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Gene: Wdr53 (WD repeat domain 53) Rattus norvegicus

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Symbol:

Wdr53

Name:

WD repeat domain 53

RGD ID:

1559546

Description:

Orthologous to human WDR53 (WD repeat domain 53); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC498097; RGD1559546; similar to WD repeat domain 53; WD repeat-containing protein 53

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR53 (WD repeat domain 53)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Wdr53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wdr53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WDR53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wdr53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WDR53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Wdr53 (WD repeat domain 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	WDR53 (WD repeat domain 53)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wdr53 (WD repeat domain 53)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wdr53 (WD repeat domain 53)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	wdr53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	82,047,674 - 82,056,217 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	82,047,678 - 82,056,044 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,542,647 - 68,551,148 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,542,650 - 68,551,112 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,379,703 - 77,388,093 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	70,037,090 - 70,045,486 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,068,811 - 69,077,203 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	71,787,454 - 71,796,258 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	71,787,457 - 71,795,796 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	74,871,566 - 74,880,361 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,362,385 - 70,370,721 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	67,967,039 - 67,975,246 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

cisplatin (ISO)

Dibutyl phosphate (ISO)

folic acid (ISO)

gentamycin (EXP)

paracetamol (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

senecionine (ISO)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Wdr53
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	82,047,674 - 82,056,217 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	82,047,678 - 82,056,044 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,542,647 - 68,551,148 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,542,650 - 68,551,112 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,379,703 - 77,388,093 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	70,037,090 - 70,045,486 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,068,811 - 69,077,203 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	71,787,454 - 71,796,258 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	71,787,457 - 71,795,796 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	74,871,566 - 74,880,361 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,362,385 - 70,370,721 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	67,967,039 - 67,975,246 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

WDR53
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	196,554,177 - 196,568,554 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	196,552,228 - 196,569,263 (-)	Ensembl			hg38	GRCh38
GRCh37	3	196,281,048 - 196,295,425 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	197,765,456 - 197,779,810 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	197,769,370 - 197,783,723	NCBI
Celera	3	194,863,098 - 194,877,452 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	193,578,491 - 193,592,848 (-)	NCBI		HuRef
CHM1_1	3	196,252,299 - 196,266,667 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	199,273,436 - 199,287,838 (-)	NCBI		T2T-CHM13v2.0

Wdr53
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	32,066,047 - 32,075,901 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	32,066,045 - 32,075,901 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	32,247,227 - 32,257,085 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	32,247,227 - 32,257,083 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	32,247,313 - 32,257,169 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	32,167,033 - 32,176,819 (+)	NCBI		MGSCv36	mm8
Celera	16	32,732,270 - 32,742,151 (+)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	22.47	NCBI

Wdr53
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	12,694,237 - 12,714,613 (-)	Ensembl
ChiLan1.0	NW_004955420	12,694,208 - 12,714,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

WDR53
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	194,424,833 - 194,439,366 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	194,429,560 - 194,444,070 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	193,899,185 - 193,913,716 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	203,841,809 - 203,856,569 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	203,841,809 - 203,855,792 (-)	Ensembl			panPan2	panpan1.1

WDR53
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	29,614,542 - 29,627,983 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	29,638,532 - 29,651,882 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	29,857,639 - 29,871,325 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	29,857,650 - 29,871,274 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	29,635,621 - 29,648,729 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	29,690,901 - 29,704,244 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	30,313,244 - 30,326,591 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Wdr53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	124,722,731 - 124,736,061 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936784	1,149,125 - 1,162,679 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936784	1,149,208 - 1,162,661 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR53
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	133,561,021 - 133,574,376 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	133,560,832 - 133,573,042 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

WDR53
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	90,647,680 - 90,662,427 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	90,647,718 - 90,662,641 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	64,444,900 - 64,459,838 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wdr53
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	61,641,450 - 61,666,975 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	61,644,358 - 61,667,005 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Wdr53
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	17,059,915 - 17,068,588 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Wdr53
25 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	117
Interacting mature miRNAs:	131
Transcripts:	ENSRNOT00000002392
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	73308487	96070872	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	58928336	99753367	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	79618519	99753367	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	73850894	99753367	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	54415391	96071021	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	58931822	92356038	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	57754837	96071021	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	67962184	99753367	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	68599321	96497754	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	69855943	99753367	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	73308315	99753367	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	51071021	96071021	Rat

