Camp (cathelicidin antimicrobial peptide) - Rat Genome Database

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Gene: Camp (cathelicidin antimicrobial peptide) Rattus norvegicus
Analyze
Symbol: Camp
Name: cathelicidin antimicrobial peptide
RGD ID: 1559878
Description: Predicted to enable lipopolysaccharide binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of angiogenesis; and response to bacterium. Located in cell projection and extracellular space. Orthologous to human CAMP (cathelicidin antimicrobial peptide); PARTICIPATES IN tuberculosis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathelicidin; cathelin-related antimicrobial peptide; CRAMP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,720,184 - 118,721,998 (-)NCBIGRCr8
mRatBN7.28109,841,729 - 109,843,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,841,729 - 109,843,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,457,212 - 115,459,026 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,656,393 - 113,658,207 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,499,195 - 111,501,009 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,930,557 - 117,932,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,930,546 - 117,932,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,283,070 - 117,284,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,214,914 - 114,216,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8109,131,521 - 109,133,335 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
calcipotriol  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
genistein  (ISO)
glyoxal  (EXP)
isoflurane  (ISO)
ivermectin  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
maneb  (EXP,ISO)
manganese(II) chloride  (EXP)
metacetamol  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
pterostilbene  (ISO)
pyridaben  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
selumetinib  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells. Brandenburg LO, etal., J Neuroimmunol. 2009 Dec 10;217(1-2):55-64. Epub 2009 Oct 30.
2. Lysozyme-modified probiotic components protect rats against polymicrobial sepsis: role of macrophages and cathelicidin-related innate immunity. Bu HF, etal., J Immunol. 2006 Dec 15;177(12):8767-76.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. Yang YH, etal., J Pharmacol Exp Ther. 2006 Aug;318(2):547-54. Epub 2006 May 2.
Additional References at PubMed
PMID:7529412   PMID:9148921   PMID:9182550   PMID:12759353   PMID:12860195   PMID:14978112   PMID:15934934   PMID:16020269   PMID:16177355   PMID:17012259   PMID:18714013   PMID:19056867  
PMID:20209079   PMID:20392497   PMID:20421939   PMID:21115716   PMID:23376485   PMID:23533145   PMID:23537644   PMID:23670560  


Genomics

Comparative Map Data
Camp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,720,184 - 118,721,998 (-)NCBIGRCr8
mRatBN7.28109,841,729 - 109,843,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,841,729 - 109,843,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,457,212 - 115,459,026 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,656,393 - 113,658,207 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,499,195 - 111,501,009 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,930,557 - 117,932,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,930,546 - 117,932,518 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,283,070 - 117,284,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,214,914 - 114,216,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8109,131,521 - 109,133,335 (-)NCBICelera
Cytogenetic Map8q32NCBI
CAMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,223,495 - 48,225,485 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,223,347 - 48,225,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37348,264,985 - 48,266,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,239,866 - 48,241,979 (+)NCBINCBI36Build 36hg18NCBI36
Build 34348,239,865 - 48,241,979NCBI
Celera348,215,428 - 48,217,541 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,318,971 - 48,321,115 (+)NCBIHuRef
CHM1_1348,217,141 - 48,219,285 (+)NCBICHM1_1
T2T-CHM13v2.0348,251,295 - 48,253,285 (+)NCBIT2T-CHM13v2.0
Camp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,676,445 - 109,678,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,676,447 - 109,678,685 (-)EnsemblGRCm39 Ensembl
GRCm389109,847,377 - 109,849,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,847,379 - 109,849,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,749,891 - 109,751,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,704,793 - 109,706,855 (-)NCBIMGSCv36mm8
Celera9109,574,006 - 109,576,084 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.8NCBI
Camp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542024,911,920 - 24,914,698 (+)NCBIChiLan1.0ChiLan1.0
CAMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,190,780 - 48,192,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,195,548 - 48,197,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,137,785 - 48,139,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,222,110 - 49,224,250 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,222,110 - 49,224,250 (+)Ensemblpanpan1.1panPan2
CAMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,790,823 - 40,792,781 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,790,811 - 40,792,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,708,394 - 40,710,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,276,545 - 41,278,503 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,276,545 - 41,278,516 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,517,066 - 40,519,024 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,918,458 - 40,920,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,199,059 - 41,201,017 (-)NCBIUU_Cfam_GSD_1.0
LOC110255221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11331,011,029 - 31,013,164 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CAMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,610,180 - 9,618,629 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,610,298 - 9,613,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,484,000 - 157,493,140 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473073,429,893 - 73,431,104 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Camp
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:118
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000028130
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 18 6 18
Low 2 8 14 6 13 6 1 1 16 14 20 11 1
Below cutoff 1 18 13 10 10 4 5 35 9 13 4

Sequence


RefSeq Acc Id: ENSRNOT00000028130   ⟹   ENSRNOP00000028130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,841,729 - 109,843,543 (-)Ensembl
Rnor_6.0 Ensembl8117,930,546 - 117,932,518 (-)Ensembl
RefSeq Acc Id: NM_001100724   ⟹   NP_001094194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,720,184 - 118,721,998 (-)NCBI
mRatBN7.28109,841,729 - 109,843,543 (-)NCBI
Rnor_6.08117,930,557 - 117,932,371 (-)NCBI
Rnor_5.08117,283,070 - 117,284,884 (-)NCBI
RGSC_v3.48114,214,914 - 114,216,728 (-)RGD
Celera8109,131,521 - 109,133,335 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094194 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ05977 (Get FASTA)   NCBI Sequence Viewer  
  EDL77100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028130
  ENSRNOP00000028130.4
RefSeq Acc Id: NP_001094194   ⟸   NM_001100724
- Peptide Label: precursor
- UniProtKB: G3V8S9 (UniProtKB/TrEMBL),   A6I3C7 (UniProtKB/TrEMBL),   Q71KM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028130   ⟸   ENSRNOT00000028130
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8S9-F1-model_v2 AlphaFold G3V8S9 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559878 AgrOrtholog
BioCyc Gene G2FUF-29085 BioCyc
Ensembl Genes ENSRNOG00000020733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028130 ENTREZGENE
  ENSRNOT00000028130.8 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cathelicidin UniProtKB/TrEMBL
  Cathelicidin_CS UniProtKB/TrEMBL
  Cathlecidin_C UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
KEGG Report rno:316010 UniProtKB/TrEMBL
NCBI Gene 316010 ENTREZGENE
PANTHER CATHELICIDIN ANTIMICROBIAL PEPTIDE UniProtKB/TrEMBL
  PTHR10206 UniProtKB/TrEMBL
Pfam CAP18_C UniProtKB/TrEMBL
  Cathelicidins UniProtKB/TrEMBL
PharmGKB CAMP RGD
PhenoGen Camp PhenoGen
PROSITE CATHELICIDINS_1 UniProtKB/TrEMBL
  CATHELICIDINS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020733 RatGTEx
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A6I3C7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8S9 ENTREZGENE, UniProtKB/TrEMBL
  Q71KM5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Camp  cathelicidin antimicrobial peptide  CRAMP  cathelicidin  Symbol and Name updated 1299863 APPROVED
2006-02-09 CRAMP  cathelicidin      Symbol and Name status set to provisional 70820 PROVISIONAL