Atp5mc1l2 (ATP synthase membrane subunit c locus 1 like 2) - Rat Genome Database

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Gene: Atp5mc1l2 (ATP synthase membrane subunit c locus 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Atp5mc1l2
Name: ATP synthase membrane subunit c locus 1 like 2
RGD ID: 1559629
Description: Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of proton-transporting ATP synthase complex. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH bisphenol A; Cuprizon; fipronil.
Type: protein-coding (Ensembl: processed_pseudogene)
RefSeq Status: MODEL
Previously known as: AABR07064224.1; ATP synthase F(0) complex subunit C1, mitochondrial-like; LOC366614; RGD1559629; similar to H+ ATP synthase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8672,381,081 - 72,381,479 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl672,381,081 - 72,381,479 (+)EnsemblGRCr8
mRatBN7.2666,654,187 - 66,654,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl666,654,294 - 66,654,692 (+)EnsemblmRatBN7.2
Rnor_6.0669,950,129 - 69,951,013 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl669,950,500 - 69,950,898 (+)NCBIrn6Rnor6.0
Rnor_5.0679,512,128 - 79,512,526 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4669,197,171 - 69,197,569 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera665,581,850 - 65,582,734 (+)NCBICelera
Cytogenetic Map6q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
Cuprizon  (EXP)
fipronil  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Atp5mc1l2
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000049500
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000049500   ⟹   ENSRNOP00000048392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl672,381,081 - 72,381,479 (+)Ensembl
mRatBN7.2 Ensembl666,654,294 - 66,654,692 (+)Ensembl
RefSeq Acc Id: XM_039113178   ⟹   XP_038969106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8672,381,081 - 72,381,479 (+)NCBI
mRatBN7.2666,654,187 - 66,654,763 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038969106 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_038969106   ⟸   XM_039113178
- UniProtKB: D3Z869 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000048392   ⟸   ENSRNOT00000049500

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z869-F1-model_v2 AlphaFold D3Z869 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559629 AgrOrtholog
BioCyc Gene G2FUF-37627 BioCyc
Ensembl Genes ENSRNOG00000031317 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049500 ENTREZGENE
NCBI Gene 366614 ENTREZGENE
PhenoGen Atp5mc1l2 PhenoGen
RatGTEx ENSRNOG00000031317 RatGTEx
UniProt D3Z869 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Atp5mc1l2  ATP synthase membrane subunit c locus 1 like 2  RGD1559629  similar to H+ ATP synthase  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1559629  similar to H+ ATP synthase  AABR07064224.1    Data merged from RGD:15003874 737654 PROVISIONAL
2019-11-08 AABR07064224.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1559629  similar to H+ ATP synthase   RGD1559629_predicted  similar to H+ ATP synthase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559629_predicted  similar to H+ ATP synthase (predicted)  LOC366614  similar to H+ ATP synthase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366614  similar to H+ ATP synthase      Symbol and Name status set to provisional 70820 PROVISIONAL