Tmtc4 (transmembrane O-mannosyltransferase targeting cadherins 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tmtc4 (transmembrane O-mannosyltransferase targeting cadherins 4) Chinchilla lanigera
Analyze
Symbol: Tmtc4
Name: transmembrane O-mannosyltransferase targeting cadherins 4
RGD ID: 8955098
Description: ENCODES a protein that exhibits ATPase binding (ortholog); dolichyl-phosphate-mannose-protein mannosyltransferase activity (ortholog); INVOLVED IN endoplasmic reticulum unfolded protein response (ortholog); outer hair cell apoptotic process (ortholog); positive regulation of endoplasmic reticulum calcium ion concentration (ortholog); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); Autosomal Recessive Nonsyndromic Deafness 122 (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane and tetratricopeptide repeat containing 4; transmembrane and TPR repeat-containing protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,213,186 - 10,266,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540410,213,186 - 10,266,581 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tmtc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,213,186 - 10,266,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540410,213,186 - 10,266,581 (+)NCBIChiLan1.0ChiLan1.0
TMTC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813100,603,625 - 100,675,075 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13100,603,625 - 100,675,093 (-)EnsemblGRCh38hg38GRCh38
GRCh3713101,255,879 - 101,327,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,054,091 - 100,125,104 (-)NCBINCBI36Build 36hg18NCBI36
Celera1382,100,323 - 82,171,290 (-)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1381,852,124 - 81,922,919 (-)NCBIHuRef
CHM1_113101,226,332 - 101,297,360 (-)NCBICHM1_1
T2T-CHM13v2.01399,818,881 - 99,890,298 (-)NCBIT2T-CHM13v2.0
Tmtc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,156,383 - 123,220,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14123,156,383 - 123,221,447 (-)EnsemblGRCm39 Ensembl
GRCm3814122,918,971 - 122,983,285 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,918,971 - 122,984,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714123,318,197 - 123,382,483 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614122,054,155 - 122,118,441 (-)NCBIMGSCv36mm8
Celera14121,477,235 - 121,541,523 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1466.04NCBI
Tmtc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,406,795 - 106,463,226 (-)NCBIGRCr8
mRatBN7.215100,000,157 - 100,056,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,000,152 - 100,056,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15103,934,395 - 103,989,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,033,002 - 105,088,315 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,960,254 - 102,015,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015109,338,762 - 109,394,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,339,564 - 109,394,927 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015112,719,672 - 112,776,171 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,061,644 - 108,118,409 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1598,771,432 - 98,822,061 (-)NCBICelera
Cytogenetic Map15q25NCBI
TMTC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,128,729 - 102,198,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113100,796,197 - 100,866,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01381,771,668 - 81,841,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113100,910,362 - 100,976,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13100,910,277 - 100,976,164 (-)Ensemblpanpan1.1panPan2
TMTC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,483,799 - 50,554,421 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,485,190 - 50,555,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2250,263,878 - 50,334,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02250,925,991 - 50,996,638 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2250,926,526 - 50,996,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,572,800 - 50,643,346 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,609,172 - 50,673,857 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,646,448 - 50,717,077 (-)NCBIUU_Cfam_GSD_1.0
Tmtc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945185,837,799 - 185,889,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647210,062,827 - 10,113,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647210,062,811 - 10,114,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMTC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,361,229 - 69,443,039 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,361,219 - 69,442,769 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,623,518 - 76,705,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMTC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,228,673 - 79,299,249 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl379,228,571 - 79,293,006 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604635,737,161 - 35,806,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmtc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479310,588,037 - 10,641,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479310,587,703 - 10,640,634 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000005658   ⟹   ENSCLAP00000005557
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540410,213,186 - 10,266,116 (+)Ensembl
RefSeq Acc Id: XM_013515999   ⟹   XP_013371453
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540410,213,186 - 10,266,581 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013371453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005557
  ENSCLAP00000005557.1
Reference Protein Sequences
RefSeq Acc Id: XP_013371453   ⟸   XM_013515999
- UniProtKB: A0A8C2UZU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000005557   ⟸   ENSCLAT00000005658
Protein Domains
DUF1736


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005658 ENTREZGENE
  ENSCLAT00000005658.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TMTC_DUF1736 UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene Tmtc4 ENTREZGENE
PANTHER PROTEIN O-MANNOSYL-TRANSFERASE TMTC4 UniProtKB/TrEMBL
  PTHR44227 UniProtKB/TrEMBL
Pfam DUF1736 UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_17 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C2UZU2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 Tmtc4  transmembrane O-mannosyltransferase targeting cadherins 4  Tmtc4  transmembrane and tetratricopeptide repeat containing 4  Symbol and/or name change 5135510 APPROVED