rnor_6.015109,339,070 - 109,339,210NCBIRnor6.0
Rnor_5.015112,719,980 - 112,720,120UniSTSRnor5.0
RGSC_v3.415108,061,124 - 108,061,264UniSTSRGSC3.4
Celera1598,770,938 - 98,771,078UniSTS
Cytogenetic Map15q25UniSTS
UniSTS:237258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,000,959 - 100,001,172 (+)MAPPERmRatBN7.2
Rnor_6.015109,339,565 - 109,339,777NCBIRnor6.0
Rnor_5.015112,720,475 - 112,720,687UniSTSRnor5.0
RGSC_v3.415108,061,645 - 108,061,857UniSTSRGSC3.4
Celera1598,771,433 - 98,771,645UniSTS
Cytogenetic Map15q25UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 150 248 91 90 65 137 59 22 483 329 11 227 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019602   ⟹   ENSRNOP00000019602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,407,597 - 106,463,190 (-)Ensembl
mRatBN7.2 Ensembl15100,000,152 - 100,056,543 (-)Ensembl
Rnor_6.0 Ensembl15109,339,564 - 109,394,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078424   ⟹   ENSRNOP00000074035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,407,841 - 106,463,190 (-)Ensembl
mRatBN7.2 Ensembl15100,001,203 - 100,056,543 (-)Ensembl
Rnor_6.0 Ensembl15109,339,611 - 109,394,927 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097482   ⟹   ENSRNOP00000092219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15106,407,597 - 106,463,210 (-)Ensembl
mRatBN7.2 Ensembl15100,000,152 - 100,056,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104716   ⟹   ENSRNOP00000090051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,000,152 - 100,056,004 (-)Ensembl
RefSeq Acc Id: NM_001134414   ⟹   NP_001127886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,407,597 - 106,463,143 (-)NCBI
mRatBN7.215100,000,959 - 100,056,507 (-)NCBI
Dahl_SR_JrHsd15105,480,532 - 105,536,059 (-)NCBI
Lyon_Normotensive15104,565,581 - 104,621,098 (-)NCBI
Lyon_Hypertensive15105,357,049 - 105,412,566 (-)NCBI
F344_StmMcwi15103,341,585 - 103,396,902 (-)NCBI
Rnor_6.015109,339,564 - 109,394,905 (-)NCBI
Rnor_5.015112,719,672 - 112,776,171 (-)NCBI
RGSC_v3.415108,061,644 - 108,118,409 (-)RGD
Celera1598,771,432 - 98,822,061 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252523   ⟹   XP_006252585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,463,153 (-)NCBI
mRatBN7.215100,000,157 - 100,056,393 (-)NCBI
Rnor_6.015109,338,762 - 109,394,832 (-)NCBI
Rnor_5.015112,719,672 - 112,776,171 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252524   ⟹   XP_006252586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,463,058 (-)NCBI
mRatBN7.215100,000,157 - 100,056,395 (-)NCBI
Rnor_6.015109,338,762 - 109,394,832 (-)NCBI
Rnor_5.015112,719,672 - 112,776,171 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093206   ⟹   XP_038949134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,462,565 (-)NCBI
mRatBN7.215100,000,157 - 100,055,932 (-)NCBI
RefSeq Acc Id: XM_039093207   ⟹   XP_038949135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,463,226 (-)NCBI
mRatBN7.215100,000,157 - 100,056,573 (-)NCBI
RefSeq Acc Id: XM_039093208   ⟹   XP_038949136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,458,271 (-)NCBI
mRatBN7.215100,000,157 - 100,056,521 (-)NCBI
RefSeq Acc Id: XM_063274179   ⟹   XP_063130249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,406,795 - 106,462,567 (-)NCBI
RefSeq Acc Id: NP_001127886   ⟸   NM_001134414
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252586   ⟸   XM_006252524
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252585   ⟸   XM_006252523
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADK7 (UniProtKB/TrEMBL),   A0A8I6AB18 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019602   ⟸   ENSRNOT00000019602
Ensembl Acc Id: ENSRNOP00000074035   ⟸   ENSRNOT00000078424
RefSeq Acc Id: XP_038949135   ⟸   XM_039093207
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949136   ⟸   XM_039093208
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949134   ⟸   XM_039093206
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090051   ⟸   ENSRNOT00000104716
Ensembl Acc Id: ENSRNOP00000092219   ⟸   ENSRNOT00000097482
RefSeq Acc Id: XP_063130249   ⟸   XM_063274179
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB18 (UniProtKB/TrEMBL)
Protein Domains
DUF1736

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K726-F1-model_v2 AlphaFold A0A0G2K726 1-799 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699886
Promoter ID:EPDNEW_R10410
Type:initiation region
Name:Tmtc4_1
Description:transmembrane and tetratricopeptide repeat containing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015109,394,920 - 109,394,980EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560183 AgrOrtholog
BioCyc Gene G2FUF-12334 BioCyc
BioCyc Pathway PWY-7922 [protein O-mannosylation II (mammals, core M1 and core M2)] BioCyc
  PWY-7979 [protein O-mannosylation III (mammals, core M3)] BioCyc
BioCyc Pathway Image PWY-7922 BioCyc
  PWY-7979 BioCyc
Ensembl Genes ENSRNOG00000014310 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019602 ENTREZGENE
  ENSRNOT00000019602.9 UniProtKB/TrEMBL
  ENSRNOT00000078424.3 UniProtKB/TrEMBL
  ENSRNOT00000097482 ENTREZGENE
  ENSRNOT00000097482.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933541 IMAGE-MGC_LOAD
InterPro DUF1736 UniProtKB/TrEMBL
  O-mannosyl-transferase_TMTC UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
MGC_CLONE MGC:188439 IMAGE-MGC_LOAD
NCBI Gene 290501 ENTREZGENE
PANTHER PROTEIN O-MANNOSYL-TRANSFERASE TMTC4 UniProtKB/TrEMBL
  PTHR44227 UniProtKB/TrEMBL
Pfam DUF1736 UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_17 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PhenoGen Tmtc4 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014310 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A0G2K726_RAT UniProtKB/TrEMBL
  A0A8I6AB18 ENTREZGENE
  A0A8I6ADK7 ENTREZGENE, UniProtKB/TrEMBL
  B2RYC0_RAT UniProtKB/TrEMBL
  F1MAQ6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tmtc4  transmembrane O-mannosyltransferase targeting cadherins 4  Tmtc4  transmembrane and tetratricopeptide repeat containing 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Tmtc4  transmembrane and tetratricopeptide repeat containing 4  RGD1560183_predicted  similar to hypothetical protein FLJ14624 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560183_predicted  similar to hypothetical protein FLJ14624 (predicted)  LOC290501  similar to hypothetical protein FLJ14624  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290501  similar to hypothetical protein FLJ14624      Symbol and Name status set to provisional 70820 PROVISIONAL