Nrg3 (neuregulin 3) - Rat Genome Database

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Gene: Nrg3 (neuregulin 3) Rattus norvegicus
Analyze
Symbol: Nrg3
Name: neuregulin 3
RGD ID: 1559678
Description: Predicted to enable chemorepellent activity. Predicted to be involved in several processes, including ERBB4-ERBB4 signaling pathway; modulation of chemical synaptic transmission; and synapse assembly. Predicted to act upstream of or within mammary placode formation; pattern specification process; and regulation of cell migration. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space and glutamatergic synapse. Orthologous to human NRG3 (neuregulin 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498596; pro-neuregulin-3, membrane-bound isoform; RGD1559678; similar to neuregulin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81614,256,540 - 15,374,107 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1614,257,148 - 15,374,147 (-)EnsemblGRCr8
mRatBN7.21614,229,270 - 15,352,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1614,235,157 - 15,352,368 (-)EnsemblmRatBN7.2
Rnor_6.01615,763,031 - 16,932,208 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1615,764,632 - 15,798,974 (-)Ensemblrn6Rnor6.0
Rnor_5.01615,661,430 - 16,817,319 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41614,679,903 - 15,817,157 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1614,466,369 - 15,581,462 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Neuregulins and cancer. Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9275162   PMID:10723730   PMID:16140987   PMID:22376909   PMID:29114105   PMID:30328115  


Genomics

Comparative Map Data
Nrg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81614,256,540 - 15,374,107 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1614,257,148 - 15,374,147 (-)EnsemblGRCr8
mRatBN7.21614,229,270 - 15,352,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1614,235,157 - 15,352,368 (-)EnsemblmRatBN7.2
Rnor_6.01615,763,031 - 16,932,208 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1615,764,632 - 15,798,974 (-)Ensemblrn6Rnor6.0
Rnor_5.01615,661,430 - 16,817,319 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41614,679,903 - 15,817,157 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1614,466,369 - 15,581,462 (-)NCBICelera
Cytogenetic Map16p14NCBI
NRG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381081,875,194 - 82,987,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1081,875,194 - 82,987,179 (+)Ensemblhg38GRCh38
GRCh371083,634,950 - 84,746,935 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361083,625,077 - 84,735,341 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1077,630,757 - 78,742,147 (+)NCBICelera
Cytogenetic Map10q23.1NCBI
HuRef1077,483,814 - 78,594,633 (+)NCBIHuRef
CHM1_11083,917,602 - 85,028,760 (+)NCBICHM1_1
T2T-CHM13v2.01082,749,017 - 83,860,555 (+)NCBIT2T-CHM13v2.0
Nrg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391438,086,093 - 39,195,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1438,090,909 - 39,195,045 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381438,365,102 - 39,473,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1438,368,952 - 39,473,088 (-)Ensemblmm10GRCm38
MGSCv371439,182,137 - 40,286,376 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361437,282,204 - 38,384,967 (-)NCBIMGSCv36mm8
Celera1434,560,237 - 35,661,300 (-)NCBICelera
Cytogenetic Map14BNCBI
Nrg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555101,615,316 - 2,618,617 (+)Ensembl
ChiLan1.0NW_0049555101,615,316 - 2,620,031 (+)NCBIChiLan1.0ChiLan1.0
NRG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2893,833,755 - 94,981,643 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11093,839,076 - 94,986,963 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01078,267,693 - 79,384,895 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11081,862,024 - 82,974,743 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1081,862,036 - 82,973,334 (+)EnsemblpanPan2panpan1.1
NRG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1430,515,845 - 31,557,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl430,515,890 - 31,556,152 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha430,570,501 - 31,546,936 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0430,834,334 - 31,875,634 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl430,834,349 - 31,874,016 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1430,699,630 - 31,739,836 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0430,896,586 - 31,931,272 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0431,385,545 - 32,426,952 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101957192
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721349,019,288 - 50,047,975 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367161,362,574 - 2,391,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1483,317,019 - 84,402,943 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11483,316,962 - 84,405,347 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21490,842,758 - 91,108,804 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1948,846,287 - 49,957,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660489,110,091 - 10,240,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248414,219,084 - 5,285,240 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248414,213,089 - 5,285,255 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nrg3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11316,891,916 - 17,972,351 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nrg3
8805 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:54
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000046842, ENSRNOT00000065946
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Got15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21614,809,226 - 14,809,357 (+)MAPPERmRatBN7.2
Rnor_6.01616,381,383 - 16,381,513NCBIRnor6.0
Rnor_5.01616,270,747 - 16,270,877UniSTSRnor5.0
RGSC_v3.41615,267,951 - 15,268,082RGDRGSC3.4
RGSC_v3.41615,267,952 - 15,268,082UniSTSRGSC3.4
Celera1615,039,042 - 15,039,172UniSTS
RGSC_v3.11615,267,950 - 15,268,080RGD
RH 3.4 Map16132.5RGD
RH 3.4 Map16132.5UniSTS
RH 2.0 Map1692.9RGD
Cytogenetic Map16p14UniSTS
D16Got101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21615,085,394 - 15,085,632 (+)MAPPERmRatBN7.2
Rnor_6.01616,659,553 - 16,659,790NCBIRnor6.0
Rnor_5.01616,548,851 - 16,549,088UniSTSRnor5.0
RGSC_v3.41615,547,850 - 15,548,087UniSTSRGSC3.4
Celera1615,314,900 - 15,315,137UniSTS
Cytogenetic Map16p14UniSTS
BF412035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21614,499,115 - 14,499,330 (+)MAPPERmRatBN7.2
Rnor_6.01616,029,664 - 16,029,878NCBIRnor6.0
Rnor_5.01615,927,226 - 15,927,440UniSTSRnor5.0
RGSC_v3.41614,950,282 - 14,950,496UniSTSRGSC3.4
Celera1614,729,871 - 14,730,085UniSTS
RH 3.4 Map16126.1UniSTS
Cytogenetic Map16p14UniSTS
RH138878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21614,605,047 - 14,605,231 (+)MAPPERmRatBN7.2
Rnor_6.01616,166,733 - 16,166,916NCBIRnor6.0
Rnor_5.01616,056,547 - 16,056,730UniSTSRnor5.0
RGSC_v3.41615,059,615 - 15,059,798UniSTSRGSC3.4
Celera1614,835,871 - 14,836,054UniSTS
RH 3.4 Map16126.7UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 7 26 149 39 34 15 12 15 6 134 58 1 142 47 65 19 26 26

