Eftud2 (elongation factor Tu GTP binding domain containing 2) - Rat Genome Database

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Gene: Eftud2 (elongation factor Tu GTP binding domain containing 2) Rattus norvegicus
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Symbol: Eftud2
Name: elongation factor Tu GTP binding domain containing 2
RGD ID: 1560116
Description: Predicted to enable GTPase activity and U5 snRNA binding activity. Involved in cellular response to xenobiotic stimulus and response to cocaine. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in esophageal atresia; hepatitis B; hepatocellular carcinoma; mandibulofacial dysostosis, Guion-Almeida type; and microcephaly. Orthologous to human EFTUD2 (elongation factor Tu GTP binding domain containing 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 116 kDa U5 small nuclear ribonucleoprotein component; LOC287739; similar to 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,304,992 - 88,352,229 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,304,992 - 88,346,299 (-)EnsemblGRCr8
mRatBN7.21087,804,893 - 87,852,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,804,892 - 87,846,079 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,841,414 - 92,882,147 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,307,399 - 92,348,557 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,700,735 - 87,741,903 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,932,071 - 90,983,971 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,932,075 - 90,983,928 (-)Ensemblrn6Rnor6.0
Rnor_5.01090,705,838 - 90,756,354 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,012,161 - 92,053,043 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,508,787 - 86,548,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing. Chang TH, etal., Biochim Biophys Acta. 2013 Aug;1829(8):764-74. doi: 10.1016/j.bbagrm.2013.02.006. Epub 2013 Feb 21.
2. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. Freeman WM, etal., BMC Neurosci. 2010 Feb 26;11:29. doi: 10.1186/1471-2202-11-29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. EFTUD2 haploinsufficiency leads to syndromic oesophageal atresia. Gordon CT, etal., J Med Genet. 2012 Dec;49(12):737-46. doi: 10.1136/jmedgenet-2012-101173.
5. Investigation of the hepatotoxicity of flutamide: pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips. Legendre A, etal., Toxicol In Vitro. 2014 Aug;28(5):1075-87. doi: 10.1016/j.tiv.2014.04.008. Epub 2014 Apr 30.
6. Delineation of EFTUD2 haploinsufficiency-related phenotypes through a series of 36 patients. Lehalle D, etal., Hum Mutat. 2014 Apr;35(4):478-85. doi: 10.1002/humu.22517. Epub 2014 Mar 5.
7. Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly. Lines MA, etal., Am J Hum Genet. 2012 Feb 10;90(2):369-77. doi: 10.1016/j.ajhg.2011.12.023. Epub 2012 Feb 2.
8. Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma. Lv C, etal., Clin Transl Oncol. 2022 Jan;24(1):93-103. doi: 10.1007/s12094-021-02673-y. Epub 2021 Jul 19.
9. Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage. Lv Z, etal., Mucosal Immunol. 2019 Sep;12(5):1164-1173. doi: 10.1038/s41385-019-0184-y. Epub 2019 Jul 5.
10. Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole. Löb S, etal., J Reprod Immunol. 2020 Aug;140:103149. doi: 10.1016/j.jri.2020.103149. Epub 2020 May 18.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene (EFTUD2) Polymorphism with the Risk of Hepatitis B Virus Infection. Tian A, etal., Immunol Invest. 2022 Jul;51(5):1485-1497. doi: 10.1080/08820139.2021.1970763. Epub 2021 Aug 26.
19. Structural analyses of the pre-mRNA splicing machinery. Zhang L, etal., Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8.
