Dusp3 (dual specificity phosphatase 3) - Rat Genome Database

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Gene: Dusp3 (dual specificity phosphatase 3) Rattus norvegicus
Analyze
Symbol: Dusp3
Name: dual specificity phosphatase 3
RGD ID: 1560049
Description: Predicted to enable several functions, including phosphoprotein phosphatase activity; receptor signaling protein tyrosine kinase inhibitor activity; and receptor tyrosine kinase binding activity. Involved in in utero embryonic development. Predicted to be located in immunological synapse and nucleus. Predicted to be active in axonemal microtubule doublet inner sheath; cytosol; and sperm flagellum. Orthologous to human DUSP3 (dual specificity phosphatase 3); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related); dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like; dual specificity protein phosphatase 3; LOC100365414; LOC498003; MGC189429; RGD1560049; similar to Dual specificity protein phosphatase 3 (T-DSP11); vaccinia virus phosphatase VH1-related
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,420,213 - 87,434,202 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,419,494 - 87,434,063 (-)EnsemblGRCr8
mRatBN7.21086,920,014 - 86,933,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,949,402 - 91,961,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,425,015 - 91,436,834 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,818,327 - 86,830,145 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,904,578 - 89,918,296 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)Ensemblrn6Rnor6.0
Rnor_5.01089,697,004 - 89,710,720 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,031,206 - 91,044,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,639,184 - 85,651,010 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
deguelin  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folpet  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
indinavir  (ISO)
ivermectin  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
saquinavir  (ISO)
SB 431542  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Kang TH and Kim KT, Biochim Biophys Acta. 2008 Jan;1783(1):49-58. Epub 2007 Nov 4.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7876121   PMID:7961745   PMID:11085983   PMID:11432789   PMID:11863439   PMID:12447358   PMID:12477932   PMID:15632090   PMID:16604064   PMID:18505570   PMID:19010898   PMID:22572157  
PMID:23376485   PMID:24531476   PMID:28759036  


Genomics

Comparative Map Data
Dusp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,420,213 - 87,434,202 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,419,494 - 87,434,063 (-)EnsemblGRCr8
mRatBN7.21086,920,014 - 86,933,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,949,402 - 91,961,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,425,015 - 91,436,834 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,818,327 - 86,830,145 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,904,578 - 89,918,296 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)Ensemblrn6Rnor6.0
Rnor_5.01089,697,004 - 89,710,720 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,031,206 - 91,044,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,639,184 - 85,651,010 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
DUSP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,766,125 - 43,778,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,766,121 - 43,779,000 (-)Ensemblhg38GRCh38
GRCh371741,843,493 - 41,856,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,199,015 - 39,211,872 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341739,199,015 - 39,211,872NCBI
Celera1738,551,496 - 38,564,369 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,607,587 - 37,620,460 (-)NCBIHuRef
CHM1_11742,079,099 - 42,091,978 (-)NCBICHM1_1
T2T-CHM13v2.01744,618,675 - 44,631,521 (-)NCBIT2T-CHM13v2.0
Dusp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,861,967 - 101,877,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,861,969 - 101,877,839 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,971,141 - 101,987,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,971,143 - 101,987,013 (-)Ensemblmm10GRCm38
MGSCv3711101,835,473 - 101,846,084 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611101,790,249 - 101,800,860 (-)NCBIMGSCv36mm8
Celera11113,679,435 - 113,690,042 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Dusp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,064,685 - 17,071,219 (-)Ensembl
ChiLan1.0NW_00495545117,064,739 - 17,069,964 (-)NCBIChiLan1.0ChiLan1.0
DUSP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,129,511 - 21,142,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,093,825 - 23,106,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,618,860 - 13,631,743 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,784,618 - 13,797,045 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,784,594 - 13,797,045 (+)EnsemblpanPan2panpan1.1
DUSP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,518,302 - 19,531,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,518,746 - 19,527,624 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha918,906,433 - 18,920,193 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,212,506 - 20,226,067 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,213,966 - 20,226,637 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,065,068 - 19,078,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,248,263 - 19,261,805 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,393,335 - 19,406,908 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dusp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,856,161 - 18,869,151 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541325,403 - 340,314 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936541325,443 - 338,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,336,354 - 19,349,734 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11219,336,308 - 19,349,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,569,958 - 19,583,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,622,667 - 62,637,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,622,663 - 62,637,127 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607733,395,825 - 33,410,367 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624795994,103 - 1,001,697 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dusp3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1961,263,528 - 61,275,308 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dusp3
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:238
Interacting mature miRNAs:282
Transcripts:ENSRNOT00000055194
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH141697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,922,280 - 86,922,486 (+)MAPPERmRatBN7.2
Rnor_6.01089,906,844 - 89,907,049NCBIRnor6.0
Rnor_5.01089,699,270 - 89,699,475UniSTSRnor5.0
RGSC_v3.41091,033,473 - 91,033,678UniSTSRGSC3.4
Celera1085,641,450 - 85,641,655UniSTS
Cytogenetic Map10q32.1UniSTS
RH128660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,920,059 - 86,920,261 (+)MAPPERmRatBN7.2
Rnor_6.01089,904,624 - 89,904,825NCBIRnor6.0
Rnor_5.01089,697,050 - 89,697,251UniSTSRnor5.0
RGSC_v3.41091,031,252 - 91,031,453UniSTSRGSC3.4
Celera1085,639,230 - 85,639,431UniSTS
RH 3.4 Map10881.5UniSTS
Cytogenetic Map10q32.1UniSTS
BE102766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,931,081 - 86,931,242 (+)MAPPERmRatBN7.2
Rnor_6.01089,915,647 - 89,915,807NCBIRnor6.0
Rnor_5.01089,708,073 - 89,708,233UniSTSRnor5.0
RGSC_v3.41091,042,276 - 91,042,436UniSTSRGSC3.4
Celera1085,650,258 - 85,650,418UniSTS
RH 3.4 Map10885.3UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000055194   ⟹   ENSRNOP00000052065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)Ensembl
Rnor_6.0 Ensembl1089,904,584 - 89,916,400 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084217   ⟹   ENSRNOP00000072656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,427,916 - 87,432,035 (-)Ensembl
mRatBN7.2 Ensembl1086,927,716 - 86,931,873 (-)Ensembl
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110203   ⟹   ENSRNOP00000091785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,420,213 - 87,434,063 (-)Ensembl
mRatBN7.2 Ensembl1086,920,024 - 86,933,962 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125800   ⟹   ENSRNOP00000107984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,419,494 - 87,434,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145552   ⟹   ENSRNOP00000101282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,421,763 - 87,434,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173658   ⟹   ENSRNOP00000101066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1087,423,942 - 87,432,229 (-)Ensembl
RefSeq Acc Id: NM_001173376   ⟹   NP_001166847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,213 - 87,432,035 (-)NCBI
mRatBN7.21086,920,014 - 86,931,835 (-)NCBI
Rnor_6.01089,904,578 - 89,916,400 (-)NCBI
Rnor_5.01089,697,004 - 89,710,720 (-)NCBI
Celera1085,639,184 - 85,651,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247402   ⟹   XP_006247464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,216 - 87,434,202 (-)NCBI
mRatBN7.21086,920,014 - 86,933,739 (-)NCBI
Rnor_6.01089,904,578 - 89,918,296 (-)NCBI
Rnor_5.01089,697,004 - 89,710,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086639   ⟹   XP_038942567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,420,216 - 87,431,720 (-)NCBI
mRatBN7.21086,920,014 - 86,931,370 (-)NCBI
RefSeq Acc Id: NP_001166847   ⟸   NM_001173376
- UniProtKB: B5DFF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247464   ⟸   XM_006247402
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF61 (UniProtKB/TrEMBL),   A6HJF7 (UniProtKB/TrEMBL),   G3V9L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052065   ⟸   ENSRNOT00000055194
Ensembl Acc Id: ENSRNOP00000072656   ⟸   ENSRNOT00000084217
RefSeq Acc Id: XP_038942567   ⟸   XM_039086639
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000091785   ⟸   ENSRNOT00000110203
Ensembl Acc Id: ENSRNOP00000101066   ⟸   ENSRNOT00000173658
Ensembl Acc Id: ENSRNOP00000107984   ⟸   ENSRNOT00000125800
Ensembl Acc Id: ENSRNOP00000101282   ⟸   ENSRNOT00000145552
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3I9-F1-model_v2 AlphaFold A0A0G2K3I9 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697770
Promoter ID:EPDNEW_R8294
Type:multiple initiation site
Name:Dusp3_1
Description:dual specificity phosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,916,416 - 89,916,476EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560049 AgrOrtholog
BioCyc Gene G2FUF-23134 BioCyc
Ensembl Genes ENSRNOG00000036798 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084217.3 UniProtKB/TrEMBL
  ENSRNOT00000110203.2 UniProtKB/TrEMBL
  ENSRNOT00000125800.1 UniProtKB/TrEMBL
  ENSRNOT00000145552 ENTREZGENE
  ENSRNOT00000145552.1 UniProtKB/TrEMBL
  ENSRNOT00000173658.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Dual-sp_phosphatase_famA UniProtKB/TrEMBL
  Dual-sp_phosphatase_subgr_cat UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
NCBI Gene 498003 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 UniProtKB/TrEMBL
  PTHR45682 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PhenoGen Dusp3 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036798 RatGTEx
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2K3I9_RAT UniProtKB/TrEMBL
  A0A8I6AF61 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAJ9_RAT UniProtKB/TrEMBL
  A0ABK0LDS2_RAT UniProtKB/TrEMBL
  A0ABK0LVC6_RAT UniProtKB/TrEMBL
  A6HJF7 ENTREZGENE, UniProtKB/TrEMBL
  B5DFF7 ENTREZGENE, UniProtKB/TrEMBL
  G3V9L3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-24 Dusp3  dual specificity phosphatase 3  LOC100365414  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like  Data merged from RGD:2319066 737654 APPROVED
2010-05-05 LOC100365414  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-24 Dusp3  dual specificity phosphatase 3  Dusp3  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Dusp3  dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)  RGD1560049_predicted  similar to Dual specificity protein phosphatase 3 (T-DSP11) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560049_predicted  similar to Dual specificity protein phosphatase 3 (T-DSP11) (predicted)  LOC498003  similar to Dual specificity protein phosphatase 3 (T-DSP11)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498003  similar to Dual specificity protein phosphatase 3 (T-DSP11)      Symbol and Name status set to provisional 70820 PROVISIONAL