Sequence


Ensembl Acc Id: ENSRNOT00000046842   ⟹   ENSRNOP00000042884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1615,764,632 - 15,798,974 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065946   ⟹   ENSRNOP00000059751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1615,764,632 - 15,798,974 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099299   ⟹   ENSRNOP00000077709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1614,257,148 - 15,374,147 (-)Ensembl
mRatBN7.2 Ensembl1614,235,157 - 15,352,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111170   ⟹   ENSRNOP00000080898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1614,257,148 - 15,374,147 (-)Ensembl
mRatBN7.2 Ensembl1614,235,157 - 15,352,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169124   ⟹   ENSRNOP00000100753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1614,257,148 - 15,374,147 (-)Ensembl
RefSeq Acc Id: XM_017600398   ⟹   XP_017455887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
Rnor_6.01615,763,031 - 16,932,208 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095027   ⟹   XP_038950955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095028   ⟹   XP_038950956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095029   ⟹   XP_038950957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095030   ⟹   XP_038950958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095031   ⟹   XP_038950959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095032   ⟹   XP_038950960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_039095033   ⟹   XP_038950961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
mRatBN7.21614,229,270 - 15,352,505 (-)NCBI
RefSeq Acc Id: XM_063275921   ⟹   XP_063131991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81614,256,540 - 15,374,107 (-)NCBI
RefSeq Acc Id: XP_017455887   ⟸   XM_017600398
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059751   ⟸   ENSRNOT00000065946
Ensembl Acc Id: ENSRNOP00000042884   ⟸   ENSRNOT00000046842
RefSeq Acc Id: XP_038950957   ⟸   XM_039095029
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950961   ⟸   XM_039095033
- Peptide Label: isoform X8
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950960   ⟸   XM_039095032
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038950956   ⟸   XM_039095028
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950959   ⟸   XM_039095031
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950955   ⟸   XM_039095027
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950958   ⟸   XM_039095030
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZU04 (UniProtKB/TrEMBL),   A0A8I5Y1H8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077709   ⟸   ENSRNOT00000099299
Ensembl Acc Id: ENSRNOP00000080898   ⟸   ENSRNOT00000111170
RefSeq Acc Id: XP_063131991   ⟸   XM_063275921
- Peptide Label: isoform X9
- UniProtKB: A0A8I5Y1H8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100753   ⟸   ENSRNOT00000169124
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M182-F1-model_v2 AlphaFold F1M182 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559678 AgrOrtholog
BioCyc Gene G2FUF-11959 BioCyc
Ensembl Genes ENSRNOG00000033894 Ensembl
  ENSRNOG00000063450 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099299 ENTREZGENE
  ENSRNOT00000099299.2 UniProtKB/TrEMBL
  ENSRNOT00000111170 ENTREZGENE
  ENSRNOT00000111170.2 UniProtKB/TrEMBL
  ENSRNOT00000169124 ENTREZGENE
  ENSRNOT00000169124.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Neuregulin UniProtKB/TrEMBL
NCBI Gene 498596 ENTREZGENE
PANTHER PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM UniProtKB/TrEMBL
  PTHR11100 UniProtKB/TrEMBL
PhenoGen Nrg3 PhenoGen
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033894 RatGTEx
  ENSRNOG00000063450 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8I5Y1H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZU04 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKG2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Nrg3  neuregulin 3  Nrg3  neuregulin 3  Data merged from RGD:149736215 737654 PROVISIONAL
2021-08-09 Nrg3  neuregulin 3      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-02-28 Nrg3  neuregulin 3  RGD1559678_predicted  similar to neuregulin-3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559678_predicted  similar to neuregulin-3 (predicted)  LOC498596  similar to neuregulin-3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498596  similar to neuregulin-3      Symbol and Name status set to provisional 70820 PROVISIONAL