Rab32 (RAB32, member RAS oncogene family) - Rat Genome Database

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Gene: Rab32 (RAB32, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab32
Name: RAB32, member RAS oncogene family
RGD ID: 1559997
Description: Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-3 adaptor complex binding activity; and BLOC-2 complex binding activity. Predicted to be involved in several processes, including endosome to melanosome transport; melanosome assembly; and phagosome maturation. Predicted to be located in several cellular components, including cytoplasmic vesicle; mitochondria-associated endoplasmic reticulum membrane; and mitochondrial outer membrane. Predicted to be active in melanosome; mitochondrion; and trans-Golgi network. Orthologous to human RAB32 (RAB32, member RAS oncogene family); INTERACTS WITH 1,2-dimethylhydrazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: PROVISIONAL
Previously known as: LOC365042; ras-related protein Rab-32; RGD1559997; similar to RAB32
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr816,766,448 - 6,781,258 (-)NCBIGRCr8
mRatBN7.214,946,193 - 4,961,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14,945,036 - 4,960,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14,623,280 - 4,644,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0110,623,631 - 10,644,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014,905,472 - 4,926,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014,638,663 - 4,653,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14,637,491 - 4,653,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.016,299,748 - 6,314,539 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415,203,908 - 5,218,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera13,479,984 - 3,494,673 (-)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fragrance  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
LY294002  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:19717423   PMID:21255211   PMID:21808068   PMID:22511774   PMID:23084991   PMID:25767741   PMID:26620560   PMID:38388913  


Genomics

Comparative Map Data
Rab32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr816,766,448 - 6,781,258 (-)NCBIGRCr8
mRatBN7.214,946,193 - 4,961,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14,945,036 - 4,960,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14,623,280 - 4,644,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0110,623,631 - 10,644,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014,905,472 - 4,926,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014,638,663 - 4,653,220 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14,637,491 - 4,653,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.016,299,748 - 6,314,539 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415,203,908 - 5,218,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera13,479,984 - 3,494,673 (-)NCBICelera
Cytogenetic Map1p13NCBI
RAB32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386146,543,833 - 146,554,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6146,543,833 - 146,554,953 (+)EnsemblGRCh38hg38GRCh38
GRCh376146,864,969 - 146,876,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366146,906,521 - 146,917,782 (+)NCBINCBI36Build 36hg18NCBI36
Build 346146,906,520 - 146,917,779NCBI
Celera6147,605,264 - 147,616,521 (+)NCBICelera
Cytogenetic Map6q24.3NCBI
HuRef6144,428,711 - 144,439,665 (+)NCBIHuRef
CHM1_16147,128,062 - 147,139,320 (+)NCBICHM1_1
T2T-CHM13v2.06147,737,054 - 147,748,175 (+)NCBIT2T-CHM13v2.0
Rab32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391010,420,783 - 10,433,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1010,420,746 - 10,434,009 (-)EnsemblGRCm39 Ensembl
GRCm381010,545,039 - 10,558,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1010,545,002 - 10,558,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv371010,264,837 - 10,278,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361010,235,229 - 10,248,397 (-)NCBIMGSCv36mm8
Celera1010,440,276 - 10,453,408 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map103.44NCBI
Rab32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543614,171,123 - 14,177,577 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543614,171,123 - 14,177,255 (-)NCBIChiLan1.0ChiLan1.0
RAB32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25166,541,048 - 166,561,393 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16164,438,382 - 164,453,907 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06144,339,323 - 144,354,885 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAB32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1137,706,809 - 37,719,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl137,712,142 - 37,718,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha138,588,880 - 38,611,342 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0137,866,146 - 37,889,054 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl137,865,534 - 37,889,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1137,743,864 - 37,766,334 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0137,615,197 - 37,637,672 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0137,945,159 - 37,967,854 (+)NCBIUU_Cfam_GSD_1.0
Rab32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946132,783,627 - 132,799,818 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648935,620 - 51,809 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,075,271 - 19,097,870 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1119,076,301 - 19,097,647 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,320,352 - 21,341,852 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11325,265,831 - 25,281,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040201,227,806 - 201,242,889 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247537,900,267 - 7,917,854 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247537,900,027 - 7,917,944 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab32
151 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:616
Count of miRNA genes:274
Interacting mature miRNAs:352
Transcripts:ENSRNOT00000019121
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1416280711481482Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat

Markers in Region
RH136840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214,946,254 - 4,946,390 (+)MAPPERmRatBN7.2
Rnor_6.014,638,725 - 4,638,860NCBIRnor6.0
Rnor_5.016,299,810 - 6,299,945UniSTSRnor5.0
RGSC_v3.415,203,970 - 5,204,105UniSTSRGSC3.4
Celera13,480,046 - 3,480,181UniSTS
Cytogenetic Map1p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 24 11 18 11 35 25 11
Low 1 43 33 30 1 30 8 11 74 13 8
Below cutoff 3

Sequence


RefSeq Acc Id: ENSRNOT00000019121   ⟹   ENSRNOP00000019121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14,945,036 - 4,960,934 (-)Ensembl
Rnor_6.0 Ensembl14,637,491 - 4,653,210 (-)Ensembl
RefSeq Acc Id: NM_001108902   ⟹   NP_001102372
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr816,766,448 - 6,781,258 (-)NCBI
mRatBN7.214,946,193 - 4,961,003 (-)NCBI
Rnor_6.014,638,663 - 4,653,220 (-)NCBI
Rnor_5.016,299,748 - 6,314,539 (-)NCBI
RGSC_v3.415,203,908 - 5,218,416 (-)RGD
Celera13,479,984 - 3,494,673 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102372 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93708 (Get FASTA)   NCBI Sequence Viewer  
  EDL93709 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102372   ⟸   NM_001108902
- UniProtKB: A6JP36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019121   ⟸   ENSRNOT00000019121

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEG2-F1-model_v2 AlphaFold D4AEG2 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689487
Promoter ID:EPDNEW_R12
Type:initiation region
Name:Rab32_1
Description:RAB32, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014,653,163 - 4,653,223EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559997 AgrOrtholog
BioCyc Gene G2FUF-62413 BioCyc
Ensembl Genes ENSRNOG00000014258 Ensembl
Gene3D-CATH P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Rab29/Rab38/Rab32 UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:365042 UniProtKB/TrEMBL
NCBI Gene 365042 ENTREZGENE
PANTHER RAB FAMILY UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-32 ISOFORM X1 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rab32 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014258 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
UniProt A6JP36 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Rab32  RAB32, member RAS oncogene family  RGD1559997_predicted  similar to RAB32 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559997_predicted  similar to RAB32 (predicted)  LOC365042  similar to RAB32  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365042  similar to RAB32      Symbol and Name status set to provisional 70820 PROVISIONAL