Markers in Region

RH132100

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,542,714 - 68,542,932 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	71,787,518 - 71,787,735	NCBI	Rnor6.0
Rnor_5.0	11	74,871,630 - 74,871,847	UniSTS	Rnor5.0
RGSC_v3.4	11	70,362,446 - 70,362,663	UniSTS	RGSC3.4
Celera	11	67,967,100 - 67,967,317	UniSTS
RH 3.4 Map	11	375.82	UniSTS
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002392 ⟹ ENSRNOP00000002392

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	82,047,678 - 82,056,044 (-)	Ensembl
mRatBN7.2 Ensembl	11	68,542,654 - 68,550,990 (-)	Ensembl
Rnor_6.0 Ensembl	11	71,787,457 - 71,795,796 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095477 ⟹ ENSRNOP00000078921

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,542,650 - 68,551,112 (-)	Ensembl

RefSeq Acc Id:

NM_001109055 ⟹ NP_001102525

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,678 - 82,056,044 (-)	NCBI
mRatBN7.2	11	68,542,651 - 68,551,017 (-)	NCBI
Rnor_6.0	11	71,787,457 - 71,795,796 (-)	NCBI
Rnor_5.0	11	74,871,566 - 74,880,361 (-)	NCBI
RGSC_v3.4	11	70,362,385 - 70,370,721 (-)	RGD
Celera	11	67,967,039 - 67,975,246 (-)	RGD

Sequence:

show sequence

GTGGGATTCTGATCTGTTCTCAAGTGCGTTTTTCTGTTTTTCCTCTAATGGCCTTGAGTCGGCT
TTCCTTGGCCTCTCTTCCTACGGAGTTTCCCGTTTCATTTGCTTTCTGCTCATTCTCCAACTTT
GTTTACGACAAAGTTTGCTAGCCAGTTCTTAGATCCTTCATCTTCAGTTCGCTTGGATCCATTA
ACTTTACCTTTGGGCAGTTGGAGACCTCTTGTCGTGGTCAGGTTAGATCCATTTTACTTTATTT
TTTACCTTGAGAAATTGACATCGTCTTTTCCTGGCTAGGACAGTAGGGGACTCAACAGAACATC
TATACAGTATCCATTCTAAAAAATTTTGCAGGCCATCATGGCAGTCAAGTGGACTGGAGGACAT
TCTTCTTCAATCCTTTGCCTGAATGCAAGTAAAGACGGGCTGGTGGCTTCAGGAGGAGAAGGTG
GAGACCTTGTGGCTTGGGGTGAAGATGGGACCCCTGTAGGACACATGCAGTTGGAAGGGGCAGA
TGATGTTACCAGCATCGTGTTTTCCGCTTCCTGCCCCACCAAGCTCTATGCCTCCCATGGAGAG
TCCATCAGTGTACTAGATGTCAGGTCTCTCAAAGGGTGCCTGGACCACTTTCATGTGAATGAGG
AAGAAATCAATTGTCTTTCATTAAATGAAACTGAAAGTCTGCTGGCTTCTGCTGATGACTCTGG
GGCAATCAAAATCCTCGACTTGGAAAAGAAGAAAGTTACCAGATCCCTGAAGAGACATTCCAAC
ATTTGTTCCTCTGTGGCTTTTCGACCTCAGAGGCCTCAGAGCCTGGTGTCATGCGGCTTGGATA
TGCAGGTAATGCTGTGGAGTCTTCAAAAAGCCCGACCTGTCTGGATTACAAATTTACAGGAGGA
TGAAACAGAGGAAACGGAAGGCCCCCAGACCCCTGGTCGGCTCCTAAACCCTGCACTAGCCCAC
TCTATCTCTGTGGCATCGTGTGGCAACATTTTTAGCTGTGGTGCAGAGGATGGTAAAGTGCGCA
TCTTCAGGGTGATGGGAGTCAAATGTGAGCGAGAATTGGGATTTAAGGGACATACTCTGGGTGT
ATCCCAGGTCTGCTTTCTGCCCGAGTCCCATCTGCTGCTCACAGGAGGGAATGACGGGAAGATA
AGGTTGTGGGACGTGAGCGGCAAAATGGAGAAACAGCAGAAGAGTCCCGTGAAGCACATCCACA
GGAAGAAAACAAAGAGGGCAGTGCGCCCCACGCAGAGTGGGGACTCTAGAGCCCCGGGGGCCGA
GGACGAGGGACTTGCAAAGCTTCTACCGAAGCTCGATATTGAACACGGAGAAAAAGTGAACTGG
CTGTTGAGTACAAAAATAAAAGGGAACCAAAGCATATTAGTGGCCGATCAGACGAGTTGTGTGT
CTGTGTATCCCCTGAATGAACTTTAGGTCCAATAAAGTGCTTTGAAAGAAC

hide sequence

RefSeq Acc Id:

NM_001399295 ⟹ NP_001386224

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,678 - 82,056,074 (-)	NCBI
mRatBN7.2	11	68,542,651 - 68,551,047 (-)	NCBI

RefSeq Acc Id:

NM_001399296 ⟹ NP_001386225

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,678 - 82,056,044 (-)	NCBI
mRatBN7.2	11	68,542,651 - 68,551,017 (-)	NCBI

RefSeq Acc Id:

XM_017598046 ⟹ XP_017453535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,674 - 82,056,018 (-)	NCBI
mRatBN7.2	11	68,542,647 - 68,550,992 (-)	NCBI
Rnor_6.0	11	71,787,454 - 71,795,798 (-)	NCBI

Sequence:

show sequence

TAGTGGGATTCTGATCTGTTCTCAAAATTTTGCAGGCCATCATGGCAGTCAAGTGGACTGGAGG
ACATTCTTCTTCAATCCTTTGCCTGAATGCAAGTAAAGACGGGCTGGTGGCTTCAGGAGGAGAA
GGTGGAGACCTTGTGGCTTGGGGTGAAGATGGGACCCCTGTAGGACACATGCAGTTGGAAGGGG
CAGATGATGTTACCAGCATCGTGTTTTCCGCTTCCTGCCCCACCAAGCTCTATGCCTCCCATGG
AGAGTCCATCAGTGTACTAGATGTCAGGTCTCTCAAAGGGTGCCTGGACCACTTTCATGTGAAT
GAGGAAGAAATCAATTGTCTTTCATTAAATGAAACTGAAAGTCTGCTGGCTTCTGCTGATGACT
CTGGGGCAATCAAAATCCTCGACTTGGAAAAGAAGAAAGTTACCAGATCCCTGAAGAGACATTC
CAACATTTGTTCCTCTGTGGCTTTTCGACCTCAGAGGCCTCAGAGCCTGGTGTCATGCGGCTTG
GATATGCAGGTAATGCTGTGGAGTCTTCAAAAAGCCCGACCTGTCTGGATTACAAATTTACAGG
AGGATGAAACAGAGGAAACGGAAGGCCCCCAGACCCCTGGTCGGCTCCTAAACCCTGCACTAGC
CCACTCTATCTCTGTGGCATCGTGTGGCAACATTTTTAGCTGTGGTGCAGAGGATGGTAAAGTG
CGCATCTTCAGGGTGATGGGAGTCAAATGTGAGCGAGAATTGGGATTTAAGGGACATACTCTGG
GTGTATCCCAGGTCTGCTTTCTGCCCGAGTCCCATCTGCTGCTCACAGGAGGGAATGACGGGAA
GATAAGGTTGTGGGACGTGAGCGGCAAAATGGAGAAACAGCAGAAGAGTCCCGTGAAGCACATC
CACAGGAAGAAAACAAAGAGGGCAGTGCGCCCCACGCAGAGTGGGGACTCTAGAGCCCCGGGGG
CCGAGGACGAGGGACTTGCAAAGCTTCTACCGAAGCTCGATATTGAACACGGAGAAAAAGTGAA
CTGGCTGTTGAGTACAAAAATAAAAGGGAACCAAAGCATATTAGTGGCCGATCAGACGAGTTGT
GTGTCTGTGTATCCCCTGAATGAACTTTAGGTCCAATAAAGTGCTTTGAAAGAACCGA

hide sequence

RefSeq Acc Id:

XM_039088580 ⟹ XP_038944508

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,048,172 - 82,056,217 (-)	NCBI
mRatBN7.2	11	68,543,145 - 68,551,148 (-)	NCBI

RefSeq Acc Id:

XM_039088581 ⟹ XP_038944509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,674 - 82,051,910 (-)	NCBI
mRatBN7.2	11	68,542,647 - 68,546,881 (-)	NCBI

RefSeq Acc Id:

XM_063270707 ⟹ XP_063126777

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,674 - 82,056,060 (-)	NCBI

RefSeq Acc Id:

XM_063270708 ⟹ XP_063126778

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,047,674 - 82,051,958 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102525	(Get FASTA)	NCBI Sequence Viewer
	NP_001386224	(Get FASTA)	NCBI Sequence Viewer
	NP_001386225	(Get FASTA)	NCBI Sequence Viewer
	XP_017453535	(Get FASTA)	NCBI Sequence Viewer
	XP_038944508	(Get FASTA)	NCBI Sequence Viewer
	XP_038944509	(Get FASTA)	NCBI Sequence Viewer
	XP_063126777	(Get FASTA)	NCBI Sequence Viewer
	XP_063126778	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM11430	(Get FASTA)	NCBI Sequence Viewer
	EDM11431	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002392
	ENSRNOP00000002392.3

RefSeq Acc Id:

NP_001102525 ⟸ NM_001109055

- UniProtKB:

D4ADI9 (UniProtKB/TrEMBL), A6IRS7 (UniProtKB/TrEMBL), A0A8I5ZLS1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVKWTGGHSSSILCLNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCP
TKLYASHGESISVLDVRSLKGCLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKV
TRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPVWITNLQEDETEETEGPQTPG
RLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELGFKGHTLGVSQVCFLPESHLL
LTGGNDGKIRLWDVSGKMEKQQKSPVKHIHRKKTKRAVRPTQSGDSRAPGAEDEGLAKLLPKLD
IEHGEKVNWLLSTKIKGNQSILVADQTSCVSVYPLNEL

hide sequence

RefSeq Acc Id:	XP_017453535 ⟸ XM_017598046
- Peptide Label:	isoform X1
- UniProtKB:	D4ADI9 (UniProtKB/TrEMBL), A6IRS7 (UniProtKB/TrEMBL), A0A8I5ZLS1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVKWTGGHSSSILCLNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCP TKLYASHGESISVLDVRSLKGCLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKV TRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPVWITNLQEDETEETEGPQTPG RLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELGFKGHTLGVSQVCFLPESHLL LTGGNDGKIRLWDVSGKMEKQQKSPVKHIHRKKTKRAVRPTQSGDSRAPGAEDEGLAKLLPKLD IEHGEKVNWLLSTKIKGNQSILVADQTSCVSVYPLNEL hide sequence

Ensembl Acc Id:

ENSRNOP00000002392 ⟸ ENSRNOT00000002392

RefSeq Acc Id:	XP_038944509 ⟸ XM_039088581
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038944508 ⟸ XM_039088580
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000078921 ⟸ ENSRNOT00000095477

RefSeq Acc Id:	NP_001386224 ⟸ NM_001399295
- UniProtKB:	D4ADI9 (UniProtKB/TrEMBL), A6IRS7 (UniProtKB/TrEMBL), A0A8I5ZLS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001386225 ⟸ NM_001399296
- UniProtKB:	D4ADI9 (UniProtKB/TrEMBL), A6IRS7 (UniProtKB/TrEMBL), A0A8I5ZLS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126777 ⟸ XM_063270707
- Peptide Label:	isoform X1
- UniProtKB:	A6IRS7 (UniProtKB/TrEMBL), D4ADI9 (UniProtKB/TrEMBL), A0A8I5ZLS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126778 ⟸ XM_063270708
- Peptide Label:	isoform X3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADI9-F1-model_v2	AlphaFold	D4ADI9	1-358	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698212

Promoter ID:

EPDNEW_R8737

Type:

multiple initiation site

Name:

Wdr53_1

Description:

WD repeat domain 53

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	71,795,844 - 71,795,904	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559546	AgrOrtholog
BioCyc Gene	G2FUF-21088	BioCyc
Ensembl Genes	ENSRNOG00000001754	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002392	ENTREZGENE
	ENSRNOT00000002392.6	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WDR53	UniProtKB/TrEMBL
KEGG Report	rno:498097	UniProtKB/TrEMBL
NCBI Gene	498097	ENTREZGENE
PANTHER	PTHR44666	UniProtKB/TrEMBL
	WD REPEAT-CONTAINING PROTEIN 53	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Wdr53	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001754	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZLS1	ENTREZGENE
	A6IRS7	ENTREZGENE, UniProtKB/TrEMBL
	D4ADI9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Wdr53	WD repeat domain 53	RGD1559546_predicted	similar to WD repeat domain 53 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1559546_predicted	similar to WD repeat domain 53 (predicted)	LOC498097	similar to WD repeat domain 53	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498097	similar to WD repeat domain 53			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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