Mfsd4b4 (major facilitator superfamily domain containing 4B4) - Rat Genome Database

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Gene: Mfsd4b4 (major facilitator superfamily domain containing 4B4) Rattus norvegicus
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Symbol: Mfsd4b4 (Ensembl: Mfsd4b1)
Name: major facilitator superfamily domain containing 4B4 (Ensembl:major facilitator superfamily domain containing 4B1)
RGD ID: 1559971
Description: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC499462; major facilitator superfamily domain containing 4B; major facilitator superfamily domain containing 4B1; Mfsd4b; Mfsd4b1; RGD1559971; similar to Na+ dependent glucose transporter 1; sodium-dependent glucose transporter 1C
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,878,985 - 44,888,435 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2044,878,985 - 44,888,435 (-)EnsemblGRCr8
mRatBN7.22043,324,419 - 43,333,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,324,436 - 43,333,953 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2045,073,410 - 45,082,860 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,732,627 - 44,742,077 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,481,646 - 45,491,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,996,864 - 45,005,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,995,755 - 45,005,035 (-)Ensemblrn6Rnor6.0
Rnor_5.02046,718,040 - 46,727,449 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42044,078,646 - 44,086,235 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2044,039,369 - 44,047,636 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mfsd4b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,878,985 - 44,888,435 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2044,878,985 - 44,888,435 (-)EnsemblGRCr8
mRatBN7.22043,324,419 - 43,333,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,324,436 - 43,333,953 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2045,073,410 - 45,082,860 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,732,627 - 44,742,077 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,481,646 - 45,491,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,996,864 - 45,005,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,995,755 - 45,005,035 (-)Ensemblrn6Rnor6.0
Rnor_5.02046,718,040 - 46,727,449 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42044,078,646 - 44,086,235 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2044,039,369 - 44,047,636 (-)NCBICelera
Cytogenetic Map20q12NCBI
Mfsd4b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,766,009 - 39,775,202 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,766,009 - 39,775,234 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381039,890,013 - 39,899,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,890,013 - 39,899,238 (-)Ensemblmm10GRCm38
MGSCv371039,612,566 - 39,619,044 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361039,579,424 - 39,598,878 (-)NCBIMGSCv36mm8
Celera1040,778,667 - 40,785,147 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.27NCBI

Variants

.
Variants in Mfsd4b4
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000035047
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000035047   ⟹   ENSRNOP00000036588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2044,878,985 - 44,888,435 (-)Ensembl
mRatBN7.2 Ensembl2043,324,436 - 43,333,953 (-)Ensembl
Rnor_6.0 Ensembl2044,995,755 - 45,005,035 (-)Ensembl
RefSeq Acc Id: NM_001402082   ⟹   NP_001389011
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,878,985 - 44,888,435 (-)NCBI
mRatBN7.22043,324,419 - 43,333,869 (-)NCBI
RefSeq Acc Id: XM_039099152   ⟹   XP_038955080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,878,985 - 44,888,270 (-)NCBI
mRatBN7.22043,324,429 - 43,333,695 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389011 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955080 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87827 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036588
  ENSRNOP00000036588.6
Ensembl Acc Id: ENSRNOP00000036588   ⟸   ENSRNOT00000035047
RefSeq Acc Id: XP_038955080   ⟸   XM_039099152
- Peptide Label: isoform X1
- UniProtKB: A6KIH2 (UniProtKB/TrEMBL),   F1LTM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001389011   ⟸   NM_001402082
- UniProtKB: A6KIH2 (UniProtKB/TrEMBL),   F1LTM4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTM4-F1-model_v2 AlphaFold F1LTM4 1-568 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701664
Promoter ID:EPDNEW_R12176
Type:initiation region
Name:Mfsd4b_1
Description:major facilitator superfamily domain containing 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02045,005,120 - 45,005,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559971 AgrOrtholog
BioCyc Gene G2FUF-3462 BioCyc
Ensembl Genes ENSRNOG00000024543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035047 ENTREZGENE
  ENSRNOT00000035047.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
NCBI Gene 499462 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING 4B4 UniProtKB/TrEMBL
  SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Mfsd4b4 PhenoGen
RatGTEx ENSRNOG00000024543 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt A6KIH2 ENTREZGENE, UniProtKB/TrEMBL
  F1LTM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-01-06 Mfsd4b4  major facilitator superfamily domain containing 4B4  Mfsd4b1  major facilitator superfamily domain containing 4B1  Name and Symbol changed 629549 APPROVED
2022-07-07 Mfsd4b1  major facilitator superfamily domain containing 4B1  Mfsd4b  major facilitator superfamily domain containing 4B  Name and Symbol changed 629549 APPROVED
2016-01-15 Mfsd4b  major facilitator superfamily domain containing 4B  RGD1559971  similar to Na+ dependent glucose transporter 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559971  similar to Na+ dependent glucose transporter 1   RGD1559971_predicted  similar to Na+ dependent glucose transporter 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559971_predicted  similar to Na+ dependent glucose transporter 1 (predicted)  LOC499462  similar to Na+ dependent glucose transporter 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499462  similar to Na+ dependent glucose transporter 1      Symbol and Name status set to provisional 70820 PROVISIONAL