Dusp3 (dual specificity phosphatase 3) - Rat Genome Database

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Gene: Dusp3 (dual specificity phosphatase 3) Rattus norvegicus
Analyze
Symbol: Dusp3
Name: dual specificity phosphatase 3
RGD ID: 1560049
Description: Predicted to enable cytoskeletal protein binding activity; phosphoprotein phosphatase activity; and receptor tyrosine kinase binding activity. Involved in in utero embryonic development. Predicted to be located in immunological synapse and nucleoplasm. Predicted to be active in axonemal microtubule doublet inner sheath; cytosol; and sperm flagellum. Orthologous to human DUSP3 (dual specificity phosphatase 3); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related); dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like; dual specificity protein phosphatase 3; LOC100365414; LOC498003; MGC189429; RGD1560049; similar to Dual specificity protein phosphatase 3 (T-DSP11); vaccinia virus phosphatase VH1-related
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,420,213 - 87,434,202 (-)NCBIGRCr8
mRatBN7.21086,920,014 - 86,933,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,949,402 - 91,961,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,425,015 - 91,436,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,818,327 - 86,830,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,904,578 - 89,918,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,697,004 - 89,710,720 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,031,206 - 91,044,858 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1085,639,184 - 85,651,010 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dusp3Rathereditary breast ovarian cancer syndrome  ISODUSP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast-ovarian cancer more ...ClinVarPMID:38922859
Object Symbol
Species
Term
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Reference
Notes
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Original Reference(s)
Dusp3Ratlung non-small cell carcinoma  ISODUSP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15496427

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Dusp3Rat1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of DUSP3 mRNACTDPMID:27840820
Dusp3Rat1,2-dimethylhydrazine increases expressionISODusp3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of DUSP3 mRNACTDPMID:22206623
Dusp3Rat1-chloro-2,4-dinitrobenzene affects bindingISODUSP3 (Homo sapiens)6480464Dinitrochlorobenzene binds to DUSP3 proteinCTDPMID:32991956
Dusp3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODusp3 (Mus musculus)6480464AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DUSP3 mRNA]CTDPMID:15034205
Dusp3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of DUSP3 mRNACTDPMID:33387578
Dusp3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of DUSP3 mRNACTDPMID:34747641
Dusp3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODusp3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DUSP3 mRNACTDPMID:21570461 and PMID:24680724
Dusp3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISODusp3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of DUSP3 mRNACTDPMID:15034205
Dusp3Rat2-methylcholine affects expressionISODUSP3 (Homo sapiens)6480464beta-methylcholine affects the expression of DUSP3 mRNACTDPMID:21179406
Dusp3Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of DUSP3 mRNACTDPMID:30071829
Dusp3Rat5-aza-2'-deoxycytidine affects expressionISODUSP3 (Homo sapiens)6480464Decitabine affects the expression of DUSP3 mRNACTDPMID:23300844
Dusp3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of DUSP3 mRNACTDPMID:30047161
Dusp3Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of DUSP3 mRNACTDPMID:28959563
Dusp3Ratacrylamide increases expressionISODUSP3 (Homo sapiens)6480464Acrylamide results in increased expression of DUSP3 mRNACTDPMID:32763439
Dusp3Rataflatoxin B1 increases methylationISODUSP3 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of DUSP3 geneCTDPMID:27153756
Dusp3Ratall-trans-retinoic acid decreases expressionISODUSP3 (Homo sapiens)6480464Tretinoin results in decreased expression of DUSP3 mRNACTDPMID:33167477
Dusp3Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of DUSP3 mRNACTDPMID:30047161
Dusp3Ratamphetamine increases expressionEXP 6480464Amphetamine results in increased expression of DUSP3 mRNACTDPMID:30779732
Dusp3Ratarsane increases methylationISODUSP3 (Homo sapiens)6480464Arsenic results in increased methylation of DUSP3 promoterCTDPMID:21291286
Dusp3Ratarsenic atom increases methylationISODUSP3 (Homo sapiens)6480464Arsenic results in increased methylation of DUSP3 promoterCTDPMID:21291286

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Biological Process
1 to 20 of 26 rows

  
Object Symbol
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Reference
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Source
Original Reference(s)
Dusp3Ratcellular response to epidermal growth factor stimulus involved_inISODUSP3 (Homo sapiens)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratcellular response to epidermal growth factor stimulus involved_inISODusp3 (Mus musculus)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratdephosphorylation involved_inISODUSP3 (Homo sapiens)1624291 PMID:24531476RGDPMID:24531476
Dusp3Ratflagellated sperm motility involved_inISODusp3 (Mus musculus)1624291 PMID:37865089RGDPMID:37865089
Dusp3Ratin utero embryonic development  IDA 2317890 RGD 
Dusp3Ratnegative regulation of cell migration involved_inISODUSP3 (Homo sapiens)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratnegative regulation of chemotaxis involved_inISODUSP3 (Homo sapiens)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratnegative regulation of epidermal growth factor receptor signaling pathway involved_inISODusp3 (Mus musculus)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratnegative regulation of ERK1 and ERK2 cascade involved_inISODUSP3 (Homo sapiens)1624291 PMID:11085983RGDPMID:11085983
Dusp3Ratnegative regulation of ERK1 and ERK2 cascade involved_inIBAPANTHER:PTN000017220 and UniProtKB:P514521600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratnegative regulation of JNK cascade involved_inISODUSP3 (Homo sapiens)1624291 PMID:11085983 and PMID:19010898RGDPMID:11085983 and PMID:19010898
Dusp3Ratnegative regulation of JNK cascade involved_inIBAPANTHER:PTN000017220 and UniProtKB:P514521600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratnegative regulation of MAPK cascade involved_inISODUSP3 (Homo sapiens)1624291 PMID:16604064RGDPMID:16604064
Dusp3Ratnegative regulation of T cell activation involved_inISODUSP3 (Homo sapiens)1624291 PMID:12447358RGDPMID:12447358
Dusp3Ratnegative regulation of T cell activation involved_inIBAPANTHER:PTN000017220 and UniProtKB:P514521600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratnegative regulation of T cell receptor signaling pathway involved_inISODUSP3 (Homo sapiens)1624291 PMID:12447358RGDPMID:12447358
Dusp3Ratnegative regulation of T cell receptor signaling pathway involved_inIBAPANTHER:PTN000017220 and UniProtKB:P514521600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratpeptidyl-tyrosine dephosphorylation involved_inISODusp3 (Mus musculus)1624291 PMID:28759036RGDPMID:28759036
Dusp3Ratpeptidyl-tyrosine dephosphorylation involved_inISODUSP3 (Homo sapiens)1624291 PMID:11863439 and PMID:7876121RGDPMID:11863439 and PMID:7876121
Dusp3Ratpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity involved_inISODusp3 (Mus musculus)1624291 PMID:28759036RGDPMID:28759036
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Cellular Component
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1 to 9 of 9 rows

Molecular Function
1 to 20 of 22 rows

  
Object Symbol
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Reference
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Source
Original Reference(s)
Dusp3Ratcytoskeletal protein binding enablesISODUSP3 (Homo sapiens)1624291UniProtKB:P49023 and PMID:28759036RGDPMID:28759036
Dusp3Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Dusp3RatMAP kinase phosphatase activity enablesISODUSP3 (Homo sapiens)1624291 PMID:16604064RGDPMID:16604064
Dusp3RatMAP kinase phosphatase activity enablesIBAMGI:3647127 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratphosphatase activity enablesISODUSP3 (Homo sapiens)1624291 PMID:24531476RGDPMID:24531476
Dusp3Ratphosphatase activity enablesIEAARBA:ARBA000263931600115GO_REF:0000117UniProtGO_REF:0000117
Dusp3Ratphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Dusp3Ratphosphoprotein phosphatase activity enablesISODusp3 (Mus musculus)1624291 PMID:18035061RGDPMID:18035061
Dusp3Ratprotein binding enablesISODUSP3 (Homo sapiens)1624291UniProtKB:P50221 and PMID:32296183RGDPMID:32296183
Dusp3Ratprotein kinase binding enablesISODUSP3 (Homo sapiens)1624291 PMID:22572157RGDPMID:22572157
Dusp3Ratprotein serine/threonine phosphatase activity enablesIEARHEA:20629 and RHEA:470041600115GO_REF:0000116RHEAGO_REF:0000116
Dusp3Ratprotein serine/threonine phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Dusp3Ratprotein tyrosine kinase binding enablesISODUSP3 (Homo sapiens)1624291UniProtKB:Q05397 and PMID:28759036RGDPMID:28759036
Dusp3Ratprotein tyrosine phosphatase activity enablesISODUSP3 (Homo sapiens)1624291 PMID:11863439 and PMID:28759036RGDPMID:11863439 and PMID:28759036
Dusp3Ratprotein tyrosine phosphatase activity enablesIEARHEA:106841600115GO_REF:0000116RHEAGO_REF:0000116
Dusp3Ratprotein tyrosine phosphatase activity enablesIEAEC:3.1.3.481600115GO_REF:0000003UniProtGO_REF:0000003
Dusp3Ratprotein tyrosine/serine/threonine phosphatase activity enablesISODUSP3 (Homo sapiens)1624291 PMID:7876121 and PMID:7961745RGDPMID:7876121 and PMID:7961745
Dusp3Ratprotein tyrosine/serine/threonine phosphatase activity enablesIBAMGI:1351599 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp3Ratprotein tyrosine/serine/threonine phosphatase activity enablesISODusp3 (Mus musculus)1624291 PMID:11432789RGDPMID:11432789
Dusp3Ratprotein tyrosine/serine/threonine phosphatase activity enablesIEAUniRule:UR0011847601600115GO_REF:0000104UniProtGO_REF:0000104
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Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dusp3Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Kang TH and Kim KT, Biochim Biophys Acta. 2008 Jan;1783(1):49-58. Epub 2007 Nov 4.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
PMID:7876121   PMID:7961745   PMID:11085983   PMID:11432789   PMID:11863439   PMID:12447358   PMID:12477932   PMID:15632090   PMID:16604064   PMID:18505570   PMID:19010898   PMID:22572157  
PMID:23376485   PMID:24531476   PMID:28759036  



Dusp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,420,213 - 87,434,202 (-)NCBIGRCr8
mRatBN7.21086,920,014 - 86,933,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,949,402 - 91,961,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,425,015 - 91,436,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,818,327 - 86,830,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,904,578 - 89,918,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,697,004 - 89,710,720 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,031,206 - 91,044,858 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1085,639,184 - 85,651,010 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
DUSP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,766,125 - 43,778,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,766,125 - 43,778,977 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,843,493 - 41,856,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,199,015 - 39,211,872 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,199,015 - 39,211,872NCBI
Celera1738,551,496 - 38,564,369 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,607,587 - 37,620,460 (-)NCBIHuRef
CHM1_11742,079,099 - 42,091,978 (-)NCBICHM1_1
T2T-CHM13v2.01744,618,675 - 44,631,521 (-)NCBIT2T-CHM13v2.0
Dusp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,861,967 - 101,877,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,861,969 - 101,877,839 (-)EnsemblGRCm39 Ensembl
GRCm3811101,971,141 - 101,987,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,971,143 - 101,987,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,835,473 - 101,846,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,790,249 - 101,800,860 (-)NCBIMGSCv36mm8
Celera11113,679,435 - 113,690,042 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Dusp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,064,739 - 17,069,964 (-)NCBIChiLan1.0ChiLan1.0
DUSP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,129,511 - 21,142,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,093,825 - 23,106,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,618,860 - 13,631,743 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,784,618 - 13,797,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,784,594 - 13,797,045 (+)Ensemblpanpan1.1panPan2
DUSP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,518,302 - 19,531,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,518,746 - 19,527,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,906,433 - 18,920,193 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,212,506 - 20,226,067 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,213,966 - 20,226,637 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,065,068 - 19,078,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,248,263 - 19,261,805 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,393,335 - 19,406,908 (+)NCBIUU_Cfam_GSD_1.0
Dusp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,856,161 - 18,869,151 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936541325,443 - 338,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,336,354 - 19,349,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,336,308 - 19,349,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,569,958 - 19,583,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,622,667 - 62,637,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,622,663 - 62,637,127 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,395,825 - 33,410,367 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624795994,103 - 1,001,697 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dusp3
117 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 89700811 89700812 G A snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:238
Interacting mature miRNAs:282
Transcripts:ENSRNOT00000055194
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 77 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat

1 to 10 of 77 rows
RH141697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,922,280 - 86,922,486 (+)MAPPERmRatBN7.2
Rnor_6.01089,906,844 - 89,907,049NCBIRnor6.0
Rnor_5.01089,699,270 - 89,699,475UniSTSRnor5.0
RGSC_v3.41091,033,473 - 91,033,678UniSTSRGSC3.4
Celera1085,641,450 - 85,641,655UniSTS
Cytogenetic Map10q32.1UniSTS
RH128660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,920,059 - 86,920,261 (+)MAPPERmRatBN7.2
Rnor_6.01089,904,624 - 89,904,825NCBIRnor6.0
Rnor_5.01089,697,050 - 89,697,251UniSTSRnor5.0
RGSC_v3.41091,031,252 - 91,031,453UniSTSRGSC3.4
Celera1085,639,230 - 85,639,431UniSTS
RH 3.4 Map10881.5UniSTS
Cytogenetic Map10q32.1UniSTS
BE102766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,931,081 - 86,931,242 (+)MAPPERmRatBN7.2
Rnor_6.01089,915,647 - 89,915,807NCBIRnor6.0
Rnor_5.01089,708,073 - 89,708,233UniSTSRnor5.0
RGSC_v3.41091,042,276 - 91,042,436UniSTSRGSC3.4
Celera1085,650,258 - 85,650,418UniSTS
RH 3.4 Map10885.3UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000055194   ⟹   ENSRNOP00000052065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)Ensembl
Rnor_6.0 Ensembl1089,904,584 - 89,916,400 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084217   ⟹   ENSRNOP00000072656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,927,716 - 86,931,873 (-)Ensembl
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110203   ⟹   ENSRNOP00000091785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,920,024 - 86,933,962 (-)Ensembl
RefSeq Acc Id: NM_001173376   ⟹   NP_001166847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,213 - 87,432,035 (-)NCBI
mRatBN7.21086,920,014 - 86,931,835 (-)NCBI
Rnor_6.01089,904,578 - 89,916,400 (-)NCBI
Rnor_5.01089,697,004 - 89,710,720 (-)NCBI
Celera1085,639,184 - 85,651,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247402   ⟹   XP_006247464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,216 - 87,434,202 (-)NCBI
mRatBN7.21086,920,014 - 86,933,739 (-)NCBI
Rnor_6.01089,904,578 - 89,918,296 (-)NCBI
Rnor_5.01089,697,004 - 89,710,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086639   ⟹   XP_038942567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,216 - 87,431,720 (-)NCBI
mRatBN7.21086,920,014 - 86,931,370 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001166847 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247464 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942567 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69043 (Get FASTA)   NCBI Sequence Viewer  
  EDM06162 (Get FASTA)   NCBI Sequence Viewer  
  EDM06163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052065.4
  ENSRNOP00000072656.2
  ENSRNOP00000091785.1
  ENSRNOP00000101282
1 to 10 of 10 rows
RefSeq Acc Id: NP_001166847   ⟸   NM_001173376
- UniProtKB: B5DFF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247464   ⟸   XM_006247402
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF61 (UniProtKB/TrEMBL),   A6HJF7 (UniProtKB/TrEMBL),   G3V9L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052065   ⟸   ENSRNOT00000055194
Ensembl Acc Id: ENSRNOP00000072656   ⟸   ENSRNOT00000084217
RefSeq Acc Id: XP_038942567   ⟸   XM_039086639
- Peptide Label: isoform X2
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3I9-F1-model_v2 AlphaFold A0A0G2K3I9 1-211 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697770
Promoter ID:EPDNEW_R8294
Type:multiple initiation site
Name:Dusp3_1
Description:dual specificity phosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,916,416 - 89,916,476EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23134 BioCyc
Ensembl Genes ENSRNOG00000036798 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055194.4 UniProtKB/TrEMBL
  ENSRNOT00000084217.2 UniProtKB/TrEMBL
  ENSRNOT00000110203.1 UniProtKB/TrEMBL
  ENSRNOT00000145552 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Dual-sp_phosphatase_famA UniProtKB/TrEMBL
  Dual-sp_phosphatase_subgr_cat UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
NCBI Gene 498003 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 UniProtKB/TrEMBL
  PTHR45682 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PhenoGen Dusp3 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036798 RatGTEx
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2K3I9_RAT UniProtKB/TrEMBL
  A0A8I6AF61 ENTREZGENE, UniProtKB/TrEMBL
  A6HJF7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFF7 ENTREZGENE, UniProtKB/TrEMBL
  G3V9L3 ENTREZGENE, UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-24 Dusp3  dual specificity phosphatase 3  LOC100365414  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like  Data merged from RGD:2319066 737654 APPROVED
2010-05-05 LOC100365414  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-24 Dusp3  dual specificity phosphatase 3  Dusp3  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Dusp3  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)  RGD1560049_predicted  similar to Dual specificity protein phosphatase 3 (T-DSP11) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560049_predicted  similar to Dual specificity protein phosphatase 3 (T-DSP11) (predicted)  LOC498003  similar to Dual specificity protein phosphatase 3 (T-DSP11)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498003  similar to Dual specificity protein phosphatase 3 (T-DSP11)      Symbol and Name status set to provisional 70820 PROVISIONAL