Additional References at PubMed
PMID:11739632   PMID:11991638   PMID:15257298   PMID:19946888   PMID:22658674   PMID:22681889   PMID:23793891   PMID:23979707   PMID:24625528   PMID:28076346   PMID:29361316  


Genomics

Comparative Map Data
Eftud2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,304,992 - 88,352,229 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,304,992 - 88,346,299 (-)EnsemblGRCr8
mRatBN7.21087,804,893 - 87,852,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,804,892 - 87,846,079 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,841,414 - 92,882,147 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,307,399 - 92,348,557 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,700,735 - 87,741,903 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,932,071 - 90,983,971 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,932,075 - 90,983,928 (-)Ensemblrn6Rnor6.0
Rnor_5.01090,705,838 - 90,756,354 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,012,161 - 92,053,043 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,508,787 - 86,548,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
EFTUD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,849,948 - 44,899,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,849,948 - 44,899,626 (-)Ensemblhg38GRCh38
GRCh371742,927,316 - 42,976,813 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,283,805 - 40,332,289 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1739,638,156 - 39,687,497 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,692,747 - 38,742,046 (-)NCBIHuRef
CHM1_11743,163,795 - 43,213,134 (-)NCBICHM1_1
T2T-CHM13v2.01745,703,842 - 45,753,329 (-)NCBIT2T-CHM13v2.0
Eftud2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,729,298 - 102,771,999 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,729,299 - 102,771,811 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811102,838,472 - 102,880,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,838,473 - 102,880,985 (-)Ensemblmm10GRCm38
MGSCv3711102,699,786 - 102,742,289 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611102,654,567 - 102,697,007 (-)NCBIMGSCv36mm8
Celera11114,550,212 - 114,592,043 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.48NCBI
Eftud2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,653,125 - 17,690,117 (-)Ensembl
ChiLan1.0NW_00495545117,655,659 - 17,690,117 (-)NCBIChiLan1.0ChiLan1.0
EFTUD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,933,391 - 19,982,558 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,901,941 - 21,951,118 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,423,198 - 12,472,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,595,715 - 12,644,147 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,595,715 - 12,644,147 (+)EnsemblpanPan2panpan1.1
EFTUD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,585,918 - 18,631,743 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,585,971 - 18,635,570 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha917,971,321 - 18,017,098 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0919,259,323 - 19,325,865 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,259,393 - 19,325,861 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,136,941 - 18,182,419 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,315,956 - 18,361,505 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,472,819 - 18,518,366 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eftud2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,935,177 - 17,978,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,217,138 - 1,257,935 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,216,584 - 1,259,355 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFTUD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,474,097 - 18,517,479 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11218,474,367 - 18,514,993 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,719,238 - 18,759,628 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EFTUD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,505,796 - 61,549,720 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,505,825 - 61,551,890 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607732,254,817 - 32,301,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eftud2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795407,598 - 438,734 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624795407,228 - 435,578 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Eftud2
255 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000055176
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH143552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,810,292 - 87,810,430 (+)MAPPERmRatBN7.2
Rnor_6.01090,937,466 - 90,937,603NCBIRnor6.0
Rnor_5.01090,711,233 - 90,711,370UniSTSRnor5.0
RGSC_v3.41092,017,558 - 92,017,695UniSTSRGSC3.4
Celera1086,514,148 - 86,514,285UniSTS
RH 3.4 Map10917.6UniSTS
Cytogenetic Map10q32.1UniSTS
AA859237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,805,016 - 87,805,227 (+)MAPPERmRatBN7.2
Rnor_6.01090,932,193 - 90,932,403NCBIRnor6.0
Rnor_5.01090,705,960 - 90,706,170UniSTSRnor5.0
RGSC_v3.41092,012,285 - 92,012,495UniSTSRGSC3.4
Celera1086,508,909 - 86,509,119UniSTS
RH 3.4 Map10902.0UniSTS
Cytogenetic Map10q32.1UniSTS
UniSTS:236750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,805,809 - 87,805,913 (+)MAPPERmRatBN7.2
Rnor_6.01090,932,986 - 90,933,089NCBIRnor6.0
Rnor_5.01090,706,753 - 90,706,856UniSTSRnor5.0
RGSC_v3.41092,013,078 - 92,013,181UniSTSRGSC3.4
Celera1086,509,702 - 86,509,805UniSTS
Cytogenetic Map10q32.1UniSTS
MARC_23993-23994:1029524382:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81088,306,803 - 88,307,599 (+)Marker Load Pipeline
mRatBN7.21087,806,704 - 87,807,500 (+)MAPPERmRatBN7.2
Rnor_6.01090,933,881 - 90,934,676NCBIRnor6.0
Rnor_5.01090,707,648 - 90,708,443UniSTSRnor5.0
RGSC_v3.41092,013,973 - 92,014,768UniSTSRGSC3.4
Celera1086,510,597 - 86,511,414UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000055176   ⟹   ENSRNOP00000052049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1088,304,992 - 88,346,299 (-)Ensembl
mRatBN7.2 Ensembl1087,804,892 - 87,846,061 (-)Ensembl
Rnor_6.0 Ensembl1090,932,075 - 90,983,928 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093143   ⟹   ENSRNOP00000076344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,939,075 - 90,940,118 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,936,902 - 90,938,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,934,256 - 90,934,979 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,958,977 - 90,980,403 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1090,934,943 - 90,940,360 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,807,883 - 87,846,079 (-)Ensembl
Rnor_6.0 Ensembl1090,934,911 - 90,940,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115209   ⟹   ENSRNOP00000094590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,804,892 - 87,840,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115555   ⟹   ENSRNOP00000086991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,804,892 - 87,846,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118209   ⟹   ENSRNOP00000097682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,833,064 - 87,840,965 (-)Ensembl
RefSeq Acc Id: NM_001398598   ⟹   NP_001385527
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,304,992 - 88,346,157 (-)NCBI
mRatBN7.21087,804,893 - 87,846,061 (-)NCBI
RefSeq Acc Id: NM_001398599   ⟹   NP_001385528
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,304,992 - 88,346,157 (-)NCBI
mRatBN7.21087,804,893 - 87,846,061 (-)NCBI
RefSeq Acc Id: XM_039087769   ⟹   XP_038943697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,304,998 - 88,344,452 (-)NCBI
mRatBN7.21087,804,893 - 87,844,302 (-)NCBI
RefSeq Acc Id: XM_063268747   ⟹   XP_063124817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,304,998 - 88,352,229 (-)NCBI
RefSeq Acc Id: XM_063268748   ⟹   XP_063124818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,304,998 - 88,346,244 (-)NCBI
Ensembl Acc Id: ENSRNOP00000052049   ⟸   ENSRNOT00000055176
Ensembl Acc Id: ENSRNOP00000076344   ⟸   ENSRNOT00000093143
RefSeq Acc Id: XP_038943697   ⟸   XM_039087769
- Peptide Label: isoform X1
- UniProtKB: F1LM66 (UniProtKB/TrEMBL),   A0A8I6A4V7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086991   ⟸   ENSRNOT00000115555
Ensembl Acc Id: ENSRNOP00000094590   ⟸   ENSRNOT00000115209
Ensembl Acc Id: ENSRNOP00000097682   ⟸   ENSRNOT00000118209
RefSeq Acc Id: NP_001385528   ⟸   NM_001398599
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A4V7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385527   ⟸   NM_001398598
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A4V7 (UniProtKB/TrEMBL),   F1LM66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124817   ⟸   XM_063268747
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4V7 (UniProtKB/TrEMBL),   F1LM66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124818   ⟸   XM_063268748
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4V7 (UniProtKB/TrEMBL)
Protein Domains
116kDa U5 small nuclear ribonucleoprotein component   Elongation factor EFG   tr-type G   Translation elongation factor EFG/EF2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LM66-F1-model_v2 AlphaFold F1LM66 1-971 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697806
Promoter ID:EPDNEW_R8321
Type:initiation region
Name:Eftud2_1
Description:elongation factor Tu GTP binding domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,983,931 - 90,983,991EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560116 AgrOrtholog
BioCyc Gene G2FUF-23068 BioCyc
Ensembl Genes ENSRNOG00000002818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055176 ENTREZGENE
  ENSRNOT00000055176.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
  3.30.70.240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Elongation Factor G (Translational Gtpase), domain 3 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
  Yeast translation eEF2 (G' domain) UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7311384 IMAGE-MGC_LOAD
InterPro EF_GTP-bd_dom UniProtKB/TrEMBL
  EFG_II UniProtKB/TrEMBL
  EFG_III/V UniProtKB/TrEMBL
  EFTUD2_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Snu114_GTP-bd UniProtKB/TrEMBL
  Transl_elong_EFG/EF2_C UniProtKB/TrEMBL
  Transl_elong_EFG/EF2_IV UniProtKB/TrEMBL
  Transl_elong_EFTu/EF1A_2 UniProtKB/TrEMBL
  Transl_elong_init/rib_B-barrel UniProtKB/TrEMBL
  U5-116kD_C UniProtKB/TrEMBL
MGC_CLONE MGC:109259 IMAGE-MGC_LOAD
NCBI Gene 287739 ENTREZGENE
PANTHER 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT UniProtKB/TrEMBL
  TRANSLATION ELONGATION FACTOR-RELATED UniProtKB/TrEMBL
Pfam EFG_C UniProtKB/TrEMBL
  EFG_II UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
  EFTUD2 UniProtKB/TrEMBL
  GTP_EFTU UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
PhenoGen Eftud2 PhenoGen
PRINTS ELONGATNFCT UniProtKB/TrEMBL
PROSITE G_TR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002818 RatGTEx
SMART EFG_C UniProtKB/TrEMBL
  EFG_IV UniProtKB/TrEMBL
Superfamily-SCOP EFG_III_V UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  Translat_factor UniProtKB/TrEMBL
UniProt A0A8I6A4V7 ENTREZGENE
  A6HJN1_RAT UniProtKB/TrEMBL
  A6HJN2_RAT UniProtKB/TrEMBL
  F1LM66 ENTREZGENE, UniProtKB/TrEMBL
  Q5EB83_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Eftud2  elongation factor Tu GTP binding domain containing 2  LOC287739  similar to 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)  Symbol and Name updated 1299863 APPROVED
2006-02-09 LOC287739  similar to